Mthfd2 (methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase) - Rat Genome Database

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Gene: Mthfd2 (methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase) Mus musculus
Analyze
Symbol: Mthfd2
Name: methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
RGD ID: 1322702
MGI Page MGI
Description: Enables methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; and methylenetetrahydrofolate dehydrogenase (NADP+) activity. Predicted to be involved in tetrahydrofolate interconversion. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human MTHFD2 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW558851; bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; NMDM; NMDMC
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm19233  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,282,686 - 83,302,926 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl683,282,673 - 83,302,890 (-)EnsemblGRCm39 Ensembl
GRCm38683,305,704 - 83,326,011 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,305,691 - 83,325,908 (-)EnsemblGRCm38mm10GRCm38
MGSCv37683,255,698 - 83,267,598 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36683,271,364 - 83,283,262 (-)NCBIMGSCv36mm8
Celera685,286,788 - 85,298,680 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-butoxyethanol  (EXP)
2-methylcholine  (ISO)
3-methylcholanthrene  (EXP)
4-hydroxyphenyl retinamide  (EXP,ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (ISO)
amiodarone  (ISO)
amitrole  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
artesunate  (ISO)
atrazine  (ISO)
Azaspiracid  (ISO)
azoxystrobin  (ISO)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
bucladesine  (ISO)
buta-1,3-diene  (EXP)
butan-1-ol  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
cefaloridine  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
cisplatin  (ISO)
clobetasol  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
diclofenac  (EXP,ISO)
dioxygen  (EXP)
diquat  (EXP)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
etoposide  (EXP)
fenpyroximate  (ISO)
fluoranthene  (EXP)
folic acid  (EXP)
fructose  (EXP)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (EXP)
glycine betaine  (ISO)
indole-3-methanol  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lamivudine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dichloride  (ISO)
methamphetamine  (ISO)
methimazole  (ISO)
methylmercury chloride  (ISO)
miconazole  (EXP)
mitoxantrone  (ISO)
N(4)-hydroxycytidine  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
neomycin  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pemetrexed  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phosgene  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
potassium bromate  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
pyrimidifen  (ISO)
quinoline  (ISO)
resveratrol  (EXP)
riddelliine  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sinapic acid  (EXP)
sodium arsenite  (EXP,ISO)
sulfadimethoxine  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP)
tebufenpyrad  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
trovafloxacin  (EXP)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrion  (HDA,IBA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. In vitro synthesis of the trifunctional protein, methylenetetrahydrofolate dehydrogenase--methenyltetrahydrofolate cyclohydrolase--formyltetrahydrofolate synthetase, in normal and transformed cells. Rozen R, etal., Can J Biochem Cell Biol. 1985 Nov;63(11):1189-93.
10. Compartmentalization of Mammalian folate-mediated one-carbon metabolism. Tibbetts AS and Appling DR, Annu Rev Nutr. 2010 Aug 21;30:57-81. doi: 10.1146/annurev.nutr.012809.104810.
11. Update and new concepts in vitamin responsive disorders of folate transport and metabolism. Watkins D and Rosenblatt DS, J Inherit Metab Dis. 2012 Jul;35(4):665-70. doi: 10.1007/s10545-011-9418-1. Epub 2011 Nov 23.
Additional References at PubMed
PMID:1843253   PMID:1999293   PMID:2647744   PMID:10349636   PMID:10844592   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12024029   PMID:12061812   PMID:12477932   PMID:12646567  
PMID:14610273   PMID:14651853   PMID:14681479   PMID:15342116   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:17015433   PMID:18030499   PMID:18228065   PMID:18614015  
PMID:18799693   PMID:19948730   PMID:21677750   PMID:21873635   PMID:23375831   PMID:24194600   PMID:24733394   PMID:27106802   PMID:28202838   PMID:30457570   PMID:32325033   PMID:32679066  
PMID:34321999   PMID:34702858   PMID:34767747   PMID:36114006   PMID:36154620   PMID:36539111   PMID:37019383   PMID:37149861   PMID:37450958   PMID:38355793   PMID:38407485  


Genomics

Comparative Map Data
Mthfd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,282,686 - 83,302,926 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl683,282,673 - 83,302,890 (-)EnsemblGRCm39 Ensembl
GRCm38683,305,704 - 83,326,011 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,305,691 - 83,325,908 (-)EnsemblGRCm38mm10GRCm38
MGSCv37683,255,698 - 83,267,598 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36683,271,364 - 83,283,262 (-)NCBIMGSCv36mm8
Celera685,286,788 - 85,298,680 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
MTHFD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38274,198,615 - 74,217,565 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl274,186,172 - 74,217,565 (+)EnsemblGRCh38hg38GRCh38
GRCh37274,425,742 - 74,444,692 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,279,198 - 74,295,933 (+)NCBINCBI36Build 36hg18NCBI36
Build 34274,337,366 - 74,354,067NCBI
Celera274,256,899 - 74,273,604 (+)NCBICelera
Cytogenetic Map2p13.1NCBI
HuRef274,161,958 - 74,178,696 (+)NCBIHuRef
CHM1_1274,355,004 - 74,371,783 (+)NCBICHM1_1
T2T-CHM13v2.0274,207,390 - 74,226,316 (+)NCBIT2T-CHM13v2.0
Mthfd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,368,833 - 117,380,350 (-)NCBIGRCr8
mRatBN7.24115,811,135 - 115,822,663 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,811,139 - 115,822,608 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4121,288,124 - 121,299,748 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04117,063,296 - 117,074,920 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,677,666 - 115,689,194 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04115,004,433 - 115,015,965 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4115,004,448 - 115,015,965 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04179,592,799 - 179,604,331 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,517,611 - 117,529,128 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4104,805,220 - 104,816,732 (-)NCBICelera
Cytogenetic Map4q34NCBI
Mthfd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,539,399 - 11,550,220 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542411,538,344 - 11,550,119 (-)NCBIChiLan1.0ChiLan1.0
MTHFD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21252,172,141 - 52,189,641 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A52,174,894 - 52,192,394 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A74,270,161 - 74,285,790 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A75,777,023 - 75,792,699 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A75,777,028 - 75,792,699 (+)Ensemblpanpan1.1panPan2
MTHFD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,882,838 - 48,896,816 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,883,724 - 48,941,949 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1748,522,746 - 48,538,308 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01749,740,851 - 49,756,419 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1749,742,732 - 49,756,640 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11748,757,467 - 48,773,023 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01748,824,290 - 48,839,869 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01749,382,307 - 49,398,081 (-)NCBIUU_Cfam_GSD_1.0
Mthfd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629210,262,753 - 10,274,900 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936556462,974 - 475,159 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936556462,998 - 475,092 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTHFD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl368,818,119 - 68,833,600 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1368,819,171 - 68,833,641 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2372,058,348 - 72,067,128 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MTHFD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11433,063,485 - 33,080,703 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1433,064,542 - 33,080,366 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604579,087,248 - 79,105,477 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mthfd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474929,264,577 - 29,276,769 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1029
Count of miRNA genes:571
Interacting mature miRNAs:676
Transcripts:ENSMUST00000005810, ENSMUST00000139802, ENSMUST00000141044, ENSMUST00000141193
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671958006105958152Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67707698389976982Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671958006105958152Mouse
10412119Stv_mstriatal volumne (mouse)Not determined660026991100026967Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67797698396976961Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67552133992584431Mouse
12792979Fbmd2_mfemoral bone mineral density 2, females only (mouse)675026989115026943Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67552133994202936Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65115613485156284Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65842456692424693Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671552042105552160Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67129960593441074Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64529099387403016Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7129960586252701Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5435041188356155Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675424566104480516Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65851741692517416Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675584287109584431Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670402880104403016Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676440930110441074Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670402880104403016Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652138693116132228Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
15039373Adip28_madiposity 28 (mouse)65628519490285194Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66346172197461888Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65628519490285194Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675693484109693678Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666690851100691013Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670402880104403016Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681476981102176961Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67552133994202936Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66003466394034782Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678606487121092347Mouse

Markers in Region
AW558851  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38683,306,631 - 83,306,725UniSTSGRCm38
MGSCv37683,256,625 - 83,256,719UniSTSGRCm37
Celera685,287,715 - 85,287,809UniSTS
Cytogenetic Map6C3UniSTS
cM Map635.15UniSTS
Whitehead/MRC_RH6852.97UniSTS
M63445  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38683,306,091 - 83,306,251UniSTSGRCm38
MGSCv37683,256,085 - 83,256,245UniSTSGRCm37
Celera685,287,175 - 85,287,335UniSTS
Cytogenetic Map6C3UniSTS
cM Map635.15UniSTS
Whitehead/MRC_RH6853.17UniSTS
Mthfd2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38683,305,793 - 83,306,703UniSTSGRCm38
MGSCv37683,255,787 - 83,256,697UniSTSGRCm37
Celera685,286,877 - 85,287,787UniSTS
Cytogenetic Map6C3UniSTS
cM Map635.15UniSTS
PMC133862P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38683,305,798 - 83,306,712UniSTSGRCm38
MGSCv37683,255,792 - 83,256,706UniSTSGRCm37
Celera685,286,882 - 85,287,796UniSTS
Cytogenetic Map6C3UniSTS
cM Map635.15UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006505697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011241245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC159713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY068806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV651355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M74185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S52980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000005810   ⟹   ENSMUSP00000005810
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl683,282,673 - 83,294,588 (-)Ensembl
GRCm38.p6 Ensembl683,305,691 - 83,317,606 (-)Ensembl
Ensembl Acc Id: ENSMUST00000139802
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl683,286,316 - 83,287,530 (-)Ensembl
GRCm38.p6 Ensembl683,309,334 - 83,310,548 (-)Ensembl
Ensembl Acc Id: ENSMUST00000141044
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl683,283,540 - 83,286,289 (-)Ensembl
GRCm38.p6 Ensembl683,306,558 - 83,309,307 (-)Ensembl
Ensembl Acc Id: ENSMUST00000141193
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl683,286,534 - 83,288,575 (-)Ensembl
GRCm38.p6 Ensembl683,309,552 - 83,311,593 (-)Ensembl
Ensembl Acc Id: ENSMUST00000203375
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl683,288,327 - 83,289,387 (-)Ensembl
GRCm38.p6 Ensembl683,311,345 - 83,312,405 (-)Ensembl
Ensembl Acc Id: ENSMUST00000203847   ⟹   ENSMUSP00000145266
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl683,283,384 - 83,294,535 (-)Ensembl
GRCm38.p6 Ensembl683,306,402 - 83,317,553 (-)Ensembl
Ensembl Acc Id: ENSMUST00000204472   ⟹   ENSMUSP00000145222
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl683,288,853 - 83,302,890 (-)Ensembl
GRCm38.p6 Ensembl683,311,871 - 83,325,908 (-)Ensembl
RefSeq Acc Id: NM_008638   ⟹   NP_032664
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39683,282,686 - 83,294,586 (-)NCBI
GRCm38683,305,704 - 83,317,604 (-)NCBI
MGSCv37683,255,698 - 83,267,598 (-)RGD
Celera685,286,788 - 85,298,680 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006505697   ⟹   XP_006505760
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39683,282,686 - 83,302,926 (-)NCBI
GRCm38683,305,704 - 83,326,011 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011241245   ⟹   XP_011239547
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39683,282,686 - 83,302,926 (-)NCBI
GRCm38683,305,704 - 83,326,011 (-)NCBI
Sequence:
RefSeq Acc Id: NP_032664   ⟸   NM_008638
- Peptide Label: precursor
- UniProtKB: Q3TMN4 (UniProtKB/Swiss-Prot),   P18155 (UniProtKB/Swiss-Prot),   Q3U8E7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006505760   ⟸   XM_006505697
- Peptide Label: isoform X2
- UniProtKB: Q3U8E7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011239547   ⟸   XM_011241245
- Peptide Label: isoform X1
- UniProtKB: Q3U8E7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000145266   ⟸   ENSMUST00000203847
Ensembl Acc Id: ENSMUSP00000145222   ⟸   ENSMUST00000204472
Ensembl Acc Id: ENSMUSP00000005810   ⟸   ENSMUST00000005810
Protein Domains
Tetrahydrofolate dehydrogenase/cyclohydrolase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18155-F1-model_v2 AlphaFold P18155 1-350 view protein structure

Promoters
RGD ID:6839664
Promoter ID:MM_KWN:46601
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour
Transcripts:OTTMUST00000055881
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36683,261,041 - 83,261,541 (-)MPROMDB
RGD ID:6839663
Promoter ID:MM_KWN:46602
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   Spleen
Transcripts:OTTMUST00000055880
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36683,267,194 - 83,267,694 (-)MPROMDB
RGD ID:6890156
Promoter ID:EPDNEW_M8529
Type:initiation region
Name:Mthfd2_1
Description:Mus musculus methylenetetrahydrofolate dehydrogenase (NAD+ dependent),methenyltetrahydrofolate cyclohydrolase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38683,317,553 - 83,317,613EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1338850 AgrOrtholog
Ensembl Genes ENSMUSG00000005667 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000005810 ENTREZGENE
  ENSMUST00000005810.9 UniProtKB/Swiss-Prot
  ENSMUST00000203847.3 UniProtKB/TrEMBL
  ENSMUST00000204472.2 UniProtKB/TrEMBL
Gene3D-CATH Leucine Dehydrogenase, chain A, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aminiacid_DH-like_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THF_DH/CycHdrlase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THF_DH/CycHdrlase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THF_DH/CycHdrlase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THF_DH/CycHdrlase_NAD-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17768 UniProtKB/Swiss-Prot
MGD MGI:1338850 ENTREZGENE
NCBI Gene 17768 ENTREZGENE
PANTHER BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam THF_DHG_CYH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THF_DHG_CYH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MTHFD2 RGD
PhenoGen Mthfd2 PhenoGen
PRINTS THFDHDRGNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THF_DHG_CYH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THF_DHG_CYH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53223 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0N4SVS2_MOUSE UniProtKB/TrEMBL
  A0A0N4SVW2_MOUSE UniProtKB/TrEMBL
  MTDC_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TMN4 ENTREZGENE
  Q3U8E7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q3TMN4 UniProtKB/Swiss-Prot