Slc9a9 (solute carrier family 9 (sodium/hydrogen exchanger), member 9) - Rat Genome Database
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Gene: Slc9a9 (solute carrier family 9 (sodium/hydrogen exchanger), member 9) Mus musculus
Analyze
Symbol: Slc9a9
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 9
RGD ID: 1314948
MGI Page MGI
Description: Predicted to have potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to localize to plasma membrane and recycling endosome. Is expressed in several structures, including ear; hemolymphoid system; nervous system; tail somite; and urinary system. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human SLC9A9 (solute carrier family 9 member A9); INTERACTS WITH 3-methylcholanthrene; 4-hydroxyphenyl retinamide; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5730527A11Rik; 9930105B05; AI854429; Na(+)/H(+) exchanger 9; Nhe; Nhe9; sodium/hydrogen exchanger 9; solute carrier family 9 member 9
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39994,551,945 - 95,112,505 (+)NCBIGRCm39mm39
GRCm38994,669,557 - 95,230,453 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl994,669,909 - 95,230,445 (+)EnsemblGRCm38mm10GRCm38
MGSCv37994,570,311 - 95,130,871 (+)NCBIGRCm37mm9NCBIm37
MGSCv36994,479,270 - 95,039,797 (+)NCBImm8
Celera994,219,657 - 94,782,256 (+)NCBICelera
Cytogenetic Map9E3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14569117   PMID:14681479   PMID:15522866   PMID:16141072   PMID:16141073  
PMID:17005858   PMID:19521566   PMID:21267068   PMID:21677750   PMID:21873635   PMID:24035762   PMID:24065030   PMID:24952961   PMID:26755066   PMID:29362376  


Genomics

Comparative Map Data
Slc9a9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39994,551,945 - 95,112,505 (+)NCBIGRCm39mm39
GRCm38994,669,557 - 95,230,453 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl994,669,909 - 95,230,445 (+)EnsemblGRCm38mm10GRCm38
MGSCv37994,570,311 - 95,130,871 (+)NCBIGRCm37mm9NCBIm37
MGSCv36994,479,270 - 95,039,797 (+)NCBImm8
Celera994,219,657 - 94,782,256 (+)NCBICelera
Cytogenetic Map9E3.3NCBI
SLC9A9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3143,265,222 - 143,848,485 (-)EnsemblGRCh38hg38GRCh38
GRCh383143,265,222 - 143,848,492 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373142,984,063 - 143,567,373 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363144,466,754 - 145,049,979 (-)NCBINCBI36hg18NCBI36
Build 343144,466,762 - 145,049,987NCBI
Celera3141,407,434 - 141,990,172 (-)NCBI
Cytogenetic Map3q24NCBI
HuRef3140,356,277 - 140,939,100 (-)NCBIHuRef
CHM1_13142,947,047 - 143,530,815 (-)NCBICHM1_1
Slc9a9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08102,304,095 - 103,022,619 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8102,304,095 - 103,022,619 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08102,104,238 - 102,486,426 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.08101,786,869 - 101,923,361 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4899,736,831 - 100,324,858 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1899,756,279 - 99,825,026 (+)NCBI
Celera894,706,240 - 95,249,454 (+)NCBICelera
Cytogenetic Map8q31NCBI
Slc9a9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555082,090,609 - 2,670,240 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555082,060,078 - 2,671,792 (+)NCBIChiLan1.0ChiLan1.0
SLC9A9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13147,882,700 - 148,466,360 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3147,980,965 - 148,466,151 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03140,292,336 - 140,875,991 (-)NCBIMhudiblu_PPA_v0panPan3
SLC9A9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2338,817,875 - 39,355,217 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12338,816,387 - 39,471,678 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Slc9a9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365404,843,798 - 5,384,305 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC9A9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1383,962,618 - 84,502,327 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11383,962,613 - 84,636,878 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21391,734,511 - 92,260,592 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC9A9
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1546,781,271 - 47,360,525 (+)Ensembl
ChlSab1.11546,781,220 - 47,362,031 (+)NCBI
Slc9a9
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473019,902,504 - 20,514,138 (-)NCBI

Position Markers
G67038  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38994,851,711 - 94,852,172UniSTSGRCm38
MGSCv37994,752,130 - 94,752,591UniSTSGRCm37
Celera994,408,823 - 94,409,284UniSTS
Cytogenetic Map9E3.3UniSTS
44.MMHAP64FRG11.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38995,061,371 - 95,061,544UniSTSGRCm38
MGSCv37994,961,790 - 94,961,963UniSTSGRCm37
Celera994,612,147 - 94,612,320UniSTS
Cytogenetic Map9E3.3UniSTS
Whitehead_YAC7 UniSTS
MPC1452  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38994,981,301 - 94,981,419UniSTSGRCm38
MGSCv37994,881,720 - 94,881,838UniSTSGRCm37
Celera994,533,584 - 94,533,704UniSTS
Cytogenetic Map9E3.3UniSTS
cM Map949.0UniSTS
Whitehead Genetic943.7UniSTS
D9Mit112.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38994,981,424 - 94,981,548UniSTSGRCm38
MGSCv37994,881,843 - 94,881,967UniSTSGRCm37
Celera994,533,709 - 94,533,833UniSTS
Cytogenetic Map9E3.3UniSTS
cM Map949.0UniSTS
cM Map9 UniSTS
Whitehead Genetic943.7UniSTS
AI854429  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38995,230,056 - 95,230,183UniSTSGRCm38
MGSCv37995,130,475 - 95,130,602UniSTSGRCm37
Celera994,781,860 - 94,781,987UniSTS
Cytogenetic Map9E3.3UniSTS
Whitehead/MRC_RH9991.66UniSTS
RH140366  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38994,736,191 - 94,736,305UniSTSGRCm38
MGSCv37994,636,610 - 94,636,724UniSTSGRCm37
Celera994,293,243 - 94,293,357UniSTS
Cytogenetic Map9E3.3UniSTS
BB209181  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38994,718,561 - 94,718,672UniSTSGRCm38
MGSCv37994,618,980 - 94,619,091UniSTSGRCm37
Celera994,275,716 - 94,275,827UniSTS
Cytogenetic Map9E3.3UniSTS
Whitehead/MRC_RH2398.97UniSTS
Slc9a9  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9E3.3UniSTS
cM Map949.22UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93739490198819654Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49541121101528921Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95212317899910428Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
1301611Lrnx3_mlearning contextual 3 (mouse)Not determined96224248596242599Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
11081165Psl6_mpromotion susceptibility QTL 6 (mouse)96513390995640755Mouse
1301636Lith5_mlithogenic gene 5 (mouse)Not determined966207024100207122Mouse
10045638Heal29_mwound healing/regeneration 29 (mouse)Not determined967124167101124167Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968897510102897652Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968897510102897652Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969239845103239920Mouse
10412174Habiir4_mhyperoxic acute lung injury imprinted region 4 (mouse)Not determined96936046598819654Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969546513103546645Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301869Tbbmd4_mtotal body bone mineral density 4 (mouse)Not determined976117105101528921Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:716
Count of miRNA genes:462
Interacting mature miRNAs:547
Transcripts:ENSMUST00000033463, ENSMUST00000162329, ENSMUST00000162870
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000033463   ⟹   ENSMUSP00000033463
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl994,669,909 - 95,230,445 (+)Ensembl
RefSeq Acc Id: ENSMUST00000162329
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl995,121,686 - 95,124,551 (+)Ensembl
RefSeq Acc Id: ENSMUST00000162870
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl994,669,932 - 94,718,846 (+)Ensembl
RefSeq Acc Id: NM_177909   ⟹   NP_808577
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39994,551,945 - 95,112,505 (+)NCBI
GRCm38994,669,892 - 95,230,452 (+)ENTREZGENE
MGSCv37994,570,311 - 95,130,871 (+)RGD
Celera994,219,657 - 94,782,256 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_808577   ⟸   NM_177909
- UniProtKB: Q8BZ00 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000033463   ⟸   ENSMUST00000033463
Protein Domains
Na_H_Exchanger

Promoters
RGD ID:6845173
Promoter ID:MM_KWN:58386
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:OTTMUST00000081766,   OTTMUST00000081768
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36994,570,381 - 94,570,881 (+)MPROMDB
RGD ID:8670454
Promoter ID:EPDNEW_M13258
Type:initiation region
Name:Slc9a9_1
Description:Mus musculus solute carrier family 9 (sodium/hydrogen exchanger),member 9 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38994,669,921 - 94,669,981EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2679732 AgrOrtholog
Ensembl Genes ENSMUSG00000031129 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000033463 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000033463 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Cation/H_exchanger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cation/H_exchanger_CPA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na/H_exchanger_6 UniProtKB/Swiss-Prot
  Na/H_exchanger_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NaH_exchanger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NHE6_7_9 UniProtKB/TrEMBL
KEGG Report mmu:331004 UniProtKB/Swiss-Prot
MGD MGI:2679732 ENTREZGENE
NCBI Gene 331004 ENTREZGENE
PANTHER PTHR10110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10110:SF61 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Na_H_Exchanger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc9a9 PhenoGen
PRINTS NAHEXCHNGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAHEXCHNGR6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs b_cpa1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.326125 ENTREZGENE
UniProt A8E634_MOUSE UniProtKB/TrEMBL
  Q3T994_MOUSE UniProtKB/TrEMBL
  Q499E9_MOUSE UniProtKB/TrEMBL
  Q8BZ00 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q3U0X0 UniProtKB/Swiss-Prot