Akr1a1 (aldo-keto reductase family 1, member A1) - Rat Genome Database

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Gene: Akr1a1 (aldo-keto reductase family 1, member A1) Mus musculus
Analyze
Symbol: Akr1a1
Name: aldo-keto reductase family 1, member A1
RGD ID: 1331936
MGI Page MGI
Description: Enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in cellular detoxification of aldehyde and glucuronate catabolic process to xylulose 5-phosphate. Acts upstream of or within D-glucuronate catabolic process; L-ascorbic acid biosynthetic process; and aldehyde catabolic process. Located in apical plasma membrane. Is active in cytosol and synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human AKR1A1 (aldo-keto reductase family 1 member A1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2610201A18Rik; Akr; Akr1a4; alcohol dehydrogenase; alcohol dehydrogenase [NADP(+)]; alcohol dehydrogenase [NADP+]; aldehyde reductase; aldo-keto reductase family 1 member A1; aldo-keto reductase family 1, member A1 (aldehyde reductase); aldo-keto reductase family 1, member A4 (aldehyde reductase); glucuronate reductase; glucuronolactone reductase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394116,493,707 - 116,508,871 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4116,493,707 - 116,508,877 (-)EnsemblGRCm39 Ensembl
GRCm384116,636,510 - 116,651,674 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4116,636,510 - 116,651,680 (-)EnsemblGRCm38mm10GRCm38
MGSCv374116,309,115 - 116,324,256 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364116,134,442 - 116,149,583 (-)NCBIMGSCv36mm8
Celera4115,370,207 - 115,385,626 (-)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (EXP)
1,2-naphthoquinone  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
13-dihydrodaunorubicin  (ISO)
16-Ketoestrone  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
1H-pyrazole  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-formylbenzoic acid  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-nitrobenzaldehyde  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
9,10-phenanthroquinone  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
amiodarone  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[a]pyrene-7,8-dione  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
capsaicin  (ISO)
carbamazepine  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (EXP)
copper(II) sulfate  (ISO)
crotonaldehyde  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
D-glyceraldehyde  (ISO)
daunorubicin  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dichlorine  (ISO)
diethyl maleate  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
Fidarestat  (EXP)
flutamide  (ISO)
folic acid  (EXP)
fumonisin B1  (EXP)
furan  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glucose  (EXP)
glucuronic acid  (ISO)
glyceraldehyde  (ISO)
glycidyl methacrylate  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hexane-2,3-dione  (ISO)
hydralazine  (ISO)
hypochlorous acid  (EXP)
indometacin  (ISO)
inulin  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (EXP)
L-ethionine  (ISO)
methidathion  (EXP)
methylglyoxal  (ISO)
monosodium L-glutamate  (EXP)
Muconic dialdehyde  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nefazodone  (ISO)
nicotine  (EXP)
nimesulide  (ISO)
ochratoxin A  (ISO)
omeprazole  (ISO)
ozone  (ISO)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
Phenylglyoxal  (ISO)
phlorizin  (EXP)
pirinixic acid  (ISO)
pyrogallol  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
streptozocin  (ISO)
succinic semialdehyde  (ISO)
tetrachloroethene  (EXP)
thioacetamide  (EXP,ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
Yessotoxin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients. Hlaváč V, etal., Medicine (Baltimore). 2014 Dec;93(28):e255. doi: 10.1097/MD.0000000000000255.
2. Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury. Homma T, etal., Toxicol Lett. 2018 Sep 15;294:37-43. doi: 10.1016/j.toxlet.2018.05.015. Epub 2018 May 12.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. Evaluation of the prostaglandin F synthase activity of human and bovine aldo-keto reductases: AKR1A1s complement AKR1B1s as potent PGF synthases. Lacroix Pepin N, etal., Prostaglandins Other Lipid Mediat. 2013 Oct;106:124-32. doi: 10.1016/j.prostaglandins.2013.05.005. Epub 2013 Jun 6.
5. Identification of a novel glycolysis-related gene signature that can predict the survival of patients with lung adenocarcinoma. Liu C, etal., Cell Cycle. 2019 Mar;18(5):568-579. doi: 10.1080/15384101.2019.1578146. Epub 2019 Feb 17.
6. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. New developments in anthracycline-induced cardiotoxicity. Mordente A, etal., Curr Med Chem. 2009;16(13):1656-72.
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Doxorubicin pathways: pharmacodynamics and adverse effects. Thorn CF, etal., Pharmacogenet Genomics. 2011 Jul;21(7):440-6. doi: 10.1097/FPC.0b013e32833ffb56.
14. Author Correction: Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury. Zhou HL, etal., Nature. 2019 Jun;570(7759):E23. doi: 10.1038/s41586-019-1225-0.
Additional References at PubMed
PMID:38160   PMID:8889548   PMID:10349636   PMID:10842086   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:14667815  
PMID:14681479   PMID:15489334   PMID:15769935   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16635246   PMID:18799693   PMID:20097305   PMID:20410296   PMID:21677750   PMID:21873635  
PMID:22820017   PMID:23143230   PMID:25512491   PMID:27288086   PMID:27501753   PMID:27888021   PMID:28060768   PMID:30487609   PMID:30538128   PMID:31649033   PMID:32142766   PMID:33549889  
PMID:35679914   PMID:36288700  


Genomics

Comparative Map Data
Akr1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394116,493,707 - 116,508,871 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4116,493,707 - 116,508,877 (-)EnsemblGRCm39 Ensembl
GRCm384116,636,510 - 116,651,674 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4116,636,510 - 116,651,680 (-)EnsemblGRCm38mm10GRCm38
MGSCv374116,309,115 - 116,324,256 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364116,134,442 - 116,149,583 (-)NCBIMGSCv36mm8
Celera4115,370,207 - 115,385,626 (-)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.26NCBI
AKR1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38145,550,826 - 45,570,049 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl145,550,543 - 45,570,049 (+)EnsemblGRCh38hg38GRCh38
GRCh37146,016,498 - 46,035,721 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36145,789,085 - 45,808,308 (+)NCBINCBI36Build 36hg18NCBI36
Build 34145,685,590 - 45,704,813NCBI
Celera144,300,464 - 44,319,706 (+)NCBICelera
Cytogenetic Map1p34.1NCBI
HuRef144,127,818 - 44,147,063 (+)NCBIHuRef
CHM1_1146,133,579 - 46,152,870 (+)NCBICHM1_1
T2T-CHM13v2.0145,423,192 - 45,442,415 (+)NCBIT2T-CHM13v2.0
Akr1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85135,329,605 - 135,367,037 (-)NCBIGRCr8
mRatBN7.25130,092,945 - 130,130,277 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5130,092,732 - 130,113,674 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5132,717,057 - 132,734,057 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05134,471,650 - 134,488,650 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05134,494,047 - 134,511,049 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05135,482,068 - 135,498,693 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5135,482,068 - 135,498,822 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05139,278,242 - 139,294,867 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45136,920,561 - 136,937,422 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15136,925,785 - 136,942,923 (-)NCBI
Celera5128,620,481 - 128,637,092 (-)NCBICelera
Cytogenetic Map5q35NCBI
Akr1a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546412,714,717 - 12,729,662 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546412,715,238 - 12,729,034 (-)NCBIChiLan1.0ChiLan1.0
AKR1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21181,239,683 - 181,257,580 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11180,381,197 - 180,399,087 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,853,867 - 44,871,764 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1146,211,859 - 46,230,072 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl146,211,859 - 46,230,072 (+)Ensemblpanpan1.1panPan2
AKR1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11514,792,398 - 14,808,805 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1514,742,012 - 14,808,592 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1514,913,465 - 14,929,729 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01514,947,192 - 14,963,694 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1514,896,489 - 14,963,353 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11514,744,329 - 14,760,787 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01514,814,053 - 14,828,473 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01514,884,045 - 14,900,543 (-)NCBIUU_Cfam_GSD_1.0
Akr1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505860,855,920 - 60,872,212 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647426,680,676 - 26,697,214 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647426,680,736 - 26,696,996 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKR1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6165,811,247 - 165,824,896 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16165,811,245 - 165,825,168 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
AKR1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12087,228,348 - 87,245,511 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2087,228,189 - 87,245,466 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603329,719,096 - 29,738,521 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Akr1a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249061,462,693 - 1,474,214 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249061,463,201 - 1,474,001 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Akr1a1
438 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:806
Count of miRNA genes:440
Interacting mature miRNAs:490
Transcripts:ENSMUST00000030455, ENSMUST00000126146, ENSMUST00000128010, ENSMUST00000128059
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123127211Mouse
4141900Skts-fp1_mskin tumor susceptibility in FVB and PWK 1 (mouse)Not determined453550839124055180Mouse
27095905Scvln3_msacral vertebrae length 2, 5 week (mouse)455600000128993793Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
27095939Ulnl9_mulna length 9, 16 week (mouse)465318237118857197Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
27095917Scvln14_msacral vertebrae length 2, 16 week (mouse)468018237130277062Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
27095924Pglq2_mpelvic girdle length QTL 2, 5 week (mouse)469118237130727311Mouse
1301597Anxty_manxiety (mouse)Not determined474137574128009280Mouse
1301867Idd11_minsulin dependent diabetes susceptibility 11 (mouse)Not determined483604870117605006Mouse
1357726Lnopy1_mlens opacity 1 (mouse)Not determined485428838119429037Mouse
1301556Cd4vts1_mCD4 virgin T cell subset 1 (mouse)Not determined485428838119429037Mouse
1301930Papg1_mpulmonary adenoma progression 1 (mouse)Not determined485781167119781279Mouse
1301118Bbaa23_mB.burgdorferi-associated arthritis 23 (mouse)Not determined485781167119781279Mouse
27226716Metcl2_mmetatarsal-calcaneal length 2, 5 week (mouse)488118237118557197Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined88982069140468203Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined88982069140468203Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)488982069140468203Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
13824982Svwq1_mseminal vesicle weight QTL 1 (mouse)489888237118857197Mouse
1300918Stheal4_msoft tissue heal 4 (mouse)Not determined489969627123969747Mouse
11553870Cmmm_mcarcinoma modifier of MSM (mouse)490590668124590781Mouse
15039368Nmrs19_mNAFLD-associated magnetic resonance shift 19 (mouse)490882780124882780Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
12904002Opfaq9_mopen field activity QTL 9 (mouse)492975790126975790Mouse
1301731Cafq2_mcaffeine metabolism QTL 2 (mouse)Not determined494732255128732454Mouse
1301233Sbw2_msplenomegaly-NZB x NZW 2 (mouse)Not determined494957579128009280Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1300580Lbw2_mlupus NZB x NZW 2 (mouse)Not determined498545539128009280Mouse
1301106Skts7_mskin tumor susceptibility 7 (mouse)Not determined4100071971134072206Mouse
1301847Fecq2_mfecundity QTL 2 (mouse)Not determined4100071971134072206Mouse
14696689Gdq2_mgrooming duration QTL 2, females (mouse)4100857197124893793Mouse
12880433Fgf23lq1_mFGF23 serum level QTL 1 (mouse)4101157197135157197Mouse
1300689Dob1_mDietary obesity 1 (mouse)Body weight4101574601123127211Mouse
15039377Bw45_mbody weight QTL 45 (mouse)4105705794139705794Mouse
15039378Adip30_madiposity 30 (mouse)4105705794139705794Mouse
15039382Ltgq7_mliver triglyceride QTL 7 (mouse)4105705794139705794Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105835310141433838Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105835310141433838Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105835310141433838Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105835310141433838Mouse
1357800Tgq3_mtriglyceride QTL 3 (mouse)Not determined4107055093141055180Mouse
1300809Ccrs2_mcorpus callosum hemisphere surface size 2 (mouse)Not determined4107264957141265153Mouse
1300781Lith8_mlithogenic gene 8 (mouse)Not determined4107264957141265153Mouse
1300663Start2_mstartle response 2 (mouse)Not determined4107264957141265153Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107791564141791756Mouse
10755522Hgb1_mhemoglobin 1 (mouse)4108477692142477692Mouse
10755521Hct1_mhematocrit 1 (mouse)4108477692142477692Mouse
10755520Rbc1_mred blood cell count 1 (mouse)4108477692142477692Mouse
10412072Ssen1_msuseptibility to Sendai virus 1 (mouse)Not determined4109658132133154782Mouse
13208565Bmiq6_mbody mass index QTL 6 (mouse)4110857197125893793Mouse
1300839Dyscalc2_mdystrophic cardiac calcinosis 2 (mouse)Not determined4111009051145009280Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111009051145009280Mouse
15039385Mvlq3_mmacrovesicular liver lesion QTL 3 (mouse)4112182386146182386Mouse
4141001Tgq17_mtriglyceride QTL 17 (mouse)Not determined112523489146523489Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112824389146824389Mouse
1300655Nidds_mnon-insulin-dependent diabetes mellitus in SJL (mouse)Not determined4115030777129465915Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1301996Mmtg2_mmodifier of mammary tumor growth 2 (mouse)Not determined4116270979124055180Mouse


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_021473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF225564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK005162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK005376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK009462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK128906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL831786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY207463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY329410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000030455   ⟹   ENSMUSP00000030455
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4116,493,707 - 116,508,877 (-)Ensembl
GRCm38.p6 Ensembl4116,636,510 - 116,651,680 (-)Ensembl
RefSeq Acc Id: ENSMUST00000126146
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4116,493,708 - 116,495,211 (-)Ensembl
GRCm38.p6 Ensembl4116,636,511 - 116,638,014 (-)Ensembl
RefSeq Acc Id: ENSMUST00000128010
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4116,493,708 - 116,508,593 (-)Ensembl
GRCm38.p6 Ensembl4116,636,511 - 116,651,396 (-)Ensembl
RefSeq Acc Id: ENSMUST00000128059   ⟹   ENSMUSP00000114861
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4116,496,299 - 116,506,671 (-)Ensembl
GRCm38.p6 Ensembl4116,639,102 - 116,649,474 (-)Ensembl
RefSeq Acc Id: NM_021473   ⟹   NP_067448
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394116,493,707 - 116,508,871 (-)NCBI
GRCm384116,636,510 - 116,651,674 (-)ENTREZGENE
MGSCv374116,309,115 - 116,324,256 (-)RGD
Celera4115,370,207 - 115,385,649 (-)ENTREZGENE
cM Map4 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_067448 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF67111 (Get FASTA)   NCBI Sequence Viewer  
  AAH39926 (Get FASTA)   NCBI Sequence Viewer  
  AAH46762 (Get FASTA)   NCBI Sequence Viewer  
  AAO72144 (Get FASTA)   NCBI Sequence Viewer  
  AAO72145 (Get FASTA)   NCBI Sequence Viewer  
  BAB23853 (Get FASTA)   NCBI Sequence Viewer  
  BAB26303 (Get FASTA)   NCBI Sequence Viewer  
  BAB27437 (Get FASTA)   NCBI Sequence Viewer  
  BAB27469 (Get FASTA)   NCBI Sequence Viewer  
  BAB27543 (Get FASTA)   NCBI Sequence Viewer  
  BAB27586 (Get FASTA)   NCBI Sequence Viewer  
  BAB27767 (Get FASTA)   NCBI Sequence Viewer  
  BAB27846 (Get FASTA)   NCBI Sequence Viewer  
  BAB27883 (Get FASTA)   NCBI Sequence Viewer  
  BAB27907 (Get FASTA)   NCBI Sequence Viewer  
  BAB27909 (Get FASTA)   NCBI Sequence Viewer  
  BAB27915 (Get FASTA)   NCBI Sequence Viewer  
  BAE25762 (Get FASTA)   NCBI Sequence Viewer  
  BAE26885 (Get FASTA)   NCBI Sequence Viewer  
  BAE27036 (Get FASTA)   NCBI Sequence Viewer  
  BAE30936 (Get FASTA)   NCBI Sequence Viewer  
  BAE37798 (Get FASTA)   NCBI Sequence Viewer  
  BAE40756 (Get FASTA)   NCBI Sequence Viewer  
  EDL30595 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000030455
  ENSMUSP00000030455.9
  ENSMUSP00000114861.2
GenBank Protein Q9JII6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_067448   ⟸   NM_021473
- UniProtKB: Q9D0I7 (UniProtKB/Swiss-Prot),   Q9D016 (UniProtKB/Swiss-Prot),   Q9D012 (UniProtKB/Swiss-Prot),   Q9CT53 (UniProtKB/Swiss-Prot),   Q9CQT8 (UniProtKB/Swiss-Prot),   Q9CQI5 (UniProtKB/Swiss-Prot),   Q9D0P3 (UniProtKB/Swiss-Prot),   Q9JII6 (UniProtKB/Swiss-Prot),   Q540D7 (UniProtKB/TrEMBL),   Q80XJ7 (UniProtKB/TrEMBL),   Q3UJW9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000114861   ⟸   ENSMUST00000128059
RefSeq Acc Id: ENSMUSP00000030455   ⟸   ENSMUST00000030455
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JII6-F1-model_v2 AlphaFold Q9JII6 1-325 view protein structure

Promoters
RGD ID:6834848
Promoter ID:MM_KWN:39173
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   MEF_B6
Transcripts:OTTMUST00000021821
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364116,310,206 - 116,311,552 (-)MPROMDB
RGD ID:6847814
Promoter ID:MM_ACW:35433
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:AKR1A4.FSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364116,314,326 - 116,314,826 (-)MPROMDB
RGD ID:6834845
Promoter ID:MM_KWN:39174
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   MEF_B6
Transcripts:OTTMUST00000021820
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364116,322,156 - 116,323,007 (-)MPROMDB
RGD ID:6834847
Promoter ID:MM_KWN:39175
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000021818,   UC008UHB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364116,323,876 - 116,324,787 (-)MPROMDB
RGD ID:6884318
Promoter ID:EPDNEW_M5610
Type:initiation region
Name:Akr1a1_2
Description:Mus musculus aldo-keto reductase family 1, member A1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M5611  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384116,651,396 - 116,651,456EPDNEW
RGD ID:6884320
Promoter ID:EPDNEW_M5611
Type:initiation region
Name:Akr1a1_1
Description:Mus musculus aldo-keto reductase family 1, member A1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M5610  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384116,651,627 - 116,651,687EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1929955 AgrOrtholog
Ensembl Genes ENSMUSG00000028692 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000030455 ENTREZGENE
  ENSMUST00000030455.15 UniProtKB/Swiss-Prot
  ENSMUST00000128059.2 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AKR1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldo/ket_reductase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldo/keto_reductase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:58810 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1929955 ENTREZGENE
NCBI Gene 58810 ENTREZGENE
PANTHER ALDO-KETO REDUCTASE FAMILY 1 MEMBER A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDO/KETO REDUCTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB AKR1A1 RGD
PhenoGen Akr1a1 PhenoGen
PIRSF AKR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ALDKETRDTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt AK1A1_MOUSE UniProtKB/Swiss-Prot
  B1AXW3_MOUSE UniProtKB/TrEMBL
  Q3UJW9 ENTREZGENE, UniProtKB/TrEMBL
  Q540D7 ENTREZGENE, UniProtKB/TrEMBL
  Q80XJ7 ENTREZGENE, UniProtKB/TrEMBL
  Q9CQI5 ENTREZGENE
  Q9CQT8 ENTREZGENE
  Q9CT53 ENTREZGENE
  Q9D012 ENTREZGENE
  Q9D016 ENTREZGENE
  Q9D0I7 ENTREZGENE
  Q9D0P3 ENTREZGENE
  Q9JII6 ENTREZGENE
UniProt Secondary Q9CQI5 UniProtKB/Swiss-Prot
  Q9CQT8 UniProtKB/Swiss-Prot
  Q9CT53 UniProtKB/Swiss-Prot
  Q9D012 UniProtKB/Swiss-Prot
  Q9D016 UniProtKB/Swiss-Prot
  Q9D0I7 UniProtKB/Swiss-Prot
  Q9D0P3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-27 Akr1a1  aldo-keto reductase family 1, member A1  Akr1a1  aldo-keto reductase family 1, member A1 (aldehyde reductase)  Symbol and/or name change 5135510 APPROVED
2011-10-25 Akr1a1  aldo-keto reductase family 1, member A1 (aldehyde reductase)  Akr1a4  aldo-keto reductase family 1, member A4 (aldehyde reductase)  Symbol and/or name change 5135510 APPROVED