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Gene: Adra2a (adrenergic receptor, alpha 2a) Mus musculus

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Symbol:

Adra2a

Name:

adrenergic receptor, alpha 2a

RGD ID:

10098

MGI Page

MGI

Description:

Enables alpha2-adrenergic receptor activity. Involved in negative regulation of insulin secretion and presynaptic modulation of chemical synaptic transmission. Acts upstream of or within G protein-coupled receptor signaling pathway and fear response. Is active in dopaminergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb segment; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; attention deficit hyperactivity disorder; familial partial lipodystrophy; nicotine dependence; and type 2 diabetes mellitus. Orthologous to human ADRA2A (adrenoceptor alpha 2A).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Adr; Adra-2; Adra-2a; al; alp; alph; alpha(2A)AR; alpha-2A adrenergic receptor; alpha-2A adrenoceptor; alpha-2A adrenoreceptor; alpha-2AAR; alpha2-C10; alpha2A; alpha2A-adrenergic receptor; alpha2A-AR; AW122659; subtype alpha2-C10

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ADRA2A (adrenoceptor alpha 2A)	HGNC	Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	Adra2a (adrenoceptor alpha 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Adra2a (adrenoceptor alpha 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ADRA2A (adrenoceptor alpha 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ADRA2A (adrenoceptor alpha 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Adra2a (adrenoceptor alpha 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ADRA2A (adrenoceptor alpha 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ADRA2A (adrenoceptor alpha 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Adra2a (adrenoceptor alpha 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Adra2a (adrenoceptor alpha 2A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ADRA2A (adrenoceptor alpha 2A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	adra2a (adrenoceptor alpha 2A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Drosophila melanogaster (fruit fly):	Octalpha2R	Alliance	DIOPT (InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	octr-1	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	54,033,690 - 54,037,413 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	54,032,582 - 54,037,413 (+)	Ensembl		GRCm39 Ensembl
GRCm38	19	54,045,259 - 54,048,982 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	54,044,151 - 54,048,982 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	54,119,672 - 54,123,472 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	54,098,545 - 54,102,294 (+)	NCBI		MGSCv36	mm8
Celera	19	56,240,003 - 56,243,840 (+)	NCBI		Celera
Cytogenetic Map	19	D2	NCBI
cM Map	19	49.04	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Lung Injury (ISO)

alcohol dependence (ISO)

anxiety disorder (ISO)

attention deficit hyperactivity disorder (ISO)

Cardiomegaly (ISO)

Cornelia de Lange syndrome 3 (ISO)

depressive disorder (ISO)

Endotoxemia (ISO)

epilepsy (ISO)

Familial Partial Lipodystrophy Type 8 (ISO)

Fibrosis (ISO)

heart disease (ISO)

Hyperalgesia (ISO)

hypertension (ISO)

Hypotension (ISO)

metabolic dysfunction and alcohol associated liver disease (ISO)

metabolic dysfunction-associated steatohepatitis (ISO)

morphine dependence (ISO)

Muscle Spasticity (ISO)

Neuralgia (ISO)

nicotine dependence (ISO)

obesity (ISO)

panic disorder (ISO)

RASopathy (ISO)

Sepsis (ISO)

substance abuse (ISO)

type 2 diabetes mellitus (ISO)

Visceral Pain (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(R)-adrenaline (EXP,ISO)

(R)-noradrenaline (EXP,ISO)

1,2-dimethylhydrazine (EXP)

17beta-estradiol (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,4,7,8-Pentachlorodibenzofuran (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

2-methoxyidazoxan (ISO)

2-phenylethylamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3-methylcholanthrene (EXP,ISO)

4,4'-sulfonyldiphenol (EXP)

5-aza-2'-deoxycytidine (ISO)

8-Br-cAMP (ISO)

acrolein (ISO)

acrylamide (ISO)

aflatoxin B1 (EXP)

all-trans-retinoic acid (ISO)

amiodarone (ISO)

amitraz (ISO)

amphotericin B (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

atenolol (ISO)

atrazine (ISO)

Azoxymethane (EXP)

benzalkonium chloride (EXP)

benzo[a]pyrene (EXP,ISO)

bisphenol A (ISO)

bisphenol F (EXP,ISO)

brimonidine tartrate (EXP,ISO)

C60 fullerene (ISO)

calcium atom (ISO)

calcium(0) (ISO)

capsaicin (EXP)

carbamazepine (ISO)

carbon nanotube (EXP)

CGP 52608 (ISO)

chlorpyrifos (EXP,ISO)

choline (EXP)

clonidine (EXP,ISO)

clonidine (amino form) (EXP,ISO)

clonidine (imino form) (EXP,ISO)

coumestrol (ISO)

crocidolite asbestos (EXP,ISO)

Cuprizon (ISO)

cyanazine (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dexmedetomidine (ISO)

dextran sulfate (EXP)

diarsenic trioxide (ISO)

diazinon (ISO)

dobutamine (ISO)

dopamine (EXP)

dorsomorphin (ISO)

doxazosin (ISO)

entinostat (ISO)

fipronil (ISO)

folic acid (EXP)

glycidol (ISO)

idazoxan (ISO)

indapamide (ISO)

indometacin (ISO)

inulin (EXP)

isotretinoin (ISO)

L-methionine (EXP)

lead(0) (ISO)

malathion (ISO)

medetomidine (EXP)

methylisothiazolinone (ISO)

morphine (ISO)

Moxonidine (ISO)

naloxone (ISO)

nickel atom (ISO)

niclosamide (ISO)

oxcarbazepine (ISO)

oxymetazoline (ISO)

ozone (EXP)

panobinostat (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (EXP)

phenobarbital (EXP)

phentolamine (ISO)

phenylephrine (ISO)

phenylmercury acetate (ISO)

phenylpropanolamine (ISO)

phorbol 13-acetate 12-myristate (EXP)

picrotoxin (ISO)

pirinixic acid (EXP)

potassium atom (ISO)

potassium dichromate (EXP)

prazosin (ISO)

pregabalin (EXP)

progesterone (EXP)

reserpine (ISO)

Rilmenidine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

synephrine (ISO)

Talipexole dihydrochloride (ISO)

tamoxifen (EXP)

testosterone (EXP)

tetrachloromethane (ISO)

thapsigargin (ISO)

titanium dioxide (EXP)

topiramate (EXP)

trichloroethene (ISO)

trichostatin A (ISO)

triclosan (ISO)

triptonide (EXP)

U-73122 (ISO)

valproic acid (ISO)

xylazine (ISO)

Xylometazoline (ISO)

yohimbine (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of protein kinase activity (ISO)

activation of protein kinase B activity (ISO)

adenylate cyclase-activating adrenergic receptor signaling pathway (ISO)

adenylate cyclase-activating G protein-coupled receptor signaling pathway (ISO)

adenylate cyclase-inhibiting adrenergic receptor signaling pathway (IEA,ISO)

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ISO)

adrenergic receptor signaling pathway (ISO)

cellular response to hormone stimulus (IEA,ISO)

DNA replication (IEA,ISO)

fear response (IMP)

female pregnancy (IEA,ISO)

G protein-coupled receptor signaling pathway (IDA,ISO)

glucose homeostasis (IEA,ISO)

negative regulation of calcium ion transport (ISO)

negative regulation of calcium ion-dependent exocytosis (IEA,ISO)

negative regulation of insulin secretion (IDA,IMP,ISO)

negative regulation of insulin secretion involved in cellular response to glucose stimulus (IEA,ISO)

negative regulation of lipid catabolic process (IEA,ISO)

negative regulation of uterine smooth muscle contraction (IEA,ISO)

phospholipase C-activating adrenergic receptor signaling pathway (IEA,ISO)

platelet activation (IEA)

positive regulation of cell migration (IEA,ISO)

positive regulation of cytokine production (IEA,ISO)

positive regulation of epidermal growth factor receptor signaling pathway (IEA,ISO)

positive regulation of MAP kinase activity (ISO)

positive regulation of MAPK cascade (IEA,ISO)

positive regulation of membrane protein ectodomain proteolysis (IEA,ISO)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ISO)

positive regulation of potassium ion transport (ISO)

positive regulation of wound healing (IEA,ISO)

presynaptic modulation of chemical synaptic transmission (EXP,IDA,IMP)

regulation of vasoconstriction (IEA)

response to alcohol (IEA,ISO)

response to morphine (IEA,ISO)

thermoception (IEA,ISO)

vasodilation (IEA,ISO)

Cellular Component

axon terminus (IEA,ISO)

cytoplasm (IEA,ISO)

dopaminergic synapse (EXP,IDA,IMP)

GABA-ergic synapse (IEA,ISO)

glutamatergic synapse (IEA,ISO)

neuronal cell body (IEA,ISO)

plasma membrane (IBA,ISO)

postsynaptic density membrane (IEA,ISO)

postsynaptic membrane (ISO)

presynaptic active zone membrane (IEA,ISO)

receptor complex (IEA,ISO)

Molecular Function

adrenergic receptor activity (IMP)

alpha-1B adrenergic receptor binding (ISO)

alpha-2C adrenergic receptor binding (IEA,ISO)

alpha2-adrenergic receptor activity (IBA,IMP,ISO,TAS)

epinephrine binding (IBA,IEA,ISO)

heterotrimeric G-protein binding (IEA,ISO)

norepinephrine binding (IEA,ISO)

protein binding (IPI)

protein heterodimerization activity (IEA,ISO)

protein homodimerization activity (IEA,ISO)

protein kinase binding (IEA,ISO)

thioesterase binding (IEA,ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal glucose homeostasis (IAGP)

abnormal placenta development (IAGP)

abnormal spike wave discharge (IAGP)

abnormal synaptic norepinephrine release (IAGP)

abnormal systemic arterial blood pressure (IAGP)

abnormal testis morphology (IEA)

abnormal visceral yolk sac morphology (IAGP)

cardiac hypertrophy (IAGP)

decreased circulating glucose level (IEA)

decreased fasting circulating glucose level (IEA)

decreased heart rate (IAGP)

decreased prepulse inhibition (IEA)

decreased startle reflex (IEA)

embryonic lethality during organogenesis, complete penetrance (IAGP)

hyperactivity (IEA)

hypoglycemia (IAGP)

improved glucose tolerance (IEA)

increased circulating insulin level (IEA)

increased heart rate (IAGP)

no abnormal phenotype detected (IAGP)

small testis (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Abnormal regulation of the sympathetic nervous system in alpha2A-adrenergic receptor knockout mice.	Altman JD, etal., Mol Pharmacol. 1999 Jul;56(1):154-61.
2.	The genetic association database.	Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3.	Naloxone-precipitated withdrawal in morphine-dependent rats increases the expression of alpha 2a-adrenoceptor mRNA in brain.	Busquets X, etal., Brain Res Mol Brain Res. 1997 Apr;45(1):154-8. doi: 10.1016/s0169-328x(96)00307-5.
4.	Association between homozygosity of a G allele of the alpha-2a-adrenergic receptor gene and methylphenidate response in Korean children and adolescents with attention-deficit/hyperactivity disorder.	Cheon KA, etal., Biol Psychiatry. 2009 Apr 1;65(7):564-70. Epub 2009 Jan 15.
5.	Multiple polymorphisms in genes of the adrenergic stress system confer vulnerability to alcohol abuse.	Clarke TK, etal., Addict Biol. 2012 Jan;17(1):202-8. doi: 10.1111/j.1369-1600.2010.00263.x. Epub 2010 Nov 11.
6.	Αlpha 2a-Adrenoceptor Gene Expression and Early Life Stress-Mediated Propensity to Alcohol Drinking in Outbred Rats.	Comasco E, etal., Int J Environ Res Public Health. 2015 Jun 25;12(7):7154-71. doi: 10.3390/ijerph120707154.
7.	Association between the adrenergic alpha 2A receptor gene (ADRA2A) and measures of irritability, hostility, impulsivity and memory in normal subjects.	Comings DE, etal., Psychiatr Genet 2000 Mar;10(1):39-42.
8.	Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain.	De Felice M, etal., Pain. 2011 Dec;152(12):2701-9. Epub 2011 Jul 13.
9.	Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism.	Dwyer JM, etal., Int J Neuropsychopharmacol. 2010 Oct;13(9):1193-205. Epub 2010 Jan 5.
10.	Potent suppression of stretch reflex activity after systemic or spinal delivery of tizanidine in rats with spinal ischemia-induced chronic spastic paraplegia.	Fuchigami T, etal., Neuroscience. 2011 Oct 27;194:160-9. Epub 2011 Aug 16.
11.	Different roles of FAT10, FOXO1, and ADRA2A in hepatocellular carcinoma tumorigenesis in patients with alcoholic steatohepatitis (ASH) vs non-alcoholic steatohepatitis (NASH).	Jia Y, etal., Exp Mol Pathol. 2018 Aug;105(1):144-149. doi: 10.1016/j.yexmp.2018.07.005. Epub 2018 Jul 17.
12.	Decreased spinal alpha2a- and alpha2c-adrenergic receptor subtype mRNA in a rat model of neuropathic pain.	Leiphart JW, etal., Neurosci Lett. 2003 Sep 25;349(1):5-8.
13.	Aging-related hyperinflammation in endotoxemia is mediated by the alpha2A-adrenoceptor and CD14/TLR4 pathways.	Leong J, etal., Life Sci. 2010 May 8;86(19-20):740-6. Epub 2010 Mar 17.
14.	Do allelic variants in alpha2A and alpha2C adrenergic receptors predispose to hypertension in blacks?	Li JL, etal., Hypertension. 2006 Jun;47(6):1140-6. Epub 2006 Apr 24.
15.	Yohimbine protects against endotoxin-induced acute lung injury by blockade of alpha 2A adrenergic receptor in rats.	Lin Y, etal., Chin Med J (Engl). 2011 Apr;124(7):1069-74.
16.	Effects of the serotonin transporter (5-HTTLPR) and α2A-adrenoceptor (C-1291G) genotypes on substance use in children and adolescents: a longitudinal study.	Merenäkk L, etal., Psychopharmacology (Berl). 2011 May;215(1):13-22. doi: 10.1007/s00213-010-2109-z. Epub 2010 Dec 8.
17.	Electronic Transfer of Homolog Data	MGD and Homologene mouse data transfer
18.	MGDs mouse GO annotations	MGD data from the GO Consortium
19.	MGD IEA	MGD IEA
20.	Adrenal alpha(2)-adrenergic receptors in the aging normotensive and spontaneously hypertensive rat.	Moura E, etal., Neurobiol Aging. 2012 May;33(5):969-78. Epub 2010 Aug 5.
21.	Comparative mapping of novel simple sequence repeat markers in a hypertension-related region on rat chromosome 1.	Nabika T, etal., Mamm Genome 1997 Mar;8(3):215-7.
22.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
23.	Placental alpha(2)-adrenoceptors control vascular development at the interface between mother and embryo.	Philipp M, etal., Nat Genet. 2002 Jul;31(3):311-5. Epub 2002 Jun 17.
24.	Tobacco smoking and the ADRA2A C-1291G polymorphism.	Prestes AP, etal., J Neural Transm (Vienna). 2007;114(11):1503-6. doi: 10.1007/s00702-007-0769-6. Epub 2007 Jul 6.
25.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
26.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
27.	Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes.	Rosengren AH, etal., Science. 2010 Jan 8;327(5962):217-20. Epub 2009 Nov 19.
28.	Attention deficit hyperactivity disorder with reading disabilities: preliminary genetic findings on the involvement of the ADRA2A gene.	Stevenson J, etal., J Child Psychol Psychiatry. 2005 Oct;46(10):1081-8.
29.	The involvement of peripheral alpha 2-adrenoceptors in the antihyperalgesic effect of oxcarbazepine in a rat model of inflammatory pain.	Tomic MA, etal., Anesth Analg. 2007 Nov;105(5):1474-81, table of contents.
30.	Novelty response of rats determines the effect of prefrontal alpha-2 adrenoceptor modulation on anxiety.	Uzsoki B, etal., Neurosci Lett. 2011 Jul 25;499(3):219-23. Epub 2011 Jun 6.
31.	Antagonism of alpha2A-adrenoceptor: a novel approach to inhibit inflammatory responses in sepsis.	Zhang F, etal., J Mol Med (Berl). 2010 Mar;88(3):289-96. Epub 2009 Nov 6.

Additional References at PubMed

PMID:1353249	PMID:1358795	PMID:1360278	PMID:1655359	PMID:1676978	PMID:1898674	PMID:2154750	PMID:7873877	PMID:8177505	PMID:8530024	PMID:8666395	PMID:8670421
PMID:8843087	PMID:8889548	PMID:9070923	PMID:9139936	PMID:9235896	PMID:9275232	PMID:9415717	PMID:9482787	PMID:9606417	PMID:10217548	PMID:10349636	PMID:10489385
PMID:10598793	PMID:10647009	PMID:10737629	PMID:10781908	PMID:10948198	PMID:11042159	PMID:11076861	PMID:11125002	PMID:11181434	PMID:11217851	PMID:11425914	PMID:11716511
PMID:11729878	PMID:11834617	PMID:11877328	PMID:11927164	PMID:12081658	PMID:12110610	PMID:12127086	PMID:12205290	PMID:12351753	PMID:12384461	PMID:12477932	PMID:12623961
PMID:12686389	PMID:12726820	PMID:12754056	PMID:12764077	PMID:12829028	PMID:12965240	PMID:14508322	PMID:14514350	PMID:14757140	PMID:14769782	PMID:15026130	PMID:15051667
PMID:15105370	PMID:15218143	PMID:15220790	PMID:15306201	PMID:15379886	PMID:15556159	PMID:15713686	PMID:15978573	PMID:16141072	PMID:16141073	PMID:16325800	PMID:16417582
PMID:16428542	PMID:16507775	PMID:16554742	PMID:16602821	PMID:16682971	PMID:16809338	PMID:17075569	PMID:17244791	PMID:17261653	PMID:17636168	PMID:17664025	PMID:17673674
PMID:17964569	PMID:17975126	PMID:17977919	PMID:17992256	PMID:18326714	PMID:18367453	PMID:18545261	PMID:18632114	PMID:18691636	PMID:19103808	PMID:19125280	PMID:19126537
PMID:19225179	PMID:19251826	PMID:19276088	PMID:19505981	PMID:19527774	PMID:19604092	PMID:19744502	PMID:19766405	PMID:20003319	PMID:20083574	PMID:20595538	PMID:20814988
PMID:21209093	PMID:21232580	PMID:21267068	PMID:21859713	PMID:21873635	PMID:21949117	PMID:22266179	PMID:22805283	PMID:22933299	PMID:23297214	PMID:23400995	PMID:23401504
PMID:23658728	PMID:23965992	PMID:24194600	PMID:24404141	PMID:24427314	PMID:24565843	PMID:24872568	PMID:24922313	PMID:24952961	PMID:25009265	PMID:25037566	PMID:25063231
PMID:25186490	PMID:25404298	PMID:25471576	PMID:25695968	PMID:25784603	PMID:25867043	PMID:26086861	PMID:26878830	PMID:27365174	PMID:27568567	PMID:27626380	PMID:27751959
PMID:28028077	PMID:28646018	PMID:28911199	PMID:29528284	PMID:29615637	PMID:30041171	PMID:30150361	PMID:30233491	PMID:30737458	PMID:31351040	PMID:31375626	PMID:31533035
PMID:32409748	PMID:32643759	PMID:33923625	PMID:34182128	PMID:34884552	PMID:34932372	PMID:34965503	PMID:36696856	PMID:36897571	PMID:37192624	PMID:37541195	PMID:37549024
PMID:37758766	PMID:37841583	PMID:37863979	PMID:38355793	PMID:38442711

Genomics

Comparative Map Data

Adra2a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	54,033,690 - 54,037,413 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	54,032,582 - 54,037,413 (+)	Ensembl		GRCm39 Ensembl
GRCm38	19	54,045,259 - 54,048,982 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	54,044,151 - 54,048,982 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	54,119,672 - 54,123,472 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	54,098,545 - 54,102,294 (+)	NCBI		MGSCv36	mm8
Celera	19	56,240,003 - 56,243,840 (+)	NCBI		Celera
Cytogenetic Map	19	D2	NCBI
cM Map	19	49.04	NCBI

ADRA2A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	111,077,029 - 111,080,907 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	111,077,029 - 111,080,907 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	112,836,787 - 112,840,665 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	112,826,911 - 112,830,560 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	112,826,910 - 112,830,560	NCBI
Celera	10	106,568,388 - 106,572,263 (+)	NCBI		Celera
Cytogenetic Map	10	q25.2	ENTREZGENE
HuRef	10	106,465,554 - 106,469,429 (+)	NCBI		HuRef
CHM1_1	10	113,118,624 - 113,122,499 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	111,960,874 - 111,964,752 (+)	NCBI		T2T-CHM13v2.0

Adra2a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	263,066,780 - 263,069,580 (+)	NCBI		GRCr8
mRatBN7.2	1	253,061,480 - 253,064,280 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	253,060,218 - 253,064,365 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	261,250,961 - 261,253,761 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	267,957,040 - 267,959,840 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	260,612,912 - 260,615,708 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	274,766,283 - 274,769,083 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	274,766,283 - 274,769,081 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	282,178,475 - 282,181,275 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	1	248,775,483 - 248,778,283 (+)	NCBI		Celera
Cytogenetic Map	1	q55	NCBI

Adra2a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955485	385,800 - 387,240 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955485	384,405 - 387,332 (-)	NCBI	ChiLan1.0	ChiLan1.0

ADRA2A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	122,957,240 - 122,972,632 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	122,963,626 - 122,966,554 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	107,669,860 - 107,673,685 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	111,119,153 - 111,122,369 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

ADRA2A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	22,366,989 - 22,392,163 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	22,367,780 - 22,370,684 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	22,520,055 - 22,522,948 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	22,892,378 - 22,895,274 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	22,892,610 - 22,893,893 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	22,451,483 - 22,454,353 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	22,458,352 - 22,461,267 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	22,592,510 - 22,595,401 (+)	NCBI		UU_Cfam_GSD_1.0

Adra2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	23,720,233 - 23,724,342 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936486	1,838,176 - 1,839,630 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936486	1,837,785 - 1,841,019 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ADRA2A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	121,469,527 - 121,470,924 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	121,469,572 - 121,470,924 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	132,403,894 - 132,405,246 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ADRA2A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	104,015,577 - 104,019,364 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	104,016,580 - 104,017,932 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	65,215,363 - 65,219,246 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Adra2a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624737	35,264,099 - 35,265,490 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624737	35,262,779 - 35,265,566 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Adra2a
121 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	483
Count of miRNA genes:	376
Interacting mature miRNAs:	404
Transcripts:	ENSMUST00000036700
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10043896	Bw21_m	body weight QTL 21 (mouse)			Not determined		19	39596066	61420004	Mouse
4141659	Pbwg20_m	postnatal body weight growth 20 (mouse)			Not determined		19	21378705	55378928	Mouse
13506250	Renmq1_m	renal mercury accumulation QTL 1 (mouse)					19	27385594	61385705	Mouse
4141019	Tgq29_m	triglyceride QTL 29 (mouse)			Not determined			34596786	61420004	Mouse
10412251	Mnp_m	modifier of Niemann Pick type C1 (mouse)			Not determined		19	20234314	54234461	Mouse
1301942	Pas13_m	pulmonary adenoma susceptibility 13 (mouse)			Not determined		19	30141231	61420004	Mouse
12790634	Ebm1_m	Epidermolysis Bullosa modifier 1 (mouse)					19	24988439	58988439	Mouse
1302170	Tanidd1_m	tally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)			Not determined		19	36752597	61420004	Mouse
1301466	T2dm2_m	type 2 diabetes mellitus 2 (mouse)			Not determined		19	38376050	61420004	Mouse
1300856	Nobq2_m	New Zealand obese QTL 2 (mouse)			Not determined		19	30897880	61420004	Mouse
1302104	Lfp1_m	long free running period 1 (mouse)			Not determined		19	39184064	61420004	Mouse
4141138	Femwf11_m	femur work to failure 11 (mouse)			Not determined			28140348	61420004	Mouse
4141650	Chldq9_m	cholesterol and HDL QTL 9 (mouse)			Not determined		19	37882982	61420004	Mouse
1301410	Cd8mts6_m	CD8 memory T cell subset 6 (mouse)			Not determined		19	30141231	61420004	Mouse
11667075	Led3_m	late embryonic death 3 (mouse)					19	51088378	59123872	Mouse
1301639	Stnn_m	striatal neuron number (mouse)			Not determined		19	33951952	61420004	Mouse
4142343	Moen2_m	modifier of engrailed QTL 2 (mouse)			Not determined		19	20234314	54234461	Mouse
1301451	Ath16_m	atherosclerosis 16 (mouse)			Not determined		19	25426917	59427005	Mouse
1300683	Fembm7_m	femoral bone morphometry 7 (mouse)			Not determined		19	30141224	61420004	Mouse
1300585	Pgia12_m	proteoglycan induced arthritis 12 (mouse)			Not determined		19	42586859	61420004	Mouse
4141412	Acsns1_m	Angiostrongylus costaricensis nematode susceptibility 1 (mouse)			Not determined			47897880	55026545	Mouse
1301741	Lith2_m	lithogenic gene 2 (mouse)			Not determined		19	32992158	61420004	Mouse

Markers in Region

AW122659

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	19	54,048,741 - 54,048,827	UniSTS	GRCm38
MGSCv37	19	54,123,231 - 54,123,317	UniSTS	GRCm37
Celera	19	56,243,599 - 56,243,685	UniSTS
Cytogenetic Map	19	D2	UniSTS
cM Map	19	50.0	UniSTS
Whitehead/MRC_RH	19	568.49	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_007417	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC113491	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK046802	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK138518	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK140461	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK141573	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AW122659	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC024512	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC138531	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CJ171295	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ479919	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M99377	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000036700 ⟹ ENSMUSP00000036203

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	19	54,032,582 - 54,037,413 (+)	Ensembl
GRCm38.p6 Ensembl	19	54,044,151 - 54,048,982 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000237285 ⟹ ENSMUSP00000157421

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	19	54,033,691 - 54,037,411 (+)	Ensembl
GRCm38.p6 Ensembl	19	54,045,260 - 54,048,980 (+)	Ensembl

RefSeq Acc Id:

NM_007417 ⟹ NP_031443

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	19	54,033,690 - 54,037,413 (+)	NCBI
GRCm38	19	54,045,259 - 54,048,982 (+)	NCBI
MGSCv37	19	54,119,672 - 54,123,472 (+)	RGD
Celera	19	56,240,003 - 56,243,840 (+)	RGD
cM Map	19		ENTREZGENE

Sequence:

show sequence

AGCAGCCTCGGCTCCCGCTTCCGTGCAGACGCCCAGCAGCCGGCGCACACCGCCCAGCCACCCA
GCGCCTCCAGCTCCAAGTCCTGCGGTCCTGCGAAAACTCACGCGGCCCTCCGACCCCCGCCGGG
TCTGTGGCGCTCAGCGCCCACCCAGATCGCGGCTAGCAGCCACCCTTGGCTCCGCCGCGGCTCC
TGGAGAGCCGGTCGCTCACCTAGCTTGGCCCTGAGGACCGAGGTGGTGGTGGTGGGGGTGCGGC
TTCATGCGGCCCCCACACCCTTCACCCCACCGCCGCCGCCCCCGAGCTCTGTGTACAGAGTCCC
AGCCCCAGCAGAGCGCACAACTTTGGAAGTCCCGTGGGGCTCCTAGAGGAGGCAGAGTCCGCGC
CTTCGCCGGAGGTCCGGCCCAGCCCTCGCCACCCCGCCTGGAGGGTAGCGACGGAGTTGGAAAT
CTCTTCGAGGGTATAAGAAGACAGACCTAGGACTCCGAGCCCACACCAACACCCCTCCGCTGCC
TCTTGGGGTAAGACTTCATGCTTTCGCTCAGCTTAAGAATCAAGGTATAGATGACTAGCTAAAT
GCATTTGTATAAATTTCTGACATCTTTCCAAATCATCAGGCCACCGATAATTTCTTTTCTCTTT
TCTTGAAGAATAAAATCTCTAACCACCAGCTGGCCCTACTCGATCCTGCCGCTTAGAAATAAAA
CTTGGCTGTGTTTGAGGAGCTGGGAGAGAGAAAGCACCCACCCGGAGCGTCGGAAGGACGAACC
GGTGCCAGTTCGCGGGCTCCAGTCCATGGACCACTAGCGGTCCCCAGCTTGGGCCCGAGCTCCC
TGCGGCCCTCTTCCTTATGTGAGGCGCGGCGGGACGAACCCCGCACCGGAGGAAGAGGAGGACC
CACGGACGCGGGGCCGGAAGGCAGCTGGCAGCAGGCCCACGAGAACCAGCACCCGCGTTCATGT
TCCGCCAGGAGCAGCCGCTGGCCGAGGGCAGCTTTGCGCCCATGGGCTCACTGCAGCCGGATGC
CGGCAACAGCAGCTGGAACGGGACCGAAGCGCCCGGAGGCGGCACCCGAGCCACCCCTTACTCC
CTGCAGGTGACACTGACGCTGGTTTGCCTGGCTGGCCTGCTCATGCTGTTCACAGTATTTGGCA
ACGTGCTGGTTATTATCGCGGTGTTCACCAGTCGCGCGCTCAAAGCTCCCCAAAACCTCTTCCT
GGTGTCCCTGGCCTCAGCGGACATCCTGGTGGCCACGCTGGTCATTCCCTTTTCTTTGGCCAAC
GAGGTTATGGGTTACTGGTACTTTGGTAAGGTGTGGTGTGAGATCTATTTGGCTCTCGACGTGC
TCTTTTGCACGTCGTCCATAGTGCACCTGTGCGCCATCAGCCTTGACCGCTACTGGTCCATCAC
GCAGGCCATCGAGTACAACCTGAAGCGCACGCCGCGTCGCATCAAGGCCATCATTGTCACCGTG
TGGGTCATCTCGGCTGTCATCTCCTTCCCGCCACTCATCTCCATAGAGAAGAAGGGCGCTGGCG
GCGGGCAGCAGCCGGCCGAGCCAAGCTGCAAGATCAACGACCAGAAGTGGTATGTCATCTCCTC
GTCCATCGGTTCCTTCTTCGCGCCTTGCCTCATCATGATCCTGGTCTACGTGCGTATTTACCAG
ATCGCCAAGCGTCGCACCCGCGTGCCTCCCAGCCGCCGGGGTCCGGACGCCTGTTCCGCGCCGC
CGGGGGGCGCCGATCGCAGGCCCAACGGGCTGGGCCCGGAGCGCGGCGCGGGTCCCACGGGCGC
TGAGGCGGAGCCGCTGCCCACCCAGCTTAACGGTGCCCCGGGGGAGCCCGCGCCCGCCGGGCCC
CGCGATGGGGATGCGCTGGACCTAGAGGAGAGTTCGTCGTCCGAGCACGCCGAGCGGCCCCCGG
GGCCCCGCAGACCCGACCGCGGCCCCCGAGCCAAGGGCAAGACCCGGGCGAGTCAGGTGAAGCC
GGGGGACAGTCTGCCGCGGCGCGGGCCCGGGGCCGCGGGGCCGGGGGCTTCGGGGTCCGGGCAC
GGAGAGGAGCGCGGCGGGGGCGCCAAAGCGTCGCGCTGGCGCGGGAGGCAAAACCGGGAGAAAC
GCTTCACGTTCGTGCTGGCGGTGGTGATCGGCGTGTTCGTGGTGTGTTGGTTTCCGTTCTTTTT
CACCTACACGCTCATAGCGGTCGGCTGCCCGGTGCCCAGCCAGCTCTTCAACTTCTTCTTCTGG
TTCGGCTACTGCAACAGCTCGCTGAACCCTGTTATCTACACCATCTTCAACCACGACTTCCGAC
GCGCCTTCAAGAAGATCCTCTGCCGTGGGGACAGAAAACGCATCGTGTGAGCGCATGGGCCTTG
CCCTGCGTGCAGACAATGGTCAGACGCAGGCCCTGGGCTTCGAGGGGGTGCGTCTACGCATGCA
GCCCCTAGCACTCTGAAACCCCGGACCTACCCAGCTGGGAGGGAGCTCCGTGGCCTTTGAGACC
TTTTGTTACAATGTGTAAAGTTCTGGCTGAGAGGGACACATGAGCCCTTTTGCTGGTTGTTGTG
GTTGTTCCCAGCCCACAGCCAGTTTCCTGGTGGGCTACCCCTGATCAGTATGGTTTCCTGATGA
TATTGTCATATCCCCAAGTCTGACTCTCCCAAGCTCTTCAGAGCAAGCACAGTACTAGAGAGGG
CATGGCTGCCAAAGGGTTAATGAACCAAGGTTTCCTCTAGTCCTGGCTAATTATCTCCTCCACA
CCCCCTTCCTTAAATAAATAAATAAAGATCATTCAGGGCGGTCCTGCCTGCCCTCCCTTCTCCC
CACTGTAAATATACATTATTTTTGATAGCATACTTTGGGTTCTTCAGTGTCGGCCTTGATGCAT
ATTGGAATCATGGCTGTGGAGATGCCCTCCAGTCAGACAGTGGGCTATCTGGTCCAGACCACGC
TCCTTTGCAATGCAAGCCCCTTTCTAGTGTTAAGTTGCTCTCAGTGCTTTTCAGCAGTAACTGG
TGACTGTCCCCTGGACACGGACCTGCTTTGACATTTCCTGACAGGGAAGGGATTTCTGCTCATT
TTCCCCTGTGCCTAACTGCATAATTGCCTTTTCCTATGTAAATATTACAGCGATGGACCAAGGC
AGAAGGAAATGAAGCCTCTGCCTTGCATCAGCCCCGTGTATAAAGCCATTATCTGCTGAGGCAC
CGCTTGCCCCAGTAACTCACTTTAGAACTGACTTTTCTTCCGTTCTCCCCTCCTCTGGGGCTTG
AAGAAGAGCGTGTATGTTTCTATCTTGTCTGTGCGCCGCCCCCTCCCCCAGAAAGTGCTGACTA
AGGGGAATCTTTTAGCTGCTGTTTTTAGACACCCAGGAGGGGAAATTATGTGGAAGAAACCAAC
CCGATACAATTTGCCAAGGTAAACAGTGTGAGGAGACAAATGGGCTGCCACACTGTATGGAGCC
AGCCCCAAGAGCTCTTGGGTATCAAAGTGTTACCTCCCCTTGCTGTCCTGGCTGAGATCATGTG
ACTACTGAATTGCCAAAGTCAGGGGGTAGGCGGAGACTTCGTGTTTACAACCTGGTTTCTACTT
ATTTTAGGCAGACTGTGGAAGGCCTGTGATCTGATTTCACGAGAGAAAAACTAAATGTCAGCAC
TTGTTGCTCGTGACGGTGGATTTTTTTTAAATAAAAGTTTACAGATCAAATGTGAAATAAACAT
GAATTAAGTGGG

hide sequence

Protein Sequences


Protein RefSeqs	NP_031443	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA37213	(Get FASTA)	NCBI Sequence Viewer
	AAI38532	(Get FASTA)	NCBI Sequence Viewer
	ABF48500	(Get FASTA)	NCBI Sequence Viewer
	BAE24742	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000036203
	ENSMUSP00000036203.6
	ENSMUSP00000157421.2
GenBank Protein	Q01338	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_031443 ⟸ NM_007417

- UniProtKB:

Q01338 (UniProtKB/Swiss-Prot), Q3URE6 (UniProtKB/TrEMBL), Q1HL33 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFRQEQPLAEGSFAPMGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVF
GNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALD
VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGA
GGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSA
PPGGADRRPNGLGPERGAGPTGAEAEPLPTQLNGAPGEPAPAGPRDGDALDLEESSSSEHAERP
PGPRRPDRGPRAKGKTRASQVKPGDSLPRRGPGAAGPGASGSGHGEERGGGAKASRWRGRQNRE
KRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPSQLFNFFFWFGYCNSSLNPVIYTIFNHDF
RRAFKKILCRGDRKRIV

hide sequence

Ensembl Acc Id:

ENSMUSP00000157421 ⟸ ENSMUST00000237285

Ensembl Acc Id:

ENSMUSP00000036203 ⟸ ENSMUST00000036700

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q01338-F1-model_v2	AlphaFold	Q01338	1-465	view protein structure

Promoters

RGD ID:

13679804

Promoter ID:

EPDNEW_M24051

Type:

multiple initiation site

Name:

Adra2a_1

Description:

Mus musculus adrenergic receptor, alpha 2a , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	19	54,045,260 - 54,045,320	EPDNEW

RGD ID:

6829775

Promoter ID:

MM_KWN:27364

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

BoneMarrow_0Hour, Brain

Transcripts:

NM_007417, UC008HXI.1

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	19	54,119,271 - 54,120,992 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:87934	AgrOrtholog
Ensembl Genes	ENSMUSG00000033717	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000036700	ENTREZGENE
	ENSMUST00000036700.7	UniProtKB/Swiss-Prot
	ENSMUST00000237285.2	UniProtKB/Swiss-Prot
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	ADR_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ADRA2A_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:11551	UniProtKB/Swiss-Prot
MGD	MGI:87934	ENTREZGENE
NCBI Gene	11551	ENTREZGENE
PANTHER	ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ALPHA-2A ADRENERGIC RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	ADRA2A	RGD
PhenoGen	Adra2a	PhenoGen
PRINTS	ADRENERGICR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ADRENRGCA2AR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCRRHODOPSN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	7TM_GPCR_Srsx	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	ADA2A_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE
	Q1HL33	ENTREZGENE, UniProtKB/TrEMBL
	Q3URE6	ENTREZGENE
UniProt Secondary	Q3URE6	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - GAD

Imported Disease Annotations - OMIM

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - GAD

Imported Disease Annotations - OMIM

Mammalian Phenotype