Cdh2 (cadherin 2) - Rat Genome Database

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Gene: Cdh2 (cadherin 2) Mus musculus
Analyze
Symbol: Cdh2
Name: cadherin 2
RGD ID: 731821
MGI Page MGI
Description: Enables calcium ion binding activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including cell junction assembly; cell-cell adhesion mediated by cadherin; and neuronal stem cell population maintenance. Acts upstream of or within several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; nervous system development; and regulation of signal transduction. Located in several cellular components, including apicolateral plasma membrane; basolateral plasma membrane; and fascia adherens. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; embryo mesenchyme; intervertebral disc; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in agenesis of corpus callosum, cardiac, ocular, and genital syndrome; arrhythmogenic right ventricular cardiomyopathy; and arrhythmogenic right ventricular dysplasia 14. Orthologous to human CDH2 (cadherin 2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cadherin-2; CDHN; N-C; N-CAD; N-cadherin; Nc; Ncad; neural cadherin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm34039  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391816,721,934 - 16,942,303 (-)NCBIGRCm39mm39
GRCm39 Ensembl1816,721,934 - 16,942,303 (-)Ensembl
GRCm381816,588,877 - 16,809,246 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1816,588,877 - 16,809,246 (-)EnsemblGRCm38mm10GRCm38
MGSCv371816,747,386 - 16,967,558 (-)NCBIGRCm37mm9NCBIm37
MGSCv361816,732,027 - 16,952,264 (-)NCBImm8
Celera1817,099,283 - 17,328,154 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map1810.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-Tetrandrine  (ISO)
(S)-amphetamine  (EXP)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (ISO)
1,2-dichloroethane  (EXP)
1,3-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-Dihydroxybenzophenone  (ISO)
2,4-dinitrotoluene  (ISO)
2-butoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
acrylonitrile  (ISO)
aflatoxin B1  (EXP)
alendronic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ametryn  (ISO)
ammonium chloride  (ISO)
andrographolide  (EXP,ISO)
antroquinonol  (ISO)
arecoline  (ISO)
aristolochic acid  (EXP,ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcidiol  (ISO)
calciol  (EXP)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP)
chloroprene  (EXP)
chloroquine  (ISO)
chrysin  (ISO)
cisatracurium  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
corticosterone  (EXP)
coumarin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DAPT  (ISO)
DDE  (ISO)
DDT  (ISO)
Deguelin  (ISO)
delphinidin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
dieckol  (ISO)
dieldrin  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP)
ethyl trans-caffeate  (ISO)
fisetin  (ISO)
flubendazole  (ISO)
fludioxonil  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
Ginkgoic acid  (ISO)
glafenine  (ISO)
Goe 6976  (ISO)
gossypol  (ISO)
hydrogen peroxide  (ISO)
hydroxyflutamide  (ISO)
isoprenaline  (EXP)
isoprene  (ISO)
jaspamide  (ISO)
L-ascorbic acid  (ISO)
lapatinib  (ISO)
lithium chloride  (ISO)
luteolin  (ISO)
LY294002  (ISO)
mebendazole  (ISO)
menadione  (ISO)
mercury dichloride  (ISO)
methapyrilene  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
morusin  (EXP)
N(6),N(6)-dimethyladenine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
niclosamide  (ISO)
nimesulide  (ISO)
nitrogen mustard  (EXP)
Nonylphenol  (EXP,ISO)
novobiocin  (ISO)
oridonin  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
p-cresol  (ISO)
p-tert-Amylphenol  (ISO)
palbociclib  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
phenol red  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pirinixic acid  (EXP,ISO)
potassium iodide  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
quercetin  (ISO)
radon atom  (EXP,ISO)
radon(0)  (EXP,ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
ridaforolimus  (ISO)
rofecoxib  (ISO)
Salidroside  (EXP)
Salinomycin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
Soman  (ISO)
sorafenib  (ISO)
streptozocin  (EXP)
sulforaphane  (EXP)
sulfur dioxide  (EXP)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thymoquinone  (EXP,ISO)
topotecan  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
trimethylarsine oxide  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
vitamin D  (ISO)
vitamin E  (ISO)
wortmannin  (ISO)
XAV939  (ISO)
zardaverine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel morphogenesis  (IBA,IMP)
brain development  (IBA)
brain morphogenesis  (IGI)
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  (IDA,ISO)
cell adhesion  (IDA)
cell migration  (IDA)
cell-cell adhesion  (IDA,ISO)
cell-cell adhesion mediated by cadherin  (IDA)
cell-cell adhesion via plasma-membrane adhesion molecules  (IBA)
cell-cell junction assembly  (IMP)
cerebral cortex development  (IGI)
glial cell differentiation  (IDA)
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  (IDA)
homeostasis of number of cells  (IGI)
homophilic cell adhesion via plasma membrane adhesion molecules  (IBA,IDA)
mesenchymal cell migration  (IMP)
modulation of chemical synaptic transmission  (ISO)
negative regulation of canonical Wnt signaling pathway  (IGI)
neural crest cell development  (IMP)
neuroepithelial cell differentiation  (IGI)
neuroligin clustering involved in postsynaptic membrane assembly  (IMP)
neuronal stem cell population maintenance  (IDA)
positive regulation of MAPK cascade  (IGI)
positive regulation of synaptic vesicle clustering  (IMP)
protein localization to plasma membrane  (IDA)
radial glial cell differentiation  (IGI)
regulation of axonogenesis  (IBA,ISO)
regulation of myelination  (ISO)
regulation of oligodendrocyte progenitor proliferation  (IGI)
regulation of postsynaptic density protein 95 clustering  (IMP)
regulation of protein localization  (ISO)
regulation of Rho protein signal transduction  (ISO)
regulation of signal transduction  (IEA)
regulation of synaptic transmission, glutamatergic  (IBA,ISO)
striated muscle cell differentiation  (IGI)
synapse assembly  (IBA,ISO)
telencephalon development  (IGI)
type B pancreatic cell development  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal brain development  (IAGP)
abnormal cardiovascular system morphology  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal cortical ventricular zone morphology  (IAGP)
abnormal embryo turning  (IAGP)
abnormal heart shape  (IAGP)
abnormal heart tube morphology  (IAGP)
abnormal impulse conducting system conduction  (IAGP)
abnormal intercalated disk morphology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal neocortex morphology  (IAGP)
abnormal nervous system tract morphology  (IAGP)
abnormal neuronal migration  (IAGP)
abnormal radial glial cell morphology  (IAGP)
abnormal somite shape  (IAGP)
abnormal spinal cord morphology  (IAGP)
abnormal spinal cord motor column morphology  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
decreased cardiac output  (IAGP)
decreased heart rate  (IAGP)
decreased ventricle muscle contractility  (IAGP)
dilated heart atrium  (IAGP)
dilated heart left ventricle  (IAGP)
dilated heart right ventricle  (IAGP)
distended pericardium  (IAGP)
ectopic neuron  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged heart  (IAGP)
incomplete somite formation  (IAGP)
increased heart rate  (IAGP)
increased neuronal precursor cell number  (IAGP)
irregular heartbeat  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
pericardial edema  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
thickened cerebral cortex  (IAGP)
wavy neural tube  (IAGP)
References

Additional References at PubMed
PMID:1406710   PMID:1427864   PMID:1528849   PMID:1644219   PMID:2059658   PMID:2144817   PMID:2762814   PMID:7493641   PMID:7556431   PMID:7601910   PMID:7721948   PMID:7750641  
PMID:7750649   PMID:7750650   PMID:7758243   PMID:7885471   PMID:7894164   PMID:7959727   PMID:8107195   PMID:8247017   PMID:8270638   PMID:8314004   PMID:8400409   PMID:8404540  
PMID:8407940   PMID:8555485   PMID:8612964   PMID:8626800   PMID:8662222   PMID:8697804   PMID:8786128   PMID:8787762   PMID:8821035   PMID:8854867   PMID:8879495   PMID:8898231  
PMID:8909549   PMID:9015265   PMID:9070650   PMID:9143504   PMID:9151674   PMID:9153187   PMID:9169087   PMID:9226036   PMID:9226037   PMID:9230075   PMID:9240562   PMID:9336230  
PMID:9367432   PMID:9441666   PMID:9655503   PMID:9922458   PMID:10021345   PMID:10021346   PMID:10333730   PMID:10349636   PMID:10428027   PMID:10545229   PMID:10631174   PMID:10707907  
PMID:10862698   PMID:10893270   PMID:11032855   PMID:11042159   PMID:11076764   PMID:11076861   PMID:11106648   PMID:11171330   PMID:11180952   PMID:11217851   PMID:11283949   PMID:11319859  
PMID:11719554   PMID:11732910   PMID:11784004   PMID:11784073   PMID:11839813   PMID:12001066   PMID:12052883   PMID:12064611   PMID:12095980   PMID:12112462   PMID:12126948   PMID:12203715  
PMID:12213839   PMID:12360290   PMID:12466851   PMID:12477932   PMID:12531901   PMID:12640032   PMID:12686612   PMID:12695331   PMID:12738802   PMID:12865344   PMID:13678586   PMID:14559901  
PMID:14561752   PMID:14610273   PMID:14622577   PMID:14645517   PMID:14645532   PMID:14657280   PMID:14681479   PMID:14687546   PMID:14960280   PMID:15169841   PMID:15192701   PMID:15194693  
PMID:15272007   PMID:15328010   PMID:15371328   PMID:15476585   PMID:15479741   PMID:15496443   PMID:15520228   PMID:15614770   PMID:15662031   PMID:15689381   PMID:15692570   PMID:15713751  
PMID:15741167   PMID:15765519   PMID:15782199   PMID:15809310   PMID:15834408   PMID:15838877   PMID:15861137   PMID:15927725   PMID:15964765   PMID:15989966   PMID:16100040   PMID:16141072  
PMID:16141073   PMID:16185771   PMID:16186258   PMID:16202998   PMID:16267237   PMID:16294273   PMID:16319177   PMID:16377805   PMID:16387292   PMID:16461340   PMID:16514057   PMID:16543460  
PMID:16543498   PMID:16571631   PMID:16602821   PMID:16624865   PMID:16632597   PMID:16687575   PMID:16705170   PMID:16715082   PMID:16807326   PMID:16829211   PMID:16892058   PMID:16895521  
PMID:16951258   PMID:16959241   PMID:16973135   PMID:17002573   PMID:17014840   PMID:17021047   PMID:17060446   PMID:17064680   PMID:17067568   PMID:17112388   PMID:17138661   PMID:17185046  
PMID:17222817   PMID:17255093   PMID:17278136   PMID:17301087   PMID:17360635   PMID:17392819   PMID:17429076   PMID:17507402   PMID:17507657   PMID:17553695   PMID:17553984   PMID:17556662  
PMID:17589506   PMID:17653278   PMID:17663722   PMID:17697936   PMID:17728342   PMID:17765222   PMID:17765678   PMID:17766470   PMID:17767158   PMID:17785185   PMID:17884088   PMID:17898204  
PMID:17916349   PMID:17921113   PMID:18201716   PMID:18224708   PMID:18239929   PMID:18353302   PMID:18356246   PMID:18371351   PMID:18377888   PMID:18383368   PMID:18397997   PMID:18456655  
PMID:18507827   PMID:18521945   PMID:18614579   PMID:18617695   PMID:18652817   PMID:18694874   PMID:18697938   PMID:18718461   PMID:18757513   PMID:18778790   PMID:18794329   PMID:18816447  
PMID:18852254   PMID:18927156   PMID:18948350   PMID:18953410   PMID:18996108   PMID:18996109   PMID:19075000   PMID:19124014   PMID:19149881   PMID:19234195   PMID:19272164   PMID:19301425  
PMID:19303107   PMID:19321785   PMID:19389377   PMID:19429912   PMID:19439492   PMID:19521566   PMID:19546217   PMID:19580633   PMID:19622544   PMID:19623611   PMID:19666823   PMID:19666824  
PMID:19705445   PMID:19723622   PMID:19729452   PMID:19835853   PMID:19865483   PMID:19913010   PMID:19923290   PMID:20011526   PMID:20040491   PMID:20051668   PMID:20067994   PMID:20093627  
PMID:20110533   PMID:20139113   PMID:20160094   PMID:20181825   PMID:20181838   PMID:20190754   PMID:20230753   PMID:20421947   PMID:20427705   PMID:20439720   PMID:20440002   PMID:20533404  
PMID:20534458   PMID:20534673   PMID:20573893   PMID:20576618   PMID:20605916   PMID:20643355   PMID:20652947   PMID:20668183   PMID:20687112   PMID:20696212   PMID:20847309   PMID:20978075  
PMID:21084302   PMID:21084383   PMID:21177343   PMID:21267068   PMID:21273444   PMID:21296051   PMID:21300292   PMID:21315259   PMID:21326203   PMID:21347296   PMID:21366346   PMID:21375242  
PMID:21397841   PMID:21414924   PMID:21451048   PMID:21478884   PMID:21502507   PMID:21507952   PMID:21516100   PMID:21557292   PMID:21559374   PMID:21565611   PMID:21572446   PMID:21610088  
PMID:21613566   PMID:21677750   PMID:21680756   PMID:21699541   PMID:21726547   PMID:21743007   PMID:21745462   PMID:21800304   PMID:21843662   PMID:21849546   PMID:21873635   PMID:21880664  
PMID:21896628   PMID:21909376   PMID:21917590   PMID:21922637   PMID:21925491   PMID:21929743   PMID:21945075   PMID:21947081   PMID:21964322   PMID:21966449   PMID:22002806   PMID:22030022  
PMID:22031545   PMID:22036570   PMID:22102727   PMID:22118475   PMID:22138644   PMID:22158044   PMID:22171010   PMID:22173065   PMID:22190459   PMID:22213797   PMID:22228100   PMID:22246030  
PMID:22252313   PMID:22276210   PMID:22318628   PMID:22321830   PMID:22323481   PMID:22342243   PMID:22354041   PMID:22395741   PMID:22398208   PMID:22410172   PMID:22424930   PMID:22427990  
PMID:22440395   PMID:22442722   PMID:22479204   PMID:22491404   PMID:22498737   PMID:22505612   PMID:22522080   PMID:22542185   PMID:22544613   PMID:22547682   PMID:22563055   PMID:22576936  
PMID:22596259   PMID:22609377   PMID:22689267   PMID:22698587   PMID:22705452   PMID:22736606   PMID:22836272   PMID:22846995   PMID:22854957   PMID:22972715   PMID:22991418   PMID:23001562  
PMID:23092738   PMID:23115176   PMID:23187741   PMID:23240058   PMID:23325811   PMID:23328398   PMID:23382872   PMID:23392350   PMID:23420609   PMID:23434913   PMID:23521771   PMID:23535656  
PMID:23578932   PMID:23618343   PMID:23658188   PMID:23723064   PMID:23798419   PMID:23817546   PMID:23861058   PMID:23861106   PMID:23895934   PMID:23920106   PMID:23931996   PMID:23975425  
PMID:23988635   PMID:24038871   PMID:24046456   PMID:24124534   PMID:24151333   PMID:24161570   PMID:24210661   PMID:24227724   PMID:24236178   PMID:24254198   PMID:24324671   PMID:24338362  
PMID:24357327   PMID:24369835   PMID:24384391   PMID:24409333   PMID:24414205   PMID:24417671   PMID:24442140   PMID:24465772   PMID:24500875   PMID:24522194   PMID:24631216   PMID:24639525  
PMID:24664975   PMID:24706806   PMID:24715457   PMID:24753151   PMID:24753442   PMID:24781755   PMID:24792116   PMID:24812355   PMID:24818888   PMID:24825879   PMID:24891510   PMID:24895407  
PMID:24931720   PMID:24952463   PMID:24952961   PMID:25014356   PMID:25038041   PMID:25084151   PMID:25088364   PMID:25088803   PMID:25100583   PMID:25139745   PMID:25143387   PMID:25168025  
PMID:25182747   PMID:25213555   PMID:25232112   PMID:25347445   PMID:25367124   PMID:25402856   PMID:25410658   PMID:25419850   PMID:25438880   PMID:25463925   PMID:25512490   PMID:25521757  
PMID:25615698   PMID:25631347   PMID:25636444   PMID:25724647   PMID:25729345   PMID:25741723   PMID:25742799   PMID:25753414   PMID:25788689   PMID:25827072   PMID:25843547   PMID:25864110  
PMID:25885041   PMID:25936505   PMID:25960350   PMID:25988834   PMID:26079812   PMID:26114479   PMID:26177727   PMID:26187182   PMID:26194766   PMID:26212757   PMID:26235615   PMID:26276819  
PMID:26288816   PMID:26324903   PMID:26403541   PMID:26405179   PMID:26455409   PMID:26477318   PMID:26598619   PMID:26628093   PMID:26657772   PMID:26733533   PMID:26750727   PMID:26802325  
PMID:26809587   PMID:26812015   PMID:26903504   PMID:26906157   PMID:26916252   PMID:26929452   PMID:26944093   PMID:26980715   PMID:27041467   PMID:27052172   PMID:27111087   PMID:27122033  
PMID:27151949   PMID:27217206   PMID:27302397   PMID:27351100   PMID:27385014   PMID:27390776   PMID:27464479   PMID:27483349   PMID:27633990   PMID:27645581   PMID:27664421   PMID:27669960  
PMID:27687499   PMID:27789627   PMID:27806288   PMID:27871306   PMID:27986432   PMID:27991863   PMID:28087631   PMID:28106089   PMID:28174271   PMID:28213973   PMID:28231465   PMID:28239148  
PMID:28240364   PMID:28337978   PMID:28429794   PMID:28482867   PMID:28535371   PMID:28552558   PMID:28552735   PMID:28558017   PMID:28619992   PMID:28628111   PMID:28641114   PMID:28671696  
PMID:28687623   PMID:28692740   PMID:28807898   PMID:28808228   PMID:28826662   PMID:28827800   PMID:28853179   PMID:28882402   PMID:28924218   PMID:29021239   PMID:29103954   PMID:29159962  
PMID:29166613   PMID:29170629   PMID:29176738   PMID:29203676   PMID:29211732   PMID:29321139   PMID:29366904   PMID:29402970   PMID:29412136   PMID:29444423   PMID:29462287   PMID:29518331  
PMID:29524576   PMID:29636380   PMID:29642003   PMID:29868845   PMID:29899142   PMID:29920846   PMID:29956664   PMID:30021842   PMID:30059908   PMID:30157281   PMID:30185604   PMID:30283008  
PMID:30389854   PMID:30463880   PMID:30504223   PMID:30562487   PMID:30597194   PMID:30626697   PMID:30630894   PMID:30650358   PMID:30709655   PMID:30728831   PMID:30735538   PMID:30787442  
PMID:30886905   PMID:30914199   PMID:30985297   PMID:31076103   PMID:31171776   PMID:31173351   PMID:31201155   PMID:31235635   PMID:31300538   PMID:31371508   PMID:31402374   PMID:31415124  
PMID:31519691   PMID:31570588   PMID:31577229   PMID:31586559   PMID:31601548   PMID:31704914   PMID:31835801   PMID:31871317   PMID:31909712   PMID:31944180   PMID:32005677   PMID:32020708  
PMID:32079489   PMID:32186707   PMID:32238932   PMID:32245946   PMID:32325033   PMID:32341084   PMID:32427396   PMID:32501282   PMID:32521258   PMID:32581705   PMID:32597756   PMID:32668208  
PMID:32741376   PMID:32792525   PMID:32855415   PMID:32859226   PMID:32868797   PMID:32882513   PMID:33051257   PMID:33060832   PMID:33103996   PMID:33132190   PMID:33144400   PMID:33158935  
PMID:33159076   PMID:33247143   PMID:33378081   PMID:33436073   PMID:33462112   PMID:33527978   PMID:33605987   PMID:33723434   PMID:33795534   PMID:33871356   PMID:33891897  


Genomics

Comparative Map Data
Cdh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391816,721,934 - 16,942,303 (-)NCBIGRCm39mm39
GRCm39 Ensembl1816,721,934 - 16,942,303 (-)Ensembl
GRCm381816,588,877 - 16,809,246 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1816,588,877 - 16,809,246 (-)EnsemblGRCm38mm10GRCm38
MGSCv371816,747,386 - 16,967,558 (-)NCBIGRCm37mm9NCBIm37
MGSCv361816,732,027 - 16,952,264 (-)NCBImm8
Celera1817,099,283 - 17,328,154 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map1810.1NCBI
CDH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1827,932,879 - 28,177,946 (-)EnsemblGRCh38hg38GRCh38
GRCh381827,932,878 - 28,177,130 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371825,530,930 - 25,757,094 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361823,784,933 - 24,011,189 (-)NCBINCBI36hg18NCBI36
Build 341823,784,933 - 24,011,189NCBI
Celera1822,342,317 - 22,568,868 (-)NCBI
Cytogenetic Map18q12.1NCBI
HuRef1822,383,072 - 22,579,896 (-)NCBIHuRef
CHM1_11825,458,398 - 25,684,881 (-)NCBICHM1_1
Cdh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2187,776,704 - 7,990,934 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl188,146,971 - 8,360,684 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0188,146,971 - 8,366,037 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0187,997,533 - 8,218,018 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4188,048,920 - 8,267,974 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1188,048,919 - 8,268,462 (-)NCBI
Celera187,938,006 - 8,155,134 (-)NCBICelera
Cytogenetic Map18p13NCBI
Cdh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540215,831,110 - 16,049,890 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540215,829,895 - 16,049,874 (-)NCBIChiLan1.0ChiLan1.0
CDH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11824,812,019 - 25,008,249 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1824,812,019 - 25,008,325 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01821,210,001 - 21,435,919 (-)NCBIMhudiblu_PPA_v0panPan3
CDH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1760,736,760 - 60,950,477 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl760,736,760 - 60,951,034 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha760,142,523 - 60,355,795 (+)NCBI
ROS_Cfam_1.0760,754,899 - 60,968,628 (+)NCBI
UMICH_Zoey_3.1760,431,048 - 60,644,193 (+)NCBI
UNSW_CanFamBas_1.0760,442,612 - 60,655,854 (+)NCBI
UU_Cfam_GSD_1.0760,744,933 - 60,958,801 (+)NCBI
Cdh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494456,749,166 - 56,930,675 (+)NCBI
SpeTri2.0NW_0049365506,885,484 - 7,067,001 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6112,396,721 - 112,628,432 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16112,396,713 - 112,629,073 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26105,317,507 - 105,518,900 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11852,426,381 - 52,652,986 (+)NCBI
ChlSab1.1 Ensembl1852,426,077 - 52,654,828 (+)Ensembl
Vero_WHO_p1.0NW_02366605027,147,394 - 27,374,174 (+)NCBI
Cdh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247704,333,643 - 4,540,817 (+)NCBI

Position Markers
RH130775  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38487,103,989 - 87,104,182UniSTSGRCm38
GRCm381816,589,766 - 16,589,959UniSTSGRCm38
MGSCv37486,749,893 - 86,750,086UniSTSGRCm37
MGSCv371816,748,275 - 16,748,468UniSTSGRCm37
Celera1817,109,053 - 17,109,246UniSTS
Cytogenetic Map18A1UniSTS
Cytogenetic Map4C4UniSTS
cM Map186.0UniSTS
D18Mit191  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381816,794,692 - 16,794,808UniSTSGRCm38
MGSCv371816,953,201 - 16,953,317UniSTSGRCm37
Celera1817,314,052 - 17,314,168UniSTS
Cytogenetic Map18A1UniSTS
cM Map184.0UniSTS
Whitehead Genetic182.2UniSTS
Whitehead_YAC18 UniSTS
REN15987  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381816,633,101 - 16,633,331UniSTSGRCm38
MGSCv371816,791,610 - 16,791,840UniSTSGRCm37
Celera1817,152,441 - 17,152,671UniSTS
Cytogenetic Map18A1UniSTS
cM Map186.0UniSTS
REN16027  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381816,623,096 - 16,623,350UniSTSGRCm38
MGSCv371816,781,605 - 16,781,859UniSTSGRCm37
Celera1817,142,435 - 17,142,689UniSTS
Cytogenetic Map18A1UniSTS
cM Map186.0UniSTS
REN16026  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381816,623,348 - 16,623,572UniSTSGRCm38
MGSCv371816,781,857 - 16,782,081UniSTSGRCm37
Celera1817,142,687 - 17,142,911UniSTS
Cytogenetic Map18A1UniSTS
cM Map186.0UniSTS
Cdh2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37486,750,269 - 86,750,914UniSTSGRCm37
MGSCv371816,747,446 - 16,748,091UniSTSGRCm37
Celera1817,108,222 - 17,108,869UniSTS
Cytogenetic Map18A1UniSTS
cM Map186.0UniSTS
cM Map186.0UniSTS
D18Wox24  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38487,104,752 - 87,104,885UniSTSGRCm38
MGSCv37486,750,656 - 86,750,789UniSTSGRCm37
Celera1817,108,349 - 17,108,482UniSTS
Celera485,628,450 - 85,628,583UniSTS
Cytogenetic Map18A1UniSTS
Cytogenetic Map4C4UniSTS
cM Map186.0UniSTS
Cdh2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18A1UniSTS
Cdh2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381816,588,937 - 16,589,582UniSTSGRCm38
GRCm38487,104,365 - 87,105,010UniSTSGRCm38
MGSCv371816,747,446 - 16,748,091UniSTSGRCm37
MGSCv37486,750,269 - 86,750,914UniSTSGRCm37
Celera1817,108,222 - 17,108,869UniSTS
Cytogenetic Map4C4UniSTS
Cytogenetic Map18A1UniSTS
Cdh2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18A1UniSTS
Cdh2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18A1UniSTS
cM Map186.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142127Rafaril_mRafar interacting locus (mouse)Not determined18123108555Mouse
14928307Manh83_mmandible shape 83 (mouse)18126902168Mouse
11354953Mom21_mmodifier of Min 21 (mouse)18128760766Mouse
12801458Intmrm3_mintima/media ratio modifier 3 (mouse)18131587699Mouse
12801462Intim3_mintima modifier 3 (mouse)18131587699Mouse
13207585Mwmlpt3_mMorris water maze latency to platform, training, 3 (mouse)18133414682Mouse
13207589Mwmlpa3_mMorris water maze latency to platform, all, 3 (mouse)18133414682Mouse
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060800000Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961139571Mouse
4142250Idd21.3_minsulin dependent diabetes susceptibility 21.3 (mouse)Not determined18610840421513420Mouse
1558873Hrtfm7_mheart failure modifier 7 (mouse)Not determined18795390741954049Mouse
13504732Cath6_mcarotid atherosclerosis 6 (mouse)181350407347504073Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181389696666965891Mouse
1300994Pvcan3_mprotection against vaginal candidiasis 3 (mouse)Not determined181606658750066723Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:806
Count of miRNA genes:350
Interacting mature miRNAs:420
Transcripts:ENSMUST00000025166, ENSMUST00000115850, ENSMUST00000152779
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_007664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA242226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB008811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC098745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC126255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC134570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK031210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK032826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK087418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB246984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M31131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S45011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000025166   ⟹   ENSMUSP00000025166
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1816,588,877 - 16,809,246 (-)Ensembl
RefSeq Acc Id: ENSMUST00000115850   ⟹   ENSMUSP00000111516
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1816,589,023 - 16,670,069 (-)Ensembl
RefSeq Acc Id: ENSMUST00000152779
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1816,771,397 - 16,808,462 (-)Ensembl
RefSeq Acc Id: NM_007664   ⟹   NP_031690
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391816,721,934 - 16,942,303 (-)NCBI
GRCm381816,588,877 - 16,809,246 (-)NCBI
MGSCv371816,747,386 - 16,967,558 (-)RGD
Celera1817,099,283 - 17,328,154 (-)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006525553   ⟹   XP_006525616
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391816,722,170 - 16,796,216 (-)NCBI
GRCm381816,589,113 - 16,663,159 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_031690   ⟸   NM_007664
- Peptide Label: preproprotein
- UniProtKB: P15116 (UniProtKB/Swiss-Prot),   Q3UIC2 (UniProtKB/TrEMBL),   Q8BSI9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006525616   ⟸   XM_006525553
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000111516   ⟸   ENSMUST00000115850
RefSeq Acc Id: ENSMUSP00000025166   ⟸   ENSMUST00000025166
Protein Domains
Cadherin

Promoters
RGD ID:13677174
Promoter ID:EPDNEW_M22736
Type:initiation region
Name:Cdh2_2
Description:Mus musculus cadherin 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M22737  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381816,808,477 - 16,808,537EPDNEW
RGD ID:13677176
Promoter ID:EPDNEW_M22737
Type:initiation region
Name:Cdh2_1
Description:Mus musculus cadherin 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M22736  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381816,809,276 - 16,809,336EPDNEW
RGD ID:6829139
Promoter ID:MM_KWN:24690
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   Brain,   Liver,   MEF_B4
Transcripts:ENSMUST00000115852,   OTTMUST00000039193
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361816,966,849 - 16,967,349 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88355 AgrOrtholog
Ensembl Genes ENSMUSG00000024304 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000025166 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000111516 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000025166 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000115850 UniProtKB/TrEMBL
Gene3D-CATH 4.10.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cadherin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin_cytoplasmic-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin_pro_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Catenin_binding_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CDH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12558 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:88355 ENTREZGENE
NCBI Gene 12558 ENTREZGENE
PANTHER PTHR24027 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24027:SF79 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin_pro UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdh2 PhenoGen
PRINTS CADHERIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CADHERIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Cadherin_pro UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49313 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CADH2_MOUSE UniProtKB/Swiss-Prot
  D3YYT0_MOUSE UniProtKB/TrEMBL
  P15116 ENTREZGENE
  Q3UIC2 ENTREZGENE, UniProtKB/TrEMBL
  Q8BSI9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q64260 UniProtKB/Swiss-Prot
  Q6GU11 UniProtKB/Swiss-Prot