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Gene: Prps1 (phosphoribosyl pyrophosphate synthetase 1) Mus musculus
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Symbol: Prps1
Name: phosphoribosyl pyrophosphate synthetase 1
Description: Predicted to have several functions, including magnesium ion binding activity; protein homodimerization activity; and purine ribonucleotide binding activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process; nervous system development; and purine-containing compound biosynthetic process. Predicted to localize to cytoplasm and ribose phosphate diphosphokinase complex. Is expressed in central nervous system; inner ear; and retina. Human ortholog(s) of this gene implicated in Arts syndrome; X-linked deafness 1; X-linked recessive disease (multiple); gout; and retinitis pigmentosa. Orthologous to human PRPS1 (phosphoribosyl pyrophosphate synthetase 1); PARTICIPATES IN de novo purine biosynthetic pathway; pentose phosphate pathway; purine metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2310010D17Rik; C76571; C76678; phosphoribosyl pyrophosphate synthase I; phosphoribosyl pyrophosphate synthetase I; Pr; Prps-1; PRS-I; ribose-phosphate pyrophosphokinase 1
Orthologs:
Homo sapiens (human) : PRPS1 (phosphoribosyl pyrophosphate synthetase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Prps1 (phosphoribosyl pyrophosphate synthetase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prps1 (phosphoribosyl pyrophosphate synthetase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PRPS1 (phosphoribosyl pyrophosphate synthetase 1)
Canis lupus familiaris (dog) : PRPS1 (phosphoribosyl pyrophosphate synthetase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prps1 (phosphoribosyl pyrophosphate synthetase 1)
Sus scrofa (pig) : PRPS1 (phosphoribosyl pyrophosphate synthetase 1)
Chlorocebus sabaeus (African green monkey) : PRPS1 (phosphoribosyl pyrophosphate synthetase 1)
more info ...
Related Pseudogenes: Gm18890  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 EnsemblX140,456,613 - 140,476,140 (+)EnsemblGRCm38mm10GRCm38
GRCm38X140,456,603 - 140,476,140 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X136,991,142 - 137,010,679 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X135,802,977 - 135,822,503 (+)NCBImm8
CeleraX123,716,011 - 123,735,469 (+)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX61.35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Prps1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62248
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.