Siva1 (SIVA1, apoptosis-inducing factor) - Rat Genome Database
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Gene: Siva1 (SIVA1, apoptosis-inducing factor) Mus musculus
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Symbol: Siva1
Name: SIVA1, apoptosis-inducing factor
RGD ID: 1558070
MGI Page MGI
Description: Exhibits CD27 receptor binding activity; tumor necrosis factor receptor binding activity; and virus receptor activity. Predicted to be involved in several processes, including activation-induced cell death of T cells; negative regulation of NF-kappaB transcription factor activity; and positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Predicted to localize to mitochondrion and nucleoplasm. Is expressed in cerebral cortex ventricular layer. Orthologous to human SIVA1 (SIVA1 apoptosis inducing factor); INTERACTS WITH 1,2-dimethylhydrazine; 3-methylcholanthrene; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: apoptosis regulatory protein Siva; Cd27 binding protein; CD27-binding protein; CD27b; CD27bp; Siva
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm12501   Gm16380  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,611,262 - 112,615,586 (+)NCBIGRCm39mm39
GRCm3812112,644,828 - 112,649,152 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,644,679 - 112,649,149 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712113,883,039 - 113,887,363 (+)NCBIGRCm37mm9NCBIm37
MGSCv3612113,092,716 - 113,096,953 (+)NCBImm8
Celera12113,858,455 - 113,862,779 (+)NCBICelera
Cytogenetic Map12F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
mitochondrion  (ISO)
nucleoplasm  (ISO)
nucleus  (IEA)

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:9177220   PMID:9692890   PMID:10349636   PMID:10597319   PMID:10756043   PMID:11042159   PMID:11076861   PMID:11601913   PMID:12011449   PMID:12477932   PMID:12478477  
PMID:12520002   PMID:14610273   PMID:15105421   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:17464332   PMID:17965021   PMID:19293149   PMID:19521500   PMID:19590512  
PMID:19643733   PMID:21307125   PMID:21768358   PMID:21873635   PMID:24194600   PMID:25813352   PMID:27626380   PMID:27773928   PMID:31164717  


Genomics

Comparative Map Data
Siva1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,611,262 - 112,615,586 (+)NCBIGRCm39mm39
GRCm3812112,644,828 - 112,649,152 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,644,679 - 112,649,149 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712113,883,039 - 113,887,363 (+)NCBIGRCm37mm9NCBIm37
MGSCv3612113,092,716 - 113,096,953 (+)NCBImm8
Celera12113,858,455 - 113,862,779 (+)NCBICelera
Cytogenetic Map12F1NCBI
SIVA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl14104,753,147 - 104,768,494 (+)EnsemblGRCh38hg38GRCh38
GRCh3814104,752,420 - 104,759,659 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714105,219,470 - 105,225,996 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614104,290,515 - 104,297,041 (+)NCBINCBI36hg18NCBI36
Celera1485,274,542 - 85,281,070 (+)NCBI
Cytogenetic Map14q32.33NCBI
HuRef1485,416,458 - 85,422,986 (+)NCBIHuRef
CHM1_114105,157,086 - 105,163,614 (+)NCBICHM1_1
Siva1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.06137,209,999 - 137,214,379 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,210,052 - 137,214,388 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06146,216,931 - 146,221,556 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46137,631,408 - 137,635,724 (+)NCBIRGSC3.4rn4RGSC3.4
Celera6129,253,021 - 129,257,273 (+)NCBICelera
Cytogenetic Map6q32NCBI
Siva1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555383,197,983 - 3,202,782 (+)NCBIChiLan1.0ChiLan1.0
SIVA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.114105,196,118 - 105,202,678 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14105,196,118 - 105,202,678 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01485,404,148 - 85,408,254 (+)NCBIMhudiblu_PPA_v0panPan3
SIVA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl872,309,447 - 72,313,640 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1872,309,400 - 72,313,726 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Siva1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936621641,456 - 650,067 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIVA1
(Sus scrofa - pig)
No map positions available.
SIVA1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12482,689,233 - 82,695,073 (+)NCBI
ChlSab1.1 Ensembl2482,689,254 - 82,695,146 (+)Ensembl
Siva1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624734530,711 - 535,281 (-)NCBI

Position Markers
UniSTS:236127  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812112,646,933 - 112,647,863UniSTSGRCm38
GRCm38953,884,295 - 53,884,433UniSTSGRCm38
MGSCv3712113,885,144 - 113,886,074UniSTSGRCm37
MGSCv37953,732,102 - 53,732,240UniSTSGRCm37
Celera951,137,595 - 51,137,733UniSTS
Celera12113,860,560 - 113,861,490UniSTS
Cytogenetic Map12F2UniSTS
Cytogenetic Map9A5.3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226793Feml10_mfemur length 10, 5 week (mouse)1268300000113400000Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80909934113419913Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80909934113419913Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80909934113419913Mouse
1357701Lvrq10_mliver weight QTL 10 (mouse)Not determined1280909934113419913Mouse
39128213Lwq23_mliver weight QTL 10 (mouse)1280909934113419913Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1281022884115022884Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282700137116700137Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283565816117565965Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283565816117565965Mouse
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285995320119995424Mouse
10412156Nociq3_mnociceptive sensitivity inflammatory QTL 3 (mouse)Not determined1286349301114868033Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288086615120129022Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288086615120129022Mouse
1301308Prdt4_mprion disease incubation time 4 (mouse)Not determined1288342095120129022Mouse
5491194Mobq3_mmultigenic obesity QTL 3 (mouse)Not determined1289697812120129022Mouse
1301836Heal5_mwound healing/regeneration 5 (mouse)Not determined1289972772120129022Mouse
1301922Bbaa6_mB.burgdorferi-associated arthritis 6 (mouse)Not determined1290342009120129022Mouse
10402491Dipa4_mdrug induced psychomotor activation 4 (mouse)Not determined1291256256120129022Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292783591120129022Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292783591120129022Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292969663120129022Mouse
1300973Abmm_mantibody mediated myocarditis (mouse)Not determined1293298027120129022Mouse
1302177Dps2_mdelta power in slow-wave sleep 2 (mouse)Not determined1294179630120129022Mouse
1302138Im6_mimmunoregulatory 6 (mouse)Not determined1296896717120129022Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296896717120129022Mouse
10412075Nils1_mneointima lesion size 1 (mouse)Not determined12102060930120129022Mouse
4141297Plyid_mPolymeric IgA dominance (mouse)Not determined109217459115921502Mouse
1558957Igan4_mIgA nephropathy 4 (mouse)Not determined12109783591119061214Mouse
15092085Igly2_mIgG glycosylation 2, GP14 (mouse)12111770863121233193Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:136
Count of miRNA genes:60
Interacting mature miRNAs:67
Transcripts:ENSMUST00000021728, ENSMUST00000109755
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001161737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC124373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF033112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF033113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF033114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF033115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW060433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB524656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000021728   ⟹   ENSMUSP00000021728
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl12112,644,679 - 112,649,145 (+)Ensembl
RefSeq Acc Id: ENSMUST00000109755   ⟹   ENSMUSP00000105377
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl12112,644,967 - 112,649,037 (+)Ensembl
RefSeq Acc Id: ENSMUST00000222353
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl12112,646,418 - 112,646,985 (+)Ensembl
RefSeq Acc Id: ENSMUST00000222368
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl12112,647,751 - 112,649,149 (+)Ensembl
RefSeq Acc Id: ENSMUST00000222729
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl12112,647,832 - 112,649,148 (+)Ensembl
RefSeq Acc Id: NM_001161737   ⟹   NP_001155209
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912112,611,262 - 112,615,586 (+)NCBI
GRCm3812112,644,828 - 112,649,152 (+)ENTREZGENE
MGSCv3712113,883,039 - 113,887,363 (+)RGD
Celera12113,858,455 - 113,862,779 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_013929   ⟹   NP_038957
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912112,611,262 - 112,615,586 (+)NCBI
GRCm3812112,644,828 - 112,649,152 (+)ENTREZGENE
MGSCv3712113,883,039 - 113,887,363 (+)RGD
Celera12113,858,455 - 113,862,779 (+)RGD
cM Map12 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_038957   ⟸   NM_013929
- Peptide Label: isoform 1
- UniProtKB: O54926 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001155209   ⟸   NM_001161737
- Peptide Label: isoform 2
- UniProtKB: O54926 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000105377   ⟸   ENSMUST00000109755
RefSeq Acc Id: ENSMUSP00000021728   ⟸   ENSMUST00000021728

Promoters
RGD ID:8679384
Promoter ID:EPDNEW_M17723
Type:initiation region
Name:Siva1_1
Description:Mus musculus SIVA1, apoptosis-inducing factor , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3812112,644,935 - 112,644,995EPDNEW
RGD ID:6823413
Promoter ID:MM_KWN:12874
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_001161737,   NM_013929
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3612113,882,616 - 113,883,302 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1353606 AgrOrtholog
Ensembl Genes ENSMUSG00000064326 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000021728 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000105377 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000021728 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000109755 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Siva UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:30954 UniProtKB/Swiss-Prot
MGD MGI:1353606 ENTREZGENE
NCBI Gene 30954 ENTREZGENE
PANTHER PTHR14365 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Siva UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Siva1 PhenoGen
PIRSF Siva_cd27_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt O54926 ENTREZGENE
  Q3TFC3_MOUSE UniProtKB/TrEMBL
  SIVA_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q3U6J2 UniProtKB/Swiss-Prot
  Q921I8 UniProtKB/Swiss-Prot
  Q9CWL1 UniProtKB/Swiss-Prot
  Q9R1Q0 UniProtKB/Swiss-Prot
  Q9R1Q1 UniProtKB/Swiss-Prot