Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Prps1 (phosphoribosyl pyrophosphate synthetase 1) Mus musculus
Symbol: Prps1
Name: phosphoribosyl pyrophosphate synthetase 1
Description: Predicted to have several functions, including magnesium ion binding activity; protein homodimerization activity; and purine ribonucleotide binding activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process; nervous system development; and purine-containing compound biosynthetic process. Predicted to localize to cytoplasm and ribose phosphate diphosphokinase complex. Is expressed in central nervous system; inner ear; and retina. Human ortholog(s) of this gene implicated in Arts syndrome; X-linked deafness 1; X-linked recessive disease (multiple); gout; and retinitis pigmentosa. Orthologous to human PRPS1 (phosphoribosyl pyrophosphate synthetase 1); PARTICIPATES IN de novo purine biosynthetic pathway; pentose phosphate pathway; purine metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2310010D17Rik; C76571; C76678; phosphoribosyl pyrophosphate synthase I; phosphoribosyl pyrophosphate synthetase I; Pr; Prps-1; PRS-I; ribose-phosphate pyrophosphokinase 1
Homo sapiens (human) : PRPS1 (phosphoribosyl pyrophosphate synthetase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Prps1 (phosphoribosyl pyrophosphate synthetase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prps1 (phosphoribosyl pyrophosphate synthetase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PRPS1 (phosphoribosyl pyrophosphate synthetase 1)
Canis lupus familiaris (dog) : PRPS1 (phosphoribosyl pyrophosphate synthetase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prps1 (phosphoribosyl pyrophosphate synthetase 1)
Sus scrofa (pig) : PRPS1 (phosphoribosyl pyrophosphate synthetase 1)
Chlorocebus sabaeus (African green monkey) : PRPS1 (phosphoribosyl pyrophosphate synthetase 1)
more info ...
Related Pseudogenes: Gm18890  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 EnsemblX140,456,613 - 140,476,140 (+)EnsemblGRCm38mm10GRCm38
GRCm38X140,456,603 - 140,476,140 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X136,991,142 - 137,010,679 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X135,802,977 - 135,822,503 (+)NCBImm8
CeleraX123,716,011 - 123,735,469 (+)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX61.35NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Prps1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62248
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.