Fgf10 (fibroblast growth factor 10) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Fgf10 (fibroblast growth factor 10) Mus musculus
Analyze
Symbol: Fgf10
Name: fibroblast growth factor 10
RGD ID: 10578
MGI Page MGI
Description: Exhibits chemoattractant activity. Involved in several processes, including animal organ development; positive regulation of cell population proliferation; and regulation of signal transduction. Localizes to extracellular space. Predicted to colocalize with collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study LADD syndrome and intestinal atresia. Human ortholog(s) of this gene implicated in LADD syndrome and aplasia of lacrimal and salivary glands. Orthologous to human FGF10 (fibroblast growth factor 10); PARTICIPATES IN melanoma pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (S)-amphetamine; 2,3,7,8-tetrachlorodibenzodioxine; 3-methylcholanthrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AEY1; AEY17; BB213776; Fgf-10; Fgf5a; fibroblast growth factor 5a; Gsfaey; Gsfaey17; keratinocyte growth factor 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913118,851,235 - 118,929,109 (+)NCBIGRCm39mm39
GRCm39 Ensembl13118,806,327 - 118,928,651 (+)Ensembl
GRCm3813118,714,699 - 118,792,573 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13118,669,791 - 118,792,115 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713119,503,506 - 119,581,380 (+)NCBIGRCm37mm9NCBIm37
MGSCv3613119,833,907 - 119,910,988 (+)NCBImm8
Celera13123,161,950 - 123,245,519 (+)NCBICelera
Cytogenetic Map13D2.3NCBI
cM Map1367.14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton reorganization  (ISO)
activation of MAPK activity  (ISO)
angiogenesis  (ISO)
animal organ formation  (IMP)
animal organ morphogenesis  (IBA,IDA,IMP)
blood vessel morphogenesis  (IMP)
blood vessel remodeling  (IGI)
branch elongation involved in salivary gland morphogenesis  (IMP)
branching involved in salivary gland morphogenesis  (IDA,IGI)
branching morphogenesis of an epithelial tube  (ISO)
bronchiole morphogenesis  (IMP)
bud elongation involved in lung branching  (IGI)
bud outgrowth involved in lung branching  (ISO)
cell differentiation  (IBA,ISO)
cell-cell signaling  (IDA,IMP)
chemotaxis  (IDA)
determination of left/right symmetry  (IMP)
digestive tract development  (IMP)
embryonic camera-type eye development  (IMP)
embryonic digestive tract development  (IMP)
embryonic digestive tract morphogenesis  (IMP)
embryonic genitalia morphogenesis  (IMP)
embryonic pattern specification  (IMP)
epidermis development  (IMP)
epidermis morphogenesis  (IMP)
epithelial cell differentiation  (IMP)
epithelial cell proliferation  (ISO)
epithelial cell proliferation involved in salivary gland morphogenesis  (IGI,IMP)
epithelial tube branching involved in lung morphogenesis  (IDA,IMP)
ERK1 and ERK2 cascade  (ISO)
establishment of mitotic spindle orientation  (IGI)
female genitalia morphogenesis  (IMP)
fibroblast growth factor receptor signaling pathway  (IBA)
fibroblast growth factor receptor signaling pathway involved in mammary gland specification  (IBA,IDA,IMP,ISO)
hair follicle morphogenesis  (IMP)
Harderian gland development  (IMP)
induction of positive chemotaxis  (IDA)
inner ear morphogenesis  (IGI,IMP)
lacrimal gland development  (IMP,ISO)
limb bud formation  (IMP)
limb development  (IBA,IMP)
limb morphogenesis  (IMP)
lung alveolus development  (IGI,IMP)
lung development  (IDA,IMP)
lung epithelium development  (ISO)
lung morphogenesis  (IMP)
lung proximal/distal axis specification  (IDA)
lung saccule development  (ISO)
male genitalia morphogenesis  (IMP)
mammary gland bud formation  (IMP)
mammary gland specification  (IGI)
mesenchymal cell differentiation involved in lung development  (IGI)
mesenchymal-epithelial cell signaling involved in lung development  (IDA)
mesonephros development  (ISO)
metanephros development  (ISO)
metanephros morphogenesis  (IMP)
muscle cell fate commitment  (IMP)
negative regulation of cell differentiation  (IDA)
negative regulation of cell population proliferation  (IDA)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (IMP)
odontogenesis of dentin-containing tooth  (IMP)
organ growth  (IMP)
organ induction  (IGI,ISO)
otic vesicle formation  (IGI,TAS)
pancreas development  (IMP)
pituitary gland development  (IMP)
positive chemotaxis  (IBA,IDA,ISO)
positive regulation of ATPase activity  (ISO)
positive regulation of canonical Wnt signaling pathway  (IBA,IMP)
positive regulation of cell population proliferation  (IBA,IDA)
positive regulation of DNA repair  (ISO)
positive regulation of epithelial cell migration  (IBA,IDA,IMP,ISO)
positive regulation of epithelial cell proliferation  (IBA,IMP,ISO)
positive regulation of ERK1 and ERK2 cascade  (IBA,IGI,IMP,ISO)
positive regulation of fibroblast proliferation  (IMP)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of gene expression  (IBA)
positive regulation of hair follicle cell proliferation  (ISO)
positive regulation of keratinocyte migration  (ISO)
positive regulation of keratinocyte proliferation  (IMP,ISO)
positive regulation of lymphocyte proliferation  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mitotic cell cycle  (IMP)
positive regulation of Notch signaling pathway  (IGI)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein phosphorylation  (IBA)
positive regulation of Ras protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA)
positive regulation of transcription, DNA-templated  (IDA)
positive regulation of urothelial cell proliferation  (ISO)
positive regulation of vascular endothelial growth factor receptor signaling pathway  (IMP)
positive regulation of white fat cell proliferation  (IMP)
positive regulation of Wnt signaling pathway  (IMP)
prostatic bud formation  (IGI)
protein localization to cell surface  (ISO)
radial glial cell differentiation  (IMP)
regulation of activin receptor signaling pathway  (IMP)
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  (IDA)
regulation of cell cycle  (ISO)
regulation of cell migration  (IBA)
regulation of gene expression  (IMP)
regulation of saliva secretion  (ISO)
regulation of smoothened signaling pathway  (IMP)
respiratory system development  (IDA)
response to estradiol  (ISO)
response to lipopolysaccharide  (ISO)
response to organic cyclic compound  (ISO)
salivary gland development  (ISO)
salivary gland morphogenesis  (IMP)
secretion by lung epithelial cell involved in lung growth  (IBA,ISO)
semicircular canal fusion  (IMP)
semicircular canal morphogenesis  (IGI)
smooth muscle cell differentiation  (IMP)
somatic stem cell population maintenance  (IMP)
spleen development  (IMP)
submandibular salivary gland formation  (IMP)
tear secretion  (ISO)
thymus development  (ISO)
thyroid gland development  (IMP)
tissue regeneration  (ISO)
type II pneumocyte differentiation  (IDA)
urothelial cell proliferation  (ISO)
white fat cell differentiation  (IMP)
wound healing  (IBA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
aberrant origin of the right subclavian artery  (IAGP)
abnormal adipose tissue morphology  (IAGP)
abnormal aortic arch morphology  (IAGP)
abnormal branching involved in trachea morphogenesis  (IAGP)
abnormal branching of the mammary ductal tree  (IAGP)
abnormal cardiac epithelial to mesenchymal transition  (IAGP)
abnormal cardiac neural crest cell migration  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal cardiovascular development  (IAGP)
abnormal cecum development  (IAGP)
abnormal cochlea morphology  (IAGP)
abnormal colon morphology  (IAGP)
abnormal common carotid artery morphology  (IAGP)
abnormal crista ampullaris morphology  (IAGP)
abnormal ear development  (IAGP)
abnormal ear morphology  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal forced expiratory flow rates  (IAGP)
abnormal fourth pharyngeal arch artery morphology  (IAGP)
abnormal gastric chief cell morphology  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair shaft morphology  (IAGP)
abnormal heart atrium auricular region morphology  (IAGP)
abnormal heart position or orientation  (IAGP)
abnormal hindgut morphology  (IAGP)
abnormal hypaxial muscle morphology  (IAGP)
abnormal incisor morphology  (IAGP)
abnormal inner ear canal morphology  (IAGP)
abnormal inner ear morphology  (IAGP)
abnormal inner ear vestibule morphology  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal kidney inner medulla morphology  (IAGP)
abnormal kidney medulla morphology  (IAGP)
abnormal kidney outer medulla morphology  (IAGP)
abnormal large intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal lateral nasal gland morphology  (IAGP)
abnormal lens epithelium morphology  (IAGP)
abnormal lens fiber morphology  (IAGP)
abnormal lens morphology  (IAGP)
abnormal limb bud morphology  (IAGP)
abnormal limb development  (IAGP)
abnormal lung bud morphology  (IAGP)
abnormal lung development  (IAGP)
abnormal lung lobe morphology  (IAGP)
abnormal male reproductive system morphology  (IAGP)
abnormal mammary fat pad morphology  (IAGP)
abnormal mammary placode morphology  (IAGP)
abnormal metanephric ureteric bud development  (IAGP)
abnormal nasal gland morphology  (IAGP)
abnormal neurohypophysis development  (IAGP)
abnormal otic vesicle development  (IAGP)
abnormal palate morphology  (IAGP)
abnormal pelvic girdle bone morphology  (IAGP)
abnormal periderm development  (IAGP)
abnormal pharyngeal arch artery morphology  (IAGP)
abnormal primitive urogenital sinus morphology  (IAGP)
abnormal prostate gland morphology  (IAGP)
abnormal pulmonary circulation  (IAGP)
abnormal pulmonary elastic fiber morphology  (IAGP)
abnormal pulmonary trunk morphology  (IAGP)
abnormal Rathke's pouch apoptosis  (IAGP)
abnormal respiratory system morphology  (IAGP)
abnormal retinal apoptosis  (IAGP)
abnormal right lung accessory lobe morphology  (IAGP)
abnormal right lung cranial lobe morphology  (IAGP)
abnormal right lung middle lobe morphology  (IAGP)
abnormal scapula morphology  (IAGP)
abnormal secondary palate development  (IAGP)
abnormal sensory neuron innervation pattern  (IAGP)
abnormal sixth pharyngeal arch artery morphology  (IAGP)
abnormal stomach submucosa morphology  (IAGP)
abnormal sublingual gland morphology  (IAGP)
abnormal submandibular duct morphology  (IAGP)
abnormal submandibular gland development  (IAGP)
abnormal third pharyngeal arch artery morphology  (IAGP)
abnormal tongue morphology  (IAGP)
abnormal tooth morphology  (IAGP)
abnormal urethra morphology  (IAGP)
abnormal utricle morphology  (IAGP)
abnormal vestibular hair cell kinocilium morphology  (IAGP)
abnormal vestibular hair cell stereociliary bundle morphology  (IAGP)
abnormal Wolffian duct morphology  (IAGP)
absent adenohypophysis  (IAGP)
absent bulbourethral gland  (IAGP)
absent colon  (IAGP)
absent forelimb  (IAGP)
absent Harderian gland  (IAGP)
absent hindlimb  (IAGP)
absent humerus  (IAGP)
absent inner ear  (IAGP)
absent lacrimal glands  (IAGP)
absent limb buds  (IAGP)
absent limbs  (IAGP)
absent lung buds  (IAGP)
absent lungs  (IAGP)
absent otic vesicle  (IAGP)
absent palatal rugae  (IAGP)
absent pituitary gland  (IAGP)
absent posterior semicircular canal  (IAGP)
absent prostate gland  (IAGP)
absent pulmonary artery  (IAGP)
absent pulmonary vein  (IAGP)
absent radius  (IAGP)
absent Rathke's pouch  (IAGP)
absent rectum  (IAGP)
absent salivary gland  (IAGP)
absent seminal vesicle  (IAGP)
absent submandibular gland  (IAGP)
absent superior semicircular canal  (IAGP)
absent thyroid gland  (IAGP)
absent ulna  (IAGP)
absent vestibulocochlear ganglion  (IAGP)
cecal atresia  (IAGP)
cleft secondary palate  (IAGP)
curly tail  (IAGP)
decreased body weight  (IAGP)
decreased colon length  (IAGP)
decreased fetal size  (IAGP)
decreased grip strength  (IEA)
decreased hair follicle number  (IAGP)
decreased heart right ventricle size  (IAGP)
decreased lateral semicircular canal size  (IAGP)
decreased lean body mass  (IEA)
decreased palatal length  (IAGP)
decreased pancreatic beta cell number  (IAGP)
decreased salivation  (IAGP)
decreased submandibular gland size  (IAGP)
decreased trachea gland number  (IAGP)
dextrocardia  (IAGP)
diaphragmatic hernia  (IAGP)
dilated kidney calyx  (IAGP)
double outlet right ventricle  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
epididymal cyst  (IAGP)
eyelids open at birth  (IAGP)
Harderian gland atrophy  (IAGP)
hypospadia  (IAGP)
impaired branching involved in bronchus morphogenesis  (IAGP)
impaired branching involved in preterminal bronchiole morphogenesis  (IAGP)
impaired lung alveolus development  (IAGP)
increased circulating cholesterol level  (IEA)
increased circulating HDL cholesterol level  (IEA)
increased hair follicle apoptosis  (IAGP)
increased total body fat amount  (IEA)
interdigital webbing  (IAGP)
lung hemorrhage  (IAGP)
microphthalmia  (IAGP)
narrow eye opening  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
palatal shelf fusion with tongue or mandible  (IAGP)
pancreas fibrosis  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
polydipsia  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
pulmonary hypoplasia  (IAGP)
reduced enamel thickness  (IAGP)
right aortic arch  (IAGP)
second pharyngeal arch hypoplasia  (IAGP)
short incisors  (IAGP)
short tail  (IAGP)
small ears  (IAGP)
small hair follicle bulb  (IAGP)
small kidney  (IAGP)
small lung  (IAGP)
small lung lobe  (IAGP)
small molars  (IAGP)
small otic capsule  (IAGP)
small otic vesicle  (IAGP)
small pancreas  (IAGP)
small salivary gland  (IAGP)
small stomach  (IAGP)
small thymus  (IAGP)
small vestibular saccule  (IAGP)
submandibular gland hypoplasia  (IAGP)
thin epidermis  (IAGP)
thin skin  (IAGP)
third pharyngeal arch hypoplasia  (IAGP)
tongue ankylosis  (IAGP)
translucent skin  (IAGP)
ventricular septal defect  (IAGP)
xerostomia  (IAGP)
References

Additional References at PubMed
PMID:7543410   PMID:8104708   PMID:9332392   PMID:9393979   PMID:9428423   PMID:9435295   PMID:9651475   PMID:9731532   PMID:9733575   PMID:9740653   PMID:9768363   PMID:9784490  
PMID:9790778   PMID:9916808   PMID:9988217   PMID:10021340   PMID:10192400   PMID:10330503   PMID:10349636   PMID:10446271   PMID:10512194   PMID:10518490   PMID:10534616   PMID:10572052  
PMID:10642790   PMID:10662638   PMID:10677252   PMID:10706142   PMID:10769235   PMID:10802662   PMID:10804187   PMID:10821755   PMID:10862743   PMID:10922068   PMID:10934262   PMID:10952944  
PMID:10964474   PMID:10984614   PMID:11042159   PMID:11062007   PMID:11066089   PMID:11076861   PMID:11101845   PMID:11101846   PMID:11152636   PMID:11165488   PMID:11180951   PMID:11217851  
PMID:11238011   PMID:11274405   PMID:11287183   PMID:11489975   PMID:11493531   PMID:11493558   PMID:11702954   PMID:11731482   PMID:11731698   PMID:11741978   PMID:11747081   PMID:11748146  
PMID:11782400   PMID:11795391   PMID:11880361   PMID:11890684   PMID:11900978   PMID:11923311   PMID:11943666   PMID:11959839   PMID:12004962   PMID:12074550   PMID:12086465   PMID:12117807  
PMID:12142021   PMID:12142027   PMID:12152071   PMID:12163410   PMID:12167404   PMID:12175489   PMID:12194867   PMID:12223415   PMID:12223416   PMID:12231626   PMID:12388344   PMID:12399308  
PMID:12399319   PMID:12413903   PMID:12413905   PMID:12421715   PMID:12441290   PMID:12466851   PMID:12477932   PMID:12489159   PMID:12490567   PMID:12496842   PMID:12508227   PMID:12569124  
PMID:12569130   PMID:12588849   PMID:12615071   PMID:12666204   PMID:12736212   PMID:12736217   PMID:12761848   PMID:12781690   PMID:12781692   PMID:12810586   PMID:12818887   PMID:12837279  
PMID:12874121   PMID:12885771   PMID:12913075   PMID:12917290   PMID:12920023   PMID:12941620   PMID:14517990   PMID:14530295   PMID:14597661   PMID:14604677   PMID:14610273   PMID:14623822  
PMID:14641326   PMID:14651921   PMID:14667410   PMID:14668414   PMID:14681479   PMID:14697353   PMID:14994542   PMID:15017552   PMID:15037319   PMID:15063181   PMID:15069081   PMID:15071597  
PMID:15086024   PMID:15108315   PMID:15130516   PMID:15136142   PMID:15175244   PMID:15199404   PMID:15208658   PMID:15234214   PMID:15260994   PMID:15280212   PMID:15328018   PMID:15328019  
PMID:15328022   PMID:15329346   PMID:15340846   PMID:15358670   PMID:15361625   PMID:15363409   PMID:15385444   PMID:15459098   PMID:15469978   PMID:15489334   PMID:15525990   PMID:15531758  
PMID:15556938   PMID:15572143   PMID:15632069   PMID:15654336   PMID:15741321   PMID:15750921   PMID:15750935   PMID:15765517   PMID:15789410   PMID:15800000   PMID:15806171   PMID:15843406  
PMID:15843416   PMID:15901664   PMID:15958512   PMID:15963767   PMID:15972105   PMID:15973734   PMID:16123981   PMID:16127717   PMID:16140987   PMID:16141072   PMID:16141073   PMID:16141225  
PMID:16151852   PMID:16169547   PMID:16172976   PMID:16308329   PMID:16313398   PMID:16324690   PMID:16326081   PMID:16375885   PMID:16380715   PMID:16386727   PMID:16427040   PMID:16452165  
PMID:16470835   PMID:16494859   PMID:16495310   PMID:16510502   PMID:16513252   PMID:16540513   PMID:16556916   PMID:16607638   PMID:16611688   PMID:16618415   PMID:16687131   PMID:16691564  
PMID:16720875   PMID:16738056   PMID:16759284   PMID:16806848   PMID:16818445   PMID:16838370   PMID:16839542   PMID:16890158   PMID:16900517   PMID:16916509   PMID:16956603   PMID:16989802  
PMID:17000704   PMID:17071719   PMID:17090159   PMID:17126317   PMID:17164422   PMID:17187775   PMID:17196193   PMID:17202188   PMID:17238155   PMID:17286298   PMID:17350578   PMID:17359964  
PMID:17367776   PMID:17369402   PMID:17394208   PMID:17467687   PMID:17500053   PMID:17515859   PMID:17519332   PMID:17522155   PMID:17537800   PMID:17560563   PMID:17576928   PMID:17583691  
PMID:17601531   PMID:17609292   PMID:17625108   PMID:17634193   PMID:17668871   PMID:17693063   PMID:17707671   PMID:17825816   PMID:17855431   PMID:17904116   PMID:17907201   PMID:17919533  
PMID:17942481   PMID:17944804   PMID:17951031   PMID:17959718   PMID:17969154   PMID:18000065   PMID:18022820   PMID:18023262   PMID:18058912   PMID:18068633   PMID:18077585   PMID:18077586  
PMID:18082381   PMID:18186922   PMID:18230614   PMID:18231602   PMID:18256198   PMID:18280296   PMID:18287057   PMID:18287559   PMID:18329286   PMID:18351662   PMID:18367557   PMID:18381212  
PMID:18393307   PMID:18404215   PMID:18412219   PMID:18462699   PMID:18533146   PMID:18559345   PMID:18703040   PMID:18718461   PMID:18723448   PMID:18773490   PMID:18773495   PMID:18799693  
PMID:18816854   PMID:18835578   PMID:18948418   PMID:18985730   PMID:18990706   PMID:19027001   PMID:19091945   PMID:19097117   PMID:19164599   PMID:19229337   PMID:19233133   PMID:19304889  
PMID:19304890   PMID:19389351   PMID:19389375   PMID:19407009   PMID:19410332   PMID:19414008   PMID:19476657   PMID:19500387   PMID:19544582   PMID:19551815   PMID:19559694   PMID:19581591  
PMID:19581825   PMID:19607792   PMID:19609448   PMID:19618463   PMID:19631635   PMID:19686689   PMID:19755711   PMID:19766620   PMID:19769959   PMID:19782673   PMID:19805295   PMID:19805408  
PMID:19842186   PMID:19855134   PMID:19855977   PMID:19898483   PMID:19906864   PMID:19913004   PMID:19913006   PMID:19934017   PMID:19969077   PMID:20035084   PMID:20040496   PMID:20084103  
PMID:20110535   PMID:20122914   PMID:20123092   PMID:20159597   PMID:20171206   PMID:20185815   PMID:20193675   PMID:20214979   PMID:20237272   PMID:20335360   PMID:20348033   PMID:20671187  
PMID:20705941   PMID:20724449   PMID:20727874   PMID:20736290   PMID:20826535   PMID:20883684   PMID:20883686   PMID:20920724   PMID:20934536   PMID:20970343   PMID:20978072   PMID:21068310  
PMID:21070765   PMID:21087601   PMID:21098569   PMID:21129374   PMID:21145505   PMID:21146598   PMID:21148187   PMID:21185278   PMID:21203390   PMID:21223962   PMID:21247964   PMID:21256124  
PMID:21281624   PMID:21307092   PMID:21311046   PMID:21350014   PMID:21357686   PMID:21362415   PMID:21364285   PMID:21384471   PMID:21385574   PMID:21385575   PMID:21402782   PMID:21420948  
PMID:21490060   PMID:21512031   PMID:21513708   PMID:21515253   PMID:21518438   PMID:21559415   PMID:21606200   PMID:21655085   PMID:21664901   PMID:21677750   PMID:21696361   PMID:21704027  
PMID:21720756   PMID:21738788   PMID:21742743   PMID:21750028   PMID:21750040   PMID:21750042   PMID:21757651   PMID:21764747   PMID:21779394   PMID:21862563   PMID:21873635   PMID:21876757  
PMID:21905163   PMID:21937598   PMID:21956870   PMID:21985786   PMID:22178153   PMID:22182523   PMID:22235191   PMID:22292060   PMID:22303449   PMID:22371266   PMID:22377357   PMID:22387209  
PMID:22411555   PMID:22421044   PMID:22438573   PMID:22461561   PMID:22465667   PMID:22537490   PMID:22629441   PMID:22643896   PMID:22662233   PMID:22682244   PMID:22705977   PMID:22719891  
PMID:22745308   PMID:22819339   PMID:22819677   PMID:22874919   PMID:22876201   PMID:22912418   PMID:22945632   PMID:22972661   PMID:22972697   PMID:23023706   PMID:23093675   PMID:23133671  
PMID:23220102   PMID:23293290   PMID:23322300   PMID:23341776   PMID:23390542   PMID:23449471   PMID:23451037   PMID:23451260   PMID:23460641   PMID:23466739   PMID:23468377   PMID:23523683  
PMID:23554498   PMID:23555292   PMID:23558680   PMID:23599340   PMID:23614009   PMID:23620511   PMID:23633510   PMID:23666531   PMID:23674600   PMID:23804023   PMID:23836893   PMID:23924632  
PMID:23951403   PMID:24058167   PMID:24068957   PMID:24145799   PMID:24167707   PMID:24173808   PMID:24191021   PMID:24194600   PMID:24198358   PMID:24274029   PMID:24320134   PMID:24353064  
PMID:24361260   PMID:24381199   PMID:24424161   PMID:24443808   PMID:24465223   PMID:24553287   PMID:24582960   PMID:24591256   PMID:24626928   PMID:24671096   PMID:24680892   PMID:24689077  
PMID:24705356   PMID:24859004   PMID:24886827   PMID:24924191   PMID:24952961   PMID:25078648   PMID:25109552   PMID:25114215   PMID:25166858   PMID:25190705   PMID:25302779   PMID:25315894  
PMID:25329657   PMID:25344367   PMID:25359721   PMID:25446127   PMID:25451979   PMID:25468972   PMID:25624266   PMID:25670795   PMID:25673119   PMID:25678108   PMID:25685806   PMID:25713296  
PMID:25721301   PMID:25805134   PMID:25820524   PMID:25848055   PMID:25907274   PMID:25916343   PMID:26075383   PMID:26116661   PMID:26123167   PMID:26160903   PMID:26220830   PMID:26235626  
PMID:26284287   PMID:26321050   PMID:26321200   PMID:26321752   PMID:26329601   PMID:26450967   PMID:26453795   PMID:26459221   PMID:26487719   PMID:26511927   PMID:26550799   PMID:26555052  
PMID:26661618   PMID:26745863   PMID:26748348   PMID:26764381   PMID:26921474   PMID:26984772   PMID:27046834   PMID:27106761   PMID:27141870   PMID:27180663   PMID:27184910   PMID:27206683  
PMID:27352137   PMID:27590203   PMID:27606604   PMID:27626380   PMID:27633990   PMID:27633995   PMID:27668656   PMID:27770432   PMID:27826253   PMID:27827819   PMID:27867035   PMID:27913639  
PMID:27917898   PMID:27930333   PMID:27992425   PMID:28069589   PMID:28082865   PMID:28172500   PMID:28192800   PMID:28287088   PMID:28323616   PMID:28336912   PMID:28346476   PMID:28357999  
PMID:28370670   PMID:28387977   PMID:28501478   PMID:28506989   PMID:28506998   PMID:28511845   PMID:28527696   PMID:28538179   PMID:28619823   PMID:28644741   PMID:28675425   PMID:28807898  
PMID:28818950   PMID:28827394   PMID:28859094   PMID:28923684   PMID:28938441   PMID:28939119   PMID:28941984   PMID:28981091   PMID:28982687   PMID:29017029   PMID:29028795   PMID:29031500  
PMID:29126155   PMID:29222391   PMID:29361553   PMID:29367466   PMID:29408236   PMID:29409032   PMID:29420474   PMID:29509905   PMID:29562183   PMID:29700203   PMID:29866044   PMID:29899403  
PMID:29950483   PMID:30016433   PMID:30022023   PMID:30228991   PMID:30305289   PMID:30377232   PMID:30389913   PMID:30504125   PMID:30566624   PMID:30578393   PMID:30651296   PMID:30651543  
PMID:30653268   PMID:30929920   PMID:30965042   PMID:31056475   PMID:31118233   PMID:31144392   PMID:31242446   PMID:31242448   PMID:31431501   PMID:31486675   PMID:31843520   PMID:32001436  
PMID:32127497   PMID:32243674   PMID:32661019   PMID:32662771   PMID:32715478   PMID:32778568   PMID:32804075   PMID:33057360   PMID:33141892   PMID:33158935   PMID:33363172  


Genomics

Comparative Map Data
Fgf10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913118,851,235 - 118,929,109 (+)NCBIGRCm39mm39
GRCm39 Ensembl13118,806,327 - 118,928,651 (+)Ensembl
GRCm3813118,714,699 - 118,792,573 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13118,669,791 - 118,792,115 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713119,503,506 - 119,581,380 (+)NCBIGRCm37mm9NCBIm37
MGSCv3613119,833,907 - 119,910,988 (+)NCBImm8
Celera13123,161,950 - 123,245,519 (+)NCBICelera
Cytogenetic Map13D2.3NCBI
cM Map1367.14NCBI
FGF10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl544,303,544 - 44,389,706 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl544,300,247 - 44,389,706 (-)EnsemblGRCh38hg38GRCh38
GRCh38544,300,247 - 44,389,706 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37544,300,349 - 44,389,522 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36544,340,854 - 44,424,541 (-)NCBINCBI36hg18NCBI36
Build 34544,340,853 - 44,424,541NCBI
Celera544,197,375 - 44,281,044 (-)NCBI
Cytogenetic Map5p12NCBI
HuRef544,258,055 - 44,341,703 (-)NCBIHuRef
CHM1_1544,306,497 - 44,390,196 (-)NCBICHM1_1
Fgf10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2250,801,897 - 50,875,428 (+)NCBI
Rnor_6.0 Ensembl251,672,722 - 51,750,369 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0251,673,480 - 51,747,533 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0270,046,331 - 70,120,384 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4250,866,799 - 50,940,319 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1250,795,031 - 50,868,552 (+)NCBI
Celera246,463,913 - 46,537,376 (+)NCBICelera
Cytogenetic Map2q15NCBI
Fgf10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544618,163,117 - 18,245,199 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544618,163,117 - 18,244,840 (+)NCBIChiLan1.0ChiLan1.0
FGF10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1571,028,324 - 71,111,713 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl571,028,187 - 71,111,706 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0565,979,443 - 66,069,314 (+)NCBIMhudiblu_PPA_v0panPan3
FGF10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1465,851,130 - 65,930,944 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl465,851,069 - 65,928,192 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha465,597,673 - 65,676,839 (+)NCBI
ROS_Cfam_1.0466,343,407 - 66,423,104 (+)NCBI
UMICH_Zoey_3.1466,096,317 - 66,176,025 (+)NCBI
UNSW_CanFamBas_1.0466,218,509 - 66,297,862 (+)NCBI
UU_Cfam_GSD_1.0466,768,760 - 66,848,396 (+)NCBI
Fgf10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213209,177,124 - 209,259,405 (+)NCBI
SpeTri2.0NW_00493648018,114,231 - 18,195,884 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1628,695,469 - 28,777,541 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11628,695,465 - 28,779,953 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21630,234,658 - 30,317,449 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGF10
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1443,080,387 - 43,163,355 (-)NCBI
ChlSab1.1 Ensembl443,081,831 - 43,163,432 (-)Ensembl
Fgf10
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475910,904,626 - 10,983,509 (+)NCBI

Position Markers
BE627415  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813118,792,019 - 118,792,106UniSTSGRCm38
MGSCv3713119,580,826 - 119,580,913UniSTSGRCm37
Celera13123,244,965 - 123,245,052UniSTS
Cytogenetic Map13A3-A4UniSTS
Whitehead/MRC_RH131030.7UniSTS
BB213776  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813118,791,026 - 118,791,125UniSTSGRCm38
MGSCv3713119,579,833 - 119,579,932UniSTSGRCm37
Celera13123,243,972 - 123,244,071UniSTS
Cytogenetic Map13A3-A4UniSTS
Whitehead/MRC_RH131045.33UniSTS
Fgf10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv3713119,504,266 - 119,504,491UniSTSGRCm37
Celera13123,162,710 - 123,162,935UniSTS
Cytogenetic Map13A3-A4UniSTS
cM Map1375.0UniSTS
Fgf10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A3-A4UniSTS
Fgf10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A3-A4UniSTS
Fgf10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A3-A4UniSTS
cM Map1375.0UniSTS
Fgf10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A3-A4UniSTS
Fgf10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A3-A4UniSTS
Fgf10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813118,715,459 - 118,715,684UniSTSGRCm38
MGSCv3713119,504,266 - 119,504,491UniSTSGRCm37
Celera13123,162,710 - 123,162,935UniSTS
Cytogenetic Map13A3-A4UniSTS
Fgf10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A3-A4UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
14700691Cisaq1_mcoxsackieviral infection serum ALT QTL 1 (mouse)1386000000120000000Mouse
4140995Fbtq6_mfemoral bone trait QTL 6 (mouse)Not determined1386205109120205250Mouse
1300939Hrtfm6_mheart failure modifier 6 (mouse)Not determined1391247158120421639Mouse
1300876Tanidd2_mtally ho associated non-insulin dependednt diabetes mellitus 2 (mouse)Not determined1391828769120421639Mouse
1301142Heal2_mwound healing/regeneration 2 (mouse)Not determined1393738733120421639Mouse
4142338Skmw18_mskeletal muscle weight 18 (mouse)Not determined1394391865120421639Mouse
1558763Gct9_mgranulosa cell tumorigenesis 9 (mouse)Not determined1394900290120421639Mouse
1357468Rplag_mreduced platelet aggregation (mouse)Not determined1395365596120421639Mouse
14746974Manh75_mmandible shape 75 (mouse)1399250111120421639Mouse
12879496Fexq2_mfear expression QTL 2 (mouse)13100604983120421639Mouse
4142400Tgq24_mtriglyceride QTL 24 (mouse)Not determined102466094120421639Mouse
4142334Svtms_msurvival time modifier of Sod2 (mouse)Not determined13107477080119339836Mouse
4141704Hipq1_mhyperinsulin production QTL 1 (mouse)Not determined110272953119339836Mouse
4141005Ssrq11_mstress response QTL 11 (mouse)Not determined116906406118829453Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir31mmu-miR-31-5pMirtarbaseexternal_infoReporter assayFunctional MTI20522784
Mir31mmu-miR-31-5pTarbaseexternal_infoReporter GenePOSITIVE

Predicted Target Of
Summary Value
Count of predictions:959
Count of miRNA genes:504
Interacting mature miRNAs:642
Transcripts:ENSMUST00000022246, ENSMUST00000128103, ENSMUST00000146674
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000022246   ⟹   ENSMUSP00000022246
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl13118,714,699 - 118,792,115 (+)Ensembl
RefSeq Acc Id: ENSMUST00000128103
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl13118,669,791 - 118,789,334 (+)Ensembl
RefSeq Acc Id: ENSMUST00000146674
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl13118,669,824 - 118,781,577 (+)Ensembl
RefSeq Acc Id: NM_008002   ⟹   NP_032028
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3913118,851,235 - 118,929,109 (+)NCBI
GRCm3813118,714,699 - 118,792,573 (+)ENTREZGENE
MGSCv3713119,503,506 - 119,581,380 (+)RGD
Celera13123,161,950 - 123,245,519 (+)RGD
cM Map13 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032028   ⟸   NM_008002
- Peptide Label: precursor
- UniProtKB: O35565 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000022246   ⟸   ENSMUST00000022246

Promoters
RGD ID:8681378
Promoter ID:EPDNEW_M18720
Type:initiation region
Name:Fgf10_1
Description:Mus musculus fibroblast growth factor 10 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M18721  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3813118,714,663 - 118,714,723EPDNEW
RGD ID:8681380
Promoter ID:EPDNEW_M18721
Type:single initiation site
Name:Fgf10_2
Description:Mus musculus fibroblast growth factor 10 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M18720  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3813118,715,019 - 118,715,079EPDNEW
RGD ID:6823932
Promoter ID:MM_KWN:15361
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3
Transcripts:AK044039_GM3247,   NM_008002
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3613119,503,546 - 119,504,437 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1099809 AgrOrtholog
Ensembl Genes ENSMUSG00000021732 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000022246 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000022246 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro FGF10 UniProtKB/Swiss-Prot
  Fibroblast_GF_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14165 UniProtKB/Swiss-Prot
MGD MGI:1099809 ENTREZGENE
NCBI Gene 14165 ENTREZGENE
PANTHER PTHR11486 UniProtKB/Swiss-Prot
  PTHR11486:SF21 UniProtKB/Swiss-Prot
Pfam FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fgf10 PhenoGen
PRINTS HBGFFGF UniProtKB/Swiss-Prot
PROSITE HBGF_FGF UniProtKB/Swiss-Prot
SMART FGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt FGF10_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q76LY2_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q543V5 UniProtKB/Swiss-Prot