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Gene: Dnmt3a (DNA methyltransferase 3A) Mus musculus
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Symbol: Dnmt3a
Name: DNA methyltransferase 3A
Description: Exhibits DNA (cytosine-5-)-methyltransferase activity; DNA binding activity; and chromatin binding activity. Involved in several processes, including DNA methylation; regulation of gene expression by genetic imprinting; and regulation of nucleobase-containing compound metabolic process. Localizes to the chromosome and cytoplasm. Human ortholog(s) of this gene implicated in acute myeloid leukemia; myelodysplastic syndrome; precursor T-lymphoblastic lymphoma/leukemia; precursor lymphoblastic lymphoma/leukemia; and stomach cancer. Is expressed in several structures, including 1st branchial arch; central nervous system; limb mesenchyme; reproductive system; and urethra. Orthologous to human DNMT3A (DNA methyltransferase 3 alpha).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AU015806; DNA (cytosine-5)-methyltransferase 3A; DNA methyltransferase MmuIIIA; DNA MTase MmuIIIA; m.MmuIIIA; MmuIIIA; W91664
Orthologs:
Homo sapiens (human) : DNMT3A (DNA methyltransferase 3 alpha)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dnmt3a (DNA methyltransferase 3 alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dnmt3a (DNA methyltransferase 3 alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : DNMT3A (DNA methyltransferase 3 alpha)
Canis lupus familiaris (dog) : DNMT3A (DNA methyltransferase 3 alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dnmt3a (DNA methyltransferase 3 alpha)
Sus scrofa (pig) : DNMT3A (DNA methyltransferase 3 alpha)
more info ...
Related Pseudogenes: Dnmt3a-ps1  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl123,806,007 - 3,914,443 (+)Ensembl
GRCm38123,801,559 - 3,914,443 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37123,806,980 - 3,914,443 (+)NCBIGRCm37mm9NCBIm37
MGSCv36123,835,027 - 3,914,455 (+)NCBImm8
Celera123,763,156 - 3,842,112 (+)NCBICelera
Cytogenetic Map12 A1.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Dnmt3a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1620920
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.