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Gene: Cask (calcium/calmodulin-dependent serine protein kinase (MAGUK family)) Mus musculus
Symbol: Cask
Name: calcium/calmodulin-dependent serine protein kinase (MAGUK family)
Description: Exhibits neurexin family protein binding activity. Involved in several processes, including calcium ion import; positive regulation of calcium ion import; and regulation of synaptic vesicle exocytosis. Localizes to several cellular components, including Schaffer collateral - CA1 synapse; basolateral plasma membrane; and cell-cell junction. Colocalizes with basement membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in FG syndrome and syndromic X-linked intellectual disability Najm type. Orthologous to human CASK (calcium/calmodulin dependent serine protein kinase); PARTICIPATES IN syndecan signaling pathway; INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; 3-methylcholanthrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DXPri1; DXRib1; LIN-2; MGC7449; mLin-2; Pals3; peripheral plasma membrane protein CASK
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 EnsemblX13,517,080 - 13,851,367 (-)EnsemblGRCm38mm10GRCm38
GRCm38X13,517,080 - 13,846,783 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X13,094,206 - 13,423,667 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X12,678,006 - 13,003,515 (-)NCBImm8
MGSCv36X10,595,356 - 10,921,350 (-)NCBImm8
CeleraX11,186,392 - 11,514,710 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX8.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cask
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62296
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.