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Gene: Mlph (melanophilin) Mus musculus
Symbol: Mlph
Name: melanophilin
Description: Exhibits Rab GTPase binding activity and cytoskeletal protein binding activity. Involved in melanocyte differentiation; melanosome localization; and protein targeting. Localizes to the cytoskeleton and melanosome. Colocalizes with the microtubule plus-end. Human ortholog(s) of this gene implicated in Griscelli syndrome type 3. Is expressed in several structures, including genitourinary system; gut; liver; lung; and spleen. Orthologous to human MLPH (melanophilin); INTERACTS WITH 1,1-dichloroethene; 4-hydroxyphenyl retinamide; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2210418F23Rik; 5031433I09Rik; AW228792; D1Wsu84e; exophilin-3; l(1)-3Rk; l1Rk3; leaden protein; ln; Slac-2a; slaC2-a; slp homolog lacking C2 domains a; synaptotagmin-like protein 2a
Homo sapiens (human) : MLPH (melanophilin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mlph (melanophilin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mlph (melanophilin)
Pan paniscus (bonobo/pygmy chimpanzee) : MLPH (melanophilin)
Canis lupus familiaris (dog) : MLPH (melanophilin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mlph (melanophilin)
Sus scrofa (pig) : MLPH (melanophilin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl190,915,085 - 90,951,142 (+)Ensembl
GRCm38190,915,024 - 90,951,142 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37192,811,677 - 92,847,719 (+)NCBIGRCm37mm9NCBIm37
MGSCv36192,745,513 - 92,780,165 (+)NCBImm8
Celera193,860,662 - 93,896,365 (+)NCBICelera
Cytogenetic Map1 DNCBI
cM Map145.73NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Mlph
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1321809
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.