Lef1 (lymphoid enhancer binding factor 1) - Rat Genome Database

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Gene: Lef1 (lymphoid enhancer binding factor 1) Mus musculus
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Symbol: Lef1
Name: lymphoid enhancer binding factor 1
RGD ID: 735737
MGI Page MGI
Description: Enables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and chromatin binding activity. Involved in several processes, including T-helper 1 cell differentiation; positive regulation of gamma-delta T cell differentiation; and secondary palate development. Acts upstream of or within several processes, including blood vessel morphogenesis; brain development; and embryonic morphogenesis. Located in cytoplasm and nucleus. Part of beta-catenin-TCF complex. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human LEF1 (lymphoid enhancer binding factor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3000002B05; AI451430; Lef-; Lef-1; lymphoid enhancer factor 1; lymphoid enhancer-binding factor 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393130,903,946 - 131,018,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3130,904,120 - 131,018,005 (+)EnsemblGRCm39 Ensembl
GRCm383131,110,297 - 131,224,357 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3131,110,471 - 131,224,356 (+)EnsemblGRCm38mm10GRCm38
MGSCv373130,813,389 - 130,926,252 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363131,099,626 - 131,212,489 (+)NCBIMGSCv36mm8
Celera3137,630,007 - 137,744,454 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map360.78NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dibromoethane  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-butoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-nitrotoluene  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-methylcholanthrene  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-formyltetrahydrofolic acid  (ISO)
8-Br-cAMP  (ISO)
acetaldehyde  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
aristolochic acid  (ISO)
arotinoid acid  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (EXP)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
casticin  (ISO)
celastrol  (EXP)
CGP 52608  (ISO)
CHIR 99021  (ISO)
choline  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cortisol  (ISO)
curcumin  (ISO)
cyclophosphamide  (EXP)
D-glucose  (ISO)
deguelin  (ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
emodin  (EXP)
endosulfan  (ISO)
entinostat  (ISO)
etacrynic acid  (ISO)
ethosuximide  (ISO)
flavonoids  (ISO)
flusilazole  (EXP)
folic acid  (EXP)
gentamycin  (ISO)
glucose  (ISO)
glycidol  (EXP)
hydralazine  (ISO)
hydroquinone  (ISO)
isoorientin  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (EXP)
lamivudine  (EXP)
lithium chloride  (EXP)
lovastatin  (ISO)
menadione  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl carbamate  (EXP)
methylarsonic acid  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-Vinyl-2-pyrrolidone  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nitrofen  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (EXP)
quercetin  (ISO)
quercitrin  (ISO)
quinolin-8-ol  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
saquinavir  (EXP)
SB 415286  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
Soman  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
tungsten  (EXP)
valproic acid  (EXP,ISO)
XAV939  (ISO)
zidovudine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alpha-beta T cell differentiation  (IGI)
anatomical structure regression  (IMP)
animal organ regeneration  (ISO)
apoptotic process involved in blood vessel morphogenesis  (IMP)
apoptotic process involved in morphogenesis  (IMP)
B cell proliferation  (IMP)
BMP signaling pathway  (IDA)
branching involved in blood vessel morphogenesis  (IMP)
canonical Wnt signaling pathway  (IBA,IDA,IGI,IMP,ISO)
cell adhesion  (ISO)
cell chemotaxis  (ISO)
cell development  (IGI)
cellular response to cytokine stimulus  (ISO)
cellular response to interleukin-4  (ISO)
chorio-allantoic fusion  (IGI)
dentate gyrus development  (IMP)
embryonic limb morphogenesis  (IGI)
epithelial cell apoptotic process  (IMP)
epithelial to mesenchymal transition  (IMP)
face morphogenesis  (IGI)
forebrain neuroblast division  (IGI)
forebrain radial glial cell differentiation  (IGI)
formation of radial glial scaffolds  (IGI)
hippocampus development  (IMP)
histone H3 acetylation  (ISO)
histone H3-K56 acetylation  (IMP)
histone H4 acetylation  (ISO)
kidney development  (ISO)
mammary gland development  (IMP)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic process in bone marrow cell  (ISO)
negative regulation of cell-cell adhesion  (ISO)
negative regulation of DNA binding  (ISO)
negative regulation of DNA-templated transcription  (IDA,ISO)
negative regulation of interleukin-13 production  (ISO)
negative regulation of interleukin-4 production  (ISO)
negative regulation of interleukin-5 production  (ISO)
negative regulation of striated muscle tissue development  (IDA)
negative regulation of transcription by RNA polymerase II  (IDA)
neutrophil differentiation  (ISO)
odontoblast differentiation  (ISO)
odontogenesis of dentin-containing tooth  (IGI,IMP)
osteoblast differentiation  (ISO)
paraxial mesoderm formation  (IGI)
positive regulation by host of viral transcription  (ISO)
positive regulation of cell cycle process  (ISO)
positive regulation of cell differentiation  (IC)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell proliferation in bone marrow  (ISO)
positive regulation of cell-cell adhesion  (ISO)
positive regulation of chondrocyte proliferation  (IMP)
positive regulation of DNA-templated transcription  (IDA,IMP,ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of gamma-delta T cell differentiation  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of granulocyte differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,IMP,ISO)
positive regulation of Wnt signaling pathway  (IMP)
regulation of cell-cell adhesion  (IMP)
regulation of DNA-templated transcription  (IMP)
regulation of neurogenesis  (IC)
regulation of transcription by RNA polymerase II  (IBA,IDA)
regulation of Wnt signaling pathway  (IGI)
response to lithium ion  (ISO)
response to organic cyclic compound  (ISO)
secondary palate development  (IMP)
sensory perception of taste  (IMP)
skin development  (ISO)
somitogenesis  (IGI,IMP)
sprouting angiogenesis  (IMP)
T cell receptor V(D)J recombination  (IGI)
T-helper 1 cell differentiation  (IDA)
tongue development  (IMP)
trachea gland development  (IMP)
transcription by RNA polymerase II  (IMP)
vasculature development  (IMP)
Wnt signaling pathway  (IEA)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal allantois morphology  (IAGP)
abnormal brain morphology  (IAGP)
abnormal craniofacial morphology  (IEA)
abnormal ectomesenchyme morphology  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal endometrial gland development  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal heart morphology  (IEA)
abnormal hippocampus development  (IAGP)
abnormal hippocampus region morphology  (IAGP)
abnormal limb bud morphology  (IAGP)
abnormal mammary gland bud morphology  (IAGP)
abnormal memory T cell physiology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal retina vasculature morphology  (IAGP)
abnormal vascular regression  (IAGP)
absent alveolar process  (IAGP)
absent apical ectodermal ridge  (IAGP)
absent barrels in primary somatosensory cortex  (IAGP)
absent dentate gyrus  (IAGP)
absent endometrial glands  (IAGP)
absent hair follicle melanin granules  (IAGP)
absent hippocampus  (IAGP)
absent incisors  (IAGP)
absent lower incisors  (IAGP)
absent mammary gland  (IAGP)
absent mesencephalic trigeminal nucleus  (IAGP)
absent molars  (IAGP)
absent subcutaneous adipose tissue  (IAGP)
absent teeth  (IAGP)
absent upper incisors  (IAGP)
absent vibrissae  (IAGP)
alopecia  (IAGP)
arrest of tooth development  (IAGP)
decreased body size  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased hair follicle number  (IAGP)
decreased prepulse inhibition  (IEA)
decreased tumor necrosis factor secretion  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
enlarged heart  (IEA)
incomplete somite formation  (IAGP)
increased monocyte cell number  (IEA)
persistence of hyaloid vascular system  (IAGP)
pointed snout  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
small embryonic telencephalon  (IAGP)
small forelimb buds  (IAGP)
thin skin  (IAGP)
underdeveloped hair follicles  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Expression and colocalization of beta-catenin and lymphoid enhancing factor-1 in prostate cancer progression. Bauman TM, etal., Hum Pathol. 2016 May;51:124-33. doi: 10.1016/j.humpath.2015.12.024. Epub 2016 Jan 19.
2. Neuropilin-2 regulates the development of selective cranial and sensory nerves and hippocampal mossy fiber projections. Chen H, etal., Neuron 2000 Jan;25(1):43-56.
3. The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy. Chen X, etal., Mol Cell Biol. 2006 Jun;26(12):4462-73.
4. WNT10A/ß-catenin pathway in tumorigenesis of papillary thyroid carcinoma. Dong T, etal., Oncol Rep. 2017 Aug;38(2):1287-1294. doi: 10.3892/or.2017.5777. Epub 2017 Jul 3.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. Wnt signalling and its impact on development and cancer. Klaus A and Birchmeier W, Nat Rev Cancer. 2008 May;8(5):387-98.
7. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. MGD IEA MGD IEA
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. Wnt-signalling pathway in ovarian epithelial tumours: increased expression of beta-catenin and GSK3beta. Rask K, etal., Br J Cancer. 2003 Oct 6;89(7):1298-304.
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. TCF transcription factors: molecular switches in carcinogenesis. Roose J and Clevers H, Biochim Biophys Acta. 1999 Oct 29;1424(2-3):M23-37.
16. Wnt signaling activation during bone regeneration and the role of Dishevelled in chondrocyte proliferation and differentiation. Zhong N, etal., Bone. 2006 Jul;39(1):5-16. Epub 2006 Feb 3.
Additional References at PubMed
PMID:1783375   PMID:1827423   PMID:2108401   PMID:7537238   PMID:7651541   PMID:7760812   PMID:7774816   PMID:7958926   PMID:8223271   PMID:8415007   PMID:8647435   PMID:8892228  
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PMID:9799429   PMID:9853970   PMID:10021340   PMID:10090727   PMID:10098408   PMID:10227293   PMID:10349636   PMID:10363979   PMID:10415326   PMID:10436162   PMID:10498680   PMID:10498690  
PMID:10631168   PMID:10694745   PMID:10742104   PMID:10824856   PMID:10933391   PMID:10966653   PMID:11042159   PMID:11044393   PMID:11044609   PMID:11076861   PMID:11091071   PMID:11171335  
PMID:11203701   PMID:11335128   PMID:11371349   PMID:11445543   PMID:11447280   PMID:11696550   PMID:11731265   PMID:11731474   PMID:11751639   PMID:11782400   PMID:11782404   PMID:11854293  
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PMID:14610273   PMID:14623238   PMID:14681479   PMID:14691138   PMID:14715945   PMID:14960276   PMID:15024079   PMID:15057272   PMID:15094381   PMID:15121182   PMID:15136142   PMID:15147765  
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PMID:15618518   PMID:15630473   PMID:15649466   PMID:15713628   PMID:15728254   PMID:15729346   PMID:15750622   PMID:15768032   PMID:15778374   PMID:15790735   PMID:15800025   PMID:15858069  
PMID:15866164   PMID:15866165   PMID:15917450   PMID:15936755   PMID:16140987   PMID:16141072   PMID:16141073   PMID:16142310   PMID:16163358   PMID:16222716   PMID:16267835   PMID:16291758  
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PMID:16720875   PMID:16809539   PMID:16813524   PMID:16818445   PMID:16890158   PMID:16892173   PMID:16920270   PMID:16925795   PMID:16936075   PMID:17002498   PMID:17011173   PMID:17065530  
PMID:17071745   PMID:17121988   PMID:17126317   PMID:17187062   PMID:17198697   PMID:17257418   PMID:17270735   PMID:17284610   PMID:17335794   PMID:17360773   PMID:17360796   PMID:17445771  
PMID:17452626   PMID:17468181   PMID:17585052   PMID:17644613   PMID:17681174   PMID:17699607   PMID:17785445   PMID:17885813   PMID:17919533   PMID:17945188   PMID:17951031   PMID:17971297  
PMID:18022614   PMID:18156176   PMID:18192238   PMID:18202148   PMID:18247340   PMID:18250098   PMID:18256198   PMID:18280717   PMID:18287559   PMID:18316418   PMID:18351662   PMID:18351675  
PMID:18359901   PMID:18367557   PMID:18434416   PMID:18445004   PMID:18533146   PMID:18572160   PMID:18579517   PMID:18593557   PMID:18635608   PMID:18651655   PMID:18676816   PMID:18684741  
PMID:18689798   PMID:18723525   PMID:18772112   PMID:18775421   PMID:18799693   PMID:19020049   PMID:19023080   PMID:19056892   PMID:19060336   PMID:19097117   PMID:19141668   PMID:19149881  
PMID:19154719   PMID:19233133   PMID:19251632   PMID:19303461   PMID:19304756   PMID:19412553   PMID:19427408   PMID:19463158   PMID:19474150   PMID:19487454   PMID:19515997   PMID:19557172  
PMID:19591821   PMID:19596317   PMID:19619491   PMID:19631205   PMID:19643084   PMID:19650108   PMID:19700620   PMID:19705445   PMID:19766620   PMID:19783677   PMID:19805379   PMID:19806668  
PMID:19890917   PMID:19906978   PMID:19913006   PMID:19924825   PMID:19952280   PMID:19956733   PMID:19961844   PMID:20006729   PMID:20059953   PMID:20123092   PMID:20159597   PMID:20185815  
PMID:20211142   PMID:20335364   PMID:20371816   PMID:20386748   PMID:20412781   PMID:20436479   PMID:20448247   PMID:20510229   PMID:20599763   PMID:20659708   PMID:20724449   PMID:20802155  
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PMID:24269234   PMID:24284212   PMID:24309208   PMID:24336287   PMID:24371086   PMID:24394376   PMID:24440154   PMID:24442519   PMID:24487391   PMID:24492243   PMID:24501377   PMID:24550112  
PMID:24586192   PMID:24596249   PMID:24610003   PMID:24659776   PMID:24681597   PMID:24748645   PMID:24785493   PMID:24803588   PMID:24836425   PMID:24847765   PMID:24859004   PMID:24936779  
PMID:24946806   PMID:24948604   PMID:24982158   PMID:25038042   PMID:25082703   PMID:25114215   PMID:25168025   PMID:25180455   PMID:25204429   PMID:25249463   PMID:25329657   PMID:25398052  
PMID:25422376   PMID:25451153   PMID:25452386   PMID:25545010   PMID:25546423   PMID:25576928   PMID:25641696   PMID:25651362   PMID:25727890   PMID:25758227   PMID:25810530   PMID:25820239  
PMID:25864637   PMID:25885041   PMID:25896202   PMID:25897173   PMID:25978641   PMID:26023097   PMID:26120030   PMID:26141512   PMID:26186931   PMID:26214741   PMID:26235626   PMID:26297872  
PMID:26333992   PMID:26371318   PMID:26371508   PMID:26438731   PMID:26450968   PMID:26457609   PMID:26459221   PMID:26490636   PMID:26525672   PMID:26526197   PMID:26581094   PMID:26621269  
PMID:26656997   PMID:26658320   PMID:26661618   PMID:26677825   PMID:26856890   PMID:26893350   PMID:26921296   PMID:26934381   PMID:26967474   PMID:26969725   PMID:26992132   PMID:27019111  
PMID:27035511   PMID:27044748   PMID:27111144   PMID:27122169   PMID:27141870   PMID:27184910   PMID:27194944   PMID:27300315   PMID:27302397   PMID:27432740   PMID:27433921   PMID:27445154  
PMID:27510977   PMID:27655933   PMID:27660324   PMID:27701636   PMID:27713059   PMID:27736991   PMID:27748998   PMID:27789627   PMID:27864382   PMID:27871306   PMID:27913639   PMID:27932380  
PMID:28009287   PMID:28031177   PMID:28154153   PMID:28219675   PMID:28389425   PMID:28438836   PMID:28512199   PMID:28589954   PMID:28604778   PMID:28605600   PMID:28675425   PMID:28698625  
PMID:28746823   PMID:28765611   PMID:28800889   PMID:28827394   PMID:28837622   PMID:28844837   PMID:28893947   PMID:28911199   PMID:29031500   PMID:29056552   PMID:29109083   PMID:29180744  
PMID:29184203   PMID:29212953   PMID:29223978   PMID:29229772   PMID:29337183   PMID:29437780   PMID:29449451   PMID:29459093   PMID:29596840   PMID:29602800   PMID:29712641   PMID:29735715  
PMID:29751817   PMID:29874522   PMID:29879378   PMID:29891551   PMID:29913133   PMID:29915186   PMID:29927026   PMID:30037996   PMID:30042129   PMID:30063881   PMID:30084950   PMID:30085028  
PMID:30185805   PMID:30188322   PMID:30220568   PMID:30235284   PMID:30254141   PMID:30286078   PMID:30347193   PMID:30352686   PMID:30504829   PMID:30509557   PMID:30568578   PMID:30575813  
PMID:30595533   PMID:30615824   PMID:30635573   PMID:30659184   PMID:30728831   PMID:30837262   PMID:30886049   PMID:30887098   PMID:30944305   PMID:30952667   PMID:30991025   PMID:31082736  
PMID:31142573   PMID:31216480   PMID:31235634   PMID:31351040   PMID:31405607   PMID:31638440   PMID:31729356   PMID:31844321   PMID:31845891   PMID:32022899   PMID:32098917   PMID:32141129  
PMID:32186512   PMID:32253237   PMID:32290615   PMID:32296071   PMID:32324134   PMID:32369449   PMID:32414917   PMID:32464196   PMID:32504627   PMID:32541007   PMID:32554463   PMID:32571845  
PMID:32586976   PMID:32664967   PMID:32675279   PMID:32760291   PMID:32820720   PMID:32845239   PMID:32866472   PMID:33013468   PMID:33075808   PMID:33084572   PMID:33155500   PMID:33159086  
PMID:33184221   PMID:33195246   PMID:33214242   PMID:33329029   PMID:33372138   PMID:33393905   PMID:33436499   PMID:33453998   PMID:33587034   PMID:33723039   PMID:33811421   PMID:34032267  
PMID:34032268   PMID:34168324   PMID:34172578   PMID:34301885   PMID:34376651   PMID:34446717   PMID:34449628   PMID:34525377   PMID:34615872   PMID:34721405   PMID:34757798   PMID:34851738  
PMID:34878095   PMID:34921112   PMID:35110543   PMID:35114852   PMID:35132438   PMID:35252804   PMID:35318743   PMID:35364055   PMID:35371057   PMID:35421372   PMID:35552394   PMID:35594394  
PMID:35781558   PMID:35831952   PMID:36026468  


Genomics

Comparative Map Data
Lef1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393130,903,946 - 131,018,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3130,904,120 - 131,018,005 (+)EnsemblGRCm39 Ensembl
GRCm383131,110,297 - 131,224,357 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3131,110,471 - 131,224,356 (+)EnsemblGRCm38mm10GRCm38
MGSCv373130,813,389 - 130,926,252 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363131,099,626 - 131,212,489 (+)NCBIMGSCv36mm8
Celera3137,630,007 - 137,744,454 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map360.78NCBI
LEF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384108,047,548 - 108,168,932 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4108,047,545 - 108,168,956 (-)EnsemblGRCh38hg38GRCh38
GRCh374108,968,704 - 109,090,088 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364109,188,150 - 109,309,027 (-)NCBINCBI36Build 36hg18NCBI36
Build 344109,326,304 - 109,447,182NCBI
Celera4106,263,513 - 106,384,975 (-)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4104,700,344 - 104,821,596 (-)NCBIHuRef
CHM1_14108,945,152 - 109,066,566 (-)NCBICHM1_1
T2T-CHM13v2.04111,349,885 - 111,471,256 (-)NCBIT2T-CHM13v2.0
Lef1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22219,666,549 - 219,779,815 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2219,666,592 - 219,779,794 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2227,324,033 - 227,418,775 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02225,223,708 - 225,318,451 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02220,081,321 - 220,176,071 (+)NCBIRnor_WKY
Rnor_6.02236,232,115 - 236,345,061 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2236,233,239 - 236,345,056 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02254,781,171 - 254,893,756 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42228,550,263 - 228,673,131 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12228,537,002 - 228,659,871 (+)NCBI
Celera2211,924,784 - 212,018,812 (+)NCBICelera
Cytogenetic Map2q43NCBI
Lef1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554961,728,840 - 1,828,698 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554961,728,840 - 1,827,749 (+)NCBIChiLan1.0ChiLan1.0
LEF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14111,125,312 - 111,245,980 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4111,125,312 - 111,245,980 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04100,552,959 - 100,674,156 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LEF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13228,516,002 - 28,633,759 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3228,517,108 - 28,634,019 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3213,389,033 - 13,506,807 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03228,744,891 - 28,862,596 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3228,744,919 - 28,862,904 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13228,737,873 - 28,855,560 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03228,482,671 - 28,600,623 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03211,256,345 - 11,374,064 (+)NCBIUU_Cfam_GSD_1.0
Lef1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530112,484,346 - 12,597,999 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936818453,635 - 567,469 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936818453,635 - 569,194 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LEF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8113,825,161 - 113,944,070 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18113,824,511 - 113,944,078 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28122,085,854 - 122,204,415 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LEF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1755,974,770 - 56,096,214 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl755,990,621 - 56,094,110 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603734,601,310 - 34,723,183 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lef1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248301,321,387 - 1,424,389 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248301,320,034 - 1,422,774 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir218-2mmu-miR-218-5pOncomiRDBexternal_infoNANA22766851
Mir26bmmu-miR-26b-5pMirtarbaseexternal_infoImmunohistochemistry//Luciferase reporter assay//MFunctional MTI20807761

Predicted Target Of
Summary Value
Count of predictions:1559
Count of miRNA genes:401
Interacting mature miRNAs:447
Transcripts:ENSMUST00000029611, ENSMUST00000066849, ENSMUST00000098611, ENSMUST00000106341, ENSMUST00000132737, ENSMUST00000136147
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396607316147805636Mouse
10043955Wt10q4_mbody weight, 10 weeks, QTL 4 (mouse)Not determined398624041132624197Mouse
11533920Mvb3_mmodifier of vibrator 3 (mouse)398635284132635383Mouse
12792984Modn1_mmodifier of Dstn neovascularization 1 (mouse)398635284132635383Mouse
1302114Tbs1_mtuberculosis severity 1 (mouse)Not determined398924105132924250Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100372912147045722Mouse
26884419Bzwq6_mbi-zygomatic width QTL 6, 10 week (mouse)3100607316137205761Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101307316149805637Mouse
1301805Mors2_mmodifier of obesity related sterility 2 (mouse)Not determined3103482659137482783Mouse
1302093Orgwq5_morgan weight QTL 5 (mouse)Not determined3107376936147304689Mouse
1300619Cdcs1_mcytokine deficiency colitis susceptibility 1 (mouse)Not determined3109834882143835005Mouse
12910793Pwbwq7_mpost-weaning body weight QTL 7 (mouse)3110084357135715812Mouse
12910796Pwbwq6_mpost-weaning body weight QTL 6 (mouse)3110084357135715812Mouse
12910815Ogrq1_moverall growth rate QTL 1 (mouse)3110084357135715812Mouse
1301381Bomb1_mbone marrow pre-B 1 (mouse)Not determined3111133243145133417Mouse
1301100Bdt2_mbone density traits 2 (mouse)Not determined3114736617148736784Mouse
10043919Afpq8_mabdominal fat percent QTL 8 (mouse)Not determined3119057332153057456Mouse
1558868Ses9_msalmonella enteritidis susceptibility 9 (mouse)Not determined3119057332153057456Mouse
4141935Tgq15_mtriglyceride QTL 15 (mouse)Not determined119318586153318586Mouse
4142449Tgq14_mtriglyceride QTL 14 (mouse)Not determined119318586153318586Mouse
1302151Lprm2_mlymphoproliferation modifier 2 (mouse)Not determined3119778857153779044Mouse
10412240Alpq6_malcohol preference QTL 6 (mouse)Not determined3120772078154772078Mouse
26884415Bzwq11_mbi-zygomatic width QTL 11, 16 week (mouse)3124993649137205761Mouse
4142245Pstc1_mperiosteal circumference 1 (mouse)Not determined3126270248159745316Mouse
1301218Letohc1_mlow ethanol consumption 1 (mouse)Not determined3126352986159745316Mouse
1301347Fpli_mfasting plasma insulin (mouse)Not determined3126460514159745316Mouse
1301563Alcp3_malcohol preference locus 3 (mouse)Not determined3130736935159745316Mouse
11039523Tbbr1_mTrypanosoma brucei brucei response 1 (mouse)3130849375159745316Mouse

Markers in Region
Lef1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv373130,926,110 - 130,926,356UniSTSGRCm37
Celera3137,744,312 - 137,744,558UniSTS
Cytogenetic Map3G3UniSTS
cM Map361.6UniSTS
cM Map361.6UniSTS
X58636  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383131,223,154 - 131,223,321UniSTSGRCm38
MGSCv373130,926,072 - 130,926,239UniSTSGRCm37
Celera3137,744,274 - 137,744,441UniSTS
Cytogenetic Map3G3UniSTS
cM Map361.6UniSTS
Whitehead_YAC3 UniSTS
D3Mit290  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383131,127,782 - 131,127,906UniSTSGRCm38
MGSCv373130,830,700 - 130,830,824UniSTSGRCm37
Celera3137,647,295 - 137,647,419UniSTS
Cytogenetic Map3G3UniSTS
cM Map364.1UniSTS
Whitehead Genetic344.8UniSTS
Whitehead_YAC3 UniSTS
UniSTS:234825  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383131,192,133 - 131,192,439UniSTSGRCm38
MGSCv373130,895,051 - 130,895,357UniSTSGRCm37
Celera3137,713,248 - 137,713,554UniSTS
Cytogenetic Map3G3UniSTS
cM Map361.6UniSTS
AI451430  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383131,224,069 - 131,224,188UniSTSGRCm38
MGSCv373130,926,987 - 130,927,106UniSTSGRCm37
Celera3137,745,189 - 137,745,308UniSTS
Cytogenetic Map3G3UniSTS
cM Map361.6UniSTS
Whitehead/MRC_RH31507.09UniSTS
Lef1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383131,223,192 - 131,223,438UniSTSGRCm38
MGSCv373130,926,110 - 130,926,356UniSTSGRCm37
Celera3137,744,312 - 137,744,558UniSTS
Cytogenetic Map3G3UniSTS
Lef1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3G3UniSTS
Lef1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3G3UniSTS
Lef1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3G3UniSTS
cM Map361.6UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001276402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001276403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001379059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001379060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001379061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001379062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006501070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030252440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC114668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC123634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK028246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK131979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC038305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE632124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU052889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X58636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000029611   ⟹   ENSMUSP00000029611
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3130,904,120 - 131,018,005 (+)Ensembl
GRCm38.p6 Ensembl3131,110,471 - 131,224,356 (+)Ensembl
RefSeq Acc Id: ENSMUST00000066849   ⟹   ENSMUSP00000067808
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3130,904,120 - 131,018,005 (+)Ensembl
GRCm38.p6 Ensembl3131,110,471 - 131,224,356 (+)Ensembl
RefSeq Acc Id: ENSMUST00000098611   ⟹   ENSMUSP00000096211
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3130,906,446 - 131,018,005 (+)Ensembl
GRCm38.p6 Ensembl3131,112,797 - 131,224,356 (+)Ensembl
RefSeq Acc Id: ENSMUST00000106341   ⟹   ENSMUSP00000101948
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3130,904,120 - 131,018,005 (+)Ensembl
GRCm38.p6 Ensembl3131,110,471 - 131,224,356 (+)Ensembl
RefSeq Acc Id: ENSMUST00000132737
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3130,906,455 - 130,981,731 (+)Ensembl
GRCm38.p6 Ensembl3131,112,806 - 131,188,082 (+)Ensembl
RefSeq Acc Id: ENSMUST00000136147
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3130,906,446 - 130,911,036 (+)Ensembl
GRCm38.p6 Ensembl3131,112,797 - 131,117,387 (+)Ensembl
RefSeq Acc Id: ENSMUST00000198624
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3130,907,505 - 130,997,911 (+)Ensembl
GRCm38.p6 Ensembl3131,113,856 - 131,204,262 (+)Ensembl
RefSeq Acc Id: ENSMUST00000200166
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3130,907,463 - 130,978,393 (+)Ensembl
GRCm38.p6 Ensembl3131,113,814 - 131,184,744 (+)Ensembl
RefSeq Acc Id: NM_001276402   ⟹   NP_001263331
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393130,903,946 - 131,018,006 (+)NCBI
GRCm383131,110,297 - 131,224,357 (+)NCBI
Celera3137,629,833 - 137,745,477 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001276403   ⟹   NP_001263332
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393130,906,440 - 131,018,006 (+)NCBI
GRCm383131,112,791 - 131,224,357 (+)NCBI
Celera3137,629,833 - 137,745,477 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001379059   ⟹   NP_001365988
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393130,903,972 - 131,017,970 (+)NCBI
GRCm383131,110,323 - 131,224,321 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001379060   ⟹   NP_001365989
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393130,903,972 - 131,017,970 (+)NCBI
GRCm383131,110,323 - 131,224,321 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001379061   ⟹   NP_001365990
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393130,906,440 - 131,017,970 (+)NCBI
GRCm383131,112,791 - 131,224,321 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001379062   ⟹   NP_001365991
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393130,949,943 - 131,017,970 (+)NCBI
GRCm383131,156,294 - 131,224,321 (+)NCBI
Sequence:
RefSeq Acc Id: NM_010703   ⟹   NP_034833
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393130,903,946 - 131,018,006 (+)NCBI
GRCm383131,110,297 - 131,224,357 (+)NCBI
MGSCv373130,813,389 - 130,926,252 (+)RGD
Celera3137,629,833 - 137,745,477 (+)NCBI
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006501070   ⟹   XP_006501133
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393130,905,876 - 131,017,967 (+)NCBI
GRCm383131,112,227 - 131,224,318 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030252440   ⟹   XP_030108300
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393130,905,871 - 131,017,973 (+)NCBI
GRCm383131,112,227 - 131,224,318 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036162910   ⟹   XP_036018803
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393130,950,122 - 131,017,967 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036162911   ⟹   XP_036018804
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393130,950,123 - 131,017,967 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034833   ⟸   NM_010703
- Peptide Label: isoform a
- UniProtKB: P27782 (UniProtKB/Swiss-Prot),   Q3TYB0 (UniProtKB/TrEMBL),   Q8BGZ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001263331   ⟸   NM_001276402
- Peptide Label: isoform b
- UniProtKB: Q8BGZ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001263332   ⟸   NM_001276403
- Peptide Label: isoform c
- UniProtKB: Q8BGZ9 (UniProtKB/TrEMBL),   Q8C402 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006501133   ⟸   XM_006501070
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_030108300   ⟸   XM_030252440
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001365988   ⟸   NM_001379059
- Peptide Label: isoform d
RefSeq Acc Id: NP_001365989   ⟸   NM_001379060
- Peptide Label: isoform e
- UniProtKB: D3Z654 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001365990   ⟸   NM_001379061
- Peptide Label: isoform f
RefSeq Acc Id: NP_001365991   ⟸   NM_001379062
- Peptide Label: isoform g
RefSeq Acc Id: ENSMUSP00000067808   ⟸   ENSMUST00000066849
RefSeq Acc Id: ENSMUSP00000029611   ⟸   ENSMUST00000029611
RefSeq Acc Id: ENSMUSP00000101948   ⟸   ENSMUST00000106341
RefSeq Acc Id: ENSMUSP00000096211   ⟸   ENSMUST00000098611
RefSeq Acc Id: XP_036018803   ⟸   XM_036162910
- Peptide Label: isoform X3
RefSeq Acc Id: XP_036018804   ⟸   XM_036162911
- Peptide Label: isoform X4
Protein Domains
CTNNB1_binding   HMG box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27782-F1-model_v2 AlphaFold P27782 1-397 view protein structure

Promoters
RGD ID:6834010
Promoter ID:MM_KWN:36108
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   Kidney,   Lung
Transcripts:ENSMUST00000029611,   ENSMUST00000066849,   ENSMUST00000106341
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363130,812,486 - 130,813,882 (+)MPROMDB
RGD ID:6834011
Promoter ID:MM_KWN:36110
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:OTTMUST00000048124,   OTTMUST00000048125,   UC008RJJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363130,815,066 - 130,815,566 (+)MPROMDB
RGD ID:6882378
Promoter ID:EPDNEW_M4640
Type:initiation region
Name:Lef1_1
Description:Mus musculus lymphoid enhancer binding factor 1 , transcriptvariant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4641  EPDNEW_M4642  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383131,110,323 - 131,110,383EPDNEW
RGD ID:6882380
Promoter ID:EPDNEW_M4641
Type:multiple initiation site
Name:Lef1_3
Description:Mus musculus lymphoid enhancer binding factor 1 , transcriptvariant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4640  EPDNEW_M4642  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383131,110,826 - 131,110,886EPDNEW
RGD ID:6882382
Promoter ID:EPDNEW_M4642
Type:multiple initiation site
Name:Lef1_2
Description:Mus musculus lymphoid enhancer binding factor 1 , transcriptvariant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4640  EPDNEW_M4641  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383131,112,794 - 131,112,854EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96770 AgrOrtholog
Ensembl Genes ENSMUSG00000027985 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000029611 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000067808 ENTREZGENE
  ENSMUSP00000067808.7 UniProtKB/TrEMBL
  ENSMUSP00000096211 ENTREZGENE
  ENSMUSP00000096211.4 UniProtKB/TrEMBL
  ENSMUSP00000101948 ENTREZGENE
  ENSMUSP00000101948.3 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000029611 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000066849 ENTREZGENE
  ENSMUST00000066849.13 UniProtKB/TrEMBL
  ENSMUST00000098611 ENTREZGENE
  ENSMUST00000098611.4 UniProtKB/TrEMBL
  ENSMUST00000106341 ENTREZGENE
  ENSMUST00000106341.9 UniProtKB/TrEMBL
Gene3D-CATH 1.10.30.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Catenin_binding_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTNNB1-bd_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_box_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LEF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TCF/LEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16842 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96770 ENTREZGENE
NCBI Gene 16842 ENTREZGENE
PANTHER PTHR10373 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10373:SF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CTNNB1_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lef1 PhenoGen
PROSITE HMG_BOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HMG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47095 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3Z654 ENTREZGENE, UniProtKB/TrEMBL
  LEF1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TEN5_MOUSE UniProtKB/TrEMBL
  Q3TYB0 ENTREZGENE, UniProtKB/TrEMBL
  Q8BGZ9 ENTREZGENE, UniProtKB/TrEMBL
  Q8C402 ENTREZGENE, UniProtKB/TrEMBL