Mthfd2 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Mthfd2 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase) Chinchilla lanigera
Analyze
Symbol: Mthfd2
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
RGD ID: 8858436
Description: ENCODES a protein that exhibits magnesium ion binding (ortholog); methenyltetrahydrofolate cyclohydrolase activity (ortholog); methylenetetrahydrofolate dehydrogenase (NAD+) activity (ortholog); INVOLVED IN tetrahydrofolate metabolic process (ortholog); PARTICIPATES IN folate cycle metabolic pathway; folate mediated one-carbon metabolic pathway; folate metabolic pathway; ASSOCIATED WITH congenital disorder of glycosylation type IIb (ortholog); congestive heart failure (ortholog); COVID-19 (ortholog); FOUND IN mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,539,399 - 11,550,220 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542411,538,344 - 11,550,119 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mthfd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,539,399 - 11,550,220 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542411,538,344 - 11,550,119 (-)NCBIChiLan1.0ChiLan1.0
MTHFD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38274,198,615 - 74,217,565 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl274,186,172 - 74,217,565 (+)EnsemblGRCh38hg38GRCh38
GRCh37274,425,742 - 74,444,692 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,279,198 - 74,295,933 (+)NCBINCBI36Build 36hg18NCBI36
Build 34274,337,366 - 74,354,067NCBI
Celera274,256,899 - 74,273,604 (+)NCBICelera
Cytogenetic Map2p13.1NCBI
HuRef274,161,958 - 74,178,696 (+)NCBIHuRef
CHM1_1274,355,004 - 74,371,783 (+)NCBICHM1_1
T2T-CHM13v2.0274,207,390 - 74,226,316 (+)NCBIT2T-CHM13v2.0
Mthfd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,282,686 - 83,302,926 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl683,282,673 - 83,302,890 (-)EnsemblGRCm39 Ensembl
GRCm38683,305,704 - 83,326,011 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,305,691 - 83,325,908 (-)EnsemblGRCm38mm10GRCm38
MGSCv37683,255,698 - 83,267,598 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36683,271,364 - 83,283,262 (-)NCBIMGSCv36mm8
Celera685,286,788 - 85,298,680 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
Mthfd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,368,833 - 117,380,350 (-)NCBIGRCr8
mRatBN7.24115,811,135 - 115,822,663 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,811,139 - 115,822,608 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4121,288,124 - 121,299,748 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04117,063,296 - 117,074,920 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,677,666 - 115,689,194 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04115,004,433 - 115,015,965 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4115,004,448 - 115,015,965 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04179,592,799 - 179,604,331 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,517,611 - 117,529,128 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4104,805,220 - 104,816,732 (-)NCBICelera
Cytogenetic Map4q34NCBI
MTHFD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21252,172,141 - 52,189,641 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A52,174,894 - 52,192,394 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A74,270,161 - 74,285,790 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A75,777,023 - 75,792,699 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A75,777,028 - 75,792,699 (+)Ensemblpanpan1.1panPan2
MTHFD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,882,838 - 48,896,816 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,883,724 - 48,941,949 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1748,522,746 - 48,538,308 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01749,740,851 - 49,756,419 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1749,742,732 - 49,756,640 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11748,757,467 - 48,773,023 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01748,824,290 - 48,839,869 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01749,382,307 - 49,398,081 (-)NCBIUU_Cfam_GSD_1.0
Mthfd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629210,262,753 - 10,274,900 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936556462,974 - 475,159 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936556462,998 - 475,092 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTHFD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl368,818,119 - 68,833,600 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1368,819,171 - 68,833,641 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2372,058,348 - 72,067,128 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MTHFD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11433,063,485 - 33,080,703 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1433,064,542 - 33,080,366 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604579,087,248 - 79,105,477 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mthfd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474929,264,577 - 29,276,769 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000009196   ⟹   ENSCLAP00000009067
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542411,539,399 - 11,550,220 (-)Ensembl
RefSeq Acc Id: XM_005385524   ⟹   XP_005385581
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542411,538,344 - 11,550,119 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005385581 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000009067
  ENSCLAP00000009067.1
RefSeq Acc Id: XP_005385581   ⟸   XM_005385524
- UniProtKB: A0A8C2V448 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000009067   ⟸   ENSCLAT00000009196
Protein Domains
Tetrahydrofolate dehydrogenase/cyclohydrolase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000006326 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000009196 ENTREZGENE
  ENSCLAT00000009196.1 UniProtKB/TrEMBL
Gene3D-CATH Leucine Dehydrogenase, chain A, domain 1 UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro Aminiacid_DH-like_N_sf UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  THF_DH/CycHdrlase UniProtKB/TrEMBL
  THF_DH/CycHdrlase_cat_dom UniProtKB/TrEMBL
  THF_DH/CycHdrlase_CS UniProtKB/TrEMBL
  THF_DH/CycHdrlase_NAD-bd_dom UniProtKB/TrEMBL
NCBI Gene Mthfd2 ENTREZGENE
PANTHER BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL UniProtKB/TrEMBL
  C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED UniProtKB/TrEMBL
Pfam THF_DHG_CYH UniProtKB/TrEMBL
  THF_DHG_CYH_C UniProtKB/TrEMBL
PRINTS THFDHDRGNASE UniProtKB/TrEMBL
PROSITE THF_DHG_CYH_1 UniProtKB/TrEMBL
  THF_DHG_CYH_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
  SSF53223 UniProtKB/TrEMBL
UniProt A0A8C2V448 ENTREZGENE, UniProtKB/TrEMBL