Osr2 (odd-skipped related 2) - Rat Genome Database

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Gene: Osr2 (odd-skipped related 2) Mus musculus
Analyze
Symbol: Osr2
Name: odd-skipped related 2
RGD ID: 1314073
MGI Page MGI
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; embryonic limb morphogenesis; and regulation of transcription by RNA polymerase II. Localizes to nucleus. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human OSR2 (odd-skipped related transciption factor 2); INTERACTS WITH 17beta-estradiol; 3-methylcholanthrene; aldrin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5430409I15Rik; O; Os; Osr2A; Osr2B; protein odd-skipped-related 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391535,296,244 - 35,303,451 (+)NCBIGRCm39mm39
GRCm39 Ensembl1535,296,244 - 35,303,451 (+)Ensembl
GRCm381535,296,098 - 35,303,305 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1535,296,098 - 35,303,305 (+)EnsemblGRCm38mm10GRCm38
MGSCv371535,225,867 - 35,233,060 (+)NCBIGRCm37mm9NCBIm37
MGSCv361535,240,701 - 35,247,894 (+)NCBImm8
Celera1535,916,195 - 35,923,389 (+)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1514.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,IDA)

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11520675   PMID:12477932   PMID:15175245   PMID:15489334   PMID:15670784   PMID:15716346   PMID:16141072   PMID:16141073   PMID:16436053  
PMID:16554187   PMID:16602821   PMID:17547533   PMID:17609113   PMID:17941042   PMID:18287559   PMID:18391535   PMID:18470539   PMID:18634775   PMID:18948418   PMID:19251632   PMID:19304890  
PMID:19341725   PMID:19389375   PMID:19631205   PMID:19769959   PMID:20059953   PMID:20510229   PMID:20599744   PMID:20981831   PMID:21185278   PMID:21262216   PMID:21267068   PMID:21281489  
PMID:21420399   PMID:21490069   PMID:21491542   PMID:21854845   PMID:21873635   PMID:22174793   PMID:22432025   PMID:22510988   PMID:22542937   PMID:22972697   PMID:23250216   PMID:23362348  
PMID:23362349   PMID:23460641   PMID:23506836   PMID:23816882   PMID:23872338   PMID:24146773   PMID:24167250   PMID:24173808   PMID:24433583   PMID:24565867   PMID:24766886   PMID:24785830  
PMID:25515778   PMID:25645944   PMID:25673119   PMID:25916343   PMID:26238476   PMID:26395480   PMID:26745863   PMID:26826126   PMID:27405802   PMID:27713059   PMID:28069795   PMID:28467430  
PMID:28501478   PMID:28605600   PMID:28731788   PMID:29712641   PMID:30254141   PMID:30292786   PMID:30653268   PMID:31259687   PMID:31340933   PMID:31427537   PMID:31685872   PMID:32160556  
PMID:33323370   PMID:33482080  


Genomics

Comparative Map Data
Osr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391535,296,244 - 35,303,451 (+)NCBIGRCm39mm39
GRCm39 Ensembl1535,296,244 - 35,303,451 (+)Ensembl
GRCm381535,296,098 - 35,303,305 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1535,296,098 - 35,303,305 (+)EnsemblGRCm38mm10GRCm38
MGSCv371535,225,867 - 35,233,060 (+)NCBIGRCm37mm9NCBIm37
MGSCv361535,240,701 - 35,247,894 (+)NCBImm8
Celera1535,916,195 - 35,923,389 (+)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1514.46NCBI
OSR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl898,944,403 - 98,952,104 (+)EnsemblGRCh38hg38GRCh38
GRCh38898,944,442 - 98,952,100 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37899,956,670 - 99,964,328 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368100,025,862 - 100,033,504 (+)NCBINCBI36hg18NCBI36
Build 348100,025,861 - 100,033,500NCBI
Celera896,142,339 - 96,150,050 (+)NCBI
Cytogenetic Map8q22.2NCBI
HuRef895,159,407 - 95,167,108 (+)NCBIHuRef
CHM1_1899,997,298 - 100,004,999 (+)NCBICHM1_1
Osr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2766,487,841 - 66,495,003 (+)NCBI
Rnor_6.0 Ensembl774,047,814 - 74,055,256 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0774,047,820 - 74,055,096 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0774,213,945 - 74,221,077 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4770,769,123 - 70,776,248 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1770,789,852 - 70,796,977 (+)NCBI
Celera763,576,550 - 63,583,675 (+)NCBICelera
Cytogenetic Map7q22NCBI
Osr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541714,502,451 - 14,510,160 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541714,502,450 - 14,510,015 (+)NCBIChiLan1.0ChiLan1.0
OSR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1897,768,980 - 97,776,663 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl897,768,980 - 97,776,669 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0895,590,753 - 95,598,491 (+)NCBIMhudiblu_PPA_v0panPan3
OSR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1131,019,167 - 1,031,622 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl131,023,879 - 1,031,225 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha131,014,427 - 1,026,867 (+)NCBI
ROS_Cfam_1.0131,171,210 - 1,183,651 (+)NCBI
UMICH_Zoey_3.1131,013,686 - 1,026,136 (+)NCBI
UNSW_CanFamBas_1.0131,121,661 - 1,134,096 (+)NCBI
UU_Cfam_GSD_1.0131,128,475 - 1,140,925 (+)NCBI
Osr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530336,598,337 - 36,606,291 (-)NCBI
SpeTri2.0NW_00493647044,024,497 - 44,032,429 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OSR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl437,852,587 - 37,897,935 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1437,890,200 - 37,897,935 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2440,894,623 - 40,902,347 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OSR2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1893,831,218 - 93,839,098 (+)NCBI
ChlSab1.1 Ensembl893,831,480 - 93,839,263 (+)Ensembl
Osr2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247636,035,923 - 6,043,682 (+)NCBI

Position Markers
Osr2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371535,230,619 - 35,231,724UniSTSGRCm37
Celera1535,920,948 - 35,922,053UniSTS
Cytogenetic Map15B3.1UniSTS
cM Map1514.0UniSTS
Osr2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381535,300,864 - 35,301,969UniSTSGRCm38
MGSCv371535,230,619 - 35,231,724UniSTSGRCm37
Celera1535,920,948 - 35,922,053UniSTS
Cytogenetic Map15B3.1UniSTS
Osr2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15B3.1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401902Sicd2_mseizure-induced cell death 2 (mouse)Not determined15344490771325689Mouse
4141952W3q7_mweight 3 weeks QTL 7 (mouse)Not determined346021278717086Mouse
4142448Tailq6_mtail length QTL 6 (mouse)Not determined346021278717086Mouse
4142252Tailaq4_mtail length adjusted QTL 4 (mouse)Not determined346021278717086Mouse
1357559Scfq2_msubcutaneous fat pad weight QTL 2 (mouse)Not determined15346021278717086Mouse
1357659Epfpq4_mepididymal fat percentage QTL 4 (mouse)Not determined15346021278717086Mouse
4141358Ath22_matherosclerosis 22 (mouse)Not determined346456637464566Mouse
11252136Modvl4_mmodifier of vacuolated lens (mouse)15562040839620528Mouse
26884409Bzwq16_mbi-zygomatic width QTL 16, 16 week (mouse)15610000038000000Mouse
26884384Skwq12_mskull length QTL 12, 16 week (mouse)15610000050900000Mouse
26884387Skwq8_mskull length QTL 8, 10 week (mouse)15610000068400000Mouse
26884412Bzwq10_mbi-zygomatic width QTL 10, 10 week (mouse)15610000071600000Mouse
26884417Bzwq4_mbi-zygomatic width QTL 4, 5 week (mouse)15610000072600000Mouse
27226786Feml11_mfemur length 11, 5 week (mouse)15610000076000000Mouse
27095932Ulnl11_mulna length 11, 16 week (mouse)15610000076500000Mouse
27226717Tibw4_mtibia width 4, proximal, 10 week (mouse)15610000078800000Mouse
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15610000086800000Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156100000100900000Mouse
26884429Zlq6_mzygomatic length QTL 6, 10 week (mouse)15680000045100000Mouse
27226721Tibw8_mtibia width 8, proximal, 16 week (mouse)15690000076000000Mouse
27226773Tibl16_mtibia length 16, 10 week (mouse)15690000076000000Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15690000084700000Mouse
27095940Ulnl8_mulna length 8, 10 week (mouse)15720000055400000Mouse
27226759Feml17_mfemur length 17, 10 week (mouse)15760000055400000Mouse
27226755Feml22_mfemur length 22, 16 week (mouse)15760000059400000Mouse
27095922Pglq11_mpelvic girdle length QTL 11, 10 week (mouse)15810000038900000Mouse
26884439Sklq11_mskull length QTL 11, 10 week (mouse)15810000047800000Mouse
4140994Shali3_msurvival time to hyperoxic acute lung injury 3 (mouse)Not determined927293643448484Mouse
10412172Habiir5_mhyperoxic acute lung injury imprinted region 5 (mouse)Not determined15927293643448484Mouse
4141192Ssrq2_mstress response QTL 2 (mouse)Not determined927293656323454Mouse
1301433Rapop5_mradiation-induced apoptosis 5 (mouse)Not determined15927293679590561Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402117102988123Mouse
1302165Yv_myellow value (mouse)Not determined151384686047847002Mouse
1301020Pheo_mpheomelanin (mouse)Not determined151384686047847002Mouse
1301951Eila3_methanol induced locomotor activity 3 (mouse)Not determined151492744148927610Mouse
4141423Nstr2_mnerve sheath tumor resistance QTL 2 (mouse)Not determined1492744148927610Mouse
1302007Bbaa14_mB.burgdorferi-associated arthritis 14 (mouse)Not determined151492744148927610Mouse
1301499Bdln2_mbody length 2 (mouse)Not determined151564519749645324Mouse
12859288Criq1_mCitrobacter rodentium infection QTL 1 (mouse)151603380850033808Mouse
26884423Zlq10_mzygomatic length QTL 10, 16 week (mouse)152060000050900000Mouse
14928313Manh78_mmandible shape 78 (mouse)152148439755484397Mouse
12859289Criq3_mCitrobacter rodentium infection QTL 3 (mouse)152273036956730369Mouse
4142160Femwf10_mfemur work to failure 10 (mouse)Not determined2302961857029764Mouse
1301557Bbaa22_mB.burgdorferi-associated arthritis 22 (mouse)Not determined152459917658599409Mouse
1300967Bdt6_mbone density traits 6 (mouse)Not determined152543241059432532Mouse
4141409Radsvq1_mradiation sensitivity QTL 1 (mouse)Not determined2562158259621582Mouse
1301063Dob4_mdietary obesity 4 (mouse)4.3Body weightmesenteric152603559437781057Mouse
1301760Dob9_mdietary obesity 9 (mouse)Body fat amountadiposity index152603559437781057Mouse
1301345Bgeq14_mbody growth early QTL 14 (mouse)Not determined152644838460448484Mouse
1300772Bglq16_mbody growth late QTL 16 (mouse)Not determined152644838460448484Mouse
1357514Mbis3_mMycobacterium bovis-induced systemic lupus erythematosus 3 (mouse)Not determined162644838460448484Mouse
1301406Egrd2_mearly growth rate (mouse)Not determined152644838460448484Mouse
27226800Scvln20_msacral vertebrae length 2, 16 week (mouse)152660000066500000Mouse
1301450Bpq6_mblood pressure QTL 6 (mouse)Not determined152841925062419343Mouse
1357512Bsbob5_mBSB obesity 5 (mouse)Not determined152841925062419343Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800000102100000Mouse
26884392Humsd8_mhumerus midshaft diameter 8, 16 week (mouse)152930000076200000Mouse
26884452Sklq17_mskull length QTL 17, 16 week (mouse)153020000058100000Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578270103517472Mouse
1300578Cd8ts3_mCD8 T cell subset 3 (mouse)Not determined153414129868141408Mouse
12904003Opfaq12_mopen field activity QTL 12 (mouse)153435876538447657Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:202
Count of miRNA genes:164
Interacting mature miRNAs:181
Transcripts:ENSMUST00000022952
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000022952   ⟹   ENSMUSP00000022952
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1535,296,098 - 35,303,305 (+)Ensembl
RefSeq Acc Id: ENSMUST00000226838
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1535,296,098 - 35,297,684 (+)Ensembl
RefSeq Acc Id: ENSMUST00000227655
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1535,296,098 - 35,303,304 (+)Ensembl
RefSeq Acc Id: ENSMUST00000228152   ⟹   ENSMUSP00000154286
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1535,300,300 - 35,303,304 (+)Ensembl
RefSeq Acc Id: ENSMUST00000228684
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1535,296,111 - 35,302,940 (+)Ensembl
RefSeq Acc Id: NM_001368665   ⟹   NP_001355594
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391535,296,244 - 35,303,451 (+)NCBI
GRCm381535,296,098 - 35,303,305 (+)NCBI
Sequence:
RefSeq Acc Id: NM_054049   ⟹   NP_473390
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391535,296,244 - 35,303,451 (+)NCBI
GRCm381535,296,098 - 35,303,305 (+)NCBI
MGSCv371535,225,867 - 35,233,060 (+)RGD
Celera1535,916,195 - 35,923,389 (+)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_004938784
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391535,296,525 - 35,302,137 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_473390   ⟸   NM_054049
- Peptide Label: isoform 2
- UniProtKB: Q91ZD1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001355594   ⟸   NM_001368665
- Peptide Label: isoform 1
RefSeq Acc Id: ENSMUSP00000154286   ⟸   ENSMUST00000228152
RefSeq Acc Id: ENSMUSP00000022952   ⟸   ENSMUST00000022952

Promoters
RGD ID:6826293
Promoter ID:MM_KWN:18242
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   Brain,   Kidney,   Lung,   MEF_B4
Transcripts:ENSMUST00000022952
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361535,225,474 - 35,225,974 (+)MPROMDB
RGD ID:6826294
Promoter ID:MM_KWN:18243
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:UC007VMB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361535,230,274 - 35,230,774 (+)MPROMDB
RGD ID:8683570
Promoter ID:EPDNEW_M19816
Type:multiple initiation site
Name:Osr2_1
Description:Mus musculus odd-skipped related 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19817  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381535,296,098 - 35,296,158EPDNEW
RGD ID:8683572
Promoter ID:EPDNEW_M19817
Type:single initiation site
Name:Osr2_2
Description:Mus musculus odd-skipped related 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19816  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381535,299,408 - 35,299,468EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1930813 AgrOrtholog
Ensembl Genes ENSMUSG00000022330 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000022952 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000154286 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000022952 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000228152 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report mmu:107587 UniProtKB/Swiss-Prot
MGD MGI:1930813 ENTREZGENE
NCBI Gene 107587 ENTREZGENE
Pfam zf-C2H2 UniProtKB/Swiss-Prot
PhenoGen Osr2 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
SMART ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot
UniProt OSR2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q8BPV6 UniProtKB/Swiss-Prot
  Q91V54 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-10 Osr2  odd-skipped related 2  Osr2  odd-skipped related 2 (Drosophila)  Symbol and/or name change 5135510 APPROVED