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Gene: Cask (calcium/calmodulin-dependent serine protein kinase (MAGUK family)) Mus musculus
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Symbol: Cask
Name: calcium/calmodulin-dependent serine protein kinase (MAGUK family)
Description: Exhibits neurexin family protein binding activity. Involved in several processes, including calcium ion import; positive regulation of calcium ion import; and regulation of synaptic vesicle exocytosis. Localizes to several cellular components, including Schaffer collateral - CA1 synapse; basolateral plasma membrane; and cell-cell junction. Colocalizes with basement membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in FG syndrome and syndromic X-linked intellectual disability Najm type. Orthologous to human CASK (calcium/calmodulin dependent serine protein kinase); PARTICIPATES IN syndecan signaling pathway; INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; 3-methylcholanthrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DXPri1; DXRib1; LIN-2; MGC7449; mLin-2; Pals3; peripheral plasma membrane protein CASK
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 EnsemblX13,517,080 - 13,851,367 (-)EnsemblGRCm38mm10GRCm38
GRCm38X13,517,080 - 13,846,783 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X13,094,206 - 13,423,667 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X12,678,006 - 13,003,515 (-)NCBImm8
MGSCv36X10,595,356 - 10,921,350 (-)NCBImm8
CeleraX11,186,392 - 11,514,710 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX8.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Cask
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62296
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.