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Gene: Sos1 (SOS Ras/Rac guanine nucleotide exchange factor 1) Mus musculus
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Symbol: Sos1
Name: SOS Ras/Rac guanine nucleotide exchange factor 1
Description: Exhibits Ras guanyl-nucleotide exchange factor activity. Involved in several processes, including animal organ development; regulation of T cell activation; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to localize to several cellular components, including the neuronal cell body; plasma membrane; and postsynaptic density. Used to study Noonan syndrome 4. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 4; and gingival fibromatosis. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and retina. Orthologous to human SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; Fc epsilon receptor mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; casticin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4430401P03Rik; 9630010N06; AI449023; guanine nucleotide releasing factor; ras guanine exchange factor; RIKEN cDNA 4430401P03 gene; son of sevenless homolog 1; son of sevenless homolog 1 (Drosophila); son-of-sevenless 1
Orthologs:
Homo sapiens (human) : SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sos1 (SOS Ras/Rac guanine nucleotide exchange factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sos1 (SOS Ras/Rac guanine nucleotide exchange factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)
Canis lupus familiaris (dog) : SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sos1 (SOS Ras/Rac guanine nucleotide exchange factor 1)
Sus scrofa (pig) : SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)
Chlorocebus sabaeus (African green monkey) : SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)
Heterocephalus glaber (naked mole-rat) : Sos1 (SOS Ras/Rac guanine nucleotide exchange factor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1780,393,751 - 80,480,453 (-)Ensembl
GRCm381780,393,752 - 80,480,453 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371780,793,092 - 80,879,793 (-)NCBIGRCm37mm9NCBIm37
MGSCv361780,305,779 - 80,388,265 (-)NCBImm8
Celera1784,712,016 - 84,797,777 (-)NCBICelera
Cytogenetic Map17 E3NCBI
cM Map1750.67NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Sos1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1322141
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-12-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.