C3 (complement component 3) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: C3 (complement component 3) Mus musculus
Analyze
Symbol: C3
Name: complement component 3
RGD ID: 10256
MGI Page MGI
Description: Predicted to enable C5L2 anaphylatoxin chemotactic receptor binding activity and lipid binding activity. Involved in several processes, including complement-mediated synapse pruning; nervous system development; and positive regulation of endocytosis. Acts upstream of or within several processes, including complement-dependent cytotoxicity; oviduct epithelium development; and positive regulation of immune response. Located in cell surface and extracellular space. Part of protein-containing complex. Is expressed in several structures, including adipose tissue; cerebral cortex; extraembryonic component; hemolymphoid system; and liver. Used to study complement component 3 deficiency. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; and sickle cell anemia. Orthologous to human C3 (complement C3).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acylation stimulating protein; AI255234; ASP; complement C3; complement component 3d; complement factor 3; HSE-MSF; Plp
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,510,967 - 57,535,136 (-)NCBIGRCm39mm39
GRCm39 Ensembl1757,510,970 - 57,535,136 (-)Ensembl
GRCm381757,203,967 - 57,228,136 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1757,203,970 - 57,228,136 (-)EnsemblGRCm38mm10GRCm38
MGSCv371757,343,396 - 57,367,559 (-)NCBIGRCm37mm9NCBIm37
MGSCv361756,889,309 - 56,913,426 (-)NCBImm8
Celera1761,551,995 - 61,576,136 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
acute myocardial infarction  (ISO)
adult respiratory distress syndrome  (ISO)
age related macular degeneration 7  (ISO)
age related macular degeneration 9  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
anterior uveitis  (ISO)
arteriolosclerosis  (ISO)
asthma  (IEP,IMP,ISO)
atopic dermatitis  (ISO)
atypical hemolytic-uremic syndrome  (IGI,ISO)
autosomal recessive polycystic kidney disease  (IEP,ISO)
bacterial pneumonia  (IMP)
boutonneuse fever  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Carcinoma, Lewis Lung  (IEP)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Allograft Dysfunction  (ISO)
chronic obstructive pulmonary disease  (ISO)
complement component 3 deficiency  (IEA,ISO)
congenital hemolytic anemia  (ISO)
conjunctivitis  (ISO)
COVID-19  (ISO)
Diabetic Nephropathies  (IEP,ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
erythema nodosum  (ISO)
Experimental Arthritis  (IMP,ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myasthenia Gravis  (IEP,ISO)
Experimental Autoimmune Uveoretinitis  (IMP)
factor VIII deficiency  (ISO)
Fuchs' endothelial dystrophy  (ISO)
glomerulonephritis  (ISO)
Hematuria  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (IMP)
Herpesviridae Infections  (IMP)
high grade glioma  (IMP)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (IMP)
Hyperalgesia  (ISO)
hypertension  (ISO)
IgA glomerulonephritis  (ISO)
Insulin Resistance  (ISO)
Kidney Reperfusion Injury  (ISO)
Kuhnt-Junius degeneration  (ISO)
leishmaniasis  (IMP)
lepromatous leprosy  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (IMP)
lupus nephritis  (ISO)
macular degeneration  (IMP,ISO)
mastitis  (IEP)
melanoma  (IEP)
membranoproliferative glomerulonephritis  (ISO)
membranous glomerulonephritis  (ISO)
Meningococcal Infections  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
obesity  (ISO)
ocular hypertension  (ISO)
Optic Nerve Injuries  (ISO)
otitis media  (IEP)
Otitis Media with Effusion  (ISO)
Paratuberculosis  (ISO)
paroxysmal nocturnal hemoglobinuria  (ISO)
pemphigus  (ISO)
pleurisy  (IEP)
Pneumococcal Pneumonia  (IMP,ISO)
pneumocystosis  (ISO)
pneumonia  (ISO)
pre-eclampsia  (ISO)
primary immunodeficiency disease  (ISO)
primary ovarian insufficiency  (ISO)
pulmonary eosinophilia  (IMP)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
Radiation Pneumonitis  (ISO)
Refractory Anemia with Excess of Blasts  (ISO)
Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (IEP,ISO)
sickle cell anemia  (ISO)
silicosis  (ISO)
Sjogren's syndrome  (IMP)
Subarachnoid Hemorrhage  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
thrombophilia  (IMP)
Thrombotic Microangiopathies  (ISO)
transient cerebral ischemia  (ISO)
tropical spastic paraparesis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Viral Bronchiolitis  (IMP,ISO)
vitiligo  (IMP)
Wounds, Penetrating  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(S)-colchicine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-Hydroxypyrene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dichloroaniline  (ISO)
3-methylcholanthrene  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-tert-Octylphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
9-phenanthrol  (ISO)
acetamide  (ISO)
afimoxifene  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
aluminium oxide  (EXP)
ammonium chloride  (ISO)
amphibole asbestos  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (EXP)
carbon nanotube  (EXP,ISO)
chlordecone  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
chondroitin sulfate  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (EXP)
D-glucose  (EXP)
D-penicillamine  (ISO)
daidzein  (ISO)
danazol  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diethyl malate  (EXP)
diethylstilbestrol  (EXP,ISO)
dioxygen  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
entinostat  (ISO)
fenvalerate  (ISO)
ferulic acid  (EXP)
flutamide  (ISO)
folic acid  (EXP,ISO)
fulvestrant  (ISO)
furan  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
glucose  (EXP)
glycidol  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GW 4064  (EXP)
heparin  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
isoflavones  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (EXP)
magnesium atom  (EXP)
mangiferin  (EXP)
medroxyprogesterone acetate  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
methacholine chloride  (EXP)
methotrexate  (EXP,ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
methyltestosterone  (ISO)
mifepristone  (ISO)
Mizoribine  (ISO)
mycotoxin  (EXP)
N-acetyl-L-cysteine  (ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
neoechinulin A  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nilotinib  (EXP)
nitrofen  (ISO)
nitroglycerin  (ISO)
Nonylphenol  (EXP,ISO)
olanzapine  (ISO)
ozone  (EXP,ISO)
p-tert-Amylphenol  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pemetrexed  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
poly(styrene)  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
procymidone  (ISO)
progesterone  (EXP,ISO)
propofol  (ISO)
raloxifene  (EXP)
reactive oxygen species  (EXP)
reserpine  (ISO)
resveratrol  (EXP,ISO)
rofecoxib  (ISO)
rosuvastatin calcium  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
Soman  (ISO)
sophoraflavanone B  (ISO)
succimer  (EXP)
sulforaphane  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (EXP,ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
trimegestone  (ISO)
trimellitic anhydride  (EXP)
Triptolide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc sulfate  (EXP)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance  (IGI,IMP)
blood coagulation  (ISO)
cell surface receptor signaling pathway involved in cell-cell signaling  (IMP)
complement activation  (IBA,IDA,IMP,ISO)
complement activation, alternative pathway  (IEA)
complement activation, classical pathway  (IEA)
complement-dependent cytotoxicity  (IMP)
complement-mediated synapse pruning  (IMP)
fatty acid metabolic process  (IEA)
immune system process  (IEA)
inflammatory response  (IEA)
innate immune response  (IEA,ISO)
lipid metabolic process  (IEA)
neuron remodeling  (IMP)
oviduct epithelium development  (IGI)
positive regulation of activation of membrane attack complex  (IMP)
positive regulation of angiogenesis  (IMP)
positive regulation of apoptotic cell clearance  (ISO)
positive regulation of developmental growth  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of glucose transmembrane transport  (ISO)
positive regulation of lipid storage  (ISO)
positive regulation of phagocytosis  (IMP)
positive regulation of phagocytosis, engulfment  (IGI,IMP)
positive regulation of protein phosphorylation  (ISO)
positive regulation of receptor-mediated endocytosis  (IGI,IMP)
positive regulation of type IIa hypersensitivity  (IMP)
positive regulation of vascular endothelial growth factor production  (ISO)
regulation of triglyceride biosynthetic process  (ISO)
response to bacterium  (IEP)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to glucocorticoid  (ISO)
response to magnesium ion  (ISO)
response to paclitaxel  (ISO)
response to progesterone  (ISO)
retina development in camera-type eye  (IGI)
tolerance induction  (ISO)
vascular associated smooth muscle cell differentiation  (IGI)
vertebrate eye-specific patterning  (IMP)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blastocyst morphology  (IAGP)
abnormal blood coagulation  (IAGP)
abnormal blood homeostasis  (IAGP)
abnormal c-wave shape  (IAGP)
abnormal cell-mediated immunity  (IAGP)
abnormal complement pathway  (IAGP)
abnormal dendritic spine morphology  (IAGP)
abnormal energy expenditure  (IAGP)
abnormal enzyme/coenzyme level  (IAGP)
abnormal eye electrophysiology  (IAGP)
abnormal female reproductive system physiology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal hippocampus CA3 region morphology  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal immune system morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal induced morbidity/mortality  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal intestinal lipid absorption  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver physiology  (IAGP)
abnormal mast cell physiology  (IAGP)
abnormal motor learning  (IEA)
abnormal neutrophil morphology  (IAGP)
abnormal oxygen consumption  (IAGP)
abnormal peripheral nervous system regeneration  (IAGP)
abnormal physical strength  (IAGP)
abnormal platelet physiology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal retinal horizontal cell morphology  (IAGP)
abnormal retinal rod bipolar cell morphology  (IAGP)
abnormal skeletal muscle morphology  (IAGP)
abnormal spatial working memory  (IAGP)
abnormal spleen germinal center morphology  (IAGP)
abnormal synaptic plasticity  (IAGP)
abnormal synaptic vesicle number  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
amyloid beta deposits  (IAGP)
brain inflammation  (IAGP)
decreased anxiety-related response  (IAGP)
decreased b-wave amplitude  (IAGP)
decreased body weight  (IAGP)
decreased cerebral infarct size  (IAGP)
decreased circulating alanine transaminase level  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating interleukin-6 level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased circulating tumor necrosis factor level  (IAGP)
decreased exploration in new environment  (IEA)
decreased fetal weight  (IAGP)
decreased hepatocyte proliferation  (IAGP)
decreased IgM level  (IAGP)
decreased liver regeneration  (IAGP)
decreased mast cell number  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased placental labyrinth size  (IAGP)
decreased spleen germinal center number  (IAGP)
decreased spleen germinal center size  (IAGP)
decreased spongiotrophoblast size  (IAGP)
decreased susceptibility to alcohol-induced hepatic steatosis  (IAGP)
decreased susceptibility to autoimmune diabetes  (IAGP)
decreased susceptibility to autoimmune disorder  (IAGP)
decreased susceptibility to autoimmune hemolytic anemia  (IAGP)
decreased susceptibility to Coronaviridae infection  (IAGP)
decreased susceptibility to induced arthritis  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased total body fat amount  (IAGP)
decreased urine albumin level  (IAGP)
decreased vascular permeability  (IAGP)
decreased white adipose tissue amount  (IAGP)
dystrophic muscle  (IAGP)
enhanced contextual conditioning behavior  (IAGP)
enhanced long term potentiation  (IAGP)
enhanced paired-pulse facilitation  (IAGP)
enhanced spatial learning  (IAGP)
enlarged cervical lymph nodes  (IAGP)
enlarged spleen  (IAGP)
extended life span  (IAGP)
focal hepatic necrosis  (IAGP)
glomerulonephritis  (IAGP)
hepatic steatosis  (IAGP)
impaired complement alternative pathway  (IAGP)
impaired embryo implantation  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased body weight  (IAGP)
increased brown adipose tissue amount  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating bilirubin level  (IAGP)
increased circulating free fatty acids level  (IAGP)
increased IgG level  (IAGP)
increased IgM level  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased microglial cell activation  (IAGP)
increased neuron number  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased T cell proliferation  (IAGP)
increased triglyceride level  (IAGP)
insulitis  (IAGP)
liver inflammation  (IAGP)
loss of hippocampal neurons  (IAGP)
muscle weakness  (IAGP)
no abnormal phenotype detected  (IAGP)
polyphagia  (IAGP)
prolonged estrous cycle  (IAGP)
skeletal muscle interstitial fibrosis  (IAGP)
small placenta  (IAGP)
References

References - curated
1. Abdel Fattah M, etal., Indian J Pediatr. 2010 Jul;77(7):771-3. Epub 2010 Jun 29.
2. Abe K, etal., Nephron. 2001 Mar;87(3):231-9.
3. Amezcua-Guerra LM, etal., Clin Lab. 2011;57(7-8):607-13.
4. Aminudin N, etal., Proteome Sci. 2012 Mar 15;10(1):17. doi: 10.1186/1477-5956-10-17.
5. Ballow M, etal., J Allergy Clin Immunol. 1985 Sep;76(3):473-6.
6. Barnes KC, etal., Genes Immun. 2006 Jan;7(1):27-35.
7. Beatty DW, etal., Clin Exp Immunol. 1986 Jun;64(3):465-70.
8. Belmont HM, etal., Arthritis Rheum. 1994 Mar;37(3):376-83.
9. Ben-David I, etal., Am J Respir Cell Mol Biol. 2005 Nov;33(5):476-82. Epub 2005 Jul 13.
10. Botto M, etal., J Clin Invest. 1990 Oct;86(4):1158-63.
11. Cai XW, etal., Int J Radiat Oncol Biol Phys. 2010 Jul 1;77(3):867-76.
12. Chen R, etal., Biomark Med. 2011 Dec;5(6):837-46.
13. Cheng XQ, etal., Inflammation. 2012 Oct;35(5):1715-22. doi: 10.1007/s10753-012-9489-7.
14. Chudwin DS, etal., Clin Immunol Immunopathol. 1985 Oct;37(1):93-7.
15. Collier RJ, etal., Invest Ophthalmol Vis Sci. 2011 Oct 11;52(11):8108-16. doi: 10.1167/iovs.10-6418.
16. Coonrod JD and Rylko-Bauer B, Infect Immun. 1977 Oct;18(1):14-22.
17. Cowell RM, etal., J Neurosci. 2003 Oct 15;23(28):9459-68.
18. Cui YH, etal., Rhinology. 2009 Jun;47(2):187-91.
19. Dantas M, etal., Clin Exp Immunol. 2000 Jul;121(1):139-45.
20. Drouin SM, etal., J Immunol. 2001 Oct 15;167(8):4141-5.
21. Emmens RW, etal., Cardiovasc Pathol. 2016 Jan-Feb;25(1):33-9. doi: 10.1016/j.carpath.2015.09.006. Epub 2015 Sep 25.
22. Fang H, etal., J Immunol. 2014 Jun 15;192(12):5984-92. doi: 10.4049/jimmunol.1400054. Epub 2014 May 7.
23. Feghali-Bostwick CA, etal., Am J Respir Crit Care Med. 2008 Jan 15;177(2):156-63. Epub 2007 Nov 1.
24. Flierl MA, etal., PLoS One. 2008 Jul 2;3(7):e2560.
25. Fu J, etal., Biochem Biophys Res Commun. 2006 Nov 10;350(1):162-8. Epub 2006 Sep 15.
26. Gajanayake T, etal., Sci Transl Med. 2014 Aug 13;6(249):249ra110. doi: 10.1126/scitranslmed.3008778.
27. Ghebremariam YT, etal., J Surg Res. 2010 Apr;159(2):747-54. doi: 10.1016/j.jss.2009.04.049. Epub 2009 Jun 6.
28. Goudriaan JR, etal., J Lipid Res. 2003 Dec;44(12):2270-7. Epub 2003 Aug 16.
29. Guhad FA, etal., J Comp Pathol. 1995 Nov;113(4):315-25.
30. Hasegawa K, etal., Hum Genet. 2004 Sep;115(4):295-301.
31. Heijnen BH, etal., Clin Exp Immunol. 2006 Jan;143(1):15-23.
32. Herrero-Herrero JI, etal., J Infect Dis. 1988 May;157(5):1093-5.
33. Hoh Kam J, etal., Am J Pathol. 2013 Aug;183(2):480-92. doi: 10.1016/j.ajpath.2013.04.008. Epub 2013 Jun 6.
34. Hutamekalin P, etal., J Pharmacol Sci. 2010;112(1):56-63. Epub 2010 Jan 6.
35. Inoue H, etal., J Hum Genet. 2008;53(8):728-38. Epub 2008 Jun 20.
36. Izmerov NF, etal., Cent Eur J Public Health. 2002 Jun;10(1-2):35-41.
37. Jacobs T, etal., Med Microbiol Immunol. 2005 May;194(3):143-9. Epub 2004 Sep 17.
38. Jefferson JA, etal., Kidney Int. 2001 Sep;60(3):1018-25.
39. Jha P, etal., J Immunol. 2006 Jun 15;176(12):7221-31.
40. Jordan JE, etal., Circulation. 2001 Sep 18;104(12):1413-8.
41. Kapadia SB, etal., Immunity. 2002 Aug;17(2):143-55.
42. Kapp A and Schopf E, Acta Derm Venereol Suppl (Stockh). 1985;114:152-4.
43. Kellermann W, etal., Klin Wochenschr. 1989 Feb 1;67(3):190-5.
44. Kelly KJ, etal., Am J Nephrol. 2015;41(1):48-56. doi: 10.1159/000371426. Epub 2015 Jan 30.
45. Kerr AR, etal., Infect Immun. 2005 Jul;73(7):4245-52.
46. Kerwar SS, etal., J Immunopharmacol. 1981-1982;3(3-4):323-37.
47. Kojima C, etal., J Atheroscler Thromb. 2012;19(9):854-61. Epub 2012 Aug 1.
48. Korbelik M and Cooper PD, Br J Cancer. 2007 Jan 15;96(1):67-72. Epub 2006 Dec 5.
49. Krantz S, etal., Exp Clin Endocrinol. 1988 Mar;92(3):287-96.
50. Kuehn MH, etal., Exp Eye Res. 2006 Sep;83(3):620-8. Epub 2006 May 4.
51. Lajoie S, etal., Nat Immunol. 2010 Oct;11(10):928-35. Epub 2010 Aug 29.
52. Lang JT, etal., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2006 Dec;41(12):928-31.
53. Lasbury ME, etal., J Eukaryot Microbiol. 2006;53 Suppl 1:S136-7.
54. Li F, etal., J Cell Biochem. 2011 Oct;112(10):3035-43. doi: 10.1002/jcb.23228.
55. Li M, etal., Eur J Neurosci. 2007 Dec;26(12):3486-500. Epub 2007 Dec 4.
56. Li Q, etal., Infect Immun. 2011 Jul;79(7):2578-85. doi: 10.1128/IAI.00168-11. Epub 2011 Apr 18.
57. Li S, etal., Neurol Res. 2011 Oct;33(8):866-74. doi: 10.1179/1743132811Y.0000000016.
58. Lillegard KE, etal., Mol Immunol. 2013 Nov;56(1-2):91-7. doi: 10.1016/j.molimm.2013.04.009. Epub 2013 May 15.
59. Lim J, etal., FASEB J. 2013 Feb;27(2):822-31. doi: 10.1096/fj.12-220582. Epub 2012 Nov 1.
60. Luca ME, etal., Exp Nephrol. 2000 Mar-Apr;8(2):77-83.
61. Lyon MF, etal., Immunogenetics 1988;27(5):375-82.
62. Ma ZW, etal., J Surg Res. 2011 Apr;166(2):314-23. doi: 10.1016/j.jss.2009.05.037. Epub 2009 Jun 18.
63. Maga TK, etal., Hum Mutat. 2010 Jun;31(6):E1445-60. doi: 10.1002/humu.21256.
64. Malik S, etal., Exp Toxicol Pathol. 2013 Sep;65(6):767-73. doi: 10.1016/j.etp.2012.11.003. Epub 2012 Dec 12.
65. McKay GJ, etal., Mol Vis. 2010 Feb 10;16:194-9.
66. MGD and Homologene mouse data transfer
67. MGD data from the GO Consortium
68. MGD IEA
69. Mold C, etal., Clin Immunol Immunopathol. 1995 Sep;76(3 Pt 1):314-20.
70. Mondino BJ, etal., Invest Ophthalmol Vis Sci. 1984 Jul;25(7):871-3.
71. Mrug M, etal., Kidney Int. 2008 Jan;73(1):63-76. Epub 2007 Oct 24.
72. Nadeau JH, etal., Genomics 1991 Jan;9(1):78-89.
73. Najam FI, etal., Indian J Pediatr. 2005 Sep;72(9):745-9.
74. Narkio-Makela M, etal., Laryngoscope. 2000 Oct;110(10 Pt 1):1745-9.
75. Nguyen CQ, etal., J Immunol. 2007 Aug 15;179(4):2318-29.
76. Nie F, etal., Int J Mol Med. 2013 Jun;31(6):1333-42. doi: 10.3892/ijmm.2013.1344. Epub 2013 Apr 11.
77. O'Brien KB, etal., PLoS One. 2011 Mar 9;6(3):e17377.
78. Ohlsson M, etal., J Neurotrauma. 2003 Sep;20(9):895-904.
79. OMIM Disease Annotation Pipeline
80. Padilla ND, etal., Surgery. 2007 Nov;142(5):722-33.
81. Parker CJ, etal., J Clin Invest. 1982 Feb;69(2):337-46.
82. Pei XT, etal., Curr Eye Res. 2009 Aug;34(8):615-22.
83. Pickering MC, etal., J Exp Med. 2007 Jun 11;204(6):1249-56. Epub 2007 May 21.
84. Pierangeli SS, etal., Arthritis Rheum. 2005 Jul;52(7):2120-4.
85. Pipeline to import KEGG annotations from KEGG into RGD
86. Polack FP, etal., J Exp Med. 2002 Sep 16;196(6):859-65.
87. Proitsi P, etal., Neurobiol Aging. 2012 Aug;33(8):1843.e9-17. doi: 10.1016/j.neurobiolaging.2011.12.036. Epub 2012 Feb 1.
88. Propst-Graham KL, etal., BMC Microbiol. 2007 Oct 23;7:94.
89. Ramlall V, etal., Nat Med. 2020 Aug 3. pii: 10.1038/s41591-020-1021-2. doi: 10.1038/s41591-020-1021-2.
90. Read RW, etal., Exp Eye Res. 2006 Mar;82(3):389-94. Epub 2005 Sep 6.
91. RGD automated import pipeline
92. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
93. RGD automated import pipeline for gene-chemical interactions
94. Richardson MR, etal., Mol Vis. 2010 Nov 11;16:2376-83.
95. Robbins RA, etal., Am Rev Respir Dis. 1987 Mar;135(3):651-8.
96. Rosenling T, etal., J Proteome Res. 2012 Apr 6;11(4):2048-60. Epub 2012 Feb 23.
97. Rostami E, etal., J Neurotrauma. 2013 Dec 1;30(23):1954-65. doi: 10.1089/neu.2012.2583. Epub 2013 Oct 30.
98. Roy RM, etal., MBio. 2013 Apr 2;4(2). pii: e00162-13. doi: 10.1128/mBio.00162-13.
99. Rutar M, etal., Invest Ophthalmol Vis Sci. 2011 Jul 18;52(8):5347-58. doi: 10.1167/iovs.10-7119.
100. Saarloos MN, etal., J Infect Dis. 1995 Oct;172(4):1095-7.
101. Saha K, etal., Scand J Immunol. 1983 Jan;17(1):37-43.
102. Sahashi K, etal., J Neuropathol Exp Neurol. 1978 Mar-Apr;37(2):212-23.
103. Sax HC, etal., J Surg Res. 1988 Feb;44(2):109-16.
104. Schlosser RJ, etal., Am J Rhinol Allergy. 2010 Jan-Feb;24(1):21-5.
105. Sehgal VN, etal., Int J Dermatol. 1989 Jan-Feb;28(1):32-5.
106. Senaldi G, etal., Arthritis Rheum. 1989 Oct;32(10):1262-7.
107. Senbagavalli P, etal., J Clin Immunol. 2009 Sep;29(5):674-80. Epub 2009 May 27.
108. Sheth RD, etal., Pediatr Nephrol. 2000 Aug;14(8-9):797-801.
109. Shinosaki T, etal., Lab Invest. 2002 Apr;82(4):505-13.
110. Siezen CL, etal., Pediatr Infect Dis J. 2009 Apr;28(4):333-5.
111. Silva E, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2007 Mar;24(1):24-32.
112. Sinno H, etal., J Dermatolog Treat. 2013 Apr;24(2):141-7. doi: 10.3109/09546634.2011.631977. Epub 2011 Nov 21.
113. Spencer KL, etal., Hum Mol Genet. 2008 Jun 15;17(12):1821-4. doi: 10.1093/hmg/ddn075. Epub 2008 Mar 6.
114. Stott B and Korbelik M, Cancer Immunol Immunother. 2007 May;56(5):649-58. Epub 2006 Sep 1.
115. Sun S, etal., Am J Respir Cell Mol Biol. 2011 Mar 18.
116. Trcka J, etal., Immunity. 2002 Jun;16(6):861-8.
117. Undarmaa S, etal., J Hum Genet. 2010 Jun;55(6):342-9. Epub 2010 Apr 16.
118. van Oostrom AJ, etal., Atherosclerosis. 2007 Jan;190(1):167-73. Epub 2006 Feb 20.
119. Verroust F, etal., J Clin Lab Immunol. 1981 Sep;6(2):127-30.
120. Verschoor A, etal., J Immunol. 2001 Sep 1;167(5):2446-51.
121. Villaescusa Blanco R, etal., Sangre (Barc). 1998 Jun;43(3):210-2.
122. Vincek V, etal., Genomics 1989 Nov;5(4):773-86.
123. Warden CH, etal., Genomics 1993 Nov;18(2):295-307.
124. Woodruff TM, etal., J Immunol. 2008 Dec 15;181(12):8727-34.
125. Xiao X, etal., J Autoimmun. 2009 Mar;32(2):85-93. doi: 10.1016/j.jaut.2008.12.003. Epub 2009 Feb 5.
126. Yanagisawa S, etal., PLoS One. 2011;6(12):e28847. doi: 10.1371/journal.pone.0028847. Epub 2011 Dec 12.
127. Yang H, etal., Invest Ophthalmol Vis Sci. 2007 Nov;48(11):5101-11.
128. Yang J, etal., Circ Res. 2007 Apr 27;100(8):1208-17. Epub 2007 Mar 15.
129. Yuhki K, etal., J Pharmacol Exp Ther. 2008 May;325(2):601-9. Epub 2008 Feb 6.
130. Zhang X and Kohl J, Expert Rev Clin Immunol. 2010 Mar;6(2):269-77.
131. Zhang X, etal., Nature. 2020 May 20. pii: 10.1038/s41586-020-2355-0. doi: 10.1038/s41586-020-2355-0.
132. Zhang X, etal., Neurol India. 2006 Dec;54(4):402-7.
133. Zhang Y, etal., Cardiovasc Diabetol. 2015 Jun 3;14:69. doi: 10.1186/s12933-015-0234-z.
134. Zou L, etal., J Immunol. 2013 Dec 1;191(11):5625-35. doi: 10.4049/jimmunol.1301903. Epub 2013 Oct 23.
135. Zuo S, etal., Neurosci Lett. 2015 Nov 16;609:216-22. doi: 10.1016/j.neulet.2015.10.056. Epub 2015 Oct 27.
Additional References at PubMed
PMID:101594   PMID:273258   PMID:448134   PMID:458159   PMID:681746   PMID:1332870   PMID:1347473   PMID:1360278   PMID:1378280   PMID:1559701   PMID:1590761   PMID:1774067  
PMID:1869307   PMID:1970332   PMID:2002550   PMID:2065778   PMID:2578664   PMID:2759663   PMID:2885372   PMID:6094532   PMID:6208565   PMID:6356427   PMID:6548745   PMID:6609661  
PMID:6816725   PMID:6961437   PMID:6985486   PMID:7601475   PMID:7964485   PMID:8015436   PMID:8138038   PMID:8227050   PMID:8364938   PMID:8406442   PMID:8443150   PMID:8499655  
PMID:8524789   PMID:8661125   PMID:8672143   PMID:8752901   PMID:8798769   PMID:8827514   PMID:8976192   PMID:9169125   PMID:9218619   PMID:9244432   PMID:9344363   PMID:9367154  
PMID:9382884   PMID:9409643   PMID:9434950   PMID:9461092   PMID:9467654   PMID:9510159   PMID:9521809   PMID:9574561   PMID:9733869   PMID:9794381   PMID:9815267   PMID:9829481  
PMID:9874574   PMID:10066708   PMID:10319026   PMID:10383458   PMID:10408374   PMID:10447759   PMID:10477568   PMID:10484614   PMID:10501973   PMID:10523614   PMID:10565608   PMID:10587354  
PMID:10593909   PMID:10642554   PMID:10698180   PMID:10811844   PMID:10856220   PMID:10922068   PMID:10934224   PMID:11067947   PMID:11145641   PMID:11342671   PMID:11360154   PMID:11414361  
PMID:11423567   PMID:11433344   PMID:11441099   PMID:11441111   PMID:11466376   PMID:11544305   PMID:11705954   PMID:11728339   PMID:11801636   PMID:11804945   PMID:11805148   PMID:11901193  
PMID:11927943   PMID:11986227   PMID:12042808   PMID:12044978   PMID:12055255   PMID:12077276   PMID:12081998   PMID:12088875   PMID:12097416   PMID:12244109   PMID:12356574   PMID:12393518  
PMID:12452836   PMID:12466851   PMID:12477932   PMID:12496386   PMID:12496433   PMID:12514742   PMID:12517942   PMID:12526796   PMID:12756295   PMID:12874234   PMID:12874322   PMID:12975457  
PMID:14500686   PMID:14604969   PMID:14607939   PMID:14615480   PMID:14638805   PMID:14670299   PMID:14695221   PMID:14699127   PMID:14703506   PMID:14971044   PMID:15048732   PMID:15059809  
PMID:15102802   PMID:15128761   PMID:15177117   PMID:15191884   PMID:15192652   PMID:15240660   PMID:15383609   PMID:15466618   PMID:15477230   PMID:15547948   PMID:15590640   PMID:15597324  
PMID:15611275   PMID:15710649   PMID:15714502   PMID:15720803   PMID:15870025   PMID:15919902   PMID:15944323   PMID:15980239   PMID:16023208   PMID:16034123   PMID:16034139   PMID:16127466  
PMID:16177324   PMID:16210644   PMID:16239576   PMID:16272280   PMID:16272350   PMID:16286018   PMID:16288049   PMID:16294220   PMID:16297155   PMID:16299314   PMID:16301611   PMID:16301658  
PMID:16304047   PMID:16310250   PMID:16322460   PMID:16339538   PMID:16444258   PMID:16449793   PMID:16452172   PMID:16453025   PMID:16513171   PMID:16517700   PMID:16530040   PMID:16545803  
PMID:16547268   PMID:16602821   PMID:16615889   PMID:16670320   PMID:16706788   PMID:16714537   PMID:16715088   PMID:16751013   PMID:16778128   PMID:16778201   PMID:16783845   PMID:16849485  
PMID:16863905   PMID:16872848   PMID:16887189   PMID:16893077   PMID:16926426   PMID:16936276   PMID:16951374   PMID:16982921   PMID:17015743   PMID:17082645   PMID:17154261   PMID:17182593  
PMID:17196951   PMID:17237432   PMID:17237437   PMID:17255324   PMID:17314163   PMID:17317854   PMID:17322907   PMID:17330096   PMID:17353050   PMID:17363730   PMID:17363917   PMID:17379312  
PMID:17383432   PMID:17433074   PMID:17446931   PMID:17485663   PMID:17548593   PMID:17579074   PMID:17586095   PMID:17675237   PMID:17681821   PMID:17709533   PMID:17717323   PMID:17785849  
PMID:17877807   PMID:17900537   PMID:17916747   PMID:17947689   PMID:18004729   PMID:18039777   PMID:18039928   PMID:18056835   PMID:18063050   PMID:18068164   PMID:18083105   PMID:18160458  
PMID:18180310   PMID:18188184   PMID:18192019   PMID:18209093   PMID:18216258   PMID:18223656   PMID:18281503   PMID:18292556   PMID:18328742   PMID:18354030   PMID:18398012   PMID:18438414  
PMID:18452991   PMID:18483395   PMID:18490515   PMID:18490769   PMID:18524992   PMID:18541650   PMID:18562603   PMID:18567839   PMID:18572163   PMID:18587006   PMID:18615583   PMID:18624920  
PMID:18634851   PMID:18653698   PMID:18671285   PMID:18684964   PMID:18694897   PMID:18713972   PMID:18779337   PMID:18787004   PMID:18787060   PMID:18804116   PMID:18812470   PMID:18820683  
PMID:18836527   PMID:18947875   PMID:18996748   PMID:19017934   PMID:19017980   PMID:19051264   PMID:19112490   PMID:19136662   PMID:19201479   PMID:19205046   PMID:19281793   PMID:19305412  
PMID:19355789   PMID:19357704   PMID:19411110   PMID:19414754   PMID:19458267   PMID:19491392   PMID:19581397   PMID:19620784   PMID:19648268   PMID:19684087   PMID:19710450   PMID:19710463  
PMID:19729477   PMID:19729481   PMID:19740327   PMID:19752222   PMID:19767107   PMID:19770513   PMID:19815824   PMID:19843088   PMID:20018737   PMID:20199584   PMID:20213737   PMID:20223920  
PMID:20339115   PMID:20427530   PMID:20439912   PMID:20511542   PMID:20584999   PMID:20625009   PMID:20702808   PMID:20709903   PMID:20712003   PMID:20800648   PMID:20817881   PMID:20829368  
PMID:20870940   PMID:20970501   PMID:21045192   PMID:21048081   PMID:21060153   PMID:21074891   PMID:21148255   PMID:21169517   PMID:21187447   PMID:21203444   PMID:21217014   PMID:21267068  
PMID:21270401   PMID:21357400   PMID:21441447   PMID:21482685   PMID:21531981   PMID:21565611   PMID:21569105   PMID:21652682   PMID:21677637   PMID:21704012   PMID:21707943   PMID:21723612  
PMID:21763674   PMID:21767994   PMID:21801872   PMID:21813769   PMID:21816131   PMID:21873635   PMID:21943708   PMID:21979496   PMID:22019898   PMID:22037602   PMID:22069473   PMID:22184721  
PMID:22190594   PMID:22194859   PMID:22219359   PMID:22262892   PMID:22308431   PMID:22422887   PMID:22427639   PMID:22438044   PMID:22502635   PMID:22518005   PMID:22535677   PMID:22539791  
PMID:22566568   PMID:22585573   PMID:22632727   PMID:22649195   PMID:22682250   PMID:22689574   PMID:22721768   PMID:22797180   PMID:22966167   PMID:23012479   PMID:23033813   PMID:23056509  
PMID:23074214   PMID:23097680   PMID:23109726   PMID:23168409   PMID:23182714   PMID:23189195   PMID:23225913   PMID:23226093   PMID:23237573   PMID:23263555   PMID:23299310   PMID:23326231  
PMID:23345428   PMID:23345431   PMID:23390291   PMID:23427256   PMID:23430572   PMID:23454183   PMID:23487775   PMID:23511127   PMID:23526211   PMID:23527240   PMID:23530212   PMID:23619360  
PMID:23733878   PMID:23737250   PMID:23747948   PMID:23749374   PMID:23749409   PMID:23824734   PMID:23926185   PMID:23943789   PMID:23946404   PMID:24006456   PMID:24014879   PMID:24038599  
PMID:24108700   PMID:24117111   PMID:24170856   PMID:24175013   PMID:24194600   PMID:24200836   PMID:24244174   PMID:24260573   PMID:24279761   PMID:24337750   PMID:24378428   PMID:24381160  
PMID:24470120   PMID:24470395   PMID:24474777   PMID:24523933   PMID:24632830   PMID:24651866   PMID:24667943   PMID:24763049   PMID:24806427   PMID:24808362   PMID:24948809   PMID:24975369  
PMID:24981453   PMID:25039245   PMID:25127469   PMID:25187659   PMID:25284781   PMID:25308956   PMID:25367575   PMID:25480293   PMID:25559179   PMID:25573852   PMID:25733354   PMID:25802332  
PMID:25851247   PMID:25888260   PMID:26132276   PMID:26199322   PMID:26393907   PMID:26400934   PMID:26619292   PMID:26628365   PMID:26787717   PMID:26822321   PMID:26831747   PMID:26873964  
PMID:26900812   PMID:26945067   PMID:27029069   PMID:27033548   PMID:27041467   PMID:27109176   PMID:27113764   PMID:27235854   PMID:27274010   PMID:27295359   PMID:27304426   PMID:27403737  
PMID:27535705   PMID:27564415   PMID:27572255   PMID:27626380   PMID:27641978   PMID:27644882   PMID:27697835   PMID:27735945   PMID:27876407   PMID:27913632   PMID:28052876   PMID:28057640  
PMID:28139294   PMID:28223279   PMID:28279023   PMID:28283064   PMID:28301559   PMID:28348233   PMID:28378742   PMID:28446616   PMID:28462915   PMID:28539427   PMID:28566429   PMID:28605809  
PMID:28700664   PMID:28710441   PMID:28756234   PMID:28852207   PMID:28887040   PMID:28928904   PMID:29018286   PMID:29109438   PMID:29118090   PMID:29233958   PMID:29279353   PMID:29383821  
PMID:29497373   PMID:29531168   PMID:29565179   PMID:29581196   PMID:29716893   PMID:29743491   PMID:29746835   PMID:29802205   PMID:29867343   PMID:29942300   PMID:30033122   PMID:30068650  
PMID:30173917   PMID:30174588   PMID:30179254   PMID:30217731   PMID:30246940   PMID:30250184   PMID:30293775   PMID:30300579   PMID:30301856   PMID:30333137   PMID:30429287   PMID:30429364  
PMID:30573546   PMID:30647151   PMID:30714990   PMID:30850533   PMID:31040226   PMID:31175160   PMID:31209071   PMID:31231033   PMID:31274379   PMID:31292459   PMID:31309159   PMID:31433986  
PMID:31461345   PMID:31578522   PMID:31594939   PMID:31604923   PMID:31723045   PMID:31801071   PMID:31801075   PMID:31865842   PMID:31955888   PMID:32087947   PMID:32179479   PMID:32208992  
PMID:32244854   PMID:32273396   PMID:32325033   PMID:32535539   PMID:32568214   PMID:32582142   PMID:32661396   PMID:32682912   PMID:32692363   PMID:32717081   PMID:32719333   PMID:32866962  
PMID:33088172   PMID:33147456   PMID:33153107   PMID:33161108   PMID:33239388   PMID:33337564   PMID:33746963   PMID:33761330   PMID:33767691   PMID:34071589  


Genomics

Comparative Map Data
C3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,510,967 - 57,535,136 (-)NCBIGRCm39mm39
GRCm39 Ensembl1757,510,970 - 57,535,136 (-)Ensembl
GRCm381757,203,967 - 57,228,136 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1757,203,970 - 57,228,136 (-)EnsemblGRCm38mm10GRCm38
MGSCv371757,343,396 - 57,367,559 (-)NCBIGRCm37mm9NCBIm37
MGSCv361756,889,309 - 56,913,426 (-)NCBImm8
Celera1761,551,995 - 61,576,136 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.72NCBI
C3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl196,677,704 - 6,730,562 (-)EnsemblGRCh38hg38GRCh38
GRCh38196,677,704 - 6,720,650 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37196,677,715 - 6,720,661 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,628,846 - 6,671,662 (-)NCBINCBI36hg18NCBI36
Build 34196,628,877 - 6,671,660NCBI
Celera196,619,402 - 6,662,926 (-)NCBI
Cytogenetic Map19p13.3NCBI
HuRef196,440,030 - 6,483,146 (-)NCBIHuRef
CHM1_1196,678,095 - 6,720,521 (-)NCBICHM1_1
C3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.292,087,437 - 2,114,366 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl92,087,437 - 2,114,429 (-)Ensembl
Rnor_6.099,721,137 - 9,747,084 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,721,105 - 9,747,167 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.098,728,465 - 8,754,412 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,407,133 - 6,432,968 (+)NCBICelera
Cytogenetic Map9q12NCBI
C3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554952,796,663 - 2,824,697 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554952,796,601 - 2,824,233 (+)NCBIChiLan1.0ChiLan1.0
C3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1196,629,240 - 6,674,786 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,629,287 - 6,674,699 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0195,708,211 - 5,753,178 (-)NCBIMhudiblu_PPA_v0panPan3
C3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,566,226 - 53,598,365 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,566,261 - 53,598,761 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2053,314,550 - 53,347,112 (+)NCBI
ROS_Cfam_1.02054,220,548 - 54,253,547 (+)NCBI
UMICH_Zoey_3.12053,287,896 - 53,320,436 (+)NCBI
UNSW_CanFamBas_1.02053,735,894 - 53,768,908 (+)NCBI
UU_Cfam_GSD_1.02053,965,350 - 53,997,908 (+)NCBI
C3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,824,886 - 213,849,048 (+)NCBI
SpeTri2.0NW_0049365883,985,732 - 4,023,221 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl272,431,499 - 72,528,112 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1272,431,470 - 72,471,622 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2272,762,013 - 72,820,437 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2272,950,572 - 72,957,968 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2qNCBI
C3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.166,250,422 - 6,289,264 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660811,706,107 - 1,746,127 (+)NCBIVero_WHO_p1.0
C3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248283,773,816 - 3,798,077 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
AI255234  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381757,204,039 - 57,204,275UniSTSGRCm38
MGSCv371757,343,462 - 57,343,698UniSTSGRCm37
Celera1761,552,061 - 61,552,297UniSTS
Cytogenetic Map17E1-E3UniSTS
Cytogenetic Map17D-E1UniSTS
Whitehead/MRC_RH17710.44UniSTS
D17Mit20  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381757,227,447 - 57,227,623UniSTSGRCm38
MGSCv371757,366,870 - 57,367,046UniSTSGRCm37
Celera1761,575,459 - 61,575,623UniSTS
Cytogenetic Map17E1-E3UniSTS
cM Map1740.6UniSTS
cM Map1734.3UniSTS
Whitehead Genetic1729.5UniSTS
D17Mit88  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381757,229,291 - 57,229,532UniSTSGRCm38
MGSCv371757,368,714 - 57,368,955UniSTSGRCm37
Celera1761,577,291 - 61,577,532UniSTS
Cytogenetic Map17E1-E3UniSTS
cM Map1729.5UniSTS
Whitehead Genetic1729.5UniSTS
PMC156107P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381757,226,294 - 57,226,728UniSTSGRCm38
MGSCv371757,365,717 - 57,366,151UniSTSGRCm37
Celera1761,574,306 - 61,574,740UniSTS
Cytogenetic Map17E1-E3UniSTS
C3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17E1-E3UniSTS
cM Map1734.3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141272Tfv1_mtotal food volume 1 (mouse)Not determined480447765330362Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined17986241186688972Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171206732483054339Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172430185958301973Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172574029459740461Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172657408160574223Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172750432261504322Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172831148062311728Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined172982162963821740Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3072257564722705Mouse
1300885Mbis4_mMycobacterium bovis-induced systemic lupus erythematosus 4 (mouse)Not determined173495684169858931Mouse
10755514Amzn2_manatomical modifier of Zfp423 2 (mouse)173565926669659396Mouse
12904951Smmq2_msoleus muscle mass QTL 2 (mouse)173648271570482715Mouse
1300592Pcyts5_mplasmacytoma susceptibility 5 (mouse)Not determined173840588672405969Mouse
10755525Lymph2_mlymphocyte differential 2 (mouse)173849862572498625Mouse
10755534Lymph4_mlymphocyte differential 4 (mouse)173849862572498625Mouse
4141319Hmtb8_mhemostasis and thrombosis rebleeding time 8 (mouse)Not determined4022744774227623Mouse
15039324Nmrs48_mNAFLD-associated magnetic resonance shift 48 (mouse)174063218774632187Mouse
26884390Skwq9_mskull length QTL 9, 10 week (mouse)174340000067500000Mouse
26884428Cvht3_mcranial vault height 3, 5 week (mouse)174620000082100000Mouse
14700692Cihvtq1_mcoxsackieviral infection heart viral titre QTL 1 (mouse)174970000069700000Mouse
1357754Ahl3_mage related hearing loss 3 (mouse)Not determined174989696283897108Mouse
4142243Lfnq5_mlung function QTL 5 (mouse)Not determined5143195157227623Mouse
1357532Bmch7_mbone mechanical trait 7 (mouse)Not determined175145143085451617Mouse
4141879Chlq9_mcirculating hormone level QTL 9 (mouse)Not determined175145143085451617Mouse
4141758Pstc5_mperiosteal circumference 5 (mouse)Not determined175680065690800808Mouse
4141011Bmd26_mbone mineral density 26 (mouse)Not determined175680065690800808Mouse
1300735Pgia20_mproteoglycan induced arthritis 20 (mouse)Not determined175680065690800808Mouse
1357447Heal13_mwound healing/regeneration 13 (mouse)Not determined175680065690800808Mouse
12910536Nrq8a_mnoise-induced hearing loss resistant QTL 8a (mouse)175680065690800808Mouse
12910537Nrq8_mnoise-induced hearing loss resistant QTL 8 (mouse)175680065690800808Mouse
4142201Obrq15_mobesity resistance QTL 15 (mouse)Not determined5722744780578347Mouse
4142414Pregq4_mpregnancy QTL 4 (mouse)Not determined175722744793199751Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:581
Count of miRNA genes:345
Interacting mature miRNAs:401
Transcripts:ENSMUST00000024988, ENSMUST00000176457, ENSMUST00000177046, ENSMUST00000177425
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000024988   ⟹   ENSMUSP00000024988
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1757,510,970 - 57,535,136 (-)Ensembl
GRCm38.p6 Ensembl1757,203,970 - 57,228,136 (-)Ensembl
RefSeq Acc Id: ENSMUST00000176457
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1757,522,788 - 57,526,972 (-)Ensembl
GRCm38.p6 Ensembl1757,215,788 - 57,219,972 (-)Ensembl
RefSeq Acc Id: ENSMUST00000177046   ⟹   ENSMUSP00000135560
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1757,513,217 - 57,535,003 (-)Ensembl
GRCm38.p6 Ensembl1757,206,217 - 57,228,003 (-)Ensembl
RefSeq Acc Id: ENSMUST00000177425   ⟹   ENSMUSP00000135663
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1757,511,007 - 57,529,827 (-)Ensembl
GRCm38.p6 Ensembl1757,204,007 - 57,222,827 (-)Ensembl
RefSeq Acc Id: NM_009778   ⟹   NP_033908
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391757,510,967 - 57,535,136 (-)NCBI
GRCm381757,203,967 - 57,228,136 (-)NCBI
MGSCv371757,343,396 - 57,367,559 (-)RGD
Celera1761,551,995 - 61,576,136 (-)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011246258   ⟹   XP_011244560
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391757,510,973 - 57,527,965 (-)NCBI
GRCm381757,203,973 - 57,220,965 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033908   ⟸   NM_009778
- Peptide Label: preproprotein
- UniProtKB: P01027 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011244560   ⟸   XM_011246258
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000135560   ⟸   ENSMUST00000177046
RefSeq Acc Id: ENSMUSP00000135663   ⟸   ENSMUST00000177425
RefSeq Acc Id: ENSMUSP00000024988   ⟸   ENSMUST00000024988
Protein Domains
A2M_recep   Anaphylatoxin-like   NTR   TED_complement

Promoters
RGD ID:13676584
Promoter ID:EPDNEW_M22441
Type:initiation region
Name:C3_1
Description:Mus musculus complement component 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381757,228,091 - 57,228,151EPDNEW
RGD ID:6847361
Promoter ID:MM_ACW:23226
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver
Transcripts:C3.CSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361757,344,796 - 57,345,597 (-)MPROMDB
RGD ID:6849062
Promoter ID:MM_XEF:3246
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver,   Spleen
Transcripts:NM_001082286
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361757,355,076 - 57,355,642 (-)MPROMDB
RGD ID:6848674
Promoter ID:MM_TRO:4443
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver
Transcripts:MTR014700.17.1682.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361757,359,846 - 57,360,602 (-)MPROMDB
RGD ID:6847359
Promoter ID:MM_ACW:23228
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver
Transcripts:C3.BSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361757,363,346 - 57,364,802 (-)MPROMDB
RGD ID:6849061
Promoter ID:MM_XEF:3247
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:NM_000064,   NM_001040469,   NM_001172903,   NM_214009
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361757,366,134 - 57,366,634 (-)MPROMDB
RGD ID:6827900
Promoter ID:MM_KWN:23940
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver
Transcripts:NM_009778
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361757,367,044 - 57,367,544 (-)MPROMDB
RGD ID:6850410
Promoter ID:EP07093
Type:single initiation site
Name:MM_CO3
Description:Complement, C3 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Primer extension with homologous sequence ladder
Regulation:liver; (induced by or strongly expressed in) cortisol
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv371757,367,514 - 57,367,574EPD
MGSCv361757,367,514 - 57,367,574EPD

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88227 AgrOrtholog
Ensembl Genes ENSMUSG00000024164 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000024988 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000135560 UniProtKB/TrEMBL
  ENSMUSP00000135663 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000024988 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000177046 UniProtKB/TrEMBL
  ENSMUST00000177425 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.120 UniProtKB/Swiss-Prot
  2.60.40.10 UniProtKB/Swiss-Prot
  2.60.40.690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A-macroglobulin_rcpt-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A-macroglobulin_rcpt-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_N_BRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alpha-macroglobulin_TED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anaphylatoxin/fibulin UniProtKB/Swiss-Prot
  Anaphylatoxin_comp_syst UniProtKB/Swiss-Prot
  Anaphylatoxn_comp_syst_dom UniProtKB/Swiss-Prot
  C3/4/5_MG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Complement_C3-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot
  Macroglobln_a2 UniProtKB/Swiss-Prot
  MacrogloblnA2_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG2 UniProtKB/Swiss-Prot
  MG3 UniProtKB/Swiss-Prot
  MG4 UniProtKB/Swiss-Prot
  Netrin_domain UniProtKB/Swiss-Prot
  Netrin_module_non-TIMP UniProtKB/Swiss-Prot
  NTR_complement_C3 UniProtKB/Swiss-Prot
  Terpenoid_cyclase/PrenylTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/Swiss-Prot
KEGG Report mmu:12266 UniProtKB/Swiss-Prot
MGD MGI:88227 ENTREZGENE
NCBI Gene 12266 ENTREZGENE
PANTHER PTHR11412:SF81 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam A2M UniProtKB/Swiss-Prot
  A2M_BRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANATO UniProtKB/Swiss-Prot
  MG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG2 UniProtKB/Swiss-Prot
  MG3 UniProtKB/Swiss-Prot
  MG4 UniProtKB/Swiss-Prot
  NTR UniProtKB/Swiss-Prot
  TED_complement UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB C3 RGD
PhenoGen C3 PhenoGen
PRINTS ANAPHYLATOXN UniProtKB/Swiss-Prot
PROSITE ALPHA_2_MACROGLOBULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANAPHYLATOXIN_1 UniProtKB/Swiss-Prot
  ANAPHYLATOXIN_2 UniProtKB/Swiss-Prot
  NTR UniProtKB/Swiss-Prot
SMART A2M UniProtKB/Swiss-Prot
  A2M_N_2 UniProtKB/Swiss-Prot
  A2M_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANATO UniProtKB/Swiss-Prot
  C345C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47686 UniProtKB/Swiss-Prot
  SSF48239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50242 UniProtKB/Swiss-Prot
UniProt B5APU1_MOUSE UniProtKB/TrEMBL
  CO3_MOUSE UniProtKB/Swiss-Prot
  E1APH6_MOUSE UniProtKB/TrEMBL
  H3BKW9_MOUSE UniProtKB/TrEMBL
  H3BL60_MOUSE UniProtKB/TrEMBL
  P01027 ENTREZGENE
  Q207D2_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q61370 UniProtKB/Swiss-Prot
  Q80XP1 UniProtKB/Swiss-Prot