Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Ephx2 (epoxide hydrolase 2, cytoplasmic) Mus musculus
Symbol: Ephx2
Name: epoxide hydrolase 2, cytoplasmic
Description: Predicted to have several functions, including lipid phosphatase activity; magnesium ion binding activity; and protein homodimerization activity. Involved in cholesterol homeostasis; positive regulation of gene expression; and regulation of cholesterol metabolic process. Predicted to localize to the cytosol and peroxisome. Human ortholog(s) of this gene implicated in coronary artery disease; familial hypercholesterolemia; and hypertension. Is expressed in several structures, including alimentary system; heart; integumental system; nervous system; and urinary system. Orthologous to human EPHX2 (epoxide hydrolase 2); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH (2,4,5-trichlorophenoxy)acetic acid; 1-naphthyl isothiocyanate; 14,15-EET.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW106936; bifunctional epoxide hydrolase 2; CEH; cytosolic epoxide hydrolase; Eph2; epoxide hydratase; epoxide hydrolase 2; epoxide hydrolase 2C; SEH; sEP; soluble epoxide hydrolase
Homo sapiens (human) : EPHX2 (epoxide hydrolase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ephx2 (epoxide hydrolase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ephx2 (epoxide hydrolase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : EPHX2 (epoxide hydrolase 2)
Canis lupus familiaris (dog) : EPHX2 (epoxide hydrolase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ephx2 (epoxide hydrolase 2)
Sus scrofa (pig) : EPHX2 (epoxide hydrolase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381466,084,372 - 66,124,522 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371466,703,214 - 66,743,337 (-)NCBIGRCm37mm9NCBIm37
MGSCv361465,038,487 - 65,078,610 (-)NCBImm8
Celera1463,832,357 - 63,872,518 (-)NCBICelera
Cytogenetic Map14 D1NCBI
cM Map1434.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ephx2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731055
Created: 2003-12-10
Species: Mus musculus
Last Modified: 2019-10-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.