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Gene: Ppm1d (protein phosphatase 1D magnesium-dependent, delta isoform) Mus musculus
Symbol: Ppm1d
Name: protein phosphatase 1D magnesium-dependent, delta isoform
Description: Predicted to have magnesium-dependent protein serine/threonine phosphatase activity and mitogen-activated protein kinase binding activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; G2/M transition of mitotic cell cycle; and chromatin silencing. Predicted to localize to the cytosol and nucleus. Human ortholog(s) of this gene implicated in breast cancer. Is expressed in several structures, including adrenal gland; genitourinary system; gut; hemolymphoid system gland; and integumental system. Orthologous to human PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; p38 MAPK signaling pathway; p53 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AV338790; p53-induced protein phosphatase 1; PP2C-delta; protein phosphatase 1D; protein phosphatase 2C isoform delta; protein phosphatase magnesium-dependent 1 delta; Wip1
Homo sapiens (human) : PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ppm1d (protein phosphatase, Mg2+/Mn2+ dependent, 1D)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ppm1d (protein phosphatase, Mg2+/Mn2+ dependent 1D)
Pan paniscus (bonobo/pygmy chimpanzee) : PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D)
Canis lupus familiaris (dog) : PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ppm1d (protein phosphatase, Mg2+/Mn2+ dependent 1D)
Sus scrofa (pig) : PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381185,311,254 - 85,347,071 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371185,124,756 - 85,160,573 (+)NCBIGRCm37mm9NCBIm37
MGSCv361185,127,449 - 85,163,261 (+)NCBImm8
Celera1194,934,381 - 94,968,789 (+)NCBICelera
Cytogenetic Map11 CNCBI
cM Map1151.34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ppm1d
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1313499
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.