C3 (complement component 3) - Rat Genome Database

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Gene: C3 (complement component 3) Mus musculus
Analyze
Symbol: C3
Name: complement component 3
RGD ID: 10256
MGI Page MGI
Description: Predicted to enable C5L2 anaphylatoxin chemotactic receptor binding activity and lipid binding activity. Involved in several processes, including complement-mediated synapse pruning; nervous system development; and positive regulation of endocytosis. Acts upstream of or within several processes, including complement-dependent cytotoxicity; oviduct epithelium development; and positive regulation of immune response. Located in cell surface and extracellular space. Part of protein-containing complex. Is expressed in several structures, including adipose tissue; cerebral cortex; extraembryonic component; hemolymphoid system; and liver. Used to study complement component 3 deficiency. Human ortholog(s) of this gene implicated in several diseases, including complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; sickle cell anemia; and silicosis. Orthologous to human C3 (complement C3).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: acylation stimulating protein; AI255234; ASP; complement C3; complement component 3d; complement factor 3; HSE-MSF; Plp
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,510,967 - 57,535,136 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,510,970 - 57,535,136 (-)EnsemblGRCm39 Ensembl
GRCm381757,203,967 - 57,228,136 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1757,203,970 - 57,228,136 (-)EnsemblGRCm38mm10GRCm38
MGSCv371757,343,396 - 57,367,559 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361756,889,309 - 56,913,426 (-)NCBIMGSCv36mm8
Celera1761,551,995 - 61,576,136 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
acute myocardial infarction  (ISO)
adult respiratory distress syndrome  (ISO)
age related macular degeneration 7  (ISO)
age related macular degeneration 9  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
anterior uveitis  (ISO)
arteriolosclerosis  (ISO)
asthma  (IEP,IMP,ISO)
atopic dermatitis  (ISO)
atypical hemolytic-uremic syndrome  (IGI,ISO)
autosomal recessive polycystic kidney disease  (IEP,ISO)
bacterial pneumonia  (IMP)
boutonneuse fever  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Carcinoma, Lewis Lung  (IEP)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Allograft Dysfunction  (ISO)
chronic obstructive pulmonary disease  (ISO)
complement component 3 deficiency  (IAGP,ISO)
congenital hemolytic anemia  (ISO)
conjunctivitis  (ISO)
COVID-19  (ISO)
Diabetic Nephropathies  (IEP,ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
erythema nodosum  (ISO)
Experimental Arthritis  (IMP,ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myasthenia Gravis  (IEP,ISO)
Experimental Autoimmune Uveoretinitis  (IMP)
factor VIII deficiency  (ISO)
focal segmental glomerulosclerosis  (ISO)
focal segmental glomerulosclerosis 1  (ISO)
Fuchs' endothelial dystrophy  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
Hematuria  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (IMP)
Herpesviridae Infections  (IMP)
high grade glioma  (IMP)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (IMP)
Hyperalgesia  (ISO)
hypertension  (ISO)
IgA glomerulonephritis  (ISO)
Insulin Resistance  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Kuhnt-Junius degeneration  (ISO)
leishmaniasis  (IMP)
lepromatous leprosy  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (IMP)
lupus nephritis  (ISO)
macular degeneration  (IMP,ISO)
mastitis  (IEP)
melanoma  (IEP)
membranoproliferative glomerulonephritis  (ISO)
membranous glomerulonephritis  (ISO)
Meningococcal Infections  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
obesity  (ISO)
ocular hypertension  (ISO)
Optic Nerve Injuries  (ISO)
otitis media  (IEP)
Otitis Media with Effusion  (ISO)
Paratuberculosis  (ISO)
paroxysmal nocturnal hemoglobinuria  (ISO)
pemphigus  (ISO)
Penetrating Wounds  (ISO)
pleurisy  (IEP)
Pneumococcal Pneumonia  (IMP,ISO)
pneumocystosis  (ISO)
pneumonia  (ISO)
pre-eclampsia  (ISO)
primary immunodeficiency disease  (ISO)
primary ovarian insufficiency  (ISO)
pulmonary eosinophilia  (IMP)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
Radiation Pneumonitis  (ISO)
Refractory Anemia with Excess of Blasts  (ISO)
Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (IEP,ISO)
sickle cell anemia  (ISO)
silicosis  (ISO)
Sjogren's syndrome  (IMP)
Subarachnoid Hemorrhage  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
thrombophilia  (IMP)
Thrombotic Microangiopathies  (ISO)
transient cerebral ischemia  (ISO)
tropical spastic paraparesis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Viral Bronchiolitis  (IMP,ISO)
vitiligo  (IMP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(S)-colchicine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-Hydroxypyrene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dichloroaniline  (ISO)
3-methylcholanthrene  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
4-tert-Octylphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
9-phenanthrol  (ISO)
acetamide  (ISO)
afimoxifene  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
aluminium oxide  (EXP)
ammonium chloride  (ISO)
amphibole asbestos  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (EXP)
carbon nanotube  (EXP,ISO)
chlordecone  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
chondroitin sulfate  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (EXP)
D-glucose  (EXP)
D-penicillamine  (ISO)
daidzein  (ISO)
danazol  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diethyl malate  (EXP)
diethylstilbestrol  (EXP,ISO)
dioxygen  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
entinostat  (ISO)
fenthion  (EXP)
fenvalerate  (ISO)
ferulic acid  (EXP)
flutamide  (ISO)
folic acid  (EXP,ISO)
fulvestrant  (ISO)
furan  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
glucose  (EXP)
glycidol  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GW 4064  (EXP)
heparin  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
isoflavones  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (EXP)
magnesium atom  (EXP)
mangiferin  (EXP)
medroxyprogesterone acetate  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
methacholine chloride  (EXP)
methidathion  (EXP)
methotrexate  (EXP,ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
methyltestosterone  (ISO)
mifepristone  (ISO)
Mizoribine  (ISO)
mycotoxin  (EXP)
N-acetyl-L-cysteine  (ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
neoechinulin A  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nilotinib  (EXP)
nitrofen  (ISO)
nitroglycerin  (ISO)
Nonylphenol  (EXP,ISO)
olanzapine  (ISO)
ozone  (EXP,ISO)
p-tert-Amylphenol  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pemetrexed  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
poly(styrene)  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
procymidone  (ISO)
progesterone  (EXP,ISO)
propofol  (ISO)
raloxifene  (EXP)
reactive oxygen species  (EXP)
reserpine  (ISO)
resveratrol  (EXP,ISO)
rofecoxib  (ISO)
rosuvastatin calcium  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
senecionine  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
Soman  (ISO)
sophoraflavanone B  (ISO)
succimer  (EXP)
sulforaphane  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (EXP,ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
trimegestone  (ISO)
trimellitic anhydride  (EXP)
Triptolide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc sulfate  (EXP)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance  (IGI,IMP)
blood coagulation  (ISO)
cell surface receptor signaling pathway involved in cell-cell signaling  (IMP)
complement activation  (IBA,IDA,IMP,ISO,NAS)
complement activation, alternative pathway  (IEA)
complement activation, classical pathway  (IEA)
complement-dependent cytotoxicity  (IMP)
complement-mediated synapse pruning  (IMP)
fatty acid metabolic process  (IEA)
immune system process  (IEA)
inflammatory response  (IEA)
innate immune response  (IEA,ISO)
lipid metabolic process  (IEA)
neuron remodeling  (IMP)
opsonization  (ISO)
oviduct epithelium development  (IGI)
positive regulation of activation of membrane attack complex  (IMP)
positive regulation of angiogenesis  (IMP)
positive regulation of apoptotic cell clearance  (ISO)
positive regulation of apoptotic process in another organism  (NAS)
positive regulation of developmental growth  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of glucose transmembrane transport  (ISO)
positive regulation of immune response  (NAS)
positive regulation of lipid storage  (ISO)
positive regulation of opsonization  (ISO,NAS)
positive regulation of phagocytosis  (IMP,NAS)
positive regulation of phagocytosis, engulfment  (IGI,IMP)
positive regulation of protein phosphorylation  (ISO)
positive regulation of receptor-mediated endocytosis  (IGI,IMP)
positive regulation of type IIa hypersensitivity  (IMP)
positive regulation of vascular endothelial growth factor production  (ISO)
proteolysis  (ISO)
regulation of complement activation  (ISO)
regulation of complement activation, alternative pathway  (ISO)
regulation of triglyceride biosynthetic process  (ISO)
response to bacterium  (IEP)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to glucocorticoid  (ISO)
response to magnesium ion  (ISO)
response to progesterone  (ISO)
response to xenobiotic stimulus  (ISO)
retina development in camera-type eye  (IGI)
tolerance induction  (ISO)
vascular associated smooth muscle cell differentiation  (IGI)
vertebrate eye-specific patterning  (IMP)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blastocyst morphology  (IAGP)
abnormal blood coagulation  (IAGP)
abnormal blood homeostasis  (IAGP)
abnormal c-wave shape  (IAGP)
abnormal cell-mediated immunity  (IAGP)
abnormal complement pathway  (IAGP)
abnormal dendritic spine morphology  (IAGP)
abnormal energy expenditure  (IAGP)
abnormal enzyme/coenzyme level  (IAGP)
abnormal eye electrophysiology  (IAGP)
abnormal female reproductive system physiology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal hippocampus CA3 region morphology  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal immune system morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal induced morbidity/mortality  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal intestinal lipid absorption  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver physiology  (IAGP)
abnormal mast cell physiology  (IAGP)
abnormal neutrophil morphology  (IAGP)
abnormal oxygen consumption  (IAGP)
abnormal physical strength  (IAGP)
abnormal platelet physiology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal retina horizontal cell morphology  (IAGP)
abnormal retina rod bipolar cell morphology  (IAGP)
abnormal skeletal muscle morphology  (IAGP)
abnormal spatial working memory  (IAGP)
abnormal spleen germinal center morphology  (IAGP)
abnormal synaptic plasticity  (IAGP)
abnormal synaptic vesicle number  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
amyloid beta deposits  (IAGP)
brain inflammation  (IAGP)
decreased anxiety-related response  (IAGP)
decreased b-wave amplitude  (IAGP)
decreased body weight  (IAGP)
decreased cerebral infarct size  (IAGP)
decreased circulating alanine transaminase level  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating interleukin-6 level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased circulating tumor necrosis factor level  (IAGP)
decreased fetal weight  (IAGP)
decreased hepatocyte proliferation  (IAGP)
decreased IgM level  (IAGP)
decreased mast cell number  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased placental labyrinth size  (IAGP)
decreased spleen germinal center number  (IAGP)
decreased spleen germinal center size  (IAGP)
decreased spongiotrophoblast size  (IAGP)
decreased susceptibility to alcohol-induced hepatic steatosis  (IAGP)
decreased susceptibility to autoimmune diabetes  (IAGP)
decreased susceptibility to autoimmune disorder  (IAGP)
decreased susceptibility to autoimmune hemolytic anemia  (IAGP)
decreased susceptibility to Coronaviridae infection  (IAGP)
decreased susceptibility to induced arthritis  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased total body fat amount  (IAGP)
decreased urine albumin level  (IAGP)
decreased vascular permeability  (IAGP)
decreased white adipose tissue amount  (IAGP)
dystrophic muscle  (IAGP)
enhanced central nervous system regeneration  (IAGP)
enhanced contextual conditioning behavior  (IAGP)
enhanced long term potentiation  (IAGP)
enhanced paired-pulse facilitation  (IAGP)
enhanced spatial learning  (IAGP)
enlarged cervical lymph nodes  (IAGP)
enlarged spleen  (IAGP)
extended life span  (IAGP)
focal hepatic necrosis  (IAGP)
glomerulonephritis  (IAGP)
hepatic steatosis  (IAGP)
impaired complement alternative pathway  (IAGP)
impaired embryo implantation  (IAGP)
impaired liver regeneration  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased body weight  (IAGP)
increased brown adipose tissue amount  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating bilirubin level  (IAGP)
increased circulating free fatty acids level  (IAGP)
increased IgG level  (IAGP)
increased IgM level  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased microglial cell activation  (IAGP)
increased neuron number  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased T cell proliferation  (IAGP)
increased triglyceride level  (IAGP)
insulitis  (IAGP)
liver inflammation  (IAGP)
loss of hippocampal neurons  (IAGP)
muscle weakness  (IAGP)
no abnormal phenotype detected  (IAGP)
polyphagia  (IAGP)
prolonged estrous cycle  (IAGP)
skeletal muscle interstitial fibrosis  (IAGP)
small placenta  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Complement components (C3, C4) as inflammatory markers in asthma. Abdel Fattah M, etal., Indian J Pediatr. 2010 Jul;77(7):771-3. Epub 2010 Jun 29.
2. Intraglomerular synthesis of complement C3 and its activation products in IgA nephropathy. Abe K, etal., Nephron. 2001 Mar;87(3):231-9.
3. C-reactive protein and complement components but not other acute-phase reactants discriminate between clinical subsets and organ damage in systemic lupus erythematosus. Amezcua-Guerra LM, etal., Clin Lab. 2011;57(7-8):607-13.
4. Treatment with captopril abrogates the altered expression of alpha1 macroglobulin and alpha1 antiproteinase in sera of spontaneously hypertensive rats. Aminudin N, etal., Proteome Sci. 2012 Mar 15;10(1):17. doi: 10.1186/1477-5956-10-17.
5. Complement proteins and C3 anaphylatoxin in the tears of patients with conjunctivitis. Ballow M, etal., J Allergy Clin Immunol. 1985 Sep;76(3):473-6.
6. Variants in the gene encoding C3 are associated with asthma and related phenotypes among African Caribbean families. Barnes KC, etal., Genes Immun. 2006 Jan;7(1):27-35.
7. Complement abnormalities during an epidemic of group B meningococcal infection in children. Beatty DW, etal., Clin Exp Immunol. 1986 Jun;64(3):465-70.
8. Up-regulation of endothelial cell adhesion molecules characterizes disease activity in systemic lupus erythematosus. The Shwartzman phenomenon revisited. Belmont HM, etal., Arthritis Rheum. 1994 Mar;37(3):376-83.
9. Dynamics of intrapulmonary bacterial growth in a murine model of repeated microaspiration. Ben-David I, etal., Am J Respir Cell Mol Biol. 2005 Nov;33(5):476-82. Epub 2005 Jul 13.
10. Molecular basis of hereditary C3 deficiency. Botto M, etal., J Clin Invest. 1990 Oct;86(4):1158-63.
11. Plasma proteomic analysis may identify new markers for radiation-induced lung toxicity in patients with non-small-cell lung cancer. Cai XW, etal., Int J Radiat Oncol Biol Phys. 2010 Jul 1;77(3):867-76.
12. Proteomic analysis of rat plasma following transient focal cerebral ischemia. Chen R, etal., Biomark Med. 2011 Dec;5(6):837-46.
13. Beneficial effect of the polysaccharides from Bupleurum smithii var. parvifolium on "two-hit" acute lung injury in rats. Cheng XQ, etal., Inflammation. 2012 Oct;35(5):1715-22. doi: 10.1007/s10753-012-9489-7.
14. Increased activation of the alternative complement pathway in sickle cell disease. Chudwin DS, etal., Clin Immunol Immunopathol. 1985 Oct;37(1):93-7.
15. Complement deposition and microglial activation in the outer retina in light-induced retinopathy: inhibition by a 5-HT1A agonist. Collier RJ, etal., Invest Ophthalmol Vis Sci. 2011 Oct 11;52(11):8108-16. doi: 10.1167/iovs.10-6418.
16. Complement levels in pneumococcal pneumonia. Coonrod JD and Rylko-Bauer B, Infect Immun. 1977 Oct;18(1):14-22.
17. Complement activation contributes to hypoxic-ischemic brain injury in neonatal rats. Cowell RM, etal., J Neurosci. 2003 Oct 15;23(28):9459-68.
18. Increased serum complement component 3 and mannose-binding lectin levels in adult Chinese patients with chronic rhinosinusitis. Cui YH, etal., Rhinology. 2009 Jun;47(2):187-91.
19. Intravenous immunoglobulin (IVIG) attenuates antibody binding in acute haemorrhagic immunopneumonitis in a rat model of complement-dependent lung injury. Dantas M, etal., Clin Exp Immunol. 2000 Jul;121(1):139-45.
20. Cutting edge: the absence of C3 demonstrates a role for complement in Th2 effector functions in a murine model of pulmonary allergy. Drouin SM, etal., J Immunol. 2001 Oct 15;167(8):4141-5.
21. Endogenous C1-inhibitor production and expression in the heart after acute myocardial infarction. Emmens RW, etal., Cardiovasc Pathol. 2016 Jan-Feb;25(1):33-9. doi: 10.1016/j.carpath.2015.09.006. Epub 2015 Sep 25.
22. CD36-mediated hematoma absorption following intracerebral hemorrhage: negative regulation by TLR4 signaling. Fang H, etal., J Immunol. 2014 Jun 15;192(12):5984-92. doi: 10.4049/jimmunol.1400054. Epub 2014 May 7.
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PMID:18567839   PMID:18572163   PMID:18587006   PMID:18615583   PMID:18624920   PMID:18634851   PMID:18653698   PMID:18671285   PMID:18684964   PMID:18694897   PMID:18713972   PMID:18779337  
PMID:18787004   PMID:18787060   PMID:18804116   PMID:18812470   PMID:18820683   PMID:18836527   PMID:18947875   PMID:18996748   PMID:19017934   PMID:19017980   PMID:19051264   PMID:19112490  
PMID:19136662   PMID:19201479   PMID:19205046   PMID:19281793   PMID:19305412   PMID:19355789   PMID:19357704   PMID:19411110   PMID:19414754   PMID:19458267   PMID:19491392   PMID:19581397  
PMID:19620784   PMID:19648268   PMID:19684087   PMID:19710450   PMID:19710463   PMID:19729477   PMID:19729481   PMID:19740327   PMID:19752222   PMID:19767107   PMID:19770513   PMID:19815824  
PMID:19843088   PMID:20018737   PMID:20199584   PMID:20213737   PMID:20223920   PMID:20339115   PMID:20427530   PMID:20439912   PMID:20511542   PMID:20584999   PMID:20625009   PMID:20702808  
PMID:20709903   PMID:20712003   PMID:20800648   PMID:20817881   PMID:20829368   PMID:20870940   PMID:20970501   PMID:21045192   PMID:21048081   PMID:21060153   PMID:21074891   PMID:21148255  
PMID:21169517   PMID:21187447   PMID:21203444   PMID:21217014   PMID:21267068   PMID:21270401   PMID:21357400   PMID:21441447   PMID:21482685   PMID:21531981   PMID:21565611   PMID:21569105  
PMID:21652682   PMID:21677637   PMID:21704012   PMID:21707943   PMID:21723612   PMID:21763674   PMID:21767994   PMID:21801872   PMID:21813769   PMID:21816131   PMID:21873635   PMID:21943708  
PMID:21979496   PMID:22019898   PMID:22037602   PMID:22069473   PMID:22184721   PMID:22190594   PMID:22194859   PMID:22219359   PMID:22262892   PMID:22308431   PMID:22422887   PMID:22427639  
PMID:22438044   PMID:22502635   PMID:22518005   PMID:22535677   PMID:22539791   PMID:22566568   PMID:22585573   PMID:22632727   PMID:22649195   PMID:22682250   PMID:22689574   PMID:22721768  
PMID:22797180   PMID:22966167   PMID:23012479   PMID:23033813   PMID:23056509   PMID:23074214   PMID:23097680   PMID:23109726   PMID:23168409   PMID:23182714   PMID:23189195   PMID:23225913  
PMID:23226093   PMID:23237573   PMID:23263555   PMID:23299310   PMID:23326231   PMID:23345428   PMID:23345431   PMID:23390291   PMID:23427256   PMID:23430572   PMID:23454183   PMID:23487775  
PMID:23511127   PMID:23526211   PMID:23527240   PMID:23530212   PMID:23619360   PMID:23733878   PMID:23737250   PMID:23747948   PMID:23749374   PMID:23749409   PMID:23824734   PMID:23901101  
PMID:23926185   PMID:23943789   PMID:23946404   PMID:24006456   PMID:24014879   PMID:24038599   PMID:24108700   PMID:24117111   PMID:24170856   PMID:24175013   PMID:24194600   PMID:24200836  
PMID:24244174   PMID:24260573   PMID:24279761   PMID:24337750   PMID:24378428   PMID:24381160   PMID:24470120   PMID:24470395   PMID:24474777   PMID:24523933   PMID:24632830   PMID:24651866  
PMID:24667943   PMID:24673754   PMID:24763049   PMID:24806427   PMID:24808362   PMID:24948809   PMID:24975369   PMID:24981453   PMID:25039245   PMID:25127469   PMID:25187659   PMID:25284781  
PMID:25308956   PMID:25367575   PMID:25480293   PMID:25559179   PMID:25573852   PMID:25733354   PMID:25802332   PMID:25851247   PMID:25888260   PMID:26132276   PMID:26199322   PMID:26393907  
PMID:26400934   PMID:26619292   PMID:26628365   PMID:26773156   PMID:26787717   PMID:26822321   PMID:26831747   PMID:26873964   PMID:26900812   PMID:26945067   PMID:27029069   PMID:27031863  
PMID:27033548   PMID:27041467   PMID:27109176   PMID:27113764   PMID:27235854   PMID:27274010   PMID:27295359   PMID:27304426   PMID:27403737   PMID:27535705   PMID:27564415   PMID:27572255  
PMID:27626380   PMID:27641978   PMID:27644882   PMID:27697835   PMID:27735945   PMID:27782329   PMID:27876407   PMID:27913632   PMID:28052876   PMID:28057640   PMID:28139294   PMID:28223279  
PMID:28279023   PMID:28283064   PMID:28301559   PMID:28348233   PMID:28378742   PMID:28446616   PMID:28462915   PMID:28539427   PMID:28566429   PMID:28605809   PMID:28700664   PMID:28710441  
PMID:28756234   PMID:28852207   PMID:28887040   PMID:28928904   PMID:29018286   PMID:29109438   PMID:29118090   PMID:29233958   PMID:29279353   PMID:29362231   PMID:29383821   PMID:29497373  
PMID:29531168   PMID:29565179   PMID:29581196   PMID:29716893   PMID:29743491   PMID:29746835   PMID:29802205   PMID:29867343   PMID:29942300   PMID:30033122   PMID:30068650   PMID:30173917  
PMID:30174588   PMID:30179254   PMID:30217731   PMID:30246940   PMID:30250184   PMID:30293775   PMID:30300579   PMID:30301856   PMID:30333137   PMID:30429287   PMID:30429364   PMID:30573546  
PMID:30647151   PMID:30714990   PMID:30850533   PMID:31040226   PMID:31076642   PMID:31175160   PMID:31209071   PMID:31231033   PMID:31274379   PMID:31292459   PMID:31309159   PMID:31433986  
PMID:31461345   PMID:31578522   PMID:31594939   PMID:31604923   PMID:31723045   PMID:31732528   PMID:31801071   PMID:31801075   PMID:31865842   PMID:31955888   PMID:32079660   PMID:32087947  
PMID:32130954   PMID:32179479   PMID:32208992   PMID:32244854   PMID:32273396   PMID:32325033   PMID:32535539   PMID:32568214   PMID:32582142   PMID:32661396   PMID:32682912   PMID:32692363  
PMID:32717081   PMID:32719333   PMID:32866962   PMID:33088172   PMID:33147456   PMID:33153107   PMID:33161108   PMID:33239388   PMID:33305736   PMID:33314324   PMID:33337564   PMID:33746963  
PMID:33761330   PMID:33767691   PMID:33782126   PMID:33897891   PMID:33903766   PMID:33986436   PMID:34031614   PMID:34071589   PMID:34176310   PMID:34309810   PMID:34386001   PMID:34403734  
PMID:34415487   PMID:34417332   PMID:34417985   PMID:34543680   PMID:34673149   PMID:34707103   PMID:34762761   PMID:34875452   PMID:35021101   PMID:35108544   PMID:35143312   PMID:35250972  
PMID:35432387   PMID:35725556   PMID:35743302   PMID:36110094  


Genomics

Comparative Map Data
C3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,510,967 - 57,535,136 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,510,970 - 57,535,136 (-)EnsemblGRCm39 Ensembl
GRCm381757,203,967 - 57,228,136 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1757,203,970 - 57,228,136 (-)EnsemblGRCm38mm10GRCm38
MGSCv371757,343,396 - 57,367,559 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361756,889,309 - 56,913,426 (-)NCBIMGSCv36mm8
Celera1761,551,995 - 61,576,136 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.72NCBI
C3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,677,704 - 6,720,650 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl196,677,704 - 6,730,562 (-)EnsemblGRCh38hg38GRCh38
GRCh37196,677,715 - 6,720,661 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,628,846 - 6,671,662 (-)NCBINCBI36Build 36hg18NCBI36
Build 34196,628,877 - 6,671,660NCBI
Celera196,619,402 - 6,662,926 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef196,440,030 - 6,483,146 (-)NCBIHuRef
CHM1_1196,678,095 - 6,720,521 (-)NCBICHM1_1
T2T-CHM13v2.0196,667,334 - 6,710,056 (-)NCBIT2T-CHM13v2.0
C3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.292,087,437 - 2,114,366 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl92,087,437 - 2,114,429 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,515,463 - 2,542,310 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.097,864,836 - 7,891,685 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.096,820,692 - 6,847,542 (-)NCBIRnor_WKY
Rnor_6.099,721,137 - 9,747,084 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,721,105 - 9,747,167 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.098,728,465 - 8,754,412 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,407,133 - 6,432,968 (+)NCBICelera
Cytogenetic Map9q12NCBI
C3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554952,796,663 - 2,824,697 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554952,796,601 - 2,824,233 (+)NCBIChiLan1.0ChiLan1.0
C3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1196,629,240 - 6,674,786 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,629,287 - 6,674,699 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0195,708,211 - 5,753,178 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
C3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,566,226 - 53,598,365 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,566,261 - 53,598,761 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2053,314,550 - 53,347,112 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02054,220,548 - 54,253,547 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2054,219,154 - 54,438,066 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,287,896 - 53,320,436 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,735,894 - 53,768,908 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02053,965,350 - 53,997,908 (+)NCBIUU_Cfam_GSD_1.0
C3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,824,886 - 213,849,048 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365883,985,732 - 4,023,221 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl272,431,212 - 72,472,228 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1272,431,470 - 72,471,622 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2272,762,013 - 72,820,437 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2272,950,572 - 72,957,968 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2qNCBI
C3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.166,250,422 - 6,289,264 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660811,706,107 - 1,746,127 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
C3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,770,221 - 3,797,946 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248283,773,816 - 3,798,077 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:581
Count of miRNA genes:345
Interacting mature miRNAs:401
Transcripts:ENSMUST00000024988, ENSMUST00000176457, ENSMUST00000177046, ENSMUST00000177425
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172461275058612864Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172605118560051352Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172688497260885114Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172781520961815209Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172862240662622654Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined173013255564132666Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3103350065033630Mouse
1300885Mbis4_mMycobacterium bovis-induced systemic lupus erythematosus 4 (mouse)Not determined173517581770165926Mouse
10755514Amzn2_manatomical modifier of Zfp423 2 (mouse)173596629469966424Mouse
12904951Smmq2_msoleus muscle mass QTL 2 (mouse)173678974370789743Mouse
1300592Pcyts5_mplasmacytoma susceptibility 5 (mouse)Not determined173871288772712970Mouse
10755525Lymph2_mlymphocyte differential 2 (mouse)173880562672805626Mouse
10755534Lymph4_mlymphocyte differential 4 (mouse)173880562672805626Mouse
4141319Hmtb8_mhemostasis and thrombosis rebleeding time 8 (mouse)Not determined4053444774534623Mouse
15039324Nmrs48_mNAFLD-associated magnetic resonance shift 48 (mouse)174093918774939187Mouse
26884390Skwq9_mskull length QTL 9, 10 week (mouse)174371089167806995Mouse
26884428Cvht3_mcranial vault height 3, 5 week (mouse)174651092682407429Mouse
14700692Cihvtq1_mcoxsackieviral infection heart viral titre QTL 1 (mouse)175000702870006995Mouse
1357754Ahl3_mage related hearing loss 3 (mouse)Not determined175020395784204103Mouse
4142243Lfnq5_mlung function QTL 5 (mouse)Not determined5173897957534623Mouse
4141879Chlq9_mcirculating hormone level QTL 9 (mouse)Not determined175175842585758612Mouse
1357532Bmch7_mbone mechanical trait 7 (mouse)Not determined175175842585758612Mouse
1357447Heal13_mwound healing/regeneration 13 (mouse)Not determined175710765191107803Mouse
4141758Pstc5_mperiosteal circumference 5 (mouse)Not determined175710765191107803Mouse
4141011Bmd26_mbone mineral density 26 (mouse)Not determined175710765191107803Mouse
1300735Pgia20_mproteoglycan induced arthritis 20 (mouse)Not determined175710765191107803Mouse
12910536Nrq8a_mnoise-induced hearing loss resistant QTL 8a (mouse)175710765191107803Mouse
12910537Nrq8_mnoise-induced hearing loss resistant QTL 8 (mouse)175710765191107803Mouse
4142201Obrq15_mobesity resistance QTL 15 (mouse)Not determined5753444780885776Mouse
4142414Pregq4_mpregnancy QTL 4 (mouse)Not determined175753444793507179Mouse

Markers in Region
AI255234  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381757,204,039 - 57,204,275UniSTSGRCm38
MGSCv371757,343,462 - 57,343,698UniSTSGRCm37
Celera1761,552,061 - 61,552,297UniSTS
Cytogenetic Map17E1-E3UniSTS
Cytogenetic Map17D-E1UniSTS
Whitehead/MRC_RH17710.44UniSTS
D17Mit20  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381757,227,447 - 57,227,623UniSTSGRCm38
MGSCv371757,366,870 - 57,367,046UniSTSGRCm37
Celera1761,575,459 - 61,575,623UniSTS
Cytogenetic Map17E1-E3UniSTS
cM Map1740.6UniSTS
cM Map1734.3UniSTS
Whitehead Genetic1729.5UniSTS
D17Mit88  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381757,229,291 - 57,229,532UniSTSGRCm38
MGSCv371757,368,714 - 57,368,955UniSTSGRCm37
Celera1761,577,291 - 61,577,532UniSTS
Cytogenetic Map17E1-E3UniSTS
cM Map1729.5UniSTS
Whitehead Genetic1729.5UniSTS
PMC156107P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381757,226,294 - 57,226,728UniSTSGRCm38
MGSCv371757,365,717 - 57,366,151UniSTSGRCm37
Celera1761,574,306 - 61,574,740UniSTS
Cytogenetic Map17E1-E3UniSTS
C3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17E1-E3UniSTS
cM Map1734.3UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000024988   ⟹   ENSMUSP00000024988
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1757,510,970 - 57,535,136 (-)Ensembl
GRCm38.p6 Ensembl1757,203,970 - 57,228,136 (-)Ensembl
RefSeq Acc Id: ENSMUST00000176457
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1757,522,788 - 57,526,972 (-)Ensembl
GRCm38.p6 Ensembl1757,215,788 - 57,219,972 (-)Ensembl
RefSeq Acc Id: ENSMUST00000177046   ⟹   ENSMUSP00000135560
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1757,513,217 - 57,535,003 (-)Ensembl
GRCm38.p6 Ensembl1757,206,217 - 57,228,003 (-)Ensembl
RefSeq Acc Id: ENSMUST00000177425   ⟹   ENSMUSP00000135663
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1757,511,007 - 57,529,827 (-)Ensembl
GRCm38.p6 Ensembl1757,204,007 - 57,222,827 (-)Ensembl
RefSeq Acc Id: NM_009778   ⟹   NP_033908
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391757,510,967 - 57,535,136 (-)NCBI
GRCm381757,203,967 - 57,228,136 (-)NCBI
MGSCv371757,343,396 - 57,367,559 (-)RGD
Celera1761,551,995 - 61,576,136 (-)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011246258   ⟹   XP_011244560
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391757,510,973 - 57,527,965 (-)NCBI
GRCm381757,203,973 - 57,220,965 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033908   ⟸   NM_009778
- Peptide Label: preproprotein
- UniProtKB: Q80XP1 (UniProtKB/Swiss-Prot),   P01027 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011244560   ⟸   XM_011246258
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000135560   ⟸   ENSMUST00000177046
RefSeq Acc Id: ENSMUSP00000135663   ⟸   ENSMUST00000177425
RefSeq Acc Id: ENSMUSP00000024988   ⟸   ENSMUST00000024988
Protein Domains
A2M_N_2   A2M_recep   Anaphylatoxin-like   NTR   TED_complement

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01027-F1-model_v2 AlphaFold P01027 1-1663 view protein structure

Promoters
RGD ID:13676584
Promoter ID:EPDNEW_M22441
Type:initiation region
Name:C3_1
Description:Mus musculus complement component 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381757,228,091 - 57,228,151EPDNEW
RGD ID:6847361
Promoter ID:MM_ACW:23226
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver
Transcripts:C3.CSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361757,344,796 - 57,345,597 (-)MPROMDB
RGD ID:6849062
Promoter ID:MM_XEF:3246
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver,   Spleen
Transcripts:NM_001082286
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361757,355,076 - 57,355,642 (-)MPROMDB
RGD ID:6848674
Promoter ID:MM_TRO:4443
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver
Transcripts:MTR014700.17.1682.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361757,359,846 - 57,360,602 (-)MPROMDB
RGD ID:6847359
Promoter ID:MM_ACW:23228
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver
Transcripts:C3.BSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361757,363,346 - 57,364,802 (-)MPROMDB
RGD ID:6849061
Promoter ID:MM_XEF:3247
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:NM_000064,   NM_001040469,   NM_001172903,   NM_214009
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361757,366,134 - 57,366,634 (-)MPROMDB
RGD ID:6827900
Promoter ID:MM_KWN:23940
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver
Transcripts:NM_009778
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361757,367,044 - 57,367,544 (-)MPROMDB
RGD ID:6850410
Promoter ID:EP07093
Type:single initiation site
Name:MM_CO3
Description:Complement, C3 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Primer extension with homologous sequence ladder
Regulation:liver; (induced by or strongly expressed in) cortisol
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv371757,367,514 - 57,367,574EPD
MGSCv361757,367,514 - 57,367,574EPD

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88227 AgrOrtholog
Ensembl Genes ENSMUSG00000024164 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000024988 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000135560.2 UniProtKB/TrEMBL
  ENSMUSP00000135663.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000024988 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000177046.2 UniProtKB/TrEMBL
  ENSMUST00000177425.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.120 UniProtKB/Swiss-Prot
  2.60.40.10 UniProtKB/Swiss-Prot
  2.60.40.690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A-macroglobulin_rcpt-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A-macroglobulin_rcpt-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_N_BRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alpha-macroglobulin_TED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anaphylatoxin/fibulin UniProtKB/Swiss-Prot
  Anaphylatoxin_comp_syst UniProtKB/Swiss-Prot
  Anaphylatoxn_comp_syst_dom UniProtKB/Swiss-Prot
  C3/4/5_MG1 UniProtKB/Swiss-Prot
  Complement_C3-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot
  Macroglobln_a2 UniProtKB/Swiss-Prot
  MacrogloblnA2_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG2 UniProtKB/Swiss-Prot
  MG3 UniProtKB/Swiss-Prot
  MG4 UniProtKB/Swiss-Prot
  Netrin_domain UniProtKB/Swiss-Prot
  Netrin_module_non-TIMP UniProtKB/Swiss-Prot
  NTR_complement_C3 UniProtKB/Swiss-Prot
  Terpenoid_cyclase/PrenylTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/Swiss-Prot
KEGG Report mmu:12266 UniProtKB/Swiss-Prot
MGD MGI:88227 ENTREZGENE
NCBI Gene 12266 ENTREZGENE
PANTHER PTHR11412:SF81 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam A2M UniProtKB/Swiss-Prot
  A2M_BRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANATO UniProtKB/Swiss-Prot
  MG1 UniProtKB/Swiss-Prot
  MG2 UniProtKB/Swiss-Prot
  MG3 UniProtKB/Swiss-Prot
  MG4 UniProtKB/Swiss-Prot
  NTR UniProtKB/Swiss-Prot
  TED_complement UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB C3 RGD
PhenoGen C3 PhenoGen
PRINTS ANAPHYLATOXN UniProtKB/Swiss-Prot
PROSITE ALPHA_2_MACROGLOBULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANAPHYLATOXIN_1 UniProtKB/Swiss-Prot
  ANAPHYLATOXIN_2 UniProtKB/Swiss-Prot
  NTR UniProtKB/Swiss-Prot
SMART A2M UniProtKB/Swiss-Prot
  A2M_N_2 UniProtKB/Swiss-Prot
  A2M_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANATO UniProtKB/Swiss-Prot
  C345C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47686 UniProtKB/Swiss-Prot
  SSF48239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50242 UniProtKB/Swiss-Prot
UniProt B5APU1_MOUSE UniProtKB/TrEMBL
  CO3_MOUSE UniProtKB/Swiss-Prot
  E1APH6_MOUSE UniProtKB/TrEMBL
  H3BKW9_MOUSE UniProtKB/TrEMBL
  H3BL60_MOUSE UniProtKB/TrEMBL
  P01027 ENTREZGENE
  Q207D2_MOUSE UniProtKB/TrEMBL
  Q80XP1 ENTREZGENE
UniProt Secondary Q61370 UniProtKB/Swiss-Prot
  Q80XP1 UniProtKB/Swiss-Prot