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Gene: Ephx2 (epoxide hydrolase 2, cytoplasmic) Mus musculus
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Symbol: Ephx2
Name: epoxide hydrolase 2, cytoplasmic
Description: Predicted to have several functions, including lipid phosphatase activity; magnesium ion binding activity; and protein homodimerization activity. Involved in cholesterol homeostasis; positive regulation of gene expression; and regulation of cholesterol metabolic process. Predicted to localize to the cytosol and peroxisome. Human ortholog(s) of this gene implicated in coronary artery disease; familial hypercholesterolemia; and hypertension. Is expressed in several structures, including alimentary system; heart; integumental system; nervous system; and urinary system. Orthologous to human EPHX2 (epoxide hydrolase 2); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH (2,4,5-trichlorophenoxy)acetic acid; 1-naphthyl isothiocyanate; 14,15-EET.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW106936; bifunctional epoxide hydrolase 2; CEH; cytosolic epoxide hydrolase; Eph2; epoxide hydratase; epoxide hydrolase 2; epoxide hydrolase 2C; SEH; sEP; soluble epoxide hydrolase
Orthologs:
Homo sapiens (human) : EPHX2 (epoxide hydrolase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ephx2 (epoxide hydrolase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ephx2 (epoxide hydrolase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : EPHX2 (epoxide hydrolase 2)
Canis lupus familiaris (dog) : EPHX2 (epoxide hydrolase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ephx2 (epoxide hydrolase 2)
Sus scrofa (pig) : EPHX2 (epoxide hydrolase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381466,084,372 - 66,124,522 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371466,703,214 - 66,743,337 (-)NCBIGRCm37mm9NCBIm37
MGSCv361465,038,487 - 65,078,610 (-)NCBImm8
Celera1463,832,357 - 63,872,518 (-)NCBICelera
Cytogenetic Map14 D1NCBI
cM Map1434.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ephx2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731055
Created: 2003-12-10
Species: Mus musculus
Last Modified: 2019-10-29
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.