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Gene: Rffl (ring finger and FYVE like domain containing protein) Mus musculus
Symbol: Rffl
Name: ring finger and FYVE like domain containing protein
RGD ID: 1552495
Description: Predicted to have enzyme binding activity; p53 binding activity; and ubiquitin protein ligase activity. Involved in intracellular protein transport and regulation of fibroblast migration. Localizes to cytoplasmic vesicle. Is expressed in bladder; retina inner nuclear layer; retina outer nuclear layer; and ureter. Orthologous to human RFFL (ring finger and FYVE like domain containing E3 ubiquitin protein ligase); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1700051E09Rik; 4930516L10Rik; BG080975; Ca; Car; Carp2; E3 ubiquitin-protein ligase rififylin; fr; fring; MGC144763; rif; rififylin; RING finger and FYVE-like domain-containing protein 1; RING-type E3 ubiquitin transferase rififylin
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391182,694,645 - 82,762,065 (-)NCBI
GRCm381182,803,819 - 82,871,236 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,802,449 - 82,871,210 (-)EnsemblGRCm38mm10GRCm38
MGSCv371182,617,321 - 82,684,712 (-)NCBIGRCm37mm9NCBIm37
MGSCv361182,620,017 - 82,686,939 (-)NCBImm8
Celera1192,423,191 - 92,490,746 (-)NCBICelera
Cytogenetic Map11CNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Rffl
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1552495
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.