Espl1 (extra spindle pole bodies 1, separase) - Rat Genome Database

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Gene: Espl1 (extra spindle pole bodies 1, separase) Mus musculus
Analyze
Symbol: Espl1
Name: extra spindle pole bodies 1, separase
RGD ID: 1550440
MGI Page MGI
Description: Enables cysteine-type peptidase activity. Acts upstream of or within homologous chromosome segregation; meiotic spindle organization; and mitotic sister chromatid segregation. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Used to study breast cancer. Orthologous to human ESPL1 (extra spindle pole bodies like 1, separase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AL024103; AU045071; caspase-like protein ESPL1; Ce; Cerp; Cut1/ESP1 related protein; ES; ESP1; extra spindle pole bodies 1; extra spindle poles-like 1 protein; PR; PRCE; S; se; separase; separin; SSE
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915102,204,688 - 102,232,792 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15102,204,701 - 102,232,792 (+)EnsemblGRCm39 Ensembl
GRCm3815102,296,254 - 102,324,357 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,296,266 - 102,324,357 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715102,126,724 - 102,154,787 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615102,124,359 - 102,152,390 (+)NCBIMGSCv36mm8
Celera15104,453,712 - 104,481,413 (+)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1557.45NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (EXP)
2,4-diaminotoluene  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-methylcholanthrene  (EXP)
4-hydroxynon-2-enal  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alpha-amanitin  (EXP)
amitrole  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol AF  (EXP)
bleomycin A2  (EXP)
butanal  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (EXP)
carbon nanotube  (EXP)
cefaloridine  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
dioxygen  (ISO)
doxorubicin  (EXP)
Echimidine  (ISO)
Enterolactone  (ISO)
folic acid  (EXP,ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
geraniol  (ISO)
glyphosate  (ISO)
GW 4064  (ISO)
L-methionine  (EXP)
Lasiocarpine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lidocaine  (ISO)
lucanthone  (ISO)
methimazole  (ISO)
monocrotaline  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paracetamol  (ISO)
PCB138  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
phytoestrogen  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
resveratrol  (ISO)
riddelliine  (ISO)
silicon dioxide  (EXP)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (ISO)
trimellitic anhydride  (EXP)
Triptolide  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
centrosome  (IBA,IEA,ISO)
cytoplasm  (IBA,IEA)
mitotic spindle  (IBA)
nucleus  (IBA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blastocyst morphology  (IAGP)
abnormal bone marrow cell physiology  (IAGP)
abnormal cell death  (IAGP)
abnormal cell nucleus morphology  (IAGP)
abnormal centrosome morphology  (IAGP)
abnormal chromosome morphology  (IAGP)
abnormal gonadal ridge morphology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal inner cell mass proliferation  (IAGP)
abnormal liver regeneration  (IAGP)
abnormal male germ cell morphology  (IAGP)
abnormal mitosis  (IAGP)
abnormal mitotic spindle morphology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal somite development  (IAGP)
abnormal spermatocyte morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal splenocyte morphology  (IAGP)
abnormal tumor pathology  (IAGP)
absent primordial germ cells  (IAGP)
absent spermatogonia  (IAGP)
aneuploidy  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased cell proliferation  (IAGP)
decreased embryo size  (IAGP)
decreased primordial germ cell proliferation  (IAGP)
decreased spermatid number  (IAGP)
decreased tumor incidence  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality during organogenesis  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
female infertility  (IAGP)
increased carcinoma incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased metastatic potential  (IAGP)
increased mitotic index  (IAGP)
increased splenocyte proliferation  (IAGP)
infertility  (IAGP)
male infertility  (IAGP)
premature death  (IAGP)
small testis  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7671812   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11516952   PMID:11544199   PMID:11581162   PMID:11839785   PMID:11839787   PMID:12466851   PMID:12477932  
PMID:12520002   PMID:12904583   PMID:14561405   PMID:14621295   PMID:14681479   PMID:16030258   PMID:16141072   PMID:16141073   PMID:16533944   PMID:16533945   PMID:16839882   PMID:18003702  
PMID:18232736   PMID:18287559   PMID:18728194   PMID:18799693   PMID:18843049   PMID:19124608   PMID:19249208   PMID:19625504   PMID:20360068   PMID:21267068   PMID:21494564   PMID:21677750  
PMID:21799785   PMID:21865557   PMID:21873635   PMID:22516201   PMID:23122964   PMID:23975099   PMID:24276237   PMID:26410627   PMID:26496610   PMID:26858254   PMID:27113764   PMID:27694478  
PMID:30305303   PMID:31704793   PMID:32325033   PMID:32366979   PMID:33798452   PMID:34321999   PMID:35385691   PMID:35712867  


Genomics

Comparative Map Data
Espl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915102,204,688 - 102,232,792 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15102,204,701 - 102,232,792 (+)EnsemblGRCm39 Ensembl
GRCm3815102,296,254 - 102,324,357 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,296,266 - 102,324,357 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715102,126,724 - 102,154,787 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615102,124,359 - 102,152,390 (+)NCBIMGSCv36mm8
Celera15104,453,712 - 104,481,413 (+)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1557.45NCBI
ESPL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381253,268,299 - 53,293,638 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1253,268,299 - 53,293,638 (+)EnsemblGRCh38hg38GRCh38
GRCh371253,662,083 - 53,687,422 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,948,350 - 51,973,694 (+)NCBINCBI36Build 36hg18NCBI36
Build 341251,948,817 - 51,973,694NCBI
Celera1253,311,187 - 53,336,713 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,703,798 - 50,728,935 (+)NCBIHuRef
CHM1_11253,628,380 - 53,653,869 (+)NCBICHM1_1
T2T-CHM13v2.01253,233,854 - 53,259,351 (+)NCBIT2T-CHM13v2.0
Espl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,302,460 - 135,329,570 (+)NCBIGRCr8
mRatBN7.27133,424,027 - 133,450,984 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,424,130 - 133,450,984 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7135,185,119 - 135,211,984 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,414,499 - 137,441,364 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,399,660 - 137,426,528 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,896,890 - 143,923,868 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,897,014 - 143,923,868 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,692,925 - 141,719,617 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.07143,153,049 - 143,161,944 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47141,048,197 - 141,074,383 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17141,126,857 - 141,150,662 (+)NCBI
Celera7129,857,507 - 129,884,392 (+)NCBICelera
Cytogenetic Map7q36NCBI
Espl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955458530,797 - 553,985 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955458530,269 - 553,919 (+)NCBIChiLan1.0ChiLan1.0
ESPL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21040,892,230 - 40,918,541 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11240,887,281 - 40,915,313 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01235,460,500 - 35,486,794 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11236,241,364 - 36,266,594 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,241,533 - 36,266,101 (-)Ensemblpanpan1.1panPan2
ESPL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1271,911,179 - 1,934,446 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,911,193 - 1,933,807 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2744,314,872 - 44,338,083 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0271,915,651 - 1,938,901 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl271,915,665 - 1,938,966 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1271,933,939 - 1,957,164 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,918,870 - 1,942,108 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,715,570 - 44,738,805 (+)NCBIUU_Cfam_GSD_1.0
Espl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494562,588,213 - 62,619,030 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651210,556,672 - 10,576,588 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651210,556,269 - 10,576,582 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ESPL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,487,052 - 18,509,913 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1518,486,969 - 18,509,913 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,922,397 - 18,945,652 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ESPL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11149,374,333 - 49,401,801 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037196,658,194 - 196,684,208 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Espl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249041,305,000 - 1,330,761 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249041,305,040 - 1,330,505 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Espl1
837 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:54
Interacting mature miRNAs:58
Transcripts:ENSMUST00000064924
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570345653104073951Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
11528547Sluc34_msusceptibility to lung cancer 34 (mouse)1597884933102896555Mouse
1301918Skull22_mskull morphology 22 (mouse)Not determined1585901546104073951Mouse
14928306Manh79_mmandible shape 79 (mouse)1578847557104073951Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578601103102901704Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78601103102901704Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573430144104073951Mouse
11530038Sluc34b_msusceptibility to lung cancer 34b (mouse)1585896437104073951Mouse
11530037Sluc34a_msusceptibility to lung cancer 34a (mouse)1585896437104073951Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1578897881104073951Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577527592104073951Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572382669104073951Mouse
10402490Dipa5_mdrug induced psychomotor activation 5 (mouse)Not determined1579163411104073951Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570349271104073951Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564306334103425899Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556186708103425899Mouse
4141902Cia37_mcollagen induced arthritis 37 (mouse)Not determined1580884933104073951Mouse
14700689Carg5_mCandida albicans resistance gene 5 (mouse)1597697881103008427Mouse
4141581Dshv1_mdorsal hippocampal volume 1 (mouse)Not determined92788640103425899Mouse
4141897Imrfq2_mimmune response to Factor IX QTL 2 (mouse)Not determined79908940104073951Mouse
1301284Cosz3_mcocaine seizure 3 (mouse)Not determined1580313634104073951Mouse
4141511Gdcr1_mglycerolphosphate dehydrogenase regulator 1 (mouse)Not determined82615474104073951Mouse
1357614Bmca_mbile mucin accumulation (mouse)Not determined1585896437104073951Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570349271104073951Mouse
1300974Pgia9_mproteoglycan induced arthritis 9 (mouse)Not determined1580884933104073951Mouse

Markers in Region
AU045071  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3815102,324,038 - 102,324,204UniSTSGRCm38
MGSCv3715102,154,469 - 102,154,635UniSTSGRCm37
Celera15104,481,095 - 104,481,261UniSTS
Cytogenetic Map15F3UniSTS
Whitehead/MRC_RH15920.1UniSTS
RH125481  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15F3UniSTS
D10Mit157.2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6D1UniSTS
Cytogenetic Map16B4UniSTS
Cytogenetic Map18E2UniSTS
Cytogenetic Map4C3UniSTS
Cytogenetic Map7B2UniSTS
Cytogenetic Map4D2.3UniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map14E2.2UniSTS
Cytogenetic Map4C7UniSTS
Cytogenetic Map2H4UniSTS
Cytogenetic Map1FUniSTS
Cytogenetic Map6C3UniSTS
Cytogenetic Map11DUniSTS
Cytogenetic Map3G2UniSTS
Cytogenetic Map17A1UniSTS
Cytogenetic Map9F2UniSTS
Cytogenetic Map12F1UniSTS
Cytogenetic Map19C2UniSTS
Cytogenetic Map3BUniSTS
Cytogenetic Map8C1UniSTS
Cytogenetic Map18A2UniSTS
Cytogenetic Map3F2UniSTS
Cytogenetic Map14C3UniSTS
Cytogenetic Map8E1UniSTS
Cytogenetic Map8E2UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map18B1UniSTS
Cytogenetic Map9CUniSTS
Cytogenetic Map14C2UniSTS
Cytogenetic Map6A1UniSTS
Cytogenetic Map10B4UniSTS
Cytogenetic Map13D2.1UniSTS
Cytogenetic Map5E5UniSTS
Cytogenetic Map11B1.3UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map9A5.2UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map17E3UniSTS
Cytogenetic Map11B3UniSTS
Cytogenetic Map1H4UniSTS
Cytogenetic Map6A3UniSTS
Cytogenetic Map5E4-E5UniSTS
Cytogenetic Map15E1UniSTS
Cytogenetic Map13DUniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map14D1UniSTS
Cytogenetic Map7B4UniSTS
Cytogenetic Map8D3UniSTS
Cytogenetic MapXDUniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map7E2UniSTS
Cytogenetic Map1H2.3UniSTS
Cytogenetic Map7A2UniSTS
Cytogenetic Map7F3UniSTS
Cytogenetic Map9F1UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map4E2UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic Map8B3.3UniSTS
Cytogenetic Map8D2UniSTS
Cytogenetic Map3DUniSTS
Cytogenetic Map15D2UniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map16B2UniSTS
Cytogenetic Map7CUniSTS
Cytogenetic Map3F2.1UniSTS
Cytogenetic Map6F3UniSTS
Cytogenetic Map1C4UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic Map9F3UniSTS
Cytogenetic Map2BUniSTS
Cytogenetic Map13B3UniSTS
Cytogenetic Map9A4UniSTS
Cytogenetic Map5A3UniSTS
Cytogenetic Map2H1UniSTS
Cytogenetic Map16B1UniSTS
Cytogenetic Map1A5UniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map9E1UniSTS
Cytogenetic Map6G1UniSTS
Cytogenetic MapXA2UniSTS
Cytogenetic Map13B1UniSTS
Cytogenetic Map5E2UniSTS
Cytogenetic Map12C1UniSTS
Cytogenetic Map5FUniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map10C2UniSTS
Cytogenetic Map9BUniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map7F1UniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map10A4UniSTS
Cytogenetic Map8A2UniSTS
Cytogenetic Map18A1UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map1C2UniSTS
Cytogenetic Map11B2UniSTS
Cytogenetic Map6E3UniSTS
Cytogenetic Map5C3.3UniSTS
Cytogenetic Map1BUniSTS
Cytogenetic Map17A3.1UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map2E5UniSTS
Cytogenetic Map11A1UniSTS
Cytogenetic Map4B1UniSTS
Cytogenetic Map15A2UniSTS
Cytogenetic Map8C3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map5G3UniSTS
Cytogenetic Map4A3UniSTS
Cytogenetic Map2H3UniSTS
Cytogenetic Map8A1UniSTS
Cytogenetic Map8A1.1UniSTS
Cytogenetic Map16A3UniSTS
Cytogenetic Map10B1UniSTS
Cytogenetic Map19AUniSTS
Cytogenetic Map10A1UniSTS
Cytogenetic Map13D1UniSTS
Cytogenetic Map4A1UniSTS
Cytogenetic Map9A3UniSTS
Cytogenetic Map17CUniSTS
Cytogenetic Map1DUniSTS
Cytogenetic Map5E3UniSTS
Cytogenetic Map15D3UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map7D3UniSTS
Cytogenetic Map2A1UniSTS
Cytogenetic Map14C1UniSTS
Cytogenetic Map14E5UniSTS
Cytogenetic Map10CUniSTS
Cytogenetic Map18B2UniSTS
Cytogenetic Map2F1UniSTS
Cytogenetic Map10D3UniSTS
Cytogenetic Map17A2UniSTS
Cytogenetic Map2C3UniSTS
Cytogenetic Map1C3UniSTS
Cytogenetic Map17B2UniSTS
Cytogenetic Map5B2UniSTS
Cytogenetic Map5G1UniSTS
Cytogenetic Map4C6UniSTS
Cytogenetic Map13C3UniSTS
Cytogenetic Map2E1UniSTS
Cytogenetic Map17A3.2-A3.3UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map7E3UniSTS
Cytogenetic Map13C1UniSTS
Cytogenetic Map9E3.1UniSTS
Cytogenetic Map15E3UniSTS
Cytogenetic Map6B1UniSTS
Cytogenetic MapXE3UniSTS
Cytogenetic Map4C4UniSTS
Cytogenetic Map3E3UniSTS
Cytogenetic Map11A4UniSTS
Cytogenetic Map4C5UniSTS
Cytogenetic Map18B3UniSTS
Cytogenetic Map9A2UniSTS
Cytogenetic Map7E1UniSTS
Cytogenetic Map5D-E1UniSTS
Cytogenetic Map5B3UniSTS
Cytogenetic Map13A2-A3UniSTS
Cytogenetic Map5A2UniSTS
Cytogenetic Map4B3UniSTS
Cytogenetic Map1E4UniSTS
Cytogenetic Map17E4UniSTS
Cytogenetic Map1G2UniSTS
Cytogenetic Map15B3.1UniSTS
Cytogenetic Map12EUniSTS
Cytogenetic MapXA5UniSTS
Cytogenetic Map6A3.3UniSTS
Cytogenetic Map6G3UniSTS
Cytogenetic Map6F2UniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map4D2.1UniSTS
Cytogenetic Map4A5UniSTS
Cytogenetic Map3F2.2UniSTS
Cytogenetic Map1E3-E4UniSTS
Cytogenetic Map9F1-F3UniSTS
Cytogenetic Map1C1.1UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map12A2UniSTS
Cytogenetic Map17A3-BUniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map14A3UniSTS
Cytogenetic Map5G1.1UniSTS
Cytogenetic MapXF2-F4UniSTS
Cytogenetic Map7D2UniSTS
Cytogenetic Map2F3UniSTS
Cytogenetic Map10A3UniSTS
Cytogenetic MapXA7.3UniSTS
Cytogenetic Map9F1-F2UniSTS
Cytogenetic Map13A3.2UniSTS
Cytogenetic Map10A2UniSTS
Cytogenetic Map1C1UniSTS
Cytogenetic Map1A1UniSTS
Cytogenetic Map12D3UniSTS
Cytogenetic Map1A3-A5UniSTS
Cytogenetic Map2A2UniSTS
Cytogenetic Map3A1UniSTS
Cytogenetic MapXA3.3UniSTS
Cytogenetic Map16A-B1UniSTS
Cytogenetic Map1D2.3UniSTS
Cytogenetic Map6B2.3UniSTS
Cytogenetic Map2G3UniSTS
Cytogenetic MapXA2-A3.1UniSTS
Cytogenetic Map9A5.3UniSTS
Cytogenetic Map14A2-BUniSTS
Cytogenetic Map8E1-E2UniSTS
Cytogenetic Map8A3UniSTS
Cytogenetic Map1G3-H1UniSTS
Cytogenetic Map8B3-C1UniSTS
Cytogenetic Map19C1UniSTS
Cytogenetic Map8C5UniSTS
Cytogenetic Map8A4UniSTS
Cytogenetic Map15F3UniSTS
Cytogenetic Map14E4UniSTS
Cytogenetic Map4D2.2UniSTS
Cytogenetic MapXF5UniSTS
cM Map1040.0UniSTS
Whitehead Genetic1033.9UniSTS
Espl1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15F3UniSTS
cM Map1557.45UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000064924   ⟹   ENSMUSP00000064465
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,204,701 - 102,232,792 (+)Ensembl
GRCm38.p6 Ensembl15102,296,266 - 102,324,357 (+)Ensembl
Ensembl Acc Id: ENSMUST00000229050   ⟹   ENSMUSP00000155304
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,204,733 - 102,232,747 (+)Ensembl
GRCm38.p6 Ensembl15102,296,298 - 102,324,312 (+)Ensembl
Ensembl Acc Id: ENSMUST00000229942   ⟹   ENSMUSP00000155666
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,231,100 - 102,232,132 (+)Ensembl
GRCm38.p6 Ensembl15102,322,665 - 102,323,697 (+)Ensembl
Ensembl Acc Id: ENSMUST00000230116
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,224,920 - 102,225,511 (+)Ensembl
GRCm38.p6 Ensembl15102,316,485 - 102,317,076 (+)Ensembl
Ensembl Acc Id: ENSMUST00000230212   ⟹   ENSMUSP00000155074
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,204,729 - 102,207,034 (+)Ensembl
GRCm38.p6 Ensembl15102,296,294 - 102,298,599 (+)Ensembl
Ensembl Acc Id: ENSMUST00000230222
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,231,123 - 102,231,721 (+)Ensembl
GRCm38.p6 Ensembl15102,322,688 - 102,323,286 (+)Ensembl
Ensembl Acc Id: ENSMUST00000230617
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,227,545 - 102,230,541 (+)Ensembl
GRCm38.p6 Ensembl15102,319,110 - 102,322,106 (+)Ensembl
Ensembl Acc Id: ENSMUST00000231104   ⟹   ENSMUSP00000155469
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,204,740 - 102,206,834 (+)Ensembl
GRCm38.p6 Ensembl15102,296,305 - 102,298,399 (+)Ensembl
Ensembl Acc Id: ENSMUST00000231207
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15102,230,807 - 102,231,627 (+)Ensembl
GRCm38.p6 Ensembl15102,322,372 - 102,323,192 (+)Ensembl
RefSeq Acc Id: NM_001014976   ⟹   NP_001014976
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915102,204,728 - 102,232,791 (+)NCBI
GRCm3815102,296,293 - 102,324,356 (+)NCBI
MGSCv3715102,126,724 - 102,154,787 (+)RGD
Celera15104,453,712 - 104,481,413 (+)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001356312   ⟹   NP_001343241
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915102,204,728 - 102,232,791 (+)NCBI
GRCm3815102,296,293 - 102,324,356 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006520258   ⟹   XP_006520321
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915102,204,688 - 102,232,792 (+)NCBI
GRCm3815102,296,254 - 102,324,357 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006520259   ⟹   XP_006520322
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915102,204,688 - 102,232,792 (+)NCBI
GRCm3815102,296,254 - 102,324,357 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036159062   ⟹   XP_036014955
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915102,204,688 - 102,232,792 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036159063   ⟹   XP_036014956
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915102,204,690 - 102,232,792 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001014976   ⟸   NM_001014976
- UniProtKB: A6H6E3 (UniProtKB/Swiss-Prot),   P60330 (UniProtKB/Swiss-Prot),   A6H6E1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006520321   ⟸   XM_006520258
- Peptide Label: isoform X1
- UniProtKB: A6H6E3 (UniProtKB/Swiss-Prot),   P60330 (UniProtKB/Swiss-Prot),   A6H6E1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006520322   ⟸   XM_006520259
- Peptide Label: isoform X1
- UniProtKB: A6H6E3 (UniProtKB/Swiss-Prot),   P60330 (UniProtKB/Swiss-Prot),   A6H6E1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001343241   ⟸   NM_001356312
- UniProtKB: P60330 (UniProtKB/Swiss-Prot),   A6H6E3 (UniProtKB/Swiss-Prot),   A6H6E1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000155469   ⟸   ENSMUST00000231104
Ensembl Acc Id: ENSMUSP00000155074   ⟸   ENSMUST00000230212
Ensembl Acc Id: ENSMUSP00000064465   ⟸   ENSMUST00000064924
Ensembl Acc Id: ENSMUSP00000155666   ⟸   ENSMUST00000229942
Ensembl Acc Id: ENSMUSP00000155304   ⟸   ENSMUST00000229050
RefSeq Acc Id: XP_036014955   ⟸   XM_036159062
- Peptide Label: isoform X1
- UniProtKB: P60330 (UniProtKB/Swiss-Prot),   A6H6E3 (UniProtKB/Swiss-Prot),   A6H6E1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036014956   ⟸   XM_036159063
- Peptide Label: isoform X2
Protein Domains
Peptidase C50

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P60330-F1-model_v2 AlphaFold P60330 1-2118 view protein structure

Promoters
RGD ID:6825986
Promoter ID:MM_KWN:19841
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_001014976,   UC007XVG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3615102,126,389 - 102,126,889 (+)MPROMDB
RGD ID:8685192
Promoter ID:EPDNEW_M20627
Type:multiple initiation site
Name:Espl1_1
Description:Mus musculus extra spindle pole bodies 1, separase , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3815102,296,299 - 102,296,359EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2146156 AgrOrtholog
Ensembl Genes ENSMUSG00000058290 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000064924 ENTREZGENE
  ENSMUST00000064924.6 UniProtKB/Swiss-Prot
  ENSMUST00000229050 ENTREZGENE
  ENSMUST00000229050.2 UniProtKB/Swiss-Prot
InterPro Peptidase_C50 UniProtKB/Swiss-Prot
  SEPARIN_core_dom UniProtKB/Swiss-Prot
KEGG Report mmu:105988 UniProtKB/Swiss-Prot
MGD MGI:2146156 ENTREZGENE
NCBI Gene 105988 ENTREZGENE
PANTHER PTHR12792 UniProtKB/Swiss-Prot
  SEPARIN UniProtKB/Swiss-Prot
Pfam Peptidase_C50 UniProtKB/Swiss-Prot
PhenoGen Espl1 PhenoGen
PROSITE SEPARIN UniProtKB/Swiss-Prot
UniProt A0A2R8VHG0_MOUSE UniProtKB/TrEMBL
  A0A2R8VHV9_MOUSE UniProtKB/TrEMBL
  A0A2R8VI27_MOUSE UniProtKB/TrEMBL
  A6H6E1 ENTREZGENE, UniProtKB/TrEMBL
  A6H6E3 ENTREZGENE
  ESPL1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q0VGV2_MOUSE UniProtKB/TrEMBL
  Q56TS3_MOUSE UniProtKB/TrEMBL
UniProt Secondary A6H6E3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-18 Espl1  extra spindle pole bodies 1, separase    extra spindle pole bodies 1 (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED
2013-11-05 Espl1  extra spindle pole bodies 1 (S. cerevisiae)    extra spindle poles-like 1 (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED