Egr3 (early growth response 3) - Rat Genome Database

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Gene: Egr3 (early growth response 3) Mus musculus
Analyze
Symbol: Egr3
Name: early growth response 3
RGD ID: 736599
MGI Page MGI
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within neuromuscular synaptic transmission; peripheral nervous system development; and regulation of T cell differentiation. Predicted to be located in nucleoplasm. Is expressed in genitourinary system; limb mesenchyme; limb musculature; tooth; and vibrissa. Orthologous to human EGR3 (early growth response 3); INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; 3-methylcholanthrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: early growth response protein 3; EGR-3; MGC124006; MGC124009; P; Pilot
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,314,766 - 70,320,062 (+)NCBIGRCm39mm39
GRCm39 Ensembl1470,314,652 - 70,320,063 (+)Ensembl
GRCm381470,077,317 - 70,082,613 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,077,203 - 70,082,614 (+)EnsemblGRCm38mm10GRCm38
MGSCv371470,477,252 - 70,479,964 (+)NCBIGRCm37mm9NCBIm37
MGSCv361468,812,525 - 68,815,237 (+)NCBImm8
Celera1467,617,884 - 67,620,596 (+)NCBICelera
Cytogenetic Map14D2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Ataxia  (ISO)
COVID-19  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-demecolcine  (ISO)
(S)-nicotine  (EXP)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-methoxyethanol  (ISO)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
AP20187  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
bathocuproine disulfonic acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
buta-1,3-diene  (EXP)
C.I. Natural Red 20  (EXP)
Calcimycin  (EXP)
calcitriol  (ISO)
chloroprene  (EXP)
choline  (EXP)
clomiphene  (ISO)
clozapine  (EXP)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichloromethane  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
ellagic acid  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
estriol  (ISO)
estrone  (ISO)
ethanol  (EXP)
ethylbenzene  (ISO)
fenvalerate  (ISO)
fluoxetine  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (EXP,ISO)
hexestrol  (ISO)
hydroquinone  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
leflunomide  (ISO)
Licochalcone B  (ISO)
manganese(II) chloride  (ISO)
mestranol  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (EXP)
nicotine  (EXP)
Nonylphenol  (ISO)
o-xylene  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP)
progesterone  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
Soman  (ISO)
succimer  (EXP)
tamibarotene  (ISO)
testosterone  (EXP)
titanium dioxide  (EXP)
toluene  (ISO)
triadimefon  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
vincristine  (ISO)

References

Additional References at PubMed
PMID:1906159   PMID:7891721   PMID:9731539   PMID:9858769   PMID:10349636   PMID:10850491   PMID:11042159   PMID:11076861   PMID:11180801   PMID:11217851   PMID:11401400   PMID:11891986  
PMID:12477932   PMID:12495620   PMID:12741988   PMID:14560009   PMID:14707069   PMID:15173177   PMID:15582775   PMID:15834410   PMID:15837802   PMID:16141072   PMID:16141073   PMID:16287845  
PMID:16602821   PMID:17312150   PMID:17350282   PMID:17513727   PMID:17637609   PMID:17692471   PMID:17916431   PMID:18160659   PMID:18203138   PMID:18287559   PMID:18653557   PMID:19030180  
PMID:19124717   PMID:19169262   PMID:19369542   PMID:19386638   PMID:19706684   PMID:19954518   PMID:19965691   PMID:20059953   PMID:20213761   PMID:21267068   PMID:21677750   PMID:21737317  
PMID:21873635   PMID:21980528   PMID:22273508   PMID:22692564   PMID:22723712   PMID:23021953   PMID:23332764   PMID:23467373   PMID:23792428   PMID:23904169   PMID:23906810   PMID:23935197  
PMID:24272970   PMID:24475259   PMID:24722338   PMID:25525880   PMID:25855173   PMID:25857407   PMID:25979336   PMID:25995477   PMID:26186938   PMID:26410627   PMID:26416771   PMID:26451482  
PMID:26660356   PMID:27576048   PMID:27798109   PMID:27911796   PMID:27930290   PMID:28057087   PMID:28455436   PMID:28487311   PMID:28515211   PMID:28589041   PMID:28829946   PMID:28834742  
PMID:29314730   PMID:29728568   PMID:29867393   PMID:30012846   PMID:30318979   PMID:30926747   PMID:30943416   PMID:31858986   PMID:32576830  


Genomics

Comparative Map Data
Egr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,314,766 - 70,320,062 (+)NCBIGRCm39mm39
GRCm39 Ensembl1470,314,652 - 70,320,063 (+)Ensembl
GRCm381470,077,317 - 70,082,613 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,077,203 - 70,082,614 (+)EnsemblGRCm38mm10GRCm38
MGSCv371470,477,252 - 70,479,964 (+)NCBIGRCm37mm9NCBIm37
MGSCv361468,812,525 - 68,815,237 (+)NCBImm8
Celera1467,617,884 - 67,620,596 (+)NCBICelera
Cytogenetic Map14D2NCBI
EGR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl822,687,659 - 22,693,480 (-)EnsemblGRCh38hg38GRCh38
GRCh38822,687,659 - 22,693,480 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37822,545,172 - 22,550,993 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36822,601,119 - 22,606,760 (-)NCBINCBI36hg18NCBI36
Build 34822,601,118 - 22,606,760NCBI
Celera821,507,165 - 21,512,936 (-)NCBI
Cytogenetic Map8p21.3NCBI
HuRef821,088,681 - 21,094,160 (-)NCBIHuRef
CHM1_1822,747,408 - 22,752,963 (-)NCBICHM1_1
Egr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21545,150,335 - 45,156,052 (+)NCBI
Rnor_6.0 Ensembl1551,756,736 - 51,760,722 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01551,756,683 - 51,762,080 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01555,482,581 - 55,485,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,477,453 - 50,479,909 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11550,493,232 - 50,495,689 (+)NCBI
Celera1544,830,934 - 44,833,390 (+)NCBICelera
Cytogenetic Map15p11NCBI
Egr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540346,105,447 - 46,108,149 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540346,105,447 - 46,108,149 (-)NCBIChiLan1.0ChiLan1.0
EGR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1818,877,396 - 18,882,874 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl818,877,396 - 18,882,874 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0821,937,516 - 21,943,646 (-)NCBIMhudiblu_PPA_v0panPan3
EGR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12534,591,691 - 34,597,144 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2534,591,863 - 34,594,346 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2535,181,838 - 35,187,272 (+)NCBI
ROS_Cfam_1.02534,801,578 - 34,807,024 (+)NCBI
UMICH_Zoey_3.12534,747,844 - 34,753,287 (+)NCBI
UNSW_CanFamBas_1.02534,602,152 - 34,607,596 (+)NCBI
UU_Cfam_GSD_1.02534,757,654 - 34,763,098 (+)NCBI
EGR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl146,945,936 - 6,948,684 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1146,943,184 - 6,948,507 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2147,423,458 - 7,429,476 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EGR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1820,767,219 - 20,772,838 (-)NCBI
ChlSab1.1 Ensembl820,767,224 - 20,772,682 (-)Ensembl
Vero_WHO_p1.0NW_02366605221,453,195 - 21,459,987 (+)NCBI
Egr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475818,180,787 - 18,186,148 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420837405121032392Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142101238271648361Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143060000087700000Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143719272871192863Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4009986274099862Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144272496776725144Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144272496776725144Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144279982176799969Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144282839876828596Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144282839876828596Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144921797683218107Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145204453586044676Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145352385687524089Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145370000087700000Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145584494189845069Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145630930590309501Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1457942183101622037Mouse
1300666Fembm2_mfemoral bone morphometry 2 (mouse)Not determined146216002096160240Mouse
14747006Mancz12_mmandible centroid size 12 (mouse)1469834541103834541Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:249
Count of miRNA genes:210
Interacting mature miRNAs:235
Transcripts:ENSMUST00000035908
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000035908   ⟹   ENSMUSP00000037042
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1470,077,203 - 70,079,955 (+)Ensembl
RefSeq Acc Id: ENSMUST00000223747
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1470,078,739 - 70,082,614 (+)Ensembl
RefSeq Acc Id: ENSMUST00000223809
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1470,077,795 - 70,079,303 (+)Ensembl
RefSeq Acc Id: ENSMUST00000225200   ⟹   ENSMUSP00000153491
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1470,077,314 - 70,082,550 (+)Ensembl
RefSeq Acc Id: NM_001289925   ⟹   NP_001276854
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,314,766 - 70,320,062 (+)NCBI
GRCm381470,077,317 - 70,082,613 (+)NCBI
Celera1467,617,884 - 67,623,052 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001289927   ⟹   NP_001276856
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,315,244 - 70,320,062 (+)NCBI
GRCm381470,077,795 - 70,082,613 (+)NCBI
Celera1467,617,884 - 67,623,052 (+)NCBI
Sequence:
RefSeq Acc Id: NM_018781   ⟹   NP_061251
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,314,766 - 70,320,062 (+)NCBI
GRCm381470,077,317 - 70,082,613 (+)NCBI
MGSCv371470,477,252 - 70,479,964 (+)RGD
Celera1467,617,884 - 67,623,052 (+)NCBI
cM Map14 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_061251   ⟸   NM_018781
- Peptide Label: isoform 1
- UniProtKB: P43300 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001276854   ⟸   NM_001289925
- Peptide Label: isoform 2
- UniProtKB: Q3ZB14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001276856   ⟸   NM_001289927
- Peptide Label: isoform 3
- Sequence:
RefSeq Acc Id: ENSMUSP00000153491   ⟸   ENSMUST00000225200
RefSeq Acc Id: ENSMUSP00000037042   ⟸   ENSMUST00000035908
Protein Domains
C2H2-type

Promoters
RGD ID:8682878
Promoter ID:EPDNEW_M19470
Type:initiation region
Name:Egr3_1
Description:Mus musculus early growth response 3 , transcript variant 3,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381470,077,388 - 70,077,448EPDNEW
RGD ID:6824856
Promoter ID:MM_KWN:17353
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   Brain,   ES_Cell,   MEF_B4,   MEF_B6
Transcripts:NM_018781,   UC007UNC.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361470,476,429 - 70,476,929 (+)MPROMDB
RGD ID:6824857
Promoter ID:MM_KWN:17354
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung
Transcripts:UC007UND.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361470,478,536 - 70,479,987 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1306780 AgrOrtholog
Ensembl Genes ENSMUSG00000033730 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000037042 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000153491 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000035908 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000225200 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro EGR_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13655 UniProtKB/Swiss-Prot
MGD MGI:1306780 ENTREZGENE
NCBI Gene 13655 ENTREZGENE
Pfam DUF3446 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Egr3 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt EGR3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3ZB14 ENTREZGENE, UniProtKB/TrEMBL
  Q3ZB15_MOUSE UniProtKB/TrEMBL
  Q496R7_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q9R276 UniProtKB/Swiss-Prot