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Gene: Ncf1 (neutrophil cytosolic factor 1) Mus musculus
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Symbol: Ncf1
Name: neutrophil cytosolic factor 1
Description: Exhibits superoxide-generating NADPH oxidase activity. Involved in several processes, including hydrogen peroxide biosynthetic process; neutrophil mediated killing of symbiont cell; and superoxide anion generation. Localizes to the cytoplasm and membrane. Used to study chronic granulomatous disease. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome; autosomal recessive chronic granulomatous disease cytochrome b-positive type I; and chronic granulomatous disease. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to several human genes including NCF1 (neutrophil cytosolic factor 1); PARTICIPATES IN Leishmaniasis pathway; INTERACTS WITH 1,1-dichloroethene; 3,4-methylenedioxymethamphetamine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 47 kDa neutrophil oxidase factor; NADPH oxidase subunit (47 kD); NADPH oxidase subunit (47kDa); Ncf-1; NCF-47K; neutrophil cytosol factor 1; neutrophil NADPH oxidase factor 1; NOXO2; p47-phox; p47; p47phox
Orthologs:
Homo sapiens (human) : NCF1 (neutrophil cytosolic factor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ncf1 (neutrophil cytosolic factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ncf1 (neutrophil cytosolic factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NCF1 (neutrophil cytosolic factor 1)
Canis lupus familiaris (dog) : NCF1 (neutrophil cytosolic factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ncf1 (neutrophil cytosolic factor 1)
Sus scrofa (pig) : NCF1 (neutrophil cytosolic factor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm385134,220,053 - 134,229,628 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375134,696,130 - 134,705,495 (-)NCBIGRCm37mm9NCBIm37
MGSCv365134,504,886 - 134,514,206 (-)NCBImm8
Celera5131,223,376 - 131,232,950 (-)NCBICelera
Cytogenetic Map5 G2NCBI
cM Map574.47NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ncf1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 734055
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.