Idh2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial) - Rat Genome Database

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Gene: Idh2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial) Mus musculus
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Symbol: Idh2
Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial
RGD ID: 1557355
MGI Page MGI
Description: Enables isocitrate dehydrogenase (NADP+) activity. Predicted to be involved in several processes, including NADP biosynthetic process; carboxylic acid metabolic process; and negative regulation of matrix metallopeptidase secretion. Located in cytosol and peroxisome. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study bone remodeling disease. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; carcinoma (multiple); and lung cancer (multiple). Orthologous to human IDH2 (isocitrate dehydrogenase (NADP(+)) 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E430004F23; ICD-M; ID; IDH; Idh-; Idh-2; IDP; IDPm; isocitrate dehydrogenase [NADP], mitochondrial; NADP(+)-specific ICDH; NADP+-specific isocitrate dehydrogenase; oxalosuccinate decarboxylase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39779,744,594 - 79,768,356 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl779,744,594 - 79,765,140 (-)EnsemblGRCm39 Ensembl
GRCm38780,094,845 - 80,118,608 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,094,846 - 80,115,392 (-)EnsemblGRCm38mm10GRCm38
MGSCv37787,239,732 - 87,260,236 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36779,968,359 - 79,988,834 (-)NCBIMGSCv36mm8
Celera777,493,303 - 77,513,823 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
2-hydroxyglutaric aciduria  (ISO)
acute myeloid leukemia  (ISO)
acute myocardial infarction  (ISO)
acute promyelocytic leukemia  (ISO)
Animal Disease Models  (ISO)
Bloom syndrome  (ISO)
bone remodeling disease  (IAGP)
Brain Neoplasms  (ISO)
Cardiomegaly  (ISO)
central nervous system disease  (ISO)
Chemical and Drug Induced Liver Injury  (IMP)
cholangiocarcinoma  (ISO)
chondroma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Craniofacial Abnormalities  (ISO)
D-2-hydroxyglutaric aciduria  (IMP)
D-2-hydroxyglutaric aciduria 2  (ISO)
esophagus squamous cell carcinoma  (ISO)
genetic disease  (ISO)
Growth Disorders  (ISO)
head and neck squamous cell carcinoma  (ISO)
hemangioma  (ISO)
hepatocellular carcinoma  (ISO)
hepatocellular clear cell carcinoma  (ISO)
hereditary lymphedema  (ISO)
high grade glioma  (ISO)
hydronephrosis  (ISO)
hypertrophic cardiomyopathy  (ISO)
Immunoblastic Lymphadenopathy  (ISO)
intrahepatic cholangiocarcinoma  (IEP,ISO)
kidney failure  (ISO)
Liver Reperfusion Injury  (IMP)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
metabolic dysfunction-associated steatohepatitis  (IMP)
Metabolic Syndrome  (IMP)
multiple myeloma  (ISO)
myelodysplastic syndrome  (ISO)
Neoplasm Recurrence, Local  (ISO)
non-alcoholic fatty liver  (IMP)
oligodendroglioma  (ISO)
Ollier disease  (ISO)
osteoarthritis  (ISO)
osteochondrodysplasia  (ISO)
osteoporosis  (ISO)
Paraproteinemias  (ISO)
peripheral T-cell lymphoma  (ISO)
plasma cell neoplasm  (ISO)
status epilepticus  (ISO)
stomach cancer  (ISO)
teratoma  (ISO)
Vascular Malformations  (ISO)
Ventricular Dysfunction, Left  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
(N(omega)-L-arginino)succinic acid  (EXP)
(R)-adrenaline  (ISO)
(R)-carnitine  (EXP)
(R)-pantothenic acid  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2'-deoxycytosine 5'-monophosphate  (EXP)
2'-deoxyguanosine 5'-monophosphate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-amino-2-deoxy-D-glucopyranose 6-phosphate  (EXP)
2-bromohexadecanoic acid  (ISO)
2-hydroxyglutaric acid  (EXP)
2-hydroxypropanoic acid  (EXP)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-dehydrocarnitine  (EXP)
3-methylcholanthrene  (ISO)
3-phosphoglyceric acid  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(trimethylammonio)butanoate  (EXP)
5'-S-methyl-5'-thioadenosine  (EXP)
5-(hydroxymethyl)cytosine  (EXP)
6-propyl-2-thiouracil  (ISO)
7H-xanthine  (ISO)
8-Epidiosbulbin E acetate  (EXP)
9H-xanthine  (ISO)
acetamide  (ISO)
aconitic acid  (EXP)
acrylamide  (ISO)
adenosine  (EXP)
ADP  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine 6-phosphate  (EXP)
alendronic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-D-glucose 1-phosphate  (EXP)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amiodarone  (EXP)
amitrole  (ISO)
aristolochic acid A  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (EXP)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-fructofuranose 1,6-bisphosphate  (EXP)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
choline  (EXP)
chromium(6+)  (EXP,ISO)
cisplatin  (ISO)
clobetasol  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
creatinine  (EXP)
Cuprizon  (ISO)
cyclosporin A  (ISO)
cytidine  (EXP)
D-erythrose 4-phosphate  (EXP)
D-fructofuranose 1,6-bisphosphate  (EXP)
D-glyceric acid  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (EXP)
dihydroxyacetone phosphate  (EXP)
Diosbulbin B  (EXP)
diuron  (ISO)
doxorubicin  (EXP,ISO)
dTMP  (EXP)
endosulfan  (ISO)
ethanol  (EXP,ISO)
FMN  (EXP)
folic acid  (EXP,ISO)
GDP-alpha-D-glucose  (EXP)
glutathione  (EXP)
glyceric acid  (EXP)
glycerol 1-phosphate  (EXP)
glycine betaine  (EXP)
glyphosate  (EXP)
guanine  (EXP)
Honokiol  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
indometacin  (ISO)
inulin  (EXP)
ivermectin  (ISO)
keto-D-fructose 1,6-bisphosphate  (EXP)
L-alanine  (EXP)
L-methionine  (EXP)
lamivudine  (EXP)
malic acid  (EXP)
methapyrilene  (ISO)
methimazole  (ISO)
methylisothiazolinone  (ISO)
monosodium L-glutamate  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methylnicotinamide  (EXP)
N-nitrosodiethylamine  (EXP)
NAD zwitterion  (EXP)
NAD(+)  (EXP)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
nickel dichloride  (ISO)
O-acetyl-L-carnitine  (EXP)
O-butanoyl-L-carnitine  (EXP)
oxybenzone  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (ISO)
phlorizin  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prostaglandin A1  (EXP)
pyruvic acid  (EXP)
rac-lactic acid  (EXP)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
SB 431542  (ISO)
sedoheptulose 1,7-bisphosphate  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP,ISO)
sodium sulfide (anhydrous)  (ISO)
Soman  (ISO)
spermine  (EXP)
streptozocin  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
taurine  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
triazines  (EXP)
trilobatin  (ISO)
triptonide  (EXP)
trovafloxacin  (EXP,ISO)
tunicamycin  (ISO)
UDP  (EXP)
UDP-N-acetyl-alpha-D-glucosamine  (EXP)
uridine  (EXP)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vosaroxin  (ISO)
VX nerve agent  (ISO)
XL147  (EXP)
zidovudine  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Difference in driver gene expression patterns between perihilar and peripheral intrahepatic cholangiocarcinoma in an experimental mouse model. Adachi T, etal., J Hepatobiliary Pancreat Sci. 2020 Aug;27(8):477-486. doi: 10.1002/jhbp.772. Epub 2020 Jul 13.
2. Isocitrate dehydrogenase 2 contributes to radiation resistance of oesophageal squamous cell carcinoma via regulating mitochondrial function and ROS/pAKT signalling. Chen X, etal., Br J Cancer. 2020 Jul;123(1):126-136. doi: 10.1038/s41416-020-0852-4. Epub 2020 May 5.
3. Robust quantitative assessments of cytosine modifications and changes in the expressions of related enzymes in gastric cancer. Du C, etal., Gastric Cancer. 2015 Jul;18(3):516-25. doi: 10.1007/s10120-014-0409-4. Epub 2014 Aug 7.
4. Altered mitochondrial acetylation profiles in a kainic acid model of temporal lobe epilepsy. Gano LB, etal., Free Radic Biol Med. 2018 Aug 1;123:116-124. doi: 10.1016/j.freeradbiomed.2018.05.063. Epub 2018 May 17.
5. IDH2 protects against nonalcoholic steatohepatitis by alleviating dyslipidemia regulated by oxidative stress. Gong F, etal., Biochem Biophys Res Commun. 2019 Jun 30;514(3):593-600. doi: 10.1016/j.bbrc.2019.04.069. Epub 2019 May 4.
6. Genetic variants in genes of tricarboxylic acid cycle key enzymes are associated with prognosis of patients with non-small cell lung cancer. Guo X, etal., Lung Cancer. 2015 Feb;87(2):162-8. doi: 10.1016/j.lungcan.2014.12.005. Epub 2014 Dec 18.
7. IDH2 deficiency increases the liver susceptibility to ischemia-reperfusion injury via increased mitochondrial oxidative injury. Han SJ, etal., Redox Biol. 2018 Apr;14:142-153. doi: 10.1016/j.redox.2017.09.003. Epub 2017 Sep 8.
8. IDH2 deficiency exacerbates acetaminophen hepatotoxicity in mice via mitochondrial dysfunction-induced apoptosis. Kim H, etal., Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2333-2341. doi: 10.1016/j.bbadis.2019.05.012. Epub 2019 May 20.
9. Amelioration of late-onset hepatic steatosis in IDH2-deficient mice. Lee SJ, etal., Free Radic Res. 2017 Apr;51(4):368-374. doi: 10.1080/10715762.2017.1320554. Epub 2017 May 5.
10. A new functional IDH2 genetic variant is associated with the risk of lung cancer. Li J, etal., Mol Carcinog. 2017 Mar;56(3):1082-1087. doi: 10.1002/mc.22573. Epub 2016 Oct 24.
11. Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1α in lung cancer. Li J, etal., Theranostics. 2018 Jul 16;8(15):4050-4061. doi: 10.7150/thno.21524. eCollection 2018.
12. IDH2 is a novel diagnostic and prognostic serum biomarker for non-small-cell lung cancer. Li JJ, etal., Mol Oncol. 2018 May;12(5):602-610. doi: 10.1002/1878-0261.12182. Epub 2018 Mar 25.
13. High expression of 5-hydroxymethylcytosine and isocitrate dehydrogenase 2 is associated with favorable prognosis after curative resection of hepatocellular carcinoma. Liu WR, etal., J Exp Clin Cancer Res. 2014 Apr 10;33:32. doi: 10.1186/1756-9966-33-32.
14. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. Marcucci G, etal., J Clin Oncol. 2010 May 10;28(14):2348-55. doi: 10.1200/JCO.2009.27.3730. Epub 2010 Apr 5.
15. MGDs mouse GO annotations MGD data from the GO Consortium
16. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
17. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. IDH2 Deficiency Aggravates Fructose-Induced NAFLD by Modulating Hepatic Fatty Acid Metabolism and Activating Inflammatory Signaling in Female Mice. Pan JH, etal., Nutrients. 2018 May 27;10(6). pii: nu10060679. doi: 10.3390/nu10060679.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. Mouse MP Annotation Import Pipeline RGD automated import pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model. Wang F, etal., J Inherit Metab Dis. 2016 Nov;39(6):807-820. doi: 10.1007/s10545-016-9960-y. Epub 2016 Jul 28.
25. Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas. Wang P, etal., Oncogene. 2013 Jun 20;32(25):3091-100. doi: 10.1038/onc.2012.315. Epub 2012 Jul 23.
26. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
27. Mutations in the isocitrate dehydrogenase 2 gene and IDH1 SNP 105C > T have a prognostic value in acute myeloid leukemia. Willander K, etal., Biomark Res. 2014 Oct 8;2:18. doi: 10.1186/2050-7771-2-18. eCollection 2014.
28. Genetic variations in IDH gene as prognosis predictors in TACE-treated hepatocellular carcinoma patients. Zhang H, etal., Med Oncol. 2014 Nov;31(11):278. doi: 10.1007/s12032-014-0278-z. Epub 2014 Oct 22.
Additional References at PubMed
PMID:75870   PMID:662012   PMID:752544   PMID:6375655   PMID:7323947   PMID:8867815   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11278619  
PMID:12477932   PMID:12865426   PMID:12904583   PMID:14610273   PMID:14681479   PMID:15489334   PMID:15522197   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16916647   PMID:17626619  
PMID:17967808   PMID:18275837   PMID:18554416   PMID:18614015   PMID:18799693   PMID:21873635   PMID:22416140   PMID:24065765   PMID:24194600   PMID:24240089   PMID:24440599   PMID:24642088  
PMID:25086359   PMID:25218477   PMID:25557279   PMID:25795706   PMID:25976245   PMID:26898144   PMID:27113764   PMID:27142242   PMID:27215380   PMID:27519270   PMID:27582470   PMID:27626380  
PMID:27821630   PMID:27956631   PMID:28193779   PMID:28245920   PMID:28554049   PMID:28928092   PMID:29391208   PMID:29456784   PMID:29527922   PMID:29567975   PMID:29660504   PMID:29695796  
PMID:29913148   PMID:29987482   PMID:30072100   PMID:30457570   PMID:30526058   PMID:30550785   PMID:30713523   PMID:30947518   PMID:31040226   PMID:31376482   PMID:31479775   PMID:31503005  
PMID:31546946   PMID:31578525   PMID:31932841   PMID:32203468   PMID:32325033   PMID:32764267   PMID:32900482   PMID:33219380   PMID:34163022   PMID:34315110   PMID:34516556   PMID:34997121  
PMID:35012549   PMID:35091680   PMID:35995176   PMID:36063728   PMID:36130994   PMID:36220812   PMID:36417873   PMID:36652477   PMID:36736318   PMID:37044373   PMID:37142655   PMID:37839992  
PMID:38281628   PMID:38355793   PMID:39256649  


Genomics

Comparative Map Data
Idh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39779,744,594 - 79,768,356 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl779,744,594 - 79,765,140 (-)EnsemblGRCm39 Ensembl
GRCm38780,094,845 - 80,118,608 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,094,846 - 80,115,392 (-)EnsemblGRCm38mm10GRCm38
MGSCv37787,239,732 - 87,260,236 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36779,968,359 - 79,988,834 (-)NCBIMGSCv36mm8
Celera777,493,303 - 77,513,823 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.43NCBI
IDH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381590,083,045 - 90,102,468 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1590,083,045 - 90,102,477 (-)EnsemblGRCh38hg38GRCh38
GRCh371590,626,277 - 90,645,700 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361588,428,214 - 88,446,712 (-)NCBINCBI36Build 36hg18NCBI36
Build 341588,428,217 - 88,446,712NCBI
Celera1567,031,136 - 67,049,657 (-)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1566,738,326 - 66,745,989 (-)NCBIHuRef
CHM1_11590,468,783 - 90,487,283 (-)NCBICHM1_1
T2T-CHM13v2.01587,839,072 - 87,858,500 (-)NCBIT2T-CHM13v2.0
Idh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,447,925 - 143,467,248 (-)NCBIGRCr8
mRatBN7.21134,038,644 - 134,057,969 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,029,772 - 134,058,025 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1141,947,731 - 141,967,051 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,117,130 - 149,136,466 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,034,887 - 142,054,220 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01141,874,354 - 141,893,674 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1141,866,283 - 141,893,705 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01142,830,040 - 142,849,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41135,876,052 - 135,895,373 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1126,099,085 - 126,118,402 (-)NCBICelera
Cytogenetic Map1q31NCBI
Idh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541615,197,366 - 15,223,363 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541615,197,611 - 15,212,919 (+)NCBIChiLan1.0ChiLan1.0
IDH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21679,630,229 - 79,649,755 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11583,330,550 - 83,349,140 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01568,771,050 - 68,790,523 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11587,972,883 - 87,991,270 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1587,972,889 - 87,991,276 (-)Ensemblpanpan1.1panPan2
IDH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,070,462 - 53,077,566 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,070,695 - 53,087,496 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha355,708,523 - 55,724,976 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0353,486,432 - 53,502,992 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,486,432 - 53,503,494 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,006,922 - 53,023,434 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,217,752 - 53,234,294 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0353,558,279 - 53,574,816 (-)NCBIUU_Cfam_GSD_1.0
Idh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,470,218 - 130,488,711 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648315,845,792 - 15,864,341 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648315,845,777 - 15,864,341 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IDH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl755,651,609 - 55,675,554 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1755,654,298 - 55,675,571 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2760,539,333 - 60,549,480 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103231165
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,633,429 - 8,650,744 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl298,633,715 - 8,650,657 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605938,130,227 - 38,147,558 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Idh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476817,094,655 - 17,111,397 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476817,094,649 - 17,111,333 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Idh2
588 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:902
Count of miRNA genes:446
Interacting mature miRNAs:524
Transcripts:ENSMUST00000107384, ENSMUST00000125542, ENSMUST00000134070, ENSMUST00000134328, ENSMUST00000139178, ENSMUST00000156761
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)774849748122199223Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)761849748102749207Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
26884381Bzwq2_mbi-zygomatic width QTL 2, 5 week (mouse)76524974896949207Mouse
1301784Ses2_msalmonella enteritidis susceptibility 2 (mouse)Not determined767290094101290240Mouse
1301663Skull9_mskull morphology 9 (mouse)Not determined75732612191326352Mouse
14746989Manh62_mmandible shape 62 (mouse)775742528109742528Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
1301383Aem2_manti-erythrocyte autoantibody modifier 2 (mouse)Not determined76413542498135653Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
27095937Ulnl7_mulna length 7, 10 week (mouse)76644974898349207Mouse
11565101Tsve1_mvariable short tail (Tsv) enhancer 1 (mouse)75588950887142720Mouse
1300620Pgia21_mproteoglycan induced arthritis 21 (mouse)Not determined767290094101290240Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
10054064Bwq11_mbody weight QTL 11 (mouse)Not determined75112495485125093Mouse
1357752Tabw_mtally ho asscoiated body weight (mouse)Not determined74919327883193390Mouse
10053685Eae43_mexperimental allergic encephalomyelitis susceptibility 43 (mouse)Not determined75112495485125093Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775394215109394346Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301155Bpq7_mblood pressure QTL 7 (mouse)Not determined770143137104143379Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
4142212Png1_mPostnatal growth 1 (mouse)Not determined7432612192394346Mouse
1300654Bomd1_mbone mineral density 1 (mouse)Not determined768365595102365702Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)767849748119499223Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)767849748124199223Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
1301465Egrm3_mearly growth rate (mouse)Not determined75732612191326352Mouse
1300952Hcs1_mhepatocarcinogenesis susceptibility 1 (mouse)Not determined75732612191326352Mouse
4142319Powg_mpost-ovarectomy weight gain (mouse)Not determined7285710592582163Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301826Pgia3_mproteoglycan induced arthritis 3 (mouse)Not determined767290094101290240Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3003248581135653Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)767849748105449207Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772263372106263372Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
12880418V125Dq6_mvitamin D active form serum level QTL 6 (mouse)75214974886149748Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)774849748122199223Mouse
11532741Tbrs5_mtuberculosis resistance 5 (mouse)74915922783235415Mouse
1302141Fcsa6_mfemoral cross-sectional area 6 (mouse)Not determined74838446182384607Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
13513916Heal53_mwound healing/ regeneration 53 (mouse)77945491380630796Mouse
12801463Rta1_mretinal aging 1 (mouse)76716802789089989Mouse
11553865Stmm1c_mskin tumor modifier of MSM 1c (mouse)76578898699788986Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)767849748124999172Mouse
11553866Stmm1d_mskin tumor modifier of MSM 1d (mouse)76578898699788986Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773049748125699172Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73729942587049208Mouse
11553869Stmm2b_mskin tumor modifier of MSM 2a (mouse)773725965107725965Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)769949748120499223Mouse

Markers in Region
Idh2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37787,239,826 - 87,240,017UniSTSGRCm37
Celera777,493,397 - 77,493,588UniSTS
Cytogenetic Map7D3UniSTS
cM Map741.0UniSTS
cM Map741.0UniSTS
Idh2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38780,094,940 - 80,095,131UniSTSGRCm38
MGSCv37787,239,826 - 87,240,017UniSTSGRCm37
Celera777,493,397 - 77,493,588UniSTS
Cytogenetic Map7D3UniSTS
cM Map741.0UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_173011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006540911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003946485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC164075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF212319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK033086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ747924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY311397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000107384   ⟹   ENSMUSP00000103007
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,744,594 - 79,765,140 (-)Ensembl
GRCm38.p6 Ensembl780,094,846 - 80,115,392 (-)Ensembl
Ensembl Acc Id: ENSMUST00000125542   ⟹   ENSMUSP00000145852
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,745,776 - 79,750,629 (-)Ensembl
GRCm38.p6 Ensembl780,096,028 - 80,100,881 (-)Ensembl
Ensembl Acc Id: ENSMUST00000134070
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,747,914 - 79,748,887 (-)Ensembl
GRCm38.p6 Ensembl780,098,166 - 80,099,139 (-)Ensembl
Ensembl Acc Id: ENSMUST00000134328   ⟹   ENSMUSP00000118184
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,744,598 - 79,765,080 (-)Ensembl
GRCm38.p6 Ensembl780,094,850 - 80,115,332 (-)Ensembl
Ensembl Acc Id: ENSMUST00000139178
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,744,777 - 79,748,157 (-)Ensembl
GRCm38.p6 Ensembl780,095,029 - 80,098,409 (-)Ensembl
Ensembl Acc Id: ENSMUST00000156761
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,744,791 - 79,745,777 (-)Ensembl
GRCm38.p6 Ensembl780,095,043 - 80,096,029 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206714   ⟹   ENSMUSP00000146084
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,744,807 - 79,765,052 (-)Ensembl
GRCm38.p6 Ensembl780,095,059 - 80,115,304 (-)Ensembl
RefSeq Acc Id: NM_173011   ⟹   NP_766599
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39779,744,594 - 79,765,098 (-)NCBI
GRCm38780,094,846 - 80,115,350 (-)NCBI
MGSCv37787,239,732 - 87,260,236 (-)RGD
Celera777,493,303 - 77,513,823 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006540911   ⟹   XP_006540974
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39779,746,364 - 79,768,356 (-)NCBI
GRCm38780,096,616 - 80,118,608 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003946485
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39779,744,599 - 79,768,356 (-)NCBI
GRCm38780,094,845 - 80,118,608 (-)NCBI
Sequence:
RefSeq Acc Id: NP_766599   ⟸   NM_173011
- Peptide Label: precursor
- UniProtKB: P54071 (UniProtKB/Swiss-Prot),   Q9EQK1 (UniProtKB/Swiss-Prot),   Q8C2R9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006540974   ⟸   XM_006540911
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000145852   ⟸   ENSMUST00000125542
Ensembl Acc Id: ENSMUSP00000146084   ⟸   ENSMUST00000206714
Ensembl Acc Id: ENSMUSP00000103007   ⟸   ENSMUST00000107384
Ensembl Acc Id: ENSMUSP00000118184   ⟸   ENSMUST00000134328
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54071-F1-model_v2 AlphaFold P54071 1-452 view protein structure

Promoters
RGD ID:8664541
Promoter ID:EPDNEW_M10302
Type:initiation region
Name:Idh2_1
Description:Mus musculus isocitrate dehydrogenase 2 (NADP+), mitochondrial, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38780,115,318 - 80,115,378EPDNEW
RGD ID:6841312
Promoter ID:MM_KWN:51266
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000061461
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36787,240,601 - 87,241,682 (-)MPROMDB
RGD ID:6841314
Promoter ID:MM_KWN:51267
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000061460,   UC009HZM.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36787,242,701 - 87,243,767 (-)MPROMDB
RGD ID:6841310
Promoter ID:MM_KWN:51268
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain
Transcripts:OTTMUST00000061459
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36787,244,509 - 87,245,009 (-)MPROMDB
RGD ID:6841308
Promoter ID:MM_KWN:51269
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Kidney
Transcripts:OTTMUST00000061458
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36787,245,431 - 87,246,702 (-)MPROMDB
RGD ID:6841307
Promoter ID:MM_KWN:51270
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000061676,   OTTMUST00000061456,   OTTMUST00000061457
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36787,259,826 - 87,260,357 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96414 AgrOrtholog
Ensembl Genes ENSMUSG00000030541 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000107384 ENTREZGENE
  ENSMUST00000107384.10 UniProtKB/Swiss-Prot
  ENSMUST00000125542.3 UniProtKB/TrEMBL
  ENSMUST00000134328.8 UniProtKB/TrEMBL
  ENSMUST00000206714.2 UniProtKB/TrEMBL
Gene3D-CATH Isopropylmalate Dehydrogenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IsoCit/isopropylmalate_DH_CS UniProtKB/Swiss-Prot
  Isocitrate_DH_NADP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IsoPropMal-DH-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:269951 UniProtKB/Swiss-Prot
MGD MGI:96414 ENTREZGENE
NCBI Gene Idh2 ENTREZGENE
PANTHER ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Iso_dh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Idh2 PhenoGen
PIRSF IDH_NADP UniProtKB/Swiss-Prot
PROSITE IDH_IMDH UniProtKB/Swiss-Prot
SMART Iso_dh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Isocitrate/Isopropylmalate dehydrogenase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U1RP68_MOUSE UniProtKB/TrEMBL
  A0A0U1RPR1_MOUSE UniProtKB/TrEMBL
  D6RIL6_MOUSE UniProtKB/TrEMBL
  IDHP_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8C2R9 ENTREZGENE
  Q9EQK1 ENTREZGENE
UniProt Secondary Q8C2R9 UniProtKB/Swiss-Prot
  Q9EQK1 UniProtKB/Swiss-Prot