Car8 (carbonic anhydrase 8) - Rat Genome Database

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Gene: Car8 (carbonic anhydrase 8) Mus musculus
Analyze
Symbol: Car8
Name: carbonic anhydrase 8
RGD ID: 1312314
MGI Page MGI
Description: Predicted to have hydro-lyase activity. Involved in phosphatidylinositol-mediated signaling. Localizes to cytoplasm. Is expressed in several structures, including alimentary system; brain; ear; genitourinary system; and respiratory system. Used to study cerebellar ataxia, mental retardation and dysequlibrium syndrome. Human ortholog(s) of this gene implicated in cerebellar ataxia, mental retardation and dysequlibrium syndrome. Orthologous to human CA8 (carbonic anhydrase 8); INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW546993; C; Ca; CA-RP VIII; CA-VIII; Ca8; Cals; Cals1; carbonic anhydrase VIII; carbonic anhydrase-like sequence 1; carbonic anhydrase-related protein; Carp; wd; wdl
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm17987  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3948,141,493 - 8,239,226 (-)NCBIGRCm39mm39
GRCm39 Ensembl48,143,362 - 8,239,041 (-)Ensembl
GRCm3848,141,493 - 8,239,041 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl48,143,362 - 8,239,041 (-)EnsemblGRCm38mm10GRCm38
MGSCv3748,068,640 - 8,166,188 (-)NCBIGRCm37mm9NCBIm37
MGSCv3647,613,848 - 7,709,581 (-)NCBImm8
MGSCv3648,068,640 - 8,166,188 (-)NCBImm8
Celera48,024,484 - 8,115,866 (-)NCBICelera
Cytogenetic Map4A1NCBI
cM Map43.53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3-methylcholanthrene  (ISO)
4-hydroxyphenyl retinamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bisphenol A  (ISO)
carbon nanotube  (EXP)
clobetasol  (EXP)
clofibrate  (EXP)
cyclosporin A  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
fipronil  (ISO)
flutamide  (ISO)
folic acid  (EXP)
genistein  (EXP,ISO)
glafenine  (ISO)
hydralazine  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
nefazodone  (ISO)
nimesulide  (ISO)
oxaliplatin  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP,ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
propiconazole  (EXP)
pyrogallol  (EXP)
quercetin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium dichromate  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (EXP)
valdecoxib  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:2121526   PMID:7821612   PMID:8482548   PMID:8889548   PMID:8977131   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12531530   PMID:12611586  
PMID:14681479   PMID:14687547   PMID:15489334   PMID:15645444   PMID:16118194   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17151198   PMID:17174474   PMID:17376701   PMID:17626619  
PMID:19752021   PMID:21267068   PMID:21873635   PMID:22004450   PMID:23233153   PMID:24491816   PMID:24794067   PMID:25721739   PMID:25734498   PMID:26399641   PMID:26586559   PMID:28413018  
PMID:28467908   PMID:28489004   PMID:28547032   PMID:28940157   PMID:30538199   PMID:30867000   PMID:31157458   PMID:31202927   PMID:32123907   PMID:32325033  


Genomics

Comparative Map Data
Car8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3948,141,493 - 8,239,226 (-)NCBIGRCm39mm39
GRCm39 Ensembl48,143,362 - 8,239,041 (-)Ensembl
GRCm3848,141,493 - 8,239,041 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl48,143,362 - 8,239,041 (-)EnsemblGRCm38mm10GRCm38
MGSCv3748,068,640 - 8,166,188 (-)NCBIGRCm37mm9NCBIm37
MGSCv3647,613,848 - 7,709,581 (-)NCBImm8
MGSCv3648,068,640 - 8,166,188 (-)NCBImm8
Celera48,024,484 - 8,115,866 (-)NCBICelera
Cytogenetic Map4A1NCBI
cM Map43.53NCBI
CA8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl860,185,412 - 60,281,400 (-)EnsemblGRCh38hg38GRCh38
GRCh38860,185,412 - 60,281,400 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37861,097,971 - 61,193,959 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36861,263,977 - 61,356,508 (-)NCBINCBI36hg18NCBI36
Build 34861,263,976 - 61,356,508NCBI
Celera857,092,480 - 57,182,989 (-)NCBI
Cytogenetic Map8q12.1NCBI
HuRef856,589,359 - 56,681,767 (-)NCBIHuRef
CHM1_1861,150,010 - 61,246,037 (-)NCBICHM1_1
Ca8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2521,302,940 - 21,402,395 (-)NCBI
Rnor_6.0 Ensembl521,249,020 - 21,345,810 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0521,249,018 - 21,345,810 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0526,010,374 - 26,106,856 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4521,951,255 - 22,049,427 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1521,951,256 - 22,049,427 (-)NCBI
Celera520,578,323 - 20,675,389 (-)NCBICelera
Cytogenetic Map5q13NCBI
Ca8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544418,413,958 - 18,512,213 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544418,414,006 - 18,510,800 (+)NCBIChiLan1.0ChiLan1.0
CA8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1858,273,696 - 58,367,615 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl858,273,696 - 58,367,615 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0856,606,454 - 56,702,357 (-)NCBIMhudiblu_PPA_v0panPan3
CA8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12910,678,122 - 10,763,361 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2910,679,038 - 10,764,193 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2910,989,287 - 11,075,445 (-)NCBI
ROS_Cfam_1.02910,763,585 - 10,849,785 (-)NCBI
UMICH_Zoey_3.12910,765,703 - 10,851,540 (-)NCBI
UNSW_CanFamBas_1.02910,899,217 - 10,985,514 (-)NCBI
UU_Cfam_GSD_1.02911,167,585 - 11,253,944 (-)NCBI
Ca8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530361,800,602 - 61,889,623 (-)NCBI
SpeTri2.0NW_00493649612,895,858 - 12,984,303 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl473,047,847 - 73,141,991 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1473,047,867 - 73,172,215 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2479,510,120 - 79,573,391 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CA8
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1856,111,149 - 56,203,797 (-)NCBI
ChlSab1.1 Ensembl856,131,599 - 56,203,336 (-)Ensembl
Ca8
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474431,659,318 - 31,777,409 (+)NCBI

Position Markers
AW546993  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3848,169,594 - 8,169,694UniSTSGRCm38
MGSCv3748,096,741 - 8,096,841UniSTSGRCm37
Celera48,054,064 - 8,054,164UniSTS
Cytogenetic Map4A1UniSTS
cM Map47.7UniSTS
Whitehead/MRC_RH474.18UniSTS
Car8  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv3748,096,831 - 8,097,091UniSTSGRCm37
Celera48,054,154 - 8,054,414UniSTS
Cytogenetic Map4A1UniSTS
cM Map47.7UniSTS
cM Map47.7UniSTS
X61397  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3848,145,871 - 8,146,023UniSTSGRCm38
MGSCv3748,073,018 - 8,073,170UniSTSGRCm37
Celera48,028,869 - 8,029,021UniSTS
Cytogenetic Map4A1UniSTS
cM Map47.7UniSTS
Whitehead_YAC4 UniSTS
AA923902  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3848,145,954 - 8,146,136UniSTSGRCm38
MGSCv3748,073,101 - 8,073,283UniSTSGRCm37
Celera48,028,952 - 8,029,132UniSTS
Cytogenetic Map4A1UniSTS
cM Map47.7UniSTS
Car8  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3848,169,684 - 8,169,944UniSTSGRCm38
MGSCv3748,096,831 - 8,097,091UniSTSGRCm37
Celera48,054,154 - 8,054,414UniSTS
Cytogenetic Map4A1UniSTS
cM Map47.7UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301274Lmr9_mleishmaniasis resistance 9 (mouse)Not determined4120657234Mouse
11049579Lmr9b_mleishmaniasis resistance 9b (mouse)4120657234Mouse
11049580Lmr9a_mleishmaniasis resistance 9 (mouse)4120657234Mouse
10412079Sm1_msusceptibility to Schistosoma mansoni infection 1 (mouse)Not determined4122955614Mouse
1301510Bbaa13_mB.burgdorferi-associated arthritis 13 (mouse)Not determined4126395649Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156183778Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1099
Count of miRNA genes:540
Interacting mature miRNAs:724
Transcripts:ENSMUST00000066674
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000066674   ⟹   ENSMUSP00000063511
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl48,143,362 - 8,239,041 (-)Ensembl
RefSeq Acc Id: NM_007592   ⟹   NP_031618
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3948,141,493 - 8,239,041 (-)NCBI
GRCm3848,141,493 - 8,239,041 (-)ENTREZGENE
MGSCv3748,068,640 - 8,166,188 (-)RGD
Celera48,024,484 - 8,115,866 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_004941799
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3948,143,362 - 8,239,226 (-)NCBI
RefSeq Acc Id: XR_004941800
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3948,169,737 - 8,239,226 (-)NCBI
RefSeq Acc Id: XR_004941801
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3948,189,310 - 8,239,226 (-)NCBI
Protein Sequences
Protein RefSeqs NP_031618 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH10773 (Get FASTA)   NCBI Sequence Viewer  
  BAC25100 (Get FASTA)   NCBI Sequence Viewer  
  EDL05682 (Get FASTA)   NCBI Sequence Viewer  
  P28651 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_031618   ⟸   NM_007592
- UniProtKB: P28651 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000063511   ⟸   ENSMUST00000066674
Protein Domains
Alpha-carbonic anhydrase

Promoters
RGD ID:6834999
Promoter ID:MM_KWN:36607
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ENSMUST00000066674,   NM_007592
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3648,165,896 - 8,166,396 (-)MPROMDB
RGD ID:6882772
Promoter ID:EPDNEW_M4837
Type:single initiation site
Name:Car8_1
Description:Mus musculus carbonic anhydrase 8 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3848,239,041 - 8,239,101EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88253 AgrOrtholog
Ensembl Genes ENSMUSG00000041261 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000063511 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000066674 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.200.10 UniProtKB/Swiss-Prot
InterPro CA_dom UniProtKB/Swiss-Prot
  CA_dom_sf UniProtKB/Swiss-Prot
  Carbonic_anhydrase_a-class UniProtKB/Swiss-Prot
  Carbonic_anhydrase_a-class_CS UniProtKB/Swiss-Prot
  CARP_VIII UniProtKB/Swiss-Prot
KEGG Report mmu:12319 UniProtKB/Swiss-Prot
MGD MGI:88253 ENTREZGENE
NCBI Gene 12319 ENTREZGENE
PANTHER PTHR18952 UniProtKB/Swiss-Prot
Pfam Carb_anhydrase UniProtKB/Swiss-Prot
PhenoGen Car8 PhenoGen
PROSITE ALPHA_CA_1 UniProtKB/Swiss-Prot
  ALPHA_CA_2 UniProtKB/Swiss-Prot
SMART Carb_anhydrase UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51069 UniProtKB/Swiss-Prot
UniProt CAH8_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q8CF58 UniProtKB/Swiss-Prot
  Q91XF6 UniProtKB/Swiss-Prot