Idh2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial) - Rat Genome Database

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Gene: Idh2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial) Mus musculus
Analyze
Symbol: Idh2
Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial
RGD ID: 1557355
MGI Page MGI
Description: Exhibits isocitrate dehydrogenase (NADP+) activity. Predicted to be involved in several processes, including NADP biosynthetic process; isocitrate metabolic process; and negative regulation of matrix metallopeptidase secretion. Localizes to cytosol and peroxisome. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; hepatocellular clear cell carcinoma; and intrahepatic cholangiocarcinoma. Orthologous to human IDH2 (isocitrate dehydrogenase (NADP(+)) 2); PARTICIPATES IN citric acid cycle pathway; glutathione metabolic pathway; INTERACTS WITH (N(omega)-L-arginino)succinic acid; (R)-carnitine; (R)-pantothenic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E430004F23; ICD-M; ID; IDH; Idh-; Idh-2; IDP; IDPm; isocitrate dehydrogenase [NADP], mitochondrial; NADP(+)-specific ICDH; NADP+-specific isocitrate dehydrogenase; oxalosuccinate decarboxylase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39779,744,594 - 79,768,356 (-)NCBIGRCm39mm39
GRCm39 Ensembl779,744,594 - 79,765,140 (-)Ensembl
GRCm38780,094,845 - 80,118,608 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,094,846 - 80,115,392 (-)EnsemblGRCm38mm10GRCm38
MGSCv37787,239,732 - 87,260,236 (-)NCBIGRCm37mm9NCBIm37
MGSCv36779,968,359 - 79,988,834 (-)NCBImm8
Celera777,493,303 - 77,513,823 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(N(omega)-L-arginino)succinic acid  (EXP)
(R)-adrenaline  (ISO)
(R)-carnitine  (EXP)
(R)-pantothenic acid  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2'-deoxycytosine 5'-monophosphate  (EXP)
2'-deoxyguanosine 5'-monophosphate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose 6-phosphate  (EXP)
2-hydroxyglutaric acid  (EXP)
2-hydroxypropanoic acid  (EXP)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-dehydrocarnitine  (EXP)
3-methylcholanthrene  (ISO)
3-phosphoglyceric acid  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(trimethylammonio)butanoate  (EXP)
5'-S-methyl-5'-thioadenosine  (EXP)
5-(hydroxymethyl)cytosine  (EXP)
7H-xanthine  (ISO)
9H-xanthine  (ISO)
acetamide  (ISO)
aconitic acid  (EXP)
acrylamide  (ISO)
adenosine  (EXP)
ADP  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine 6-phosphate  (EXP)
alendronic acid  (ISO)
alpha-D-glucose 1-phosphate  (EXP)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amiodarone  (EXP)
aristolochic acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (EXP)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-fructofuranose 1,6-bisphosphate  (EXP)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
bleomycin A2  (ISO)
butan-1-ol  (ISO)
carbon nanotube  (EXP)
choline  (EXP)
chromium(6+)  (EXP)
cisplatin  (ISO)
clobetasol  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
creatinine  (EXP)
cyclosporin A  (ISO)
cytidine  (EXP)
D-erythrose 4-phosphate  (EXP)
D-fructofuranose 1,6-bisphosphate  (EXP)
D-glyceric acid  (EXP)
diarsenic trioxide  (ISO)
diclofenac  (EXP)
dihydroxyacetone phosphate  (EXP)
diuron  (ISO)
doxorubicin  (EXP,ISO)
dTMP  (EXP)
endosulfan  (ISO)
ethanol  (EXP,ISO)
FMN  (EXP)
folic acid  (EXP,ISO)
GDP-alpha-D-glucose  (EXP)
glutathione  (EXP)
glyceric acid  (EXP)
glycerol 1-phosphate  (EXP)
glycine betaine  (EXP)
guanine  (EXP)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
keto-D-fructose 1,6-bisphosphate  (EXP)
L-alanine  (EXP)
L-methionine  (EXP)
lamivudine  (EXP)
malic acid  (EXP)
methapyrilene  (ISO)
methylisothiazolinone  (ISO)
monosodium L-glutamate  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methylnicotinamide  (EXP)
N-nitrosodiethylamine  (EXP)
NAD zwitterion  (EXP)
NAD(+)  (EXP)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
nickel dichloride  (ISO)
O-acetyl-L-carnitine  (EXP)
O-butanoyl-L-carnitine  (EXP)
oxybenzone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phlorizin  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prostaglandin A1  (EXP)
pyruvic acid  (EXP)
rac-lactic acid  (EXP)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
sedoheptulose 1,7-bisphosphate  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
sodium sulfide (anhydrous)  (ISO)
Soman  (ISO)
spermine  (EXP)
streptozocin  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
taurine  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
triazines  (EXP)
trilobatin  (ISO)
triptonide  (EXP)
trovafloxacin  (ISO)
tunicamycin  (ISO)
UDP  (EXP)
UDP-N-acetyl-alpha-D-glucosamine  (EXP)
uridine  (EXP)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
VX nerve agent  (ISO)
XL147  (EXP)
zidovudine  (EXP)
zoledronic acid  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Gano LB, etal., Free Radic Biol Med. 2018 Aug 1;123:116-124. doi: 10.1016/j.freeradbiomed.2018.05.063. Epub 2018 May 17.
2. Gong F, etal., Biochem Biophys Res Commun. 2019 Jun 30;514(3):593-600. doi: 10.1016/j.bbrc.2019.04.069. Epub 2019 May 4.
3. Han SJ, etal., Redox Biol. 2018 Apr;14:142-153. doi: 10.1016/j.redox.2017.09.003. Epub 2017 Sep 8.
4. Kim H, etal., Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2333-2341. doi: 10.1016/j.bbadis.2019.05.012. Epub 2019 May 20.
5. Liu WR, etal., J Exp Clin Cancer Res. 2014 Apr 10;33:32. doi: 10.1186/1756-9966-33-32.
6. Marcucci G, etal., J Clin Oncol. 2010 May 10;28(14):2348-55. doi: 10.1200/JCO.2009.27.3730. Epub 2010 Apr 5.
7. MGD data from the GO Consortium
8. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
9. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. OMIM Disease Annotation Pipeline
11. Pan JH, etal., Nutrients. 2018 May 27;10(6). pii: nu10060679. doi: 10.3390/nu10060679.
12. Pipeline to import KEGG annotations from KEGG into RGD
13. RGD automated import pipeline
14. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. RGD automated import pipeline for gene-chemical interactions
16. Wang F, etal., J Inherit Metab Dis. 2016 Nov;39(6):807-820. doi: 10.1007/s10545-016-9960-y. Epub 2016 Jul 28.
17. Wang P, etal., Oncogene. 2013 Jun 20;32(25):3091-100. doi: 10.1038/onc.2012.315. Epub 2012 Jul 23.
18. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
19. Willander K, etal., Biomark Res. 2014 Oct 8;2:18. doi: 10.1186/2050-7771-2-18. eCollection 2014.
20. Zhang H, etal., Med Oncol. 2014 Nov;31(11):278. doi: 10.1007/s12032-014-0278-z. Epub 2014 Oct 22.
Additional References at PubMed
PMID:75870   PMID:662012   PMID:752544   PMID:6375655   PMID:7323947   PMID:8867815   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11278619  
PMID:12477932   PMID:12865426   PMID:12904583   PMID:14610273   PMID:14681479   PMID:15489334   PMID:15522197   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16916647   PMID:17626619  
PMID:17967808   PMID:18275837   PMID:18554416   PMID:18614015   PMID:18799693   PMID:21873635   PMID:22416140   PMID:24065765   PMID:24194600   PMID:24240089   PMID:24440599   PMID:24642088  
PMID:25086359   PMID:25218477   PMID:25557279   PMID:25795706   PMID:25976245   PMID:26898144   PMID:27113764   PMID:27142242   PMID:27215380   PMID:27519270   PMID:27582470   PMID:27626380  
PMID:27821630   PMID:27956631   PMID:28193779   PMID:28245920   PMID:28415887   PMID:28554049   PMID:28928092   PMID:29391208   PMID:29456784   PMID:29527922   PMID:29567975   PMID:29660504  
PMID:29695796   PMID:29913148   PMID:29987482   PMID:30072100   PMID:30457570   PMID:30526058   PMID:30550785   PMID:30713523   PMID:30947518   PMID:31040226   PMID:31376482   PMID:31479775  
PMID:31503005   PMID:31546946   PMID:31578525   PMID:32325033   PMID:32764267   PMID:32900482  


Genomics

Comparative Map Data
Idh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39779,744,594 - 79,768,356 (-)NCBIGRCm39mm39
GRCm39 Ensembl779,744,594 - 79,765,140 (-)Ensembl
GRCm38780,094,845 - 80,118,608 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,094,846 - 80,115,392 (-)EnsemblGRCm38mm10GRCm38
MGSCv37787,239,732 - 87,260,236 (-)NCBIGRCm37mm9NCBIm37
MGSCv36779,968,359 - 79,988,834 (-)NCBImm8
Celera777,493,303 - 77,513,823 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.43NCBI
IDH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1590,083,045 - 90,102,477 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1590,083,045 - 90,102,504 (-)EnsemblGRCh38hg38GRCh38
GRCh381590,083,045 - 90,102,468 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371590,626,277 - 90,645,700 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361588,428,214 - 88,446,712 (-)NCBINCBI36hg18NCBI36
Build 341588,428,217 - 88,446,712NCBI
Celera1567,031,136 - 67,049,657 (-)NCBI
Cytogenetic Map15q26.1NCBI
HuRef1566,738,326 - 66,745,989 (-)NCBIHuRef
CHM1_11590,468,783 - 90,487,361 (-)NCBICHM1_1
Idh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21134,038,644 - 134,057,969 (-)NCBI
Rnor_6.0 Ensembl1141,866,283 - 141,893,705 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01141,874,354 - 141,893,674 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01142,830,040 - 142,849,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41135,876,052 - 135,895,373 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1126,099,085 - 126,118,402 (-)NCBICelera
Cytogenetic Map1q31NCBI
Idh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541615,197,366 - 15,223,363 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541615,197,611 - 15,212,919 (+)NCBIChiLan1.0ChiLan1.0
IDH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11587,972,883 - 87,991,270 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1587,972,889 - 87,991,276 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01568,771,050 - 68,790,523 (-)NCBIMhudiblu_PPA_v0panPan3
IDH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,070,462 - 53,077,566 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,070,695 - 53,087,496 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha355,708,523 - 55,724,976 (-)NCBI
ROS_Cfam_1.0353,486,432 - 53,502,992 (-)NCBI
UMICH_Zoey_3.1353,006,922 - 53,023,434 (-)NCBI
UNSW_CanFamBas_1.0353,217,752 - 53,234,294 (-)NCBI
UU_Cfam_GSD_1.0353,558,279 - 53,574,816 (-)NCBI
Idh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,470,218 - 130,488,711 (+)NCBI
SpeTri2.0NW_00493648315,845,777 - 15,864,341 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IDH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl755,651,606 - 55,681,426 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1755,654,298 - 55,675,571 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2760,539,333 - 60,549,480 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103231165
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,633,429 - 8,650,744 (-)NCBI
ChlSab1.1 Ensembl298,633,715 - 8,650,657 (-)Ensembl
Idh2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476817,094,649 - 17,111,333 (-)NCBI

Position Markers
Idh2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37787,239,826 - 87,240,017UniSTSGRCm37
Celera777,493,397 - 77,493,588UniSTS
Cytogenetic Map7D3UniSTS
cM Map741.0UniSTS
cM Map741.0UniSTS
Idh2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38780,094,940 - 80,095,131UniSTSGRCm38
MGSCv37787,239,826 - 87,240,017UniSTSGRCm37
Celera777,493,397 - 77,493,588UniSTS
Cytogenetic Map7D3UniSTS
cM Map741.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7346321287493512Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76500000133900000Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718994869119886157Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3033306081485905Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730500000109400000Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73658059092745138Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736580590116817642Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73760000087400000Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined740024463103860803Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745512542119094307Mouse
1302141Fcsa6_mfemoral cross-sectional area 6 (mouse)Not determined74873471382734859Mouse
11532741Tbrs5_mtuberculosis resistance 5 (mouse)74950947983586207Mouse
1357752Tabw_mtally ho asscoiated body weight (mouse)Not determined74954353083543642Mouse
10054064Bwq11_mbody weight QTL 11 (mouse)Not determined75147520685475345Mouse
10053685Eae43_mexperimental allergic encephalomyelitis susceptibility 43 (mouse)Not determined75147520685475345Mouse
13208555Lgth10_mbody length 10 (mouse)752000000126000000Mouse
12880418V125Dq6_mvitamin D active form serum level QTL 6 (mouse)75250000086500000Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753600000143600000Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)755169841117223580Mouse
11565101Tsve1_mvariable short tail (Tsv) enhancer 1 (mouse)75623976087493512Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)757300000134400000Mouse
1300952Hcs1_mhepatocarcinogenesis susceptibility 1 (mouse)Not determined75767637391676604Mouse
1301465Egrm3_mearly growth rate (mouse)Not determined75767637391676604Mouse
1301663Skull9_mskull morphology 9 (mouse)Not determined75767637391676604Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)762100000121800000Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)762100000124100000Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)762200000103100000Mouse
1301383Aem2_manti-erythrocyte autoantibody modifier 2 (mouse)Not determined76448567698485905Mouse
26884381Bzwq2_mbi-zygomatic width QTL 2, 5 week (mouse)76560000097300000Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765600000126900000Mouse
11553865Stmm1c_mskin tumor modifier of MSM 1c (mouse)766139778100139778Mouse
11553866Stmm1d_mskin tumor modifier of MSM 1d (mouse)766139778100139778Mouse
27095937Ulnl7_mulna length 7, 10 week (mouse)76680000098700000Mouse
12801463Rta1_mretinal aging 1 (mouse)76751827989440781Mouse
1301784Ses2_msalmonella enteritidis susceptibility 2 (mouse)Not determined767640886101641032Mouse
1301826Pgia3_mproteoglycan induced arthritis 3 (mouse)Not determined767640886101641032Mouse
1300620Pgia21_mproteoglycan induced arthritis 21 (mouse)Not determined767640886101641032Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)768200000105800000Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)768200000119900000Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)768200000124600000Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)768200000125400000Mouse
1300654Bomd1_mbone mineral density 1 (mouse)Not determined768716387102716494Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)770300000120900000Mouse
1301155Bpq7_mblood pressure QTL 7 (mouse)Not determined770493929104494171Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772614164106614164Mouse
4142319Powg_mpost-ovarectomy weight gain (mouse)Not determined7320735792932955Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773400000126100000Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773500000143600000Mouse
11553869Stmm2b_mskin tumor modifier of MSM 2a (mouse)774076757108076757Mouse
4142212Png1_mPostnatal growth 1 (mouse)Not determined7467637392745138Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)775200000122600000Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)775200000122600000Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775745007109745138Mouse
14746989Manh62_mmandible shape 62 (mouse)776093321110093321Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)779000000137300000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:902
Count of miRNA genes:446
Interacting mature miRNAs:524
Transcripts:ENSMUST00000107384, ENSMUST00000125542, ENSMUST00000134070, ENSMUST00000134328, ENSMUST00000139178, ENSMUST00000156761
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_173011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006540911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003946485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC164075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF212319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK033086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ747924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY311397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000107384   ⟹   ENSMUSP00000103007
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl780,094,846 - 80,115,392 (-)Ensembl
RefSeq Acc Id: ENSMUST00000125542   ⟹   ENSMUSP00000145852
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl780,096,028 - 80,100,881 (-)Ensembl
RefSeq Acc Id: ENSMUST00000134070
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl780,098,166 - 80,099,139 (-)Ensembl
RefSeq Acc Id: ENSMUST00000134328   ⟹   ENSMUSP00000118184
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl780,094,850 - 80,115,332 (-)Ensembl
RefSeq Acc Id: ENSMUST00000139178
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl780,095,029 - 80,098,409 (-)Ensembl
RefSeq Acc Id: ENSMUST00000156761
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl780,095,043 - 80,096,029 (-)Ensembl
RefSeq Acc Id: ENSMUST00000206714   ⟹   ENSMUSP00000146084
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl780,095,059 - 80,115,304 (-)Ensembl
RefSeq Acc Id: NM_173011   ⟹   NP_766599
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39779,744,594 - 79,765,098 (-)NCBI
GRCm38780,094,846 - 80,115,350 (-)NCBI
MGSCv37787,239,732 - 87,260,236 (-)RGD
Celera777,493,303 - 77,513,823 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006540911   ⟹   XP_006540974
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39779,746,364 - 79,768,356 (-)NCBI
GRCm38780,096,616 - 80,118,608 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003946485
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39779,744,599 - 79,768,356 (-)NCBI
GRCm38780,094,845 - 80,118,608 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_766599   ⟸   NM_173011
- Peptide Label: precursor
- UniProtKB: P54071 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006540974   ⟸   XM_006540911
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000145852   ⟸   ENSMUST00000125542
RefSeq Acc Id: ENSMUSP00000146084   ⟸   ENSMUST00000206714
RefSeq Acc Id: ENSMUSP00000103007   ⟸   ENSMUST00000107384
RefSeq Acc Id: ENSMUSP00000118184   ⟸   ENSMUST00000134328
Protein Domains
Iso_dh

Promoters
RGD ID:8664541
Promoter ID:EPDNEW_M10302
Type:initiation region
Name:Idh2_1
Description:Mus musculus isocitrate dehydrogenase 2 (NADP+), mitochondrial, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38780,115,318 - 80,115,378EPDNEW
RGD ID:6841312
Promoter ID:MM_KWN:51266
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000061461
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36787,240,601 - 87,241,682 (-)MPROMDB
RGD ID:6841314
Promoter ID:MM_KWN:51267
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000061460,   UC009HZM.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36787,242,701 - 87,243,767 (-)MPROMDB
RGD ID:6841310
Promoter ID:MM_KWN:51268
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain
Transcripts:OTTMUST00000061459
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36787,244,509 - 87,245,009 (-)MPROMDB
RGD ID:6841308
Promoter ID:MM_KWN:51269
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Kidney
Transcripts:OTTMUST00000061458
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36787,245,431 - 87,246,702 (-)MPROMDB
RGD ID:6841307
Promoter ID:MM_KWN:51270
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000061676,   OTTMUST00000061456,   OTTMUST00000061457
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36787,259,826 - 87,260,357 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96414 AgrOrtholog
Ensembl Genes ENSMUSG00000030541 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000103007 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000118184 UniProtKB/TrEMBL
  ENSMUSP00000145852 UniProtKB/TrEMBL
  ENSMUSP00000146084 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000107384 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000125542 UniProtKB/TrEMBL
  ENSMUST00000134328 UniProtKB/TrEMBL
  ENSMUST00000206714 UniProtKB/TrEMBL
InterPro IsoCit/isopropylmalate_DH_CS UniProtKB/Swiss-Prot
  Isocitrate_DH_NADP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IsoPropMal-DH-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:269951 UniProtKB/Swiss-Prot
MGD MGI:96414 ENTREZGENE
NCBI Gene 269951 ENTREZGENE
PANTHER PTHR11822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Iso_dh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Idh2 PhenoGen
PIRSF IDH_NADP UniProtKB/Swiss-Prot
PROSITE IDH_IMDH UniProtKB/Swiss-Prot
SMART Iso_dh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs nadp_idh_euk UniProtKB/Swiss-Prot
UniProt A0A0U1RP68_MOUSE UniProtKB/TrEMBL
  A0A0U1RPR1_MOUSE UniProtKB/TrEMBL
  D6RIL6_MOUSE UniProtKB/TrEMBL
  IDHP_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q8C2R9 UniProtKB/Swiss-Prot
  Q9EQK1 UniProtKB/Swiss-Prot