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Gene: Epas1 (endothelial PAS domain protein 1) Mus musculus
Symbol: Epas1
Name: endothelial PAS domain protein 1
RGD ID: 68595
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in several processes, including animal organ development; positive regulation of cold-induced thermogenesis; and regulation of transcription by RNA polymerase II. Localizes to cytoplasm; nuclear speck; and transcription regulator complex. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and respiratory system. Used to study newborn respiratory distress syndrome. Human ortholog(s) of this gene implicated in familial erythrocytosis 4; lung non-small cell carcinoma; polycythemia; and pulmonary hypertension. Orthologous to human EPAS1 (endothelial PAS domain protein 1); PARTICIPATES IN hypoxia inducible factor pathway; renal cell carcinoma pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: bHLHe7; bHLHe73; endothelial PAS domain-containing protein 1; EPAS-1; HIF; Hif like protein; HIF-1-alpha-like factor; HIF-2; HIF-2-alpha; HIF-2alpha; HIF-related factor; HIF1 alpha-like factor; HIF1alpha-like factor; HIF2-alpha; HIF2A; HL; HLF; HLF (HIF1alpha-like factor); HR; HRF; hypoxia inducible transcription factor 2alpha; hypoxia-inducible factor 2-alpha; mHLF; MO; MOP2
Homo sapiens (human) : EPAS1 (endothelial PAS domain protein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Epas1 (endothelial PAS domain protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Epas1 (endothelial PAS domain protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : EPAS1 (endothelial PAS domain protein 1)
Canis lupus familiaris (dog) : EPAS1 (endothelial PAS domain protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Epas1 (endothelial PAS domain protein 1)
Sus scrofa (pig) : EPAS1 (endothelial PAS domain protein 1)
Chlorocebus sabaeus (African green monkey) : EPAS1 (endothelial PAS domain protein 1)
Heterocephalus glaber (naked mole-rat) : Epas1 (endothelial PAS domain protein 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1786,753,700 - 86,833,410 (+)EnsemblGRCm38mm10GRCm38
GRCm381786,753,864 - 86,833,410 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371787,153,204 - 87,232,750 (+)NCBIGRCm37mm9NCBIm37
MGSCv361786,662,228 - 86,739,908 (+)NCBImm8
Celera1791,133,927 - 91,214,803 (+)NCBICelera
Cytogenetic Map17E4NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Epas1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68595
Created: 2001-07-11
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.