Krt75 (keratin 75) - Rat Genome Database

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Gene: Krt75 (keratin 75) Mus musculus
Analyze
Symbol: Krt75
Name: keratin 75
RGD ID: 1550338
MGI Page MGI
Description: Predicted to be a structural constituent of skin epidermis. Acts upstream of or within hematopoietic progenitor cell differentiation. Is active in cornified envelope. Is expressed in incisor; larynx; skin; urethra; and ventral grey horn. Orthologous to human KRT75 (keratin 75).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 4732468K03Rik; AA589387; CK-75; cytokeratin KRT2-6HF; cytokeratin-75; K6hf; K75; keratin 75 activity-regulated; keratin, type II cytoskeletal 75; keratin-6 hair follicle; keratin-75; keratinocyte associated protein 1; Krt2-6h; Krt2-6hf; Krtc; Krtcap1; mK6hf; type II keratin-K6hf; type-II keratin Kb18
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,471,778 - 101,482,339 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,471,780 - 101,482,339 (-)EnsemblGRCm39 Ensembl
GRCm3815101,563,343 - 101,573,904 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,563,345 - 101,573,904 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715101,393,774 - 101,404,335 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615101,391,377 - 101,401,938 (-)NCBIMGSCv36mm8
Celera15103,715,517 - 103,726,077 (-)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1556.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. Hague (Hag). A new mouse hair mutation with an unstable semidominant allele. Poirier C, etal., Genetics 2002 Oct;162(2):831-40.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:16141072   PMID:16141073   PMID:16489008   PMID:16831889   PMID:17170733   PMID:17851587   PMID:19270025   PMID:21267068  
PMID:21873635   PMID:22935613   PMID:24029230   PMID:24198274   PMID:25347471   PMID:26023097   PMID:26176759   PMID:26644517   PMID:26763422   PMID:26967474   PMID:27234308   PMID:29459677  
PMID:30457570   PMID:31628189   PMID:33172478   PMID:34474245   PMID:36620220  


Genomics

Comparative Map Data
Krt75
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,471,778 - 101,482,339 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,471,780 - 101,482,339 (-)EnsemblGRCm39 Ensembl
GRCm3815101,563,343 - 101,573,904 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,563,345 - 101,573,904 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715101,393,774 - 101,404,335 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615101,391,377 - 101,401,938 (-)NCBIMGSCv36mm8
Celera15103,715,517 - 103,726,077 (-)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1556.91NCBI
KRT75
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,424,070 - 52,434,371 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,424,070 - 52,434,371 (-)EnsemblGRCh38hg38GRCh38
GRCh371252,817,854 - 52,828,155 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,104,121 - 51,114,377 (-)NCBINCBI36Build 36hg18NCBI36
Celera1252,464,010 - 52,474,265 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1249,861,751 - 49,872,007 (-)NCBIHuRef
CHM1_11252,784,713 - 52,794,968 (-)NCBICHM1_1
T2T-CHM13v2.01252,388,336 - 52,398,636 (-)NCBIT2T-CHM13v2.0
Krt75
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,565,826 - 134,576,074 (-)NCBIGRCr8
mRatBN7.27132,687,101 - 132,697,360 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,688,237 - 132,697,345 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,489,129 - 134,499,370 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,718,651 - 136,728,892 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,628,311 - 136,638,552 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,219,012 - 143,228,237 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,219,012 - 143,228,060 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,019,553 - 141,029,729 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,320,625 - 140,329,260 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,397,061 - 140,405,697 (-)NCBI
Celera7129,151,672 - 129,160,307 (-)NCBICelera
Cytogenetic Map7q36NCBI
KRT75
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21041,762,624 - 41,772,932 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11241,759,387 - 41,769,695 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01236,330,039 - 36,340,498 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11237,107,062 - 37,117,519 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1237,107,062 - 37,117,519 (+)Ensemblpanpan1.1panPan2
KRT75
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,635,210 - 2,645,687 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,591,216 - 2,661,569 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2743,608,347 - 43,618,764 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,634,298 - 2,644,714 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,590,051 - 2,660,600 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1272,651,193 - 2,661,607 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,636,825 - 2,647,235 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,006,555 - 44,016,985 (-)NCBIUU_Cfam_GSD_1.0
KRT75
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl517,749,493 - 17,760,524 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1517,749,493 - 17,760,620 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,274,588 - 18,285,740 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KRT75
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11148,569,406 - 48,581,490 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1148,570,893 - 48,580,692 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037197,511,356 - 197,521,825 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Krt75
314 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:773
Count of miRNA genes:430
Interacting mature miRNAs:517
Transcripts:ENSMUST00000042957
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548363396101708435Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556186708103425899Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564306334103425899Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570345653104073951Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570349271104073951Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570349271104073951Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572382669104073951Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573430144104073951Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577527592104073951Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78601103102901704Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578601103102901704Mouse
14928306Manh79_mmandible shape 79 (mouse)1578847557104073951Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1578897881104073951Mouse
10402490Dipa5_mdrug induced psychomotor activation 5 (mouse)Not determined1579163411104073951Mouse
4141897Imrfq2_mimmune response to Factor IX QTL 2 (mouse)Not determined79908940104073951Mouse
1301284Cosz3_mcocaine seizure 3 (mouse)Not determined1580313634104073951Mouse
4141902Cia37_mcollagen induced arthritis 37 (mouse)Not determined1580884933104073951Mouse
1300974Pgia9_mproteoglycan induced arthritis 9 (mouse)Not determined1580884933104073951Mouse
4141511Gdcr1_mglycerolphosphate dehydrogenase regulator 1 (mouse)Not determined82615474104073951Mouse
11530037Sluc34a_msusceptibility to lung cancer 34a (mouse)1585896437104073951Mouse
11530038Sluc34b_msusceptibility to lung cancer 34b (mouse)1585896437104073951Mouse
1357614Bmca_mbile mucin accumulation (mouse)Not determined1585896437104073951Mouse
1301918Skull22_mskull morphology 22 (mouse)Not determined1585901546104073951Mouse
4141581Dshv1_mdorsal hippocampal volume 1 (mouse)Not determined92788640103425899Mouse
14700689Carg5_mCandida albicans resistance gene 5 (mouse)1597697881103008427Mouse
11528547Sluc34_msusceptibility to lung cancer 34 (mouse)1597884933102896555Mouse

Markers in Region
AA589387  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3815101,564,569 - 101,564,659UniSTSGRCm38
MGSCv3715101,395,000 - 101,395,090UniSTSGRCm37
Celera15103,716,743 - 103,716,833UniSTS
Cytogenetic Map15F2UniSTS
cM Map1558.75UniSTS
Whitehead/MRC_RH15903.28UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000042957   ⟹   ENSMUSP00000036246
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15101,471,780 - 101,482,339 (-)Ensembl
GRCm38.p6 Ensembl15101,563,345 - 101,573,904 (-)Ensembl
RefSeq Acc Id: NM_133357   ⟹   NP_579935
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915101,471,778 - 101,482,339 (-)NCBI
GRCm3815101,563,343 - 101,573,904 (-)ENTREZGENE
MGSCv3715101,393,774 - 101,404,335 (-)RGD
Celera15103,715,517 - 103,726,077 (-)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_579935   ⟸   NM_133357
- UniProtKB: B2RQH6 (UniProtKB/Swiss-Prot),   Q8BGZ7 (UniProtKB/Swiss-Prot),   A0A6B9SLG6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000036246   ⟸   ENSMUST00000042957
Protein Domains
IF rod

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BGZ7-F1-model_v2 AlphaFold Q8BGZ7 1-551 view protein structure

Promoters
RGD ID:8685128
Promoter ID:EPDNEW_M20595
Type:multiple initiation site
Name:Krt75_1
Description:Mus musculus keratin 75 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3815101,573,908 - 101,573,968EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1923500 AgrOrtholog
Ensembl Genes ENSMUSG00000022986 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000042957 ENTREZGENE
  ENSMUST00000042957.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Single helix bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IF_conserved UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_rod_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Keratin_2_head UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Keratin_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:109052 UniProtKB/Swiss-Prot
MGD MGI:1923500 ENTREZGENE
NCBI Gene 109052 ENTREZGENE
PANTHER GATA-TYPE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KERATIN, TYPE II CYTOSKELETAL 75 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Keratin_2_head UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Krt75 PhenoGen
PRINTS TYPE2KERATIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_ROD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prefoldin UniProtKB/TrEMBL
UniProt A0A6B9SLG6 ENTREZGENE, UniProtKB/TrEMBL
  A0A6C0WZK9_MOUSE UniProtKB/TrEMBL
  B2RQH6 ENTREZGENE
  K2C75_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q99MH7_MOUSE UniProtKB/TrEMBL
UniProt Secondary B2RQH6 UniProtKB/Swiss-Prot