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Gene: Ppm1d (protein phosphatase 1D magnesium-dependent, delta isoform) Mus musculus
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Symbol: Ppm1d
Name: protein phosphatase 1D magnesium-dependent, delta isoform
Description: Predicted to have magnesium-dependent protein serine/threonine phosphatase activity and mitogen-activated protein kinase binding activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; G2/M transition of mitotic cell cycle; and chromatin silencing. Predicted to localize to the cytosol and nucleus. Human ortholog(s) of this gene implicated in breast cancer. Is expressed in several structures, including adrenal gland; genitourinary system; gut; hemolymphoid system gland; and integumental system. Orthologous to human PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; p38 MAPK signaling pathway; p53 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AV338790; p53-induced protein phosphatase 1; PP2C-delta; protein phosphatase 1D; protein phosphatase 2C isoform delta; protein phosphatase magnesium-dependent 1 delta; Wip1
Orthologs:
Homo sapiens (human) : PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ppm1d (protein phosphatase, Mg2+/Mn2+ dependent, 1D)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ppm1d (protein phosphatase, Mg2+/Mn2+ dependent 1D)
Pan paniscus (bonobo/pygmy chimpanzee) : PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D)
Canis lupus familiaris (dog) : PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ppm1d (protein phosphatase, Mg2+/Mn2+ dependent 1D)
Sus scrofa (pig) : PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381185,311,254 - 85,347,071 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371185,124,756 - 85,160,573 (+)NCBIGRCm37mm9NCBIm37
MGSCv361185,127,449 - 85,163,261 (+)NCBImm8
Celera1194,934,381 - 94,968,789 (+)NCBICelera
Cytogenetic Map11 CNCBI
cM Map1151.34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ppm1d
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1313499
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.