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Gene: Prps1 (phosphoribosyl pyrophosphate synthetase 1) Mus musculus

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Symbol:

Prps1

Name:

phosphoribosyl pyrophosphate synthetase 1

RGD ID:

62248

MGI Page

MGI

Description:

Enables ribose phosphate diphosphokinase activity. Involved in 5-phosphoribose 1-diphosphate biosynthetic process and pentose-phosphate shunt. Is active in cytosol. Is expressed in central nervous system; heart; inner ear; liver; and retina. Human ortholog(s) of this gene implicated in Arts syndrome; X-linked deafness 1; X-linked recessive disease (multiple); gout; and retinitis pigmentosa. Orthologous to human PRPS1 (phosphoribosyl pyrophosphate synthetase 1).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

2310010D17Rik; C76571; C76678; phosphoribosyl pyrophosphate synthase I; phosphoribosyl pyrophosphate synthetase I; Pr; Prps-1; PRS-I; ribose-phosphate pyrophosphokinase 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PRPS1 (phosphoribosyl pyrophosphate synthetase 1)	HGNC	Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	Prps1 (phosphoribosyl pyrophosphate synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Prps1 (phosphoribosyl pyrophosphate synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PRPS1 (phosphoribosyl pyrophosphate synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PRPS1 (phosphoribosyl pyrophosphate synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Prps1 (phosphoribosyl pyrophosphate synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PRPS1 (phosphoribosyl pyrophosphate synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PRPS1 (phosphoribosyl pyrophosphate synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PRPS2 (phosphoribosyl pyrophosphate synthetase 2)	HGNC	OrthoDB, OrthoMCL
Homo sapiens (human):	PRPS1L1 (phosphoribosyl pyrophosphate synthetase 1 like 1)	HGNC	OrthoDB
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Prps1 (phosphoribosyl pyrophosphate synthetase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PRPS1 (phosphoribosyl pyrophosphate synthetase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Rattus norvegicus (Norway rat):	Prps1l3 (phosphoribosyl pyrophosphate synthetase 1-like 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	prps1b (phosphoribosyl pyrophosphate synthetase 1B)	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid\|ZFIN)
Danio rerio (zebrafish):	prps1a (phosphoribosyl pyrophosphate synthetase 1A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	R151.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6767	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PRS2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PRS3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoInspector\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	PRS4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	prps1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Related Pseudogenes:

Gm18890

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	139,357,352 - 139,376,889 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	139,357,362 - 139,376,889 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	140,456,603 - 140,476,140 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	140,456,613 - 140,476,140 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	136,991,142 - 137,010,679 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	135,802,977 - 135,822,503 (+)	NCBI		MGSCv36	mm8
Celera	X	123,716,011 - 123,735,469 (+)	NCBI		Celera
Cytogenetic Map	X	F1	NCBI
cM Map	X	61.35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Prps1	Mouse	Developmental Disabilities		ISO	RGD:736625	9068941	N113S, D182H	RGD	PMID:8253776\|REF_RGD_ID:1599725
Prps1	Mouse	gout		ISO	RGD:736625	9068941	N113S, D182H	RGD	PMID:8253776\|REF_RGD_ID:1599725
Prps1	Mouse	Neurologic Manifestations		ISO	RGD:736625	5134990	associated with Gout; DNA:missense mutations:cds:multiple (human)	RGD
Prps1	Mouse	retinitis pigmentosa		ISO	RGD:736625	11056008	DNA:missense mutation:exon:p.S16P (human)	RGD
Prps1	Mouse	X-linked deafness 1		ISO	RGD:736625	11061884	DNA:missense mutation:exon:p.G306E (c.917G>A) (human)	RGD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Prps1	Mouse	Arts syndrome		ISO	RGD:736625	8554872	ClinVar Annotator: match by term: Arts syndrome \| ClinVar Annotator: match by term: MENTAL RETARDATION, more ...	ClinVar	PMID:1664177\|PMID:17701896\|PMID:17701900\|PMID:19161981\|PMID:20301731\|PMID:22246954\|PMID:24033266\|PMID:24528855\|PMID:25741868\|PMID:26089585\|PMID:28492532\|PMID:28967191\|PMID:31906484\|PMID:3278127\|PMID:32781272\|PMID:6243137\|PMID:7593598\|PMID:8253776\|PMID:8498830
Prps1	Mouse	autistic disorder		ISO	RGD:736625	8554872	ClinVar Annotator: match by term: Autism	ClinVar	PMID:21681106\|PMID:30208311
Prps1	Mouse	autosomal hemophilia A		ISO	RGD:736625	8554872	ClinVar Annotator: match by term: AUTOSOMAL HEMOPHILIA A	ClinVar	PMID:31690835
Prps1	Mouse	Charcot-Marie-Tooth disease type X		ISO	RGD:736625	8554872	ClinVar Annotator: match by term: Charcot-Marie-Tooth Neuropathy X \| ClinVar Annotator: match by term: Charcot-Marie-Tooth, more ...	ClinVar	PMID:16199547\|PMID:17576681\|PMID:17701900\|PMID:20021999\|PMID:20301731\|PMID:20301734\|PMID:24033266\|PMID:24528855\|PMID:24961627\|PMID:25182139\|PMID:25741868\|PMID:26467025\|PMID:28492532\|PMID:28967191\|PMID:29986705\|PMID:30177296\|PMID:31906484\|PMID:32528171\|PMID:3278127\|PMID:32781272\|PMID:33493137\|PMID:33532242\|PMID:8702702\|PMID:8968763\|PMID:9536098
Prps1	Mouse	Charcot-Marie-Tooth disease X-linked recessive 5		ISO	RGD:736625	8554872	ClinVar Annotator: match by term: Charcot-Marie-Tooth disease X-linked recessive 5 \| ClinVar Annotator: match by more ...	ClinVar	PMID:17701900\|PMID:20301731\|PMID:24033266\|PMID:24285972\|PMID:25182139\|PMID:25491489\|PMID:25741868\|PMID:28492532\|PMID:3278127\|PMID:32781272\|PMID:33493137
Prps1	Mouse	factor VIII deficiency		ISO	RGD:736625	8554872	ClinVar Annotator: match by term: Factor 8 deficiency, congenital	ClinVar	PMID:31690835
Prps1	Mouse	familial hypocalciuric hypercalcemia		ISO	RGD:736625	8554872	ClinVar Annotator: match by term: Nephrolithiasis/nephrocalcinosis	ClinVar	PMID:24033266\|PMID:25741868\|PMID:26467025\|PMID:28492532
Prps1	Mouse	fundus dystrophy		ISO	RGD:736625	8554872	ClinVar Annotator: match by term: Retinal dystrophy	ClinVar	PMID:24961627\|PMID:25741868\|PMID:28492532\|PMID:28967191\|PMID:3278127\|PMID:32781272
Prps1	Mouse	genetic disease		ISO	RGD:736625	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:1664177\|PMID:19161981\|PMID:25741868\|PMID:26089585\|PMID:6243137\|PMID:8253776
Prps1	Mouse	Hearing Loss		ISO	RGD:736625	8554872	ClinVar Annotator: match by term: X-linked nonsyndromic hearing loss	ClinVar
Prps1	Mouse	phosphoribosylpyrophosphate synthetase superactivity		ISO	RGD:736625	8554872	ClinVar Annotator: match by term: Phosphoribosylpyrophosphate synthetase superactivity	ClinVar	PMID:1664177\|PMID:171280\|PMID:17701900\|PMID:19161981\|PMID:20301731\|PMID:24033266\|PMID:25741868\|PMID:26089585\|PMID:28492532\|PMID:28967191\|PMID:6243137\|PMID:7593598\|PMID:8253776
Prps1	Mouse	syndromic X-linked intellectual disability Lubs type		ISO	RGD:736625	8554872	ClinVar Annotator: match by term: Syndromic X-linked intellectual disability Lubs type	ClinVar	PMID:25741868
Prps1	Mouse	X-linked deafness 1		ISO	RGD:736625	8554872	ClinVar Annotator: match by term: DEAFNESS, X-LINKED 2, SENSORINEURAL CONGENITAL \| ClinVar Annotator: match by more ...	ClinVar	PMID:10503584\|PMID:15240907\|PMID:17701900\|PMID:20021999\|PMID:20301731\|PMID:24033266\|PMID:24528855\|PMID:25182139\|PMID:25741868\|PMID:28492532\|PMID:30311386\|PMID:8968763

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Prps1	Mouse	Arts syndrome		ISO	RGD:736625	11554173	CTD Direct Evidence: marker/mechanism	CTD
Prps1	Mouse	Charcot-Marie-Tooth disease X-linked recessive 5		ISO	RGD:736625	11554173	CTD Direct Evidence: marker/mechanism	CTD
Prps1	Mouse	phosphoribosylpyrophosphate synthetase superactivity		ISO	RGD:736625	11554173	CTD Direct Evidence: marker/mechanism	CTD
Prps1	Mouse	Weight Gain		ISO	RGD:736625	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:19030233
Prps1	Mouse	X-linked deafness 1		ISO	RGD:736625	11554173	CTD Direct Evidence: marker/mechanism	CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Prps1	Mouse	Arts syndrome		ISO	RGD:736625	7240710		OMIM
Prps1	Mouse	Charcot-Marie-Tooth disease X-linked recessive 5		ISO	RGD:736625	7240710		OMIM
Prps1	Mouse	phosphoribosylpyrophosphate synthetase superactivity		ISO	RGD:736625	7240710		OMIM
Prps1	Mouse	X-linked deafness 1		ISO	RGD:736625	7240710		OMIM

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Prps1	Mouse	(+)-schisandrin B	multiple interactions	ISO	RGD:61955	6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PRPS1 mRNA]	CTD	PMID:31150632
Prps1	Mouse	(S)-nicotine	increases splicing	ISO	RGD:736625	6480464	Nicotine results in increased splicing of PRPS1 mRNA alternative form	CTD	PMID:23825647
Prps1	Mouse	(Z)-3-butylidenephthalide	decreases expression	ISO	RGD:736625	6480464	butylidenephthalide results in decreased expression of PRPS1 protein	CTD	PMID:23770345
Prps1	Mouse	1,2-dimethylhydrazine	decreases expression	EXP		6480464	1,2-Dimethylhydrazine results in decreased expression of PRPS1 mRNA	CTD	PMID:22206623
Prps1	Mouse	17alpha-ethynylestradiol	affects expression	EXP		6480464	Ethinyl Estradiol affects the expression of PRPS1 mRNA	CTD	PMID:17555576
Prps1	Mouse	17beta-estradiol	increases expression	ISO	RGD:736625	6480464	Estradiol results in increased expression of PRPS1 mRNA	CTD	PMID:19619570
Prps1	Mouse	17beta-estradiol	multiple interactions	ISO	RGD:736625	6480464	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PRPS1 mRNA	CTD	PMID:19619570
Prps1	Mouse	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	ISO	RGD:736625	6480464	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PRPS1 mRNA	CTD	PMID:19619570
Prps1	Mouse	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	RGD:61955	6480464	Tetrachlorodibenzodioxin results in increased expression of PRPS1 mRNA	CTD	PMID:26232522
Prps1	Mouse	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	RGD:736625	6480464	Tetrachlorodibenzodioxin results in increased expression of PRPS1 mRNA	CTD	PMID:19619570\|PMID:22903824
Prps1	Mouse	2,3,7,8-tetrachlorodibenzodioxine	affects expression	EXP		6480464	Tetrachlorodibenzodioxin affects the expression of PRPS1 mRNA	CTD	PMID:21570461
Prps1	Mouse	3-methylcholanthrene	multiple interactions	ISO	RGD:736625	6480464	Methylcholanthrene promotes the reaction [AHR protein binds to PRPS1 promoter]	CTD	PMID:20348232
Prps1	Mouse	3H-1,2-dithiole-3-thione	decreases expression	ISO	RGD:61955	6480464	1,2-dithiol-3-thione results in decreased expression of PRPS1 mRNA	CTD	PMID:19162173
Prps1	Mouse	4,4'-sulfonyldiphenol	increases expression	ISO	RGD:736625	6480464	bisphenol S results in increased expression of PRPS1 protein	CTD	PMID:34186270
Prps1	Mouse	4-hydroxyphenyl retinamide	decreases expression	EXP		6480464	Fenretinide results in decreased expression of PRPS1 mRNA	CTD	PMID:28973697
Prps1	Mouse	5-fluorouracil	increases expression	ISO	RGD:736625	6480464	Fluorouracil results in increased expression of PRPS1 mRNA	CTD	PMID:16584549
Prps1	Mouse	afimoxifene	increases expression	ISO	RGD:736625	6480464	afimoxifene results in increased expression of PRPS1 mRNA	CTD	PMID:16849584
Prps1	Mouse	aflatoxin B1	decreases expression	ISO	RGD:736625	6480464	Aflatoxin B1 results in decreased expression of PRPS1 mRNA	CTD	PMID:22100608
Prps1	Mouse	all-trans-retinoic acid	decreases expression	ISO	RGD:736625	6480464	Tretinoin results in decreased expression of PRPS1 mRNA	CTD	PMID:15498508\|PMID:21934132\|PMID:33167477
Prps1	Mouse	ammonium chloride	affects expression	ISO	RGD:61955	6480464	Ammonium Chloride affects the expression of PRPS1 mRNA	CTD	PMID:16483693
Prps1	Mouse	aristolochic acid A	increases expression	ISO	RGD:736625	6480464	aristolochic acid I results in increased expression of PRPS1 protein	CTD	PMID:33212167
Prps1	Mouse	arsane	increases methylation	ISO	RGD:736625	6480464	Arsenic results in increased methylation of PRPS1 promoter	CTD	PMID:21291286
Prps1	Mouse	arsenic atom	increases methylation	ISO	RGD:736625	6480464	Arsenic results in increased methylation of PRPS1 promoter	CTD	PMID:21291286
Prps1	Mouse	arsenous acid	increases expression	ISO	RGD:736625	6480464	Arsenic Trioxide results in increased expression of PRPS1 mRNA	CTD	PMID:20458559
Prps1	Mouse	arsenous acid	decreases expression	ISO	RGD:736625	6480464	Arsenic Trioxide results in decreased expression of PRPS1 protein	CTD	PMID:25419056
Prps1	Mouse	benzo[a]pyrene	increases expression	EXP		6480464	Benzo(a)pyrene results in increased expression of PRPS1 mRNA	CTD	PMID:22228805
Prps1	Mouse	benzo[a]pyrene	increases methylation	ISO	RGD:736625	6480464	Benzo(a)pyrene results in increased methylation of PRPS1 exon	CTD	PMID:27901495
Prps1	Mouse	benzo[a]pyrene	affects methylation	ISO	RGD:736625	6480464	Benzo(a)pyrene affects the methylation of PRPS1 promoter	CTD	PMID:27901495
Prps1	Mouse	bis(2-ethylhexyl) phthalate	multiple interactions	ISO	RGD:61955	6480464	[Diethylhexyl Phthalate co-treated with Genistein] results in increased expression of PRPS1 mRNA	CTD	PMID:25031359
Prps1	Mouse	bisphenol A	increases expression	ISO	RGD:61955	6480464	bisphenol A results in increased expression of PRPS1 mRNA	CTD	PMID:25181051
Prps1	Mouse	bisphenol A	decreases expression	ISO	RGD:736625	6480464	bisphenol A results in decreased expression of PRPS1 mRNA; bisphenol A results in decreased expression more ...	CTD	PMID:31121516\|PMID:33376534\|PMID:34186270\|PMID:37567409
Prps1	Mouse	bisphenol AF	increases expression	ISO	RGD:736625	6480464	bisphenol AF results in increased expression of PRPS1 protein	CTD	PMID:34186270
Prps1	Mouse	bisphenol AF	decreases expression	ISO	RGD:736625	6480464	bisphenol AF results in decreased expression of PRPS1 mRNA	CTD	PMID:31121516
Prps1	Mouse	Bisphenol B	increases expression	ISO	RGD:736625	6480464	bisphenol B results in increased expression of PRPS1 protein	CTD	PMID:34186270
Prps1	Mouse	butan-1-ol	multiple interactions	ISO	RGD:736625	6480464	[[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic more ...	CTD	PMID:29432896
Prps1	Mouse	butanal	increases expression	ISO	RGD:736625	6480464	butyraldehyde results in increased expression of PRPS1 mRNA	CTD	PMID:26079696
Prps1	Mouse	cadmium atom	multiple interactions	ISO	RGD:736625	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PRPS1 more ...	CTD	PMID:35301059
Prps1	Mouse	cadmium dichloride	decreases expression	ISO	RGD:736625	6480464	Cadmium Chloride results in decreased expression of PRPS1 mRNA	CTD	PMID:25596134
Prps1	Mouse	cadmium dichloride	multiple interactions	ISO	RGD:736625	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PRPS1 more ...	CTD	PMID:35301059
Prps1	Mouse	cannabidiol	multiple interactions	ISO	RGD:736625	6480464	[Cannabidiol co-treated with moringin] results in increased expression of PRPS1 mRNA	CTD	PMID:30096889
Prps1	Mouse	chloroacetaldehyde	increases expression	ISO	RGD:736625	6480464	chloroacetaldehyde results in increased expression of PRPS1 mRNA	CTD	PMID:25596134
Prps1	Mouse	cidofovir anhydrous	increases expression	ISO	RGD:736625	6480464	Cidofovir results in increased expression of PRPS1 mRNA	CTD	PMID:25596134
Prps1	Mouse	clofibrate	decreases expression	EXP		6480464	Clofibrate results in decreased expression of PRPS1 mRNA	CTD	PMID:17585979
Prps1	Mouse	copper atom	multiple interactions	ISO	RGD:736625	6480464	[Chelating Agents binds to Copper] which results in decreased expression of PRPS1 mRNA	CTD	PMID:31162603
Prps1	Mouse	copper(0)	multiple interactions	ISO	RGD:736625	6480464	[Chelating Agents binds to Copper] which results in decreased expression of PRPS1 mRNA	CTD	PMID:31162603
Prps1	Mouse	cyclosporin A	increases expression	ISO	RGD:736625	6480464	Cyclosporine results in increased expression of PRPS1 mRNA	CTD	PMID:20106945\|PMID:25596134
Prps1	Mouse	DDE	increases expression	ISO	RGD:736625	6480464	Dichlorodiphenyl Dichloroethylene results in increased expression of PRPS1 mRNA	CTD	PMID:38568856
Prps1	Mouse	diarsenic trioxide	decreases expression	ISO	RGD:736625	6480464	Arsenic Trioxide results in decreased expression of PRPS1 protein	CTD	PMID:25419056
Prps1	Mouse	diarsenic trioxide	increases expression	ISO	RGD:736625	6480464	Arsenic Trioxide results in increased expression of PRPS1 mRNA	CTD	PMID:20458559
Prps1	Mouse	dibutyl phthalate	decreases expression	EXP		6480464	Dibutyl Phthalate results in decreased expression of PRPS1 mRNA	CTD	PMID:21266533
Prps1	Mouse	dioxygen	decreases expression	ISO	RGD:736625	6480464	Oxygen deficiency results in decreased expression of PRPS1 mRNA	CTD	PMID:25596134
Prps1	Mouse	dorsomorphin	multiple interactions	ISO	RGD:736625	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Prps1	Mouse	doxorubicin	decreases expression	ISO	RGD:736625	6480464	Doxorubicin results in decreased expression of PRPS1 mRNA	CTD	PMID:29803840
Prps1	Mouse	enzyme inhibitor	multiple interactions	ISO	RGD:736625	6480464	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation more ...	CTD	PMID:23301498
Prps1	Mouse	ethanol	decreases expression	ISO	RGD:61955	6480464	Ethanol results in decreased expression of PRPS1 protein	CTD	PMID:19609968
Prps1	Mouse	ethanol	affects splicing	EXP		6480464	Ethanol affects the splicing of PRPS1 mRNA	CTD	PMID:30319688
Prps1	Mouse	ethanol	increases expression	EXP		6480464	Ethanol results in increased expression of PRPS1 mRNA	CTD	PMID:30319688
Prps1	Mouse	finasteride	decreases expression	ISO	RGD:61955	6480464	Finasteride results in decreased expression of PRPS1 protein	CTD	PMID:27750143
Prps1	Mouse	flutamide	increases expression	ISO	RGD:61955	6480464	Flutamide results in increased expression of PRPS1 mRNA	CTD	PMID:24136188
Prps1	Mouse	folic acid	decreases expression	EXP		6480464	Folic Acid results in decreased expression of PRPS1 mRNA	CTD	PMID:25629700
Prps1	Mouse	formaldehyde	decreases expression	ISO	RGD:736625	6480464	Formaldehyde results in decreased expression of PRPS1 mRNA	CTD	PMID:23649840
Prps1	Mouse	genistein	multiple interactions	ISO	RGD:61955	6480464	[Diethylhexyl Phthalate co-treated with Genistein] results in increased expression of PRPS1 mRNA	CTD	PMID:25031359
Prps1	Mouse	ivermectin	decreases expression	ISO	RGD:736625	6480464	Ivermectin results in decreased expression of PRPS1 protein	CTD	PMID:32959892
Prps1	Mouse	lead diacetate	affects expression	ISO	RGD:61955	6480464	lead acetate affects the expression of PRPS1 mRNA	CTD	PMID:22641619
Prps1	Mouse	methidathion	decreases expression	EXP		6480464	methidathion results in decreased expression of PRPS1 mRNA	CTD	PMID:34813904
Prps1	Mouse	nefazodone	increases expression	ISO	RGD:61955	6480464	nefazodone results in increased expression of PRPS1 mRNA	CTD	PMID:24136188
Prps1	Mouse	nicotine	increases splicing	ISO	RGD:736625	6480464	Nicotine results in increased splicing of PRPS1 mRNA alternative form	CTD	PMID:23825647
Prps1	Mouse	nimesulide	increases expression	ISO	RGD:61955	6480464	nimesulide results in increased expression of PRPS1 mRNA	CTD	PMID:24136188
Prps1	Mouse	oxaliplatin	multiple interactions	ISO	RGD:61955	6480464	[oxaliplatin co-treated with Topotecan] results in decreased expression of PRPS1 mRNA	CTD	PMID:25729387
Prps1	Mouse	ozone	multiple interactions	ISO	RGD:736625	6480464	[Air Pollutants results in increased abundance of Ozone] which affects the expression of PRPS1 mRNA	CTD	PMID:35430440
Prps1	Mouse	paracetamol	affects expression	EXP		6480464	Acetaminophen affects the expression of PRPS1 mRNA	CTD	PMID:17562736
Prps1	Mouse	paracetamol	decreases expression	ISO	RGD:736625	6480464	Acetaminophen results in decreased expression of PRPS1 mRNA	CTD	PMID:26690555
Prps1	Mouse	paraquat	increases expression	ISO	RGD:61955	6480464	Paraquat results in increased expression of PRPS1 mRNA	CTD	PMID:32680482
Prps1	Mouse	phenobarbital	increases expression	ISO	RGD:61955	6480464	Phenobarbital results in increased expression of PRPS1 mRNA	CTD	PMID:19162173
Prps1	Mouse	phenylmercury acetate	decreases expression	ISO	RGD:736625	6480464	Phenylmercuric Acetate results in decreased expression of PRPS1 mRNA	CTD	PMID:26272509
Prps1	Mouse	phenylmercury acetate	multiple interactions	ISO	RGD:736625	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Prps1	Mouse	pirinixic acid	increases expression	ISO	RGD:61955	6480464	pirinixic acid results in increased expression of PRPS1 mRNA	CTD	PMID:19162173
Prps1	Mouse	piroxicam	decreases expression	ISO	RGD:736625	6480464	Piroxicam results in decreased expression of PRPS1 mRNA	CTD	PMID:21858171
Prps1	Mouse	rimonabant	affects expression	EXP		6480464	Rimonabant affects the expression of PRPS1 mRNA	CTD	PMID:19030233
Prps1	Mouse	rimonabant	multiple interactions	EXP		6480464	Rimonabant inhibits the reaction [Dietary Fats results in increased expression of PRPS1 mRNA]	CTD	PMID:19030233
Prps1	Mouse	SB 431542	multiple interactions	ISO	RGD:736625	6480464	[LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in increased expression of PRPS1 more ...	CTD	PMID:27188386\|PMID:37664457
Prps1	Mouse	sodium arsenite	increases expression	ISO	RGD:736625	6480464	sodium arsenite results in increased expression of PRPS1 mRNA	CTD	PMID:28595984
Prps1	Mouse	sodium arsenite	affects expression	ISO	RGD:736625	6480464	sodium arsenite affects the expression of PRPS1 mRNA	CTD	PMID:34032870
Prps1	Mouse	sodium arsenite	decreases expression	ISO	RGD:736625	6480464	sodium arsenite results in decreased expression of PRPS1 mRNA	CTD	PMID:38568856
Prps1	Mouse	sodium arsenite	decreases expression	ISO	RGD:61955	6480464	sodium arsenite results in decreased expression of PRPS1 protein	CTD	PMID:29459688
Prps1	Mouse	sunitinib	decreases expression	ISO	RGD:736625	6480464	Sunitinib results in decreased expression of PRPS1 mRNA	CTD	PMID:31533062
Prps1	Mouse	tamibarotene	affects expression	ISO	RGD:736625	6480464	tamibarotene affects the expression of PRPS1 mRNA	CTD	PMID:15498508
Prps1	Mouse	tamoxifen	affects expression	EXP		6480464	Tamoxifen affects the expression of PRPS1 mRNA	CTD	PMID:17555576
Prps1	Mouse	tetrachloromethane	increases expression	EXP		6480464	Carbon Tetrachloride results in increased expression of PRPS1 mRNA	CTD	PMID:27339419\|PMID:31919559
Prps1	Mouse	tetrachloromethane	multiple interactions	ISO	RGD:61955	6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PRPS1 mRNA]	CTD	PMID:31150632
Prps1	Mouse	tetrachloromethane	increases expression	ISO	RGD:61955	6480464	Carbon Tetrachloride results in increased expression of PRPS1 mRNA	CTD	PMID:31150632
Prps1	Mouse	thapsigargin	decreases expression	ISO	RGD:736625	6480464	Thapsigargin results in decreased expression of PRPS1 mRNA	CTD	PMID:22378314
Prps1	Mouse	thapsigargin	increases expression	ISO	RGD:61955	6480464	Thapsigargin results in increased expression of PRPS1 protein	CTD	PMID:35544339
Prps1	Mouse	titanium dioxide	increases methylation	EXP		6480464	titanium dioxide results in increased methylation of PRPS1 gene	CTD	PMID:35295148
Prps1	Mouse	topotecan	multiple interactions	ISO	RGD:61955	6480464	[oxaliplatin co-treated with Topotecan] results in decreased expression of PRPS1 mRNA	CTD	PMID:25729387
Prps1	Mouse	trimellitic anhydride	increases expression	EXP		6480464	trimellitic anhydride results in increased expression of PRPS1 mRNA	CTD	PMID:19042947
Prps1	Mouse	tunicamycin	decreases expression	ISO	RGD:736625	6480464	Tunicamycin results in decreased expression of PRPS1 mRNA	CTD	PMID:22378314
Prps1	Mouse	urethane	decreases expression	ISO	RGD:736625	6480464	Urethane results in decreased expression of PRPS1 mRNA	CTD	PMID:28818685
Prps1	Mouse	valdecoxib	increases expression	ISO	RGD:61955	6480464	valdecoxib results in increased expression of PRPS1 mRNA	CTD	PMID:24136188
Prps1	Mouse	valproic acid	affects expression	EXP		6480464	Valproic Acid affects the expression of PRPS1 mRNA	CTD	PMID:17292431
Prps1	Mouse	valproic acid	increases expression	ISO	RGD:736625	6480464	Valproic Acid results in increased expression of PRPS1 mRNA	CTD	PMID:23179753
Prps1	Mouse	valproic acid	affects expression	ISO	RGD:736625	6480464	Valproic Acid affects the expression of PRPS1 mRNA	CTD	PMID:25979313

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Prps1	Mouse	5-phosphoribose 1-diphosphate biosynthetic process		ISO	RGD:61955	9068941		RGD	PMID:9366267\|REF_RGD_ID:5134981
Prps1	Mouse	5-phosphoribose 1-diphosphate biosynthetic process	involved_in	IEA	UniPathway:UPA00087	2290270		UniProt	GO_REF:0000041
Prps1	Mouse	5-phosphoribose 1-diphosphate biosynthetic process	involved_in	IDA		2290270	PMID:26175007	MGI	PMID:26175007
Prps1	Mouse	5-phosphoribose 1-diphosphate biosynthetic process	involved_in	IBA	PANTHER:PTN000025022\|SGD:S000000901\|UniProtKB:P9WKE3\|SGD:S000001003\|SGD:S000005422\|SGD:S000000164\|MGI:97776\|SGD:S000001664\|MGI:97775\|RGD:61955\|UniProtKB:P0A717\|RGD:3415	2290270		GO_Central	GO_REF:0000033
Prps1	Mouse	AMP biosynthetic process		ISO	RGD:61955	9068941		RGD	PMID:2546925\|REF_RGD_ID:5134985
Prps1	Mouse	animal organ regeneration		ISO	RGD:61955	9068941		RGD	PMID:2822704\|REF_RGD_ID:633743
Prps1	Mouse	hypoxanthine biosynthetic process	involved_in	ISO	UniProtKB:P60891	2290270		GO_Central	GO_REF:0000119
Prps1	Mouse	nervous system development	involved_in	ISO	UniProtKB:P60891	2290270		GO_Central	GO_REF:0000119
Prps1	Mouse	nucleotide biosynthetic process	involved_in	IEA	UniProtKB-KW:KW-0545	2290270		UniProt	GO_REF:0000043
Prps1	Mouse	pentose-phosphate shunt	involved_in	IMP		2290270	PMID:24855946	MGI	PMID:24855946
Prps1	Mouse	purine nucleobase metabolic process	involved_in	ISO	UniProtKB:P60891	2290270		GO_Central	GO_REF:0000119
Prps1	Mouse	purine nucleotide biosynthetic process	involved_in	ISO	UniProtKB:P60891	2290270		GO_Central	GO_REF:0000119
Prps1	Mouse	purine nucleotide biosynthetic process	involved_in	IBA	PANTHER:PTN000025022\|UniProtKB:P60891\|RGD:61955\|RGD:3415	2290270		GO_Central	GO_REF:0000033
Prps1	Mouse	ribonucleoside monophosphate biosynthetic process	involved_in	IEA	InterPro:IPR000842	2290270		InterPro	GO_REF:0000002
Prps1	Mouse	urate biosynthetic process	involved_in	ISO	UniProtKB:P60891	2290270		GO_Central	GO_REF:0000119

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Prps1	Mouse	cytoplasm	is_active_in	IBA	PANTHER:PTN000025022\|SGD:S000001664\|UniProtKB:Q57Z76\|MGI:97775\|UniProtKB:Q57ZX2\|MGI:97776\|UniProtKB:P0A717	2290270		GO_Central	GO_REF:0000033
Prps1	Mouse	cytosol	is_active_in	IDA		2290270	PMID:30379953	MGI	PMID:30379953
Prps1	Mouse	protein-containing complex		ISO	RGD:61955	9068941		RGD	PMID:2546925\|PMID:9348095\|REF_RGD_ID:2291928\|REF_RGD_ID:5134985
Prps1	Mouse	protein-containing complex	part_of	ISO	RGD:61955	2290270		GO_Central	GO_REF:0000096
Prps1	Mouse	ribose phosphate diphosphokinase complex	part_of	ISO	RGD:61955	2290270		GO_Central	GO_REF:0000096
Prps1	Mouse	ribose phosphate diphosphokinase complex	part_of	IBA	PANTHER:PTN000025022\|SGD:S000001664\|RGD:3415\|RGD:620206\|RGD:620207\|SGD:S000000901\|RGD:61955\|SGD:S000005422\|SGD:S000001003\|SGD:S000000164	2290270		GO_Central	GO_REF:0000033
Prps1	Mouse	ribose phosphate diphosphokinase complex		ISO	RGD:61955	9068941		RGD	PMID:2546925\|REF_RGD_ID:5134985

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Prps1	Mouse	ADP binding		ISO	RGD:61955	9068941		RGD	PMID:1651917\|PMID:9348095\|REF_RGD_ID:2291920\|REF_RGD_ID:2291928
Prps1	Mouse	ADP binding	enables	ISO	RGD:61955	2290270		GO_Central	GO_REF:0000096
Prps1	Mouse	AMP binding		ISO	RGD:61955	9068941		RGD	PMID:1651917\|PMID:9348095\|PMID:9748490\|REF_RGD_ID:1599724\|REF_RGD_ID:2291920\|REF_RGD_ID:2291928
Prps1	Mouse	AMP binding	enables	ISO	RGD:61955	2290270		GO_Central	GO_REF:0000096
Prps1	Mouse	ATP binding	enables	ISO	UniProtKB:P60891	2290270		GO_Central	GO_REF:0000119
Prps1	Mouse	ATP binding	enables	ISO	RGD:61955	2290270		GO_Central	GO_REF:0000096
Prps1	Mouse	ATP binding	enables	ISS	UniProtKB:P60891	2290270		UniProt	GO_REF:0000024
Prps1	Mouse	ATP binding		ISO	RGD:61955	9068941		RGD	PMID:1651917\|PMID:2546925\|PMID:9348095\|PMID:9748490\|REF_RGD_ID:1599724\|REF_RGD_ID:2291920\|REF_RGD_ID:2291928\|REF_RGD_ID:5134985
Prps1	Mouse	carbohydrate binding		ISO	RGD:61955	9068941		RGD	PMID:1651917\|PMID:2546925\|PMID:9348095\|PMID:9748490\|REF_RGD_ID:1599724\|REF_RGD_ID:2291920\|REF_RGD_ID:2291928\|REF_RGD_ID:5134985
Prps1	Mouse	carbohydrate binding	enables	ISO	RGD:61955	2290270		GO_Central	GO_REF:0000096
Prps1	Mouse	GDP binding		ISO	RGD:61955	9068941		RGD	PMID:1651917\|PMID:9348095\|PMID:9748490\|REF_RGD_ID:1599724\|REF_RGD_ID:2291920\|REF_RGD_ID:2291928
Prps1	Mouse	GDP binding	enables	ISO	RGD:61955	2290270		GO_Central	GO_REF:0000096
Prps1	Mouse	identical protein binding	enables	ISO	UniProtKB:P60891	2290270		GO_Central	GO_REF:0000119
Prps1	Mouse	kinase activity	enables	IEA	UniProtKB-KW:KW-0418	2290270		UniProt	GO_REF:0000043
Prps1	Mouse	magnesium ion binding		ISO	RGD:61955	9068941		RGD	PMID:1651917\|PMID:9348095\|PMID:9748490\|REF_RGD_ID:1599724\|REF_RGD_ID:2291920\|REF_RGD_ID:2291928
Prps1	Mouse	magnesium ion binding	enables	IEA	InterPro:IPR000842\|InterPro:IPR005946	2290270		InterPro	GO_REF:0000002
Prps1	Mouse	magnesium ion binding	enables	ISO	RGD:61955	2290270		GO_Central	GO_REF:0000096
Prps1	Mouse	protein binding	enables	ISO	UniProtKB:A1L190\|UniProtKB:A2RU56\|UniProtKB:B7Z3E8\|UniProtKB:I6L9F6\|UniProtKB:O00303\|UniProtKB:O00308\|UniProtKB:O00757\|UniProtKB:O15287\|UniProtKB:O15381-5\|UniProtKB:O15534\|UniProtKB:O15535\|UniProtKB:O43482\|UniProtKB:O60333-2\|UniProtKB:O75604-3\|UniProtKB:O75886\|UniProtKB:O76024\|UniProtKB:O77932\|UniProtKB:O94778\|UniProtKB:P02489\|UniProtKB:P02511\|UniProtKB:P05067\|UniProtKB:P11908\|UniProtKB:P13928\|UniProtKB:P15976-2\|UniProtKB:P21980-2\|UniProtKB:P22061-2\|UniProtKB:P23560-2\|UniProtKB:P45880\|UniProtKB:P51608\|UniProtKB:P52790\|UniProtKB:P57682\|UniProtKB:P58304\|UniProtKB:P61244-4\|UniProtKB:Q0VDC6\|UniProtKB:Q13148\|UniProtKB:Q13216-2\|UniProtKB:Q13569\|UniProtKB:Q14005-2\|UniProtKB:Q14457\|UniProtKB:Q14525\|UniProtKB:Q15007-2\|UniProtKB:Q15049\|UniProtKB:Q15528-2\|UniProtKB:Q15776\|UniProtKB:Q16520\|UniProtKB:Q2QGD7\|UniProtKB:Q3KNS6-3\|UniProtKB:Q58EX7-2\|UniProtKB:Q5VWN6\|UniProtKB:Q5VYS8-5\|UniProtKB:Q5W5X9-3\|UniProtKB:Q68EA5\|UniProtKB:Q6GQQ9-2\|UniProtKB:Q6P1L5\|UniProtKB:Q6P587-2\|UniProtKB:Q6XD76\|UniProtKB:Q6ZNH5\|UniProtKB:Q6ZP82-1\|UniProtKB:Q6ZU52\|UniProtKB:Q7RTV0\|UniProtKB:Q7Z698\|UniProtKB:Q86TN1\|UniProtKB:Q86V28\|UniProtKB:Q86WV5\|UniProtKB:Q86WV8\|UniProtKB:Q8IUI8\|UniProtKB:Q8IUR5-4\|UniProtKB:Q8IXL9\|UniProtKB:Q8IXS7\|UniProtKB:Q8N0Y2-2\|UniProtKB:Q8N594\|UniProtKB:Q8N5S9-2\|UniProtKB:Q8N6F8\|UniProtKB:Q8N6K7-2\|UniProtKB:Q8N865\|UniProtKB:Q8N895\|UniProtKB:Q8NEZ2\|UniProtKB:Q8TBJ4\|UniProtKB:Q8TCT7-2\|UniProtKB:Q8WUU4\|UniProtKB:Q8WZ19\|UniProtKB:Q92997\|UniProtKB:Q969T4\|UniProtKB:Q96A09\|UniProtKB:Q96D59\|UniProtKB:Q96FT7-4\|UniProtKB:Q96FW1\|UniProtKB:Q96HT8\|UniProtKB:Q96LB9\|UniProtKB:Q96LL4\|UniProtKB:Q96LX7-5\|UniProtKB:Q96MN9-2\|UniProtKB:Q96PV6\|UniProtKB:Q96SI1-2\|UniProtKB:Q99683\|UniProtKB:Q99932-2	9068941	PMID:32814053	IntAct	PMID:32814053
Prps1	Mouse	protein binding	enables	ISO	UniProtKB:P11908\|UniProtKB:Q14558\|UniProtKB:Q9NZD8	9068941	PMID:25416956	IntAct	PMID:25416956
Prps1	Mouse	protein binding	enables	ISO	UniProtKB:O60256\|UniProtKB:Q14558\|UniProtKB:Q96D03\|UniProtKB:Q9H8Y8\|UniProtKB:Q9NZD8	9068941	PMID:32296183	IntAct	PMID:32296183
Prps1	Mouse	protein binding	enables	ISO	UniProtKB:Q14558\|UniProtKB:Q9H8Y8\|UniProtKB:Q9NZD8	9068941	PMID:16189514	IntAct	PMID:16189514
Prps1	Mouse	protein binding	enables	ISO	UniProtKB:P11908-2\|UniProtKB:Q14558	9068941	PMID:25910212	IntAct	PMID:25910212
Prps1	Mouse	protein binding	enables	ISO	UniProtKB:O60256\|UniProtKB:P11908-2	9068941	PMID:28514442	IntAct	PMID:28514442
Prps1	Mouse	protein binding	enables	ISO	UniProtKB:P11908\|UniProtKB:Q14558\|UniProtKB:Q9H8Y8\|UniProtKB:Q9NZD8	9068941	PMID:31515488	IntAct	PMID:31515488
Prps1	Mouse	protein binding	enables	ISO	UniProtKB:Q9H8Y8	9068941	PMID:29892012	IntAct	PMID:29892012
Prps1	Mouse	protein binding	enables	ISO	UniProtKB:O60256\|UniProtKB:P11908	9068941	PMID:26496610	IntAct	PMID:26496610
Prps1	Mouse	protein binding	enables	ISO	UniProtKB:O60256\|UniProtKB:P11908\|UniProtKB:Q14558	9068941	PMID:33961781	IntAct	PMID:33961781
Prps1	Mouse	protein binding	enables	ISO	UniProtKB:P50053-2	9068941	PMID:27088854	IntAct	PMID:27088854
Prps1	Mouse	protein binding		ISO	RGD:620206	9068941		RGD	PMID:9366267\|REF_RGD_ID:5134981
Prps1	Mouse	protein binding	enables	ISO	UniProtKB:Q99967\|UniProtKB:Q9BRX2\|UniProtKB:Q9BRX9\|UniProtKB:Q9BSL1\|UniProtKB:Q9C004\|UniProtKB:Q9H1D9\|UniProtKB:Q9HBE1-4\|UniProtKB:Q9NP61\|UniProtKB:Q9NTN9-3\|UniProtKB:Q9NXC2\|UniProtKB:Q9NYP9\|UniProtKB:Q9NZC7-5\|UniProtKB:Q9P2K3-2\|UniProtKB:Q9UDY8-2\|UniProtKB:Q9UHY8\|UniProtKB:Q9UJW8-4\|UniProtKB:Q9UJX2\|UniProtKB:Q9Y2M5\|UniProtKB:Q9Y3D0\|UniProtKB:Q9Y4B6-3\|UniProtKB:Q9Y575-3\|UniProtKB:Q9Y5P3\|UniProtKB:Q9Y605	9068941	PMID:32814053	IntAct	PMID:32814053
Prps1	Mouse	protein homodimerization activity	enables	ISS	UniProtKB:P60891	2290270		UniProt	GO_REF:0000024
Prps1	Mouse	protein homodimerization activity	enables	ISO	UniProtKB:P60891	2290270		GO_Central	GO_REF:0000119
Prps1	Mouse	ribose phosphate diphosphokinase activity	enables	ISO	UniProtKB:P60891	2290270		GO_Central	GO_REF:0000119
Prps1	Mouse	ribose phosphate diphosphokinase activity	enables	IDA		2290270	PMID:26175007	MGI	PMID:26175007
Prps1	Mouse	ribose phosphate diphosphokinase activity	enables	ISO	RGD:61955	2290270		GO_Central	GO_REF:0000096
Prps1	Mouse	ribose phosphate diphosphokinase activity	enables	IBA	PANTHER:PTN000025022\|RGD:61955\|UniProtKB:P9WKE3\|SGD:S000005422\|UniProtKB:P60891\|UniProtKB:P0A717\|MGI:97776\|RGD:3415\|MGI:97775\|CGD:CAL0000176742	2290270		GO_Central	GO_REF:0000033
Prps1	Mouse	ribose phosphate diphosphokinase activity		ISO	RGD:61955	9068941		RGD	PMID:1651917\|PMID:2546925\|PMID:9348095\|PMID:9748490\|REF_RGD_ID:1599724\|REF_RGD_ID:2291920\|REF_RGD_ID:2291928\|REF_RGD_ID:5134985
Prps1	Mouse	ribose phosphate diphosphokinase activity	enables	ISS	UniProtKB:P60891	2290270		UniProt	GO_REF:0000024

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Prps1	Mouse	de novo purine biosynthetic pathway		ISO	RGD:736625	5135488		RGD

Imported Annotations - KEGG (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Prps1	Mouse	pentose phosphate pathway		IEA		6907045		KEGG	mmu:00030
Prps1	Mouse	purine metabolic pathway		IEA		6907045		KEGG	mmu:00230

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Prps1	Mouse	preweaning lethality, complete penetrance		IEA		5509061		MGI

#	Reference Title	Reference Citation
1.	Expanding the phenotype of PRPS1 syndromes in females: neuropathy, hearing loss and retinopathy.	Almoguera B, etal., Orphanet J Rare Dis. 2014 Dec 10;9:190. doi: 10.1186/s13023-014-0190-9.
2.	The genetic and functional basis of purine nucleotide feedback-resistant phosphoribosylpyrophosphate synthetase superactivity.	Becker MA, etal., J Clin Invest. 1995 Nov;96(5):2133-41.
3.	Pediatric neurological syndromes and inborn errors of purine metabolism.	Camici M, etal., Neurochem Int. 2010 Feb;56(3):367-78. Epub 2009 Dec 11.
4.	Mutations in PRPS1 causing syndromic or nonsyndromic hearing impairment: intrafamilial phenotypic variation complicates genetic counseling.	Gandia M, etal., Pediatr Res. 2015 Jul;78(1):97-102. doi: 10.1038/pr.2015.56. Epub 2015 Mar 18.
5.	Functional annotation of a full-length mouse cDNA collection.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6.	Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.	Ko MS, etal., Development 2000 Apr;127(8):1737-49.
7.	Electronic Transfer of Homolog Data	MGD and Homologene mouse data transfer
8.	MGDs mouse GO annotations	MGD data from the GO Consortium
9.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
11.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
12.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
13.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:2537655	PMID:7757076	PMID:7849396	PMID:7873890	PMID:8661129	PMID:9170106	PMID:10349636	PMID:10922068	PMID:11042159	PMID:11076861	PMID:12477932	PMID:14610273
PMID:14681479	PMID:15782199	PMID:16141072	PMID:16141073	PMID:16602821	PMID:20021999	PMID:21267068	PMID:21677750	PMID:21873635	PMID:22645261	PMID:22792159	PMID:23136997
PMID:24855946	PMID:26175007	PMID:26273529	PMID:27215380	PMID:27343059	PMID:27626380	PMID:28245920	PMID:30196744	PMID:30379953	PMID:30418981	PMID:30457570	PMID:30973865
PMID:32325033	PMID:33378226	PMID:35237793	PMID:36772830	PMID:38355793

Prps1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	139,357,352 - 139,376,889 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	139,357,362 - 139,376,889 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	140,456,603 - 140,476,140 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	140,456,613 - 140,476,140 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	136,991,142 - 137,010,679 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	135,802,977 - 135,822,503 (+)	NCBI		MGSCv36	mm8
Celera	X	123,716,011 - 123,735,469 (+)	NCBI		Celera
Cytogenetic Map	X	F1	NCBI
cM Map	X	61.35	NCBI

PRPS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	107,628,510 - 107,651,026 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	107,628,428 - 107,651,993 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	106,871,740 - 106,894,256 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	106,758,415 - 106,780,912 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	106,677,903 - 106,700,400	NCBI
Celera	X	107,343,160 - 107,365,584 (+)	NCBI		Celera
Cytogenetic Map	X	q22.3	NCBI
HuRef	X	96,496,454 - 96,518,960 (+)	NCBI		HuRef
CHM1_1	X	106,782,575 - 106,805,177 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	106,065,274 - 106,087,791 (+)	NCBI		T2T-CHM13v2.0

Prps1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	108,920,663 - 108,942,713 (+)	NCBI		GRCr8
mRatBN7.2	X	104,132,139 - 104,154,191 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	104,132,141 - 104,154,187 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	106,261,498 - 106,283,545 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	109,760,234 - 109,782,281 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	107,316,203 - 107,337,428 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	111,798,233 - 111,820,270 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	111,798,233 - 111,820,266 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	52,779,462 - 52,801,499 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	128,249,843 - 128,271,893 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	128,323,278 - 128,345,324 (+)	NCBI
Celera	3	43,777,612 - 43,799,661 (-)	NCBI		Celera
Cytogenetic Map	X	q32	NCBI

Prps1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955490	8,303,775 - 8,330,713 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955490	8,303,775 - 8,330,713 (-)	NCBI	ChiLan1.0	ChiLan1.0

PRPS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	107,104,116 - 107,126,928 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	107,107,719 - 107,130,532 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	96,720,988 - 96,743,594 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	107,094,898 - 107,117,117 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	107,094,898 - 107,117,117 (+)	Ensembl	panpan1.1		panPan2

PRPS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	81,150,537 - 81,171,521 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	81,150,536 - 81,212,689 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	67,269,356 - 67,290,346 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	82,796,457 - 82,817,447 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	82,796,456 - 82,817,446 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	80,256,666 - 80,277,657 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	81,968,332 - 81,989,524 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	81,759,859 - 81,781,048 (+)	NCBI		UU_Cfam_GSD_1.0

Prps1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	80,521,497 - 80,543,124 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936499	7,115,780 - 7,136,449 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936499	7,114,838 - 7,136,468 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PRPS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	88,074,965 - 88,101,910 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	88,074,861 - 88,101,925 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	102,515,177 - 102,542,941 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PRPS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	95,452,481 - 95,475,933 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666065	20,574,165 - 20,597,947 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants in Prps1
536 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	503
Count of miRNA genes:	352
Interacting mature miRNAs:	405
Transcripts:	ENSMUST00000033809, ENSMUST00000155235
Prediction methods:	Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
13208552	Wght12_m	weight 12 (mouse)					X	94043606	149782996	Mouse
1558900	Bw3_m	body weight QTL 3 (mouse)			Not determined		X	133540040	165298595	Mouse
13208556	Lgth14_m	body length 14 (mouse)					X	94043606	149782996	Mouse
13824980	Ferq1_m	genetic fertility QTL 1 (mouse)					X	54045360	148782996	Mouse
25314309	Syncl5_m	synaptonemal complex length 5 (mouse)					X	121909697	152582996	Mouse
13824981	Svwq2_m	seminal vesicle weight QTL 2 (mouse)					X	128900749	153782996	Mouse
1301209	Cia19_m	collagen induced arthritis 19 (mouse)			Not determined		X	120993165	160213038	Mouse
10412164	Cmv2_m	cytomegalovirus resistance 2 (mouse)			Not determined		X	125685149	159685269	Mouse
1357823	Spha3_m	sperm head anomaly 3 (mouse)			Not determined		X	102055848	162758941	Mouse
1357433	Dbts2_m	diabetes 2 (mouse)			Not determined		X	7226295	150107038	Mouse
1301276	Tswt_m	testis weight (mouse)			Not determined		X	138376411	150789338	Mouse

RH125998

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	X	140,475,893 - 140,476,111	UniSTS	GRCm38
MGSCv37	X	137,010,432 - 137,010,650	UniSTS	GRCm37
Celera	X	123,735,222 - 123,735,440	UniSTS
Cytogenetic Map	X	F1-F2	UniSTS
Whitehead/MRC_RH	X	1622.44	UniSTS

RH126017

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	X	140,473,802 - 140,475,280	UniSTS	GRCm38
MGSCv37	X	137,008,341 - 137,009,819	UniSTS	GRCm37
Celera	X	123,733,131 - 123,734,609	UniSTS
Cytogenetic Map	X	F1-F2	UniSTS
Whitehead/MRC_RH	12	579.93	UniSTS

PPP6C

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	X	140,473,868 - 140,475,259	UniSTS	GRCm38
MGSCv37	X	137,008,407 - 137,009,798	UniSTS	GRCm37
Celera	X	123,733,197 - 123,734,588	UniSTS
Cytogenetic Map	X	F1-F2	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	NM_021463	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB025048	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK009265	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK011034	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK011304	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK089009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK143609	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK165524	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK165987	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK166856	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK168036	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK185462	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL672297	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC054772	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY003422	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466616	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000033809 ⟹ ENSMUSP00000033809

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	X	139,357,362 - 139,376,889 (+)	Ensembl
GRCm38.p6 Ensembl	X	140,456,613 - 140,476,140 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000155235

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	X	139,357,362 - 139,366,191 (+)	Ensembl
GRCm38.p6 Ensembl	X	140,456,613 - 140,465,442 (+)	Ensembl

RefSeq Acc Id:

NM_021463 ⟹ NP_067438

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	X	139,357,352 - 139,376,889 (+)	NCBI
GRCm38	X	140,456,603 - 140,476,140 (+)	ENTREZGENE
MGSCv37	X	136,991,142 - 137,010,679 (+)	RGD
Celera	X	123,716,011 - 123,735,469 (+)	RGD
cM Map	X		ENTREZGENE

Sequence:

show sequence

GCCGCGCGCTGGGCGGGAATGTAAGATGGCGGAGTAGCAACGCGGTACTGTTGGTGTTCAGACTGCCTGCTGACTTCCGTTCCCGTGTTGGCAGCGGCGGCGGCGGCGACCACTGAGCACGTTGAGGT
AGTTACCCAAGATGCCGAATATCAAAATCTTCAGCGGGAGCTCCCACCAGGACTTATCCCAGAAAATCGCTGACCGCCTGGGCCTTGAGCTAGGCAAGGTGGTGACTAAGAAATTCAGCAACCAGGAG
ACCTGTGTGGAAATTGGCGAAAGCGTTCGTGGAGAAGATGTCTACATTGTTCAAAGTGGGTGTGGTGAGATAAATGACAATCTAATGGAGCTTTTGATCATGATTAATGCTTGTAAGATCGCTTCAGC
CAGCCGGGTTACTGCAGTCATCCCATGCTTCCCTTACGCCCGCCAAGATAAGAAGGATAAGAGCCGGGCTCCAATCTCAGCTAAGCTTGTTGCAAATATGCTATCTGTAGCAGGTGCAGATCATATTA
TCACCATGGATCTACATGCATCTCAAATTCAGGGTTTCTTTGATATCCCGGTGGACAATTTATATGCAGAGCCAGCTGTCCTAAAGTGGATACGGGAGAATATATCTGAGTGGAGAAACTGTACTATT
GTCTCACCTGATGCTGGTGGAGCCAAAAGAGTGACCTCCATTGCAGACCGGCTGAATGTGGATTTTGCTTTGATTCACAAGGAACGGAAGAAGGCCAATGAAGTGGACCGCATGGTACTTGTGGGAGA
TGTGAAGGACCGTGTGGCTATACTTGTGGATGACATGGCTGACACTTGCGGTACAATCTGTCACGCCGCTGACAAACTTCTCTCAGCTGGCGCTACCAGAGTTTATGCTATCTTGACGCATGGAATCT
TTTCTGGCCCTGCCATTTCTCGAATCAACAATGCATGCTTTGAAGCAGTAGTAGTTACCAATACCATACCTCAGGAGGACAAGATGAAACACTGCTCCAAGATACAGGTGATTGACATCTCTATGATC
CTTGCAGAAGCCATCAGGAGAACCCACAATGGAGAATCTGTCTCCTACTTGTTCAGCCATGTTCCTTTATAACATAACTTCTGAAGCATTTTGAAAATAAACCAACCCCACCCCTTGTTTTTCTTGGT
ATTGGTGAGTTGAGCAGAAGACCCAGCTTGCTTCAGTATAGCTTTTTCCATCTCACATTAGCTATATTACCATTTGTCCTAAATGGGAGAAAGACAGATTGCTATTAGCTGCTAGGATGTTCAACCTG
CATTGTTGTATCCTGGCTTTCTTGTTTATTTTGTGAACCTTGCAGCTTTAAGTTGAGCTCAGCTCTTGAAAGGTGTATAGACTGTTAAGAGAGTATTCCACAAGGTCCTTAGGACGTGATTGGCAAAG
CTCATACTCCATTGCATGTGAACGCTTTGGGGTTTTCGTCATTCAGAATAACTAGCAACAAAGCCAGCCCATGTGTAATACATTTTCAGAGGTCTGCAGCAAGAACCCTGAGCATCCTTAAACATAGT
TGAGCATCCTGTAAGGCAGGGGCAGGTAGCTCAATGCAGTAATTAGGTTTTGGGAGGAAGAAGCCTGATCCATTGCTATTTAACTCTTCTCTATCTCGCTTGGATTCTCTACACCTATTCCTTTCCAG
TTGGCTTTACCTTTAGCTATTGTGACCCTTTCCTGGCCAAATATCTTGGACTCAGTGATCATTGTAACAATATCTTCGGTAATACAGACTTGCTTCTTGCTATGTAACTGCTAACATTCACATTAGGT
AACTTGCTGTAGCACGACCTTCCTTAGCCTACTACCTCTGAGGTGGTGGGTTTAGGTGGTGTCGCAGTGCCTTTTGATTAATTTAAGTATTTAATTTTTATCTTCCTTGGATCCGTTTGGCCTCTCAA
TTGAACTTACTGTATTGTGTAGAAGAAACTTAATAAAATGTCTGTCATGTGTGCAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence


Protein RefSeqs	NP_067438	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH54772	(Get FASTA)	NCBI Sequence Viewer
	BAA84686	(Get FASTA)	NCBI Sequence Viewer
	BAB26181	(Get FASTA)	NCBI Sequence Viewer
	BAB27530	(Get FASTA)	NCBI Sequence Viewer
	BAC40697	(Get FASTA)	NCBI Sequence Viewer
	BAE25461	(Get FASTA)	NCBI Sequence Viewer
	BAE38237	(Get FASTA)	NCBI Sequence Viewer
	BAE38503	(Get FASTA)	NCBI Sequence Viewer
	BAE39073	(Get FASTA)	NCBI Sequence Viewer
	BAE40019	(Get FASTA)	NCBI Sequence Viewer
	EDL23928	(Get FASTA)	NCBI Sequence Viewer
	EDL23929	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000033809
	ENSMUSP00000033809.4
GenBank Protein	Q9D7G0	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_067438 ⟸ NM_021463

- UniProtKB:

Q76MX9 (UniProtKB/Swiss-Prot), Q9D7G0 (UniProtKB/Swiss-Prot), Q3TI27 (UniProtKB/TrEMBL), Q3UPD5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMD
LHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGP
AISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL

hide sequence

Ensembl Acc Id:

ENSMUSP00000033809 ⟸ ENSMUST00000033809

Protein Domains

Ribose-phosphate pyrophosphokinase N-terminal

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9D7G0-F1-model_v2	AlphaFold	Q9D7G0	1-318	view protein structure

RGD ID:

6846126

Promoter ID:

MM_KWN:62072

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, 3T3L1_Day6, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

OTTMUST00000045356, OTTMUST00000045357

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	X	136,990,919 - 136,991,419 (+)	MPROMDB

RGD ID:

13681504

Promoter ID:

EPDNEW_M24901

Type:

multiple initiation site

Name:

Prps1_1

Description:

Mus musculus phosphoribosyl pyrophosphate synthetase 1 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	X	140,456,625 - 140,456,685	EPDNEW

Database	Acc Id	Source(s)
Ensembl Genes	ENSMUSG00000031432	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000033809	ENTREZGENE
	ENSMUST00000033809.4	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.50.2020	UniProtKB/Swiss-Prot
InterPro	PRib_PP_synth_CS	UniProtKB/Swiss-Prot
	Pribosyltran_N	UniProtKB/Swiss-Prot
	PRibTrfase_dom	UniProtKB/Swiss-Prot
	PRTase-like	UniProtKB/Swiss-Prot
	Rib-P_diPkinase	UniProtKB/Swiss-Prot
	Rib-P_diPkinase_bac	UniProtKB/Swiss-Prot
KEGG Report	mmu:19139	UniProtKB/Swiss-Prot
MGD	MGI:97775	ENTREZGENE
NCBI Gene	19139	ENTREZGENE
PANTHER	PTHR10210	UniProtKB/Swiss-Prot
	RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 1	UniProtKB/Swiss-Prot
Pfam	Pribosyl_synth	UniProtKB/Swiss-Prot
	Pribosyltran_N	UniProtKB/Swiss-Prot
PharmGKB	PRPS1	RGD
PhenoGen	Prps1	PhenoGen
PROSITE	PRPP_SYNTHASE	UniProtKB/Swiss-Prot
SMART	Pribosyltran_N	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF53271	UniProtKB/Swiss-Prot
UniProt	PRPS1_MOUSE	UniProtKB/Swiss-Prot
	Q3TI27	ENTREZGENE, UniProtKB/TrEMBL
	Q3UPD5	ENTREZGENE, UniProtKB/TrEMBL
	Q76MX9	ENTREZGENE
	Q9D7G0	ENTREZGENE
UniProt Secondary	Q76MX9	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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