C3 (complement component 3) - Rat Genome Database

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Gene: C3 (complement component 3) Mus musculus
Symbol: C3
Name: complement component 3
RGD ID: 10256
Description: Predicted to enable C5L2 anaphylatoxin chemotactic receptor binding activity and lipid binding activity. Involved in several processes, including complement-mediated synapse pruning; nervous system development; and positive regulation of endocytosis. Acts upstream of or within several processes, including complement-dependent cytotoxicity; oviduct epithelium development; and positive regulation of immune response. Located in cell surface and extracellular space. Part of protein-containing complex. Is expressed in several structures, including adipose tissue; cerebral cortex; extraembryonic component; hemolymphoid system; and liver. Used to study complement component 3 deficiency. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; and sickle cell anemia. Orthologous to human C3 (complement C3).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acylation stimulating protein; AI255234; ASP; complement C3; complement component 3d; complement factor 3; HSE-MSF; Plp
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391757,510,967 - 57,535,136 (-)NCBIGRCm39mm39
GRCm39 Ensembl1757,510,970 - 57,535,136 (-)Ensembl
GRCm381757,203,967 - 57,228,136 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1757,203,970 - 57,228,136 (-)EnsemblGRCm38mm10GRCm38
MGSCv371757,343,396 - 57,367,559 (-)NCBIGRCm37mm9NCBIm37
MGSCv361756,889,309 - 56,913,426 (-)NCBImm8
Celera1761,551,995 - 61,576,136 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
acute myocardial infarction  (ISO)
adult respiratory distress syndrome  (ISO)
age related macular degeneration 7  (ISO)
age related macular degeneration 9  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
anterior uveitis  (ISO)
arteriolosclerosis  (ISO)
asthma  (IEP,IMP,ISO)
atopic dermatitis  (ISO)
atypical hemolytic-uremic syndrome  (IGI,ISO)
autosomal recessive polycystic kidney disease  (IEP,ISO)
bacterial pneumonia  (IMP)
boutonneuse fever  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Carcinoma, Lewis Lung  (IEP)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Allograft Dysfunction  (ISO)
chronic obstructive pulmonary disease  (ISO)
complement component 3 deficiency  (IEA,ISO)
congenital hemolytic anemia  (ISO)
conjunctivitis  (ISO)
Diabetic Nephropathies  (IEP,ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
erythema nodosum  (ISO)
Experimental Arthritis  (IMP,ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myasthenia Gravis  (IEP,ISO)
Experimental Autoimmune Uveoretinitis  (IMP)
factor VIII deficiency  (ISO)
Fuchs' endothelial dystrophy  (ISO)
glomerulonephritis  (ISO)
Hematuria  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (IMP)
Herpesviridae Infections  (IMP)
high grade glioma  (IMP)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (IMP)
Hyperalgesia  (ISO)
hypertension  (ISO)
IgA glomerulonephritis  (ISO)
Insulin Resistance  (ISO)
Kidney Reperfusion Injury  (ISO)
Kuhnt-Junius degeneration  (ISO)
leishmaniasis  (IMP)
lepromatous leprosy  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (IMP)
lupus nephritis  (ISO)
macular degeneration  (IMP,ISO)
mastitis  (IEP)
melanoma  (IEP)
membranoproliferative glomerulonephritis  (ISO)
membranous glomerulonephritis  (ISO)
Meningococcal Infections  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
obesity  (ISO)
ocular hypertension  (ISO)
Optic Nerve Injuries  (ISO)
otitis media  (IEP)
Otitis Media with Effusion  (ISO)
Paratuberculosis  (ISO)
paroxysmal nocturnal hemoglobinuria  (ISO)
pemphigus  (ISO)
pleurisy  (IEP)
Pneumococcal Pneumonia  (IMP,ISO)
pneumocystosis  (ISO)
pneumonia  (ISO)
pre-eclampsia  (ISO)
primary immunodeficiency disease  (ISO)
primary ovarian insufficiency  (ISO)
pulmonary eosinophilia  (IMP)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
Radiation Pneumonitis  (ISO)
Refractory Anemia with Excess of Blasts  (ISO)
Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (IEP,ISO)
sickle cell anemia  (ISO)
silicosis  (ISO)
Sjogren's syndrome  (IMP)
Subarachnoid Hemorrhage  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
thrombophilia  (IMP)
Thrombotic Microangiopathies  (ISO)
transient cerebral ischemia  (ISO)
tropical spastic paraparesis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Viral Bronchiolitis  (IMP,ISO)
vitiligo  (IMP)
Wounds, Penetrating  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(S)-colchicine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-Hydroxypyrene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dichloroaniline  (ISO)
3-methylcholanthrene  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-tert-Octylphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
9-phenanthrol  (ISO)
acetamide  (ISO)
afimoxifene  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
aluminium oxide  (EXP)
ammonium chloride  (ISO)
amphibole asbestos  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (EXP)
carbon nanotube  (EXP,ISO)
chlordecone  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
chondroitin sulfate  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (EXP)
D-glucose  (EXP)
D-penicillamine  (ISO)
daidzein  (ISO)
danazol  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diethyl malate  (EXP)
diethylstilbestrol  (EXP,ISO)
dioxygen  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
entinostat  (ISO)
fenvalerate  (ISO)
ferulic acid  (EXP)
flutamide  (ISO)
folic acid  (EXP,ISO)
fulvestrant  (ISO)
furan  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
glucose  (EXP)
glycidol  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GW 4064  (EXP)
heparin  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
isoflavones  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (EXP)
magnesium atom  (EXP)
mangiferin  (EXP)
medroxyprogesterone acetate  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
methacholine chloride  (EXP)
methotrexate  (EXP,ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
methyltestosterone  (ISO)
mifepristone  (ISO)
Mizoribine  (ISO)
mycotoxin  (EXP)
N-acetyl-L-cysteine  (ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
neoechinulin A  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nilotinib  (EXP)
nitrofen  (ISO)
nitroglycerin  (ISO)
Nonylphenol  (EXP,ISO)
olanzapine  (ISO)
ozone  (EXP,ISO)
p-tert-Amylphenol  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pemetrexed  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
poly(styrene)  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
procymidone  (ISO)
progesterone  (EXP,ISO)
propofol  (ISO)
raloxifene  (EXP)
reactive oxygen species  (EXP)
reserpine  (ISO)
resveratrol  (EXP,ISO)
rofecoxib  (ISO)
rosuvastatin calcium  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
Soman  (ISO)
sophoraflavanone B  (ISO)
succimer  (EXP)
sulforaphane  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (EXP,ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
trimegestone  (ISO)
trimellitic anhydride  (EXP)
Triptolide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc sulfate  (EXP)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance  (IGI,IMP)
blood coagulation  (ISO)
cell surface receptor signaling pathway involved in cell-cell signaling  (IMP)
complement activation  (IBA,IDA,IMP,ISO)
complement activation, alternative pathway  (IEA)
complement activation, classical pathway  (IEA)
complement-dependent cytotoxicity  (IMP)
complement-mediated synapse pruning  (IMP)
fatty acid metabolic process  (IEA)
immune system process  (IEA)
inflammatory response  (IEA)
innate immune response  (IEA,ISO)
lipid metabolic process  (IEA)
neuron remodeling  (IMP)
oviduct epithelium development  (IGI)
positive regulation of activation of membrane attack complex  (IMP)
positive regulation of angiogenesis  (IMP)
positive regulation of apoptotic cell clearance  (ISO)
positive regulation of developmental growth  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of glucose transmembrane transport  (ISO)
positive regulation of lipid storage  (ISO)
positive regulation of phagocytosis  (IMP)
positive regulation of phagocytosis, engulfment  (IGI,IMP)
positive regulation of protein phosphorylation  (ISO)
positive regulation of receptor-mediated endocytosis  (IGI,IMP)
positive regulation of type IIa hypersensitivity  (IMP)
positive regulation of vascular endothelial growth factor production  (ISO)
regulation of triglyceride biosynthetic process  (ISO)
response to bacterium  (IEP)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to glucocorticoid  (ISO)
response to magnesium ion  (ISO)
response to paclitaxel  (ISO)
response to progesterone  (ISO)
retina development in camera-type eye  (IGI)
tolerance induction  (ISO)
vascular associated smooth muscle cell differentiation  (IGI)
vertebrate eye-specific patterning  (IMP)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blastocyst morphology  (IAGP)
abnormal blood coagulation  (IAGP)
abnormal blood homeostasis  (IAGP)
abnormal c-wave shape  (IAGP)
abnormal cell-mediated immunity  (IAGP)
abnormal complement pathway  (IAGP)
abnormal dendritic spine morphology  (IAGP)
abnormal energy expenditure  (IAGP)
abnormal enzyme/coenzyme level  (IAGP)
abnormal eye electrophysiology  (IAGP)
abnormal female reproductive system physiology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal hippocampus CA3 region morphology  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal immune system morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal induced morbidity/mortality  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal intestinal lipid absorption  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver physiology  (IAGP)
abnormal mast cell physiology  (IAGP)
abnormal motor learning  (IEA)
abnormal neutrophil morphology  (IAGP)
abnormal oxygen consumption  (IAGP)
abnormal peripheral nervous system regeneration  (IAGP)
abnormal physical strength  (IAGP)
abnormal platelet physiology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal retinal horizontal cell morphology  (IAGP)
abnormal retinal rod bipolar cell morphology  (IAGP)
abnormal skeletal muscle morphology  (IAGP)
abnormal spatial working memory  (IAGP)
abnormal spleen germinal center morphology  (IAGP)
abnormal synaptic plasticity  (IAGP)
abnormal synaptic vesicle number  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
amyloid beta deposits  (IAGP)
brain inflammation  (IAGP)
decreased anxiety-related response  (IAGP)
decreased b-wave amplitude  (IAGP)
decreased body weight  (IAGP)
decreased cerebral infarct size  (IAGP)
decreased circulating alanine transaminase level  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating interleukin-6 level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased circulating tumor necrosis factor level  (IAGP)
decreased exploration in new environment  (IEA)
decreased fetal weight  (IAGP)
decreased hepatocyte proliferation  (IAGP)
decreased IgM level  (IAGP)
decreased liver regeneration  (IAGP)
decreased mast cell number  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased placental labyrinth size  (IAGP)
decreased spleen germinal center number  (IAGP)
decreased spleen germinal center size  (IAGP)
decreased spongiotrophoblast size  (IAGP)
decreased susceptibility to alcohol-induced hepatic steatosis  (IAGP)
decreased susceptibility to autoimmune diabetes  (IAGP)
decreased susceptibility to autoimmune disorder  (IAGP)
decreased susceptibility to autoimmune hemolytic anemia  (IAGP)
decreased susceptibility to Coronaviridae infection  (IAGP)
decreased susceptibility to induced arthritis  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased total body fat amount  (IAGP)
decreased urine albumin level  (IAGP)
decreased vascular permeability  (IAGP)
decreased white adipose tissue amount  (IAGP)
dystrophic muscle  (IAGP)
enhanced contextual conditioning behavior  (IAGP)
enhanced long term potentiation  (IAGP)
enhanced paired-pulse facilitation  (IAGP)
enhanced spatial learning  (IAGP)
enlarged cervical lymph nodes  (IAGP)
enlarged spleen  (IAGP)
extended life span  (IAGP)
focal hepatic necrosis  (IAGP)
glomerulonephritis  (IAGP)
hepatic steatosis  (IAGP)
impaired complement alternative pathway  (IAGP)
impaired embryo implantation  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased body weight  (IAGP)
increased brown adipose tissue amount  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating bilirubin level  (IAGP)
increased circulating free fatty acids level  (IAGP)
increased IgG level  (IAGP)
increased IgM level  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased microglial cell activation  (IAGP)
increased neuron number  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased T cell proliferation  (IAGP)
increased triglyceride level  (IAGP)
insulitis  (IAGP)
liver inflammation  (IAGP)
loss of hippocampal neurons  (IAGP)
muscle weakness  (IAGP)
no abnormal phenotype detected  (IAGP)
polyphagia  (IAGP)
prolonged estrous cycle  (IAGP)
skeletal muscle interstitial fibrosis  (IAGP)
small placenta  (IAGP)

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Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391757,510,967 - 57,535,136 (-)NCBIGRCm39mm39
GRCm39 Ensembl1757,510,970 - 57,535,136 (-)Ensembl
GRCm381757,203,967 - 57,228,136 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1757,203,970 - 57,228,136 (-)EnsemblGRCm38mm10GRCm38
MGSCv371757,343,396 - 57,367,559 (-)NCBIGRCm37mm9NCBIm37
MGSCv361756,889,309 - 56,913,426 (-)NCBImm8
Celera1761,551,995 - 61,576,136 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.72NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl196,677,704 - 6,730,562 (-)EnsemblGRCh38hg38GRCh38
GRCh38196,677,704 - 6,720,650 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37196,677,715 - 6,720,661 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,628,846 - 6,671,662 (-)NCBINCBI36hg18NCBI36
Build 34196,628,877 - 6,671,660NCBI
Celera196,619,402 - 6,662,926 (-)NCBI
Cytogenetic Map19p13.3NCBI
HuRef196,440,030 - 6,483,146 (-)NCBIHuRef
CHM1_1196,678,095 - 6,720,521 (-)NCBICHM1_1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.292,087,437 - 2,114,366 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl92,087,437 - 2,114,429 (-)Ensembl
Rnor_6.099,721,137 - 9,747,084 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,721,105 - 9,747,167 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.098,728,465 - 8,754,412 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,407,133 - 6,432,968 (+)NCBICelera
Cytogenetic Map9q12NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554952,796,663 - 2,824,697 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554952,796,601 - 2,824,233 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1196,629,240 - 6,674,786 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,629,287 - 6,674,699 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0195,708,211 - 5,753,178 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12053,566,226 - 53,598,365 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,566,261 - 53,598,761 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2053,314,550 - 53,347,112 (+)NCBI
ROS_Cfam_1.02054,220,548 - 54,253,547 (+)NCBI
UMICH_Zoey_3.12053,287,896 - 53,320,436 (+)NCBI
UNSW_CanFamBas_1.02053,735,894 - 53,768,908 (+)NCBI
UU_Cfam_GSD_1.02053,965,350 - 53,997,908 (+)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405118213,824,886 - 213,849,048 (+)NCBI
SpeTri2.0NW_0049365883,985,732 - 4,023,221 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl272,431,499 - 72,528,112 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1272,431,470 - 72,471,622 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2272,762,013 - 72,820,437 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2272,950,572 - 72,957,968 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2qNCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.166,250,422 - 6,289,264 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660811,706,107 - 1,746,127 (+)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046248283,773,816 - 3,798,077 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381757,204,039 - 57,204,275UniSTSGRCm38
MGSCv371757,343,462 - 57,343,698UniSTSGRCm37
Celera1761,552,061 - 61,552,297UniSTS
Cytogenetic Map17E1-E3UniSTS
Cytogenetic Map17D-E1UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381757,227,447 - 57,227,623UniSTSGRCm38
MGSCv371757,366,870 - 57,367,046UniSTSGRCm37
Celera1761,575,459 - 61,575,623UniSTS
Cytogenetic Map17E1-E3UniSTS
cM Map1740.6UniSTS
cM Map1734.3UniSTS
Whitehead Genetic1729.5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381757,229,291 - 57,229,532UniSTSGRCm38
MGSCv371757,368,714 - 57,368,955UniSTSGRCm37
Celera1761,577,291 - 61,577,532UniSTS
Cytogenetic Map17E1-E3UniSTS
cM Map1729.5UniSTS
Whitehead Genetic1729.5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381757,226,294 - 57,226,728UniSTSGRCm38
MGSCv371757,365,717 - 57,366,151UniSTSGRCm37
Celera1761,574,306 - 61,574,740UniSTS
Cytogenetic Map17E1-E3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17E1-E3UniSTS
cM Map1734.3UniSTS

QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141272Tfv1_mtotal food volume 1 (mouse)Not determined480447765330362Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined17986241186688972Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171206732483054339Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172430185958301973Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172574029459740461Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172657408160574223Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172750432261504322Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172831148062311728Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined172982162963821740Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3072257564722705Mouse
1300885Mbis4_mMycobacterium bovis-induced systemic lupus erythematosus 4 (mouse)Not determined173495684169858931Mouse
10755514Amzn2_manatomical modifier of Zfp423 2 (mouse)173565926669659396Mouse
12904951Smmq2_msoleus muscle mass QTL 2 (mouse)173648271570482715Mouse
1300592Pcyts5_mplasmacytoma susceptibility 5 (mouse)Not determined173840588672405969Mouse
10755525Lymph2_mlymphocyte differential 2 (mouse)173849862572498625Mouse
10755534Lymph4_mlymphocyte differential 4 (mouse)173849862572498625Mouse
4141319Hmtb8_mhemostasis and thrombosis rebleeding time 8 (mouse)Not determined4022744774227623Mouse
15039324Nmrs48_mNAFLD-associated magnetic resonance shift 48 (mouse)174063218774632187Mouse
26884390Skwq9_mskull length QTL 9, 10 week (mouse)174340000067500000Mouse
26884428Cvht3_mcranial vault height 3, 5 week (mouse)174620000082100000Mouse
14700692Cihvtq1_mcoxsackieviral infection heart viral titre QTL 1 (mouse)174970000069700000Mouse
1357754Ahl3_mage related hearing loss 3 (mouse)Not determined174989696283897108Mouse
4142243Lfnq5_mlung function QTL 5 (mouse)Not determined5143195157227623Mouse
1357532Bmch7_mbone mechanical trait 7 (mouse)Not determined175145143085451617Mouse
4141879Chlq9_mcirculating hormone level QTL 9 (mouse)Not determined175145143085451617Mouse
4141758Pstc5_mperiosteal circumference 5 (mouse)Not determined175680065690800808Mouse
4141011Bmd26_mbone mineral density 26 (mouse)Not determined175680065690800808Mouse
1300735Pgia20_mproteoglycan induced arthritis 20 (mouse)Not determined175680065690800808Mouse
1357447Heal13_mwound healing/regeneration 13 (mouse)Not determined175680065690800808Mouse
12910536Nrq8a_mnoise-induced hearing loss resistant QTL 8a (mouse)175680065690800808Mouse
12910537Nrq8_mnoise-induced hearing loss resistant QTL 8 (mouse)175680065690800808Mouse
4142201Obrq15_mobesity resistance QTL 15 (mouse)Not determined5722744780578347Mouse
4142414Pregq4_mpregnancy QTL 4 (mouse)Not determined175722744793199751Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:581
Count of miRNA genes:345
Interacting mature miRNAs:401
Transcripts:ENSMUST00000024988, ENSMUST00000176457, ENSMUST00000177046, ENSMUST00000177425
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.



Reference Sequences
RefSeq Acc Id: ENSMUST00000024988   ⟹   ENSMUSP00000024988
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1757,510,970 - 57,535,136 (-)Ensembl
GRCm38.p6 Ensembl1757,203,970 - 57,228,136 (-)Ensembl
RefSeq Acc Id: ENSMUST00000176457
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1757,522,788 - 57,526,972 (-)Ensembl
GRCm38.p6 Ensembl1757,215,788 - 57,219,972 (-)Ensembl
RefSeq Acc Id: ENSMUST00000177046   ⟹   ENSMUSP00000135560
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1757,513,217 - 57,535,003 (-)Ensembl
GRCm38.p6 Ensembl1757,206,217 - 57,228,003 (-)Ensembl
RefSeq Acc Id: ENSMUST00000177425   ⟹   ENSMUSP00000135663
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1757,511,007 - 57,529,827 (-)Ensembl
GRCm38.p6 Ensembl1757,204,007 - 57,222,827 (-)Ensembl
RefSeq Acc Id: NM_009778   ⟹   NP_033908
RefSeq Status: REVIEWED
Mouse AssemblyChrPosition (strand)Source
GRCm391757,510,967 - 57,535,136 (-)NCBI
GRCm381757,203,967 - 57,228,136 (-)NCBI
MGSCv371757,343,396 - 57,367,559 (-)RGD
Celera1761,551,995 - 61,576,136 (-)RGD
RefSeq Acc Id: XM_011246258   ⟹   XP_011244560
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm391757,510,973 - 57,527,965 (-)NCBI
GRCm381757,203,973 - 57,220,965 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_033908   ⟸   NM_009778
- Peptide Label: preproprotein
- UniProtKB: P01027 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011244560   ⟸   XM_011246258
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000135560   ⟸   ENSMUST00000177046
RefSeq Acc Id: ENSMUSP00000135663   ⟸   ENSMUST00000177425
RefSeq Acc Id: ENSMUSP00000024988   ⟸   ENSMUST00000024988
Protein Domains
A2M_recep   Anaphylatoxin-like   NTR   TED_complement

RGD ID:13676584
Promoter ID:EPDNEW_M22441
Type:initiation region
Description:Mus musculus complement component 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381757,228,091 - 57,228,151EPDNEW
RGD ID:6847361
Promoter ID:MM_ACW:23226
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver
Mouse AssemblyChrPosition (strand)Source
MGSCv361757,344,796 - 57,345,597 (-)MPROMDB
RGD ID:6849062
Promoter ID:MM_XEF:3246
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver,   Spleen
Mouse AssemblyChrPosition (strand)Source
MGSCv361757,355,076 - 57,355,642 (-)MPROMDB
RGD ID:6848674
Promoter ID:MM_TRO:4443
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver
Mouse AssemblyChrPosition (strand)Source
MGSCv361757,359,846 - 57,360,602 (-)MPROMDB
RGD ID:6847359
Promoter ID:MM_ACW:23228
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver
Mouse AssemblyChrPosition (strand)Source
MGSCv361757,363,346 - 57,364,802 (-)MPROMDB
RGD ID:6849061
Promoter ID:MM_XEF:3247
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:NM_000064,   NM_001040469,   NM_001172903,   NM_214009
Mouse AssemblyChrPosition (strand)Source
MGSCv361757,366,134 - 57,366,634 (-)MPROMDB
RGD ID:6827900
Promoter ID:MM_KWN:23940
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver
Mouse AssemblyChrPosition (strand)Source
MGSCv361757,367,044 - 57,367,544 (-)MPROMDB
RGD ID:6850410
Promoter ID:EP07093
Type:single initiation site
Description:Complement, C3 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Primer extension with homologous sequence ladder
Regulation:liver; (induced by or strongly expressed in) cortisol
Mouse AssemblyChrPosition (strand)Source
MGSCv371757,367,514 - 57,367,574EPD
MGSCv361757,367,514 - 57,367,574EPD

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88227 AgrOrtholog
Ensembl Genes ENSMUSG00000024164 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000024988 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000135560 UniProtKB/TrEMBL
  ENSMUSP00000135663 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000024988 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000177046 UniProtKB/TrEMBL
  ENSMUST00000177425 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot UniProtKB/Swiss-Prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A-macroglobulin_rcpt-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A-macroglobulin_rcpt-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_N_BRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alpha-macroglobulin_TED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anaphylatoxin/fibulin UniProtKB/Swiss-Prot
  Anaphylatoxin_comp_syst UniProtKB/Swiss-Prot
  Anaphylatoxn_comp_syst_dom UniProtKB/Swiss-Prot
  C3/4/5_MG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Complement_C3-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot
  Macroglobln_a2 UniProtKB/Swiss-Prot
  MacrogloblnA2_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG2 UniProtKB/Swiss-Prot
  MG3 UniProtKB/Swiss-Prot
  MG4 UniProtKB/Swiss-Prot
  Netrin_domain UniProtKB/Swiss-Prot
  Netrin_module_non-TIMP UniProtKB/Swiss-Prot
  NTR_complement_C3 UniProtKB/Swiss-Prot
  Terpenoid_cyclase/PrenylTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/Swiss-Prot
KEGG Report mmu:12266 UniProtKB/Swiss-Prot
PANTHER PTHR11412:SF81 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam A2M UniProtKB/Swiss-Prot
  A2M_BRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANATO UniProtKB/Swiss-Prot
  MG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG2 UniProtKB/Swiss-Prot
  MG3 UniProtKB/Swiss-Prot
  MG4 UniProtKB/Swiss-Prot
  NTR UniProtKB/Swiss-Prot
  TED_complement UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen C3 PhenoGen
  ANAPHYLATOXIN_1 UniProtKB/Swiss-Prot
  ANAPHYLATOXIN_2 UniProtKB/Swiss-Prot
  NTR UniProtKB/Swiss-Prot
SMART A2M UniProtKB/Swiss-Prot
  A2M_N_2 UniProtKB/Swiss-Prot
  A2M_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANATO UniProtKB/Swiss-Prot
  C345C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47686 UniProtKB/Swiss-Prot
  SSF48239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50242 UniProtKB/Swiss-Prot
  CO3_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q61370 UniProtKB/Swiss-Prot
  Q80XP1 UniProtKB/Swiss-Prot