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Gene: Sorl1 (sortilin-related receptor, LDLR class A repeats-containing) Mus musculus
Symbol: Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Description: Predicted to have ADP-ribosylation factor binding activity; amyloid-beta binding activity; and low-density lipoprotein particle binding activity. Involved in several processes, including diet induced thermogenesis; negative regulation of protein metabolic process; and regulation of signal transduction. Localizes to the nuclear envelope lumen. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is expressed in several structures, including alimentary system; brain; ganglia; metanephros; and sensory organ. Orthologous to human SORL1 (sortilin related receptor 1); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2900010L19Rik; AI596264; AW261561; gp250; LDLR relative with 11 ligand-binding repeats; low-density lipoprotein receptor relative with 11 ligand-binding repeats; LR11; mSorLA; SorLA; sorLA-1; sortilin-related receptor; sorting protein-related receptor containing LDLR class A repeats
Homo sapiens (human) : SORL1 (sortilin related receptor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sorl1 (sortilin related receptor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sorl1 (sortilin related receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SORL1 (sortilin related receptor 1)
Canis lupus familiaris (dog) : SORL1 (sortilin related receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sorl1 (sortilin related receptor 1)
Sus scrofa (pig) : SORL1 (sortilin related receptor 1)
Chlorocebus sabaeus (green monkey) : SORL1 (sortilin related receptor 1)
Heterocephalus glaber (naked mole-rat) : Sorl1 (sortilin related receptor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl941,964,720 - 42,124,297 (-)Ensembl
GRCm38941,964,709 - 42,124,297 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37941,776,572 - 41,932,372 (-)NCBIGRCm37mm9NCBIm37
MGSCv36941,719,598 - 41,875,108 (-)NCBImm8
Celera939,209,765 - 39,348,584 (-)NCBICelera
Cytogenetic Map9 A5.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Sorl1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1615161
Created: 2007-04-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.