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Gene: Epas1 (endothelial PAS domain protein 1) Mus musculus
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Symbol: Epas1
Name: endothelial PAS domain protein 1
RGD ID: 68595
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in several processes, including animal organ development; positive regulation of cold-induced thermogenesis; and regulation of transcription by RNA polymerase II. Localizes to cytoplasm; nuclear speck; and transcription regulator complex. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and respiratory system. Used to study newborn respiratory distress syndrome. Human ortholog(s) of this gene implicated in familial erythrocytosis 4; lung non-small cell carcinoma; polycythemia; and pulmonary hypertension. Orthologous to human EPAS1 (endothelial PAS domain protein 1); PARTICIPATES IN hypoxia inducible factor pathway; renal cell carcinoma pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: bHLHe7; bHLHe73; endothelial PAS domain-containing protein 1; EPAS-1; HIF; Hif like protein; HIF-1-alpha-like factor; HIF-2; HIF-2-alpha; HIF-2alpha; HIF-related factor; HIF1 alpha-like factor; HIF1alpha-like factor; HIF2-alpha; HIF2A; HL; HLF; HLF (HIF1alpha-like factor); HR; HRF; hypoxia inducible transcription factor 2alpha; hypoxia-inducible factor 2-alpha; mHLF; MO; MOP2
Orthologs:
Homo sapiens (human) : EPAS1 (endothelial PAS domain protein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Epas1 (endothelial PAS domain protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Epas1 (endothelial PAS domain protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : EPAS1 (endothelial PAS domain protein 1)
Canis lupus familiaris (dog) : EPAS1 (endothelial PAS domain protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Epas1 (endothelial PAS domain protein 1)
Sus scrofa (pig) : EPAS1 (endothelial PAS domain protein 1)
Chlorocebus sabaeus (African green monkey) : EPAS1 (endothelial PAS domain protein 1)
Heterocephalus glaber (naked mole-rat) : Epas1 (endothelial PAS domain protein 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1786,753,700 - 86,833,410 (+)EnsemblGRCm38mm10GRCm38
GRCm381786,753,864 - 86,833,410 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371787,153,204 - 87,232,750 (+)NCBIGRCm37mm9NCBIm37
MGSCv361786,662,228 - 86,739,908 (+)NCBImm8
Celera1791,133,927 - 91,214,803 (+)NCBICelera
Cytogenetic Map17E4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Epas1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68595
Created: 2001-07-11
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.