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Gene: Ncf1 (neutrophil cytosolic factor 1) Mus musculus
Symbol: Ncf1
Name: neutrophil cytosolic factor 1
Description: Exhibits superoxide-generating NADPH oxidase activity. Involved in several processes, including hydrogen peroxide biosynthetic process; neutrophil mediated killing of symbiont cell; and superoxide anion generation. Localizes to the cytoplasm and membrane. Used to study chronic granulomatous disease. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome; autosomal recessive chronic granulomatous disease cytochrome b-positive type I; and chronic granulomatous disease. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to several human genes including NCF1 (neutrophil cytosolic factor 1); PARTICIPATES IN Leishmaniasis pathway; INTERACTS WITH 1,1-dichloroethene; 3,4-methylenedioxymethamphetamine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 47 kDa neutrophil oxidase factor; NADPH oxidase subunit (47 kD); NADPH oxidase subunit (47kDa); Ncf-1; NCF-47K; neutrophil cytosol factor 1; neutrophil NADPH oxidase factor 1; NOXO2; p47-phox; p47; p47phox
Homo sapiens (human) : NCF1 (neutrophil cytosolic factor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ncf1 (neutrophil cytosolic factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ncf1 (neutrophil cytosolic factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NCF1 (neutrophil cytosolic factor 1)
Canis lupus familiaris (dog) : NCF1 (neutrophil cytosolic factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ncf1 (neutrophil cytosolic factor 1)
Sus scrofa (pig) : NCF1 (neutrophil cytosolic factor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm385134,220,053 - 134,229,628 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375134,696,130 - 134,705,495 (-)NCBIGRCm37mm9NCBIm37
MGSCv365134,504,886 - 134,514,206 (-)NCBImm8
Celera5131,223,376 - 131,232,950 (-)NCBICelera
Cytogenetic Map5 G2NCBI
cM Map574.47NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ncf1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 734055
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.