Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | decreases expression | EXP | | 6480464 | ethylene dichloride results in decreased expression of SHC4 mRNA | CTD | PMID:28960355 | 17beta-estradiol | multiple interactions | ISO | SHC4 (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in decreased expression of SHC4 mRNA | CTD | PMID:20660070 | 17beta-estradiol | increases expression | ISO | SHC4 (Homo sapiens) | 6480464 | Estradiol results in increased expression of SHC4 mRNA | CTD | PMID:31614463 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SHC4 mRNA | CTD | PMID:26377647 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Shc4 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SHC4 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Shc4 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SHC4 mRNA | CTD | PMID:32109520 | 3,4-methylenedioxymethamphetamine | increases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of SHC4 mRNA | CTD | PMID:20188158 | 3-methylcholanthrene | increases expression | EXP | | 6480464 | Methylcholanthrene results in increased expression of SHC4 mRNA | CTD | PMID:20713471 | 4,4'-sulfonyldiphenol | increases methylation | EXP | | 6480464 | bisphenol S results in increased methylation of SHC4 promoter | CTD | PMID:33297965 | acetamide | affects expression | ISO | Shc4 (Rattus norvegicus) | 6480464 | acetamide affects the expression of SHC4 mRNA | CTD | PMID:31881176 | aflatoxin B1 | increases expression | ISO | SHC4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of SHC4 mRNA | CTD | PMID:22100608 | aflatoxin B1 | decreases methylation | ISO | SHC4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of SHC4 gene | CTD | PMID:27153756 | aldehydo-D-glucose | multiple interactions | EXP | | 6480464 | fucoxanthin inhibits the reaction [Glucose results in increased expression of SHC4 mRNA] | CTD | PMID:33448797 | aldehydo-D-glucose | increases expression | EXP | | 6480464 | Glucose results in increased expression of SHC4 mRNA | CTD | PMID:33448797 | aristolochic acid A | increases expression | ISO | SHC4 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of SHC4 mRNA | CTD | PMID:33212167 | benzo[a]pyrene | decreases expression | ISO | SHC4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of SHC4 mRNA | CTD | PMID:20064835 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SHC4 mRNA | CTD | PMID:27858113 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of SHC4 mRNA | CTD | PMID:21715664 | benzo[b]fluoranthene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SHC4 mRNA | CTD | PMID:27858113 | bisphenol A | decreases methylation | ISO | SHC4 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of SHC4 gene | CTD | PMID:22576693 | bisphenol A | affects expression | ISO | Shc4 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of SHC4 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | SHC4 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of SHC4 mRNA | CTD | PMID:22576693 | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | SHC4 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to SHC4 gene] | CTD | PMID:28238834 | chrysene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SHC4 mRNA | CTD | PMID:27858113 | copper atom | multiple interactions | ISO | Shc4 (Rattus norvegicus) | 6480464 | [Copper co-treated with Dietary Sucrose] results in increased expression of SHC4 mRNA | CTD | PMID:26033743 | copper atom | increases expression | ISO | Shc4 (Rattus norvegicus) | 6480464 | Copper deficiency results in increased expression of SHC4 mRNA | CTD | PMID:26033743 | copper(0) | increases expression | ISO | Shc4 (Rattus norvegicus) | 6480464 | Copper deficiency results in increased expression of SHC4 mRNA | CTD | PMID:26033743 | copper(0) | multiple interactions | ISO | Shc4 (Rattus norvegicus) | 6480464 | [Copper co-treated with Dietary Sucrose] results in increased expression of SHC4 mRNA | CTD | PMID:26033743 | Cuprizon | increases expression | ISO | Shc4 (Rattus norvegicus) | 6480464 | Cuprizone results in increased expression of SHC4 mRNA | CTD | PMID:27523638 | D-glucose | increases expression | EXP | | 6480464 | Glucose results in increased expression of SHC4 mRNA | CTD | PMID:33448797 | D-glucose | multiple interactions | EXP | | 6480464 | fucoxanthin inhibits the reaction [Glucose results in increased expression of SHC4 mRNA] | CTD | PMID:33448797 | DDT | increases methylation | ISO | Shc4 (Rattus norvegicus) | 6480464 | DDT results in increased methylation of SHC4 gene | CTD | PMID:30207508 | dorsomorphin | multiple interactions | ISO | SHC4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SHC4 mRNA | CTD | PMID:27188386 | doxorubicin | increases expression | ISO | SHC4 (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of SHC4 mRNA | CTD | PMID:30031762 | endosulfan | increases expression | ISO | Shc4 (Rattus norvegicus) | 6480464 | Endosulfan results in increased expression of SHC4 mRNA | CTD | PMID:29391264 | epoxiconazole | increases expression | EXP | | 6480464 | epoxiconazole results in increased expression of SHC4 mRNA | CTD | PMID:35436446 | ethanol | increases expression | EXP | | 6480464 | Ethanol results in increased expression of SHC4 mRNA | CTD | PMID:30319688 | folic acid | affects expression | EXP | | 6480464 | Folic Acid affects the expression of SHC4 mRNA | CTD | PMID:25629700 | formaldehyde | increases expression | ISO | SHC4 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of SHC4 mRNA | CTD | PMID:23649840 | fucoxanthin | multiple interactions | EXP | | 6480464 | fucoxanthin inhibits the reaction [Glucose results in increased expression of SHC4 mRNA] | CTD | PMID:33448797 | genistein | decreases expression | EXP | | 6480464 | Genistein results in decreased expression of SHC4 mRNA | CTD | PMID:32186404 | gentamycin | increases expression | ISO | Shc4 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of SHC4 mRNA | CTD | PMID:33387578 | glucose | multiple interactions | EXP | | 6480464 | fucoxanthin inhibits the reaction [Glucose results in increased expression of SHC4 mRNA] | CTD | PMID:33448797 | glucose | increases expression | EXP | | 6480464 | Glucose results in increased expression of SHC4 mRNA | CTD | PMID:33448797 | glyphosate | decreases expression | ISO | SHC4 (Homo sapiens) | 6480464 | Glyphosate results in decreased expression of SHC4 mRNA | CTD | PMID:31295307 | graphene oxide | decreases expression | EXP | | 6480464 | graphene oxide analog results in decreased expression of SHC4 mRNA | CTD | PMID:33227293 | iron dichloride | decreases expression | ISO | SHC4 (Homo sapiens) | 6480464 | ferrous chloride results in decreased expression of SHC4 mRNA | CTD | PMID:35984750 | lidocaine | increases expression | ISO | Shc4 (Rattus norvegicus) | 6480464 | Lidocaine results in increased expression of SHC4 mRNA | CTD | PMID:35283115 | lucanthone | increases expression | ISO | SHC4 (Homo sapiens) | 6480464 | Lucanthone results in increased expression of SHC4 mRNA | CTD | PMID:21148553 | methoxychlor | affects methylation | ISO | Shc4 (Rattus norvegicus) | 6480464 | Methoxychlor affects the methylation of SHC4 gene | CTD | PMID:35440735 | methyl methanesulfonate | increases expression | ISO | SHC4 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of SHC4 mRNA | CTD | PMID:23649840 | methylisothiazolinone | increases expression | ISO | SHC4 (Homo sapiens) | 6480464 | 2-methyl-4-isothiazolin-3-one results in increased expression of SHC4 mRNA | CTD | PMID:31629900 | methylmercury chloride | decreases expression | ISO | SHC4 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of SHC4 mRNA | CTD | PMID:28001369 | mono(2-ethylhexyl) phthalate | increases expression | EXP | | 6480464 | mono-(2-ethylhexyl)phthalate results in increased expression of SHC4 mRNA | CTD | PMID:36189433 | N,N-diethyl-m-toluamide | multiple interactions | ISO | Shc4 (Rattus norvegicus) | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of SHC4 gene | CTD | PMID:33148267 | nickel atom | decreases expression | ISO | SHC4 (Homo sapiens) | 6480464 | Nickel results in decreased expression of SHC4 mRNA | CTD | PMID:24768652 and PMID:25583101 | ozone | multiple interactions | EXP | | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of SHC4 mRNA | CTD | PMID:34911549 | paracetamol | increases expression | ISO | Shc4 (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of SHC4 mRNA | CTD | PMID:33387578 | perfluorohexanesulfonic acid | increases expression | ISO | SHC4 (Homo sapiens) | 6480464 | perfluorohexanesulfonic acid results in increased expression of SHC4 mRNA | CTD | PMID:25812627 | perfluorooctanoic acid | increases expression | ISO | SHC4 (Homo sapiens) | 6480464 | perfluorooctanoic acid results in increased expression of SHC4 mRNA | CTD | PMID:25812627 | permethrin | multiple interactions | ISO | Shc4 (Rattus norvegicus) | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of SHC4 gene | CTD | PMID:33148267 | progesterone | multiple interactions | ISO | SHC4 (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in decreased expression of SHC4 mRNA | CTD | PMID:20660070 | propanal | increases expression | ISO | SHC4 (Homo sapiens) | 6480464 | propionaldehyde results in increased expression of SHC4 mRNA | CTD | PMID:26079696 | SB 431542 | multiple interactions | ISO | SHC4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SHC4 mRNA | CTD | PMID:27188386 | sodium arsenite | multiple interactions | ISO | SHC4 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of and affects the splicing of SHC4 mRNA | CTD | PMID:25879800 | temozolomide | increases expression | ISO | SHC4 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of SHC4 mRNA | CTD | PMID:31758290 | tetrachloromethane | increases expression | ISO | Shc4 (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in increased expression of SHC4 mRNA | CTD | PMID:30723492 | tetraphene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SHC4 mRNA | CTD | PMID:27858113 | trichloroethene | increases expression | ISO | Shc4 (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased expression of SHC4 mRNA | CTD | PMID:33387578 | trichostatin A | increases expression | ISO | SHC4 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of SHC4 mRNA | CTD | PMID:24935251 | triptonide | affects expression | EXP | | 6480464 | triptonide affects the expression of SHC4 mRNA | CTD | PMID:33045310 | trovafloxacin | decreases expression | EXP | | 6480464 | trovafloxacin results in decreased expression of SHC4 mRNA | CTD | PMID:35537566 | valproic acid | decreases methylation | ISO | SHC4 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of SHC4 gene | CTD | PMID:29154799 | valproic acid | increases expression | ISO | SHC4 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of SHC4 mRNA | CTD | PMID:24935251 | valproic acid | decreases expression | ISO | SHC4 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of SHC4 mRNA | CTD | PMID:26272509 | valproic acid | multiple interactions | ISO | SHC4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SHC4 mRNA | CTD | PMID:27188386 | vinclozolin | increases methylation | ISO | Shc4 (Rattus norvegicus) | 6480464 | vinclozolin results in increased methylation of SHC4 gene | CTD | PMID:31079544 | zoledronic acid | decreases expression | ISO | SHC4 (Homo sapiens) | 6480464 | zoledronic acid results in decreased expression of SHC4 mRNA | CTD | PMID:24714768 | |