Siva1 (SIVA1, apoptosis-inducing factor)

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Gene: Siva1 (SIVA1, apoptosis-inducing factor) Mus musculus

Analyze

Symbol:

Siva1

Name:

SIVA1, apoptosis-inducing factor

RGD ID:

1558070

MGI Page

MGI

Description:

Exhibits CD27 receptor binding activity; tumor necrosis factor receptor binding activity; and virus receptor activity. Predicted to be involved in several processes, including activation-induced cell death of T cells; negative regulation of NF-kappaB transcription factor activity; and positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Predicted to localize to mitochondrion and nucleoplasm. Is expressed in cerebral cortex ventricular layer. Orthologous to human SIVA1 (SIVA1 apoptosis inducing factor); INTERACTS WITH 1,2-dimethylhydrazine; 3-methylcholanthrene; aflatoxin B1.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

apoptosis regulatory protein Siva; Cd27 binding protein; CD27-binding protein; CD27b; CD27bp; Siva

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SIVA1 (SIVA1 apoptosis inducing factor)	HGNC	Ensembl, HGNC, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Siva1 (SIVA1, apoptosis-inducing factor)	HGNC	Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Siva1 (SIVA1 apoptosis inducing factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SIVA1 (SIVA1 apoptosis inducing factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SIVA1 (SIVA1 apoptosis inducing factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Siva1 (SIVA1 apoptosis inducing factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SIVA1 (SIVA1 apoptosis inducing factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	SIVA1 (SIVA1 apoptosis inducing factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Siva1 (SIVA1 apoptosis inducing factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Siva1 (SIVA1, apoptosis-inducing factor)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Homo sapiens (human):	SIVA1 (SIVA1 apoptosis inducing factor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Danio rerio (zebrafish):	siva1 (SIVA1, apoptosis-inducing factor)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam\|ZFIN)
Drosophila melanogaster (fruit fly):	CG13373	Alliance	DIOPT (InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB)

Related Pseudogenes:

Gm12501 Gm16380

Latest Assembly:

GRCm38 - Mouse Genome Assembly GRCm38

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	112,611,262 - 112,615,586 (+)	NCBI	GRCm39		mm39
GRCm38	12	112,644,828 - 112,649,152 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	112,644,679 - 112,649,149 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	113,883,039 - 113,887,363 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	12	113,092,716 - 113,096,953 (+)	NCBI			mm8
Celera	12	113,858,455 - 113,862,779 (+)	NCBI		Celera
Cytogenetic Map	12	F1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Coxsackievirus Infections (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

(S)-nicotine (ISO)

1,2-dimethylhydrazine (EXP)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,6-dinitrotoluene (ISO)

2-hydroxypropanoic acid (ISO)

3-methylcholanthrene (EXP)

acetamide (ISO)

acrolein (ISO)

aflatoxin B1 (EXP)

alpha-pinene (ISO)

amiodarone (EXP)

Aroclor 1254 (EXP)

arsane (ISO)

arsenic atom (ISO)

beauvericin (ISO)

benzo[a]pyrene (EXP,ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

bortezomib (ISO)

butan-1-ol (ISO)

calcitriol (ISO)

carbon nanotube (EXP)

chloroacetaldehyde (ISO)

choline (EXP)

chromium(6+) (EXP)

cidofovir anhydrous (ISO)

ciguatoxin CTX1B (EXP)

cisplatin (ISO)

clodronic acid (ISO)

cobalt dichloride (ISO)

cocaine (EXP)

copper(II) sulfate (ISO)

crocidolite asbestos (EXP)

cyclosporin A (ISO)

dicrotophos (ISO)

diethylstilbestrol (EXP)

dioxygen (ISO)

endosulfan (ISO)

fenofibrate (ISO)

folic acid (EXP)

ifosfamide (ISO)

isoprenaline (EXP)

L-methionine (EXP)

lead(0) (ISO)

lead(2+) (ISO)

metformin (ISO)

methyl methanesulfonate (ISO)

mitomycin C (EXP)

nicotine (ISO)

oxaliplatin (ISO)

ozone (ISO)

paracetamol (ISO)

phenobarbital (EXP,ISO)

pirinixic acid (EXP)

piroxicam (ISO)

rac-lactic acid (ISO)

sodium arsenite (EXP)

testosterone (EXP,ISO)

tetrachloromethane (EXP)

toluene (ISO)

topotecan (ISO)

trimellitic anhydride (EXP)

tungsten (EXP)

urethane (ISO)

valproic acid (EXP,ISO)

vincristine (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation-induced cell death of T cells (ISO)

apoptotic process (IEA)

extrinsic apoptotic signaling pathway (IBA,ISO)

intrinsic apoptotic signaling pathway (ISO)

negative regulation of NF-kappaB transcription factor activity (ISO)

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (ISO)

Cellular Component

cytoplasm (ISO)

mitochondrion (ISO)

nucleoplasm (ISO)

nucleus (IEA)

Molecular Function

CD27 receptor binding (IBA,IPI,ISO)

metal ion binding (IEA)

protein binding (ISO)

tumor necrosis factor receptor binding (IPI)

virus receptor activity (IDA)

zinc ion binding (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal lens morphology (IEA)

abnormal lung adenoma incidence (IAGP)

abnormal lung epithelium morphology (IAGP)

cataract (IEA)

decreased heart left ventricle size (IEA)

decreased lung tumor incidence (IAGP)

embryonic lethality (IAGP)

no abnormal phenotype detected (IAGP)

References

References - curated


1.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2.	MGD data from the GO Consortium
3.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4.	RGD automated import pipeline
5.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:9177220	PMID:9692890	PMID:10349636	PMID:10597319	PMID:10756043	PMID:11042159	PMID:11076861	PMID:11601913	PMID:12011449	PMID:12477932	PMID:12478477
PMID:12520002	PMID:14610273	PMID:15105421	PMID:15489334	PMID:15782199	PMID:16141072	PMID:16141073	PMID:17464332	PMID:17965021	PMID:19293149	PMID:19521500	PMID:19590512
PMID:19643733	PMID:21307125	PMID:21768358	PMID:21873635	PMID:24194600	PMID:25813352	PMID:27626380	PMID:27773928	PMID:31164717

Genomics

Comparative Map Data

Siva1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	112,611,262 - 112,615,586 (+)	NCBI	GRCm39		mm39
GRCm38	12	112,644,828 - 112,649,152 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	112,644,679 - 112,649,149 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	113,883,039 - 113,887,363 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	12	113,092,716 - 113,096,953 (+)	NCBI			mm8
Celera	12	113,858,455 - 113,862,779 (+)	NCBI		Celera
Cytogenetic Map	12	F1	NCBI

SIVA1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	14	104,753,147 - 104,768,494 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	14	104,752,420 - 104,759,659 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	14	105,219,470 - 105,225,996 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	104,290,515 - 104,297,041 (+)	NCBI	NCBI36		hg18	NCBI36
Celera	14	85,274,542 - 85,281,070 (+)	NCBI
Cytogenetic Map	14	q32.33	NCBI
HuRef	14	85,416,458 - 85,422,986 (+)	NCBI		HuRef
CHM1_1	14	105,157,086 - 105,163,614 (+)	NCBI		CHM1_1

Siva1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	6	137,209,999 - 137,214,379 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	137,210,052 - 137,214,388 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	146,216,931 - 146,221,556 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	137,631,408 - 137,635,724 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	6	129,253,021 - 129,257,273 (+)	NCBI		Celera
Cytogenetic Map	6	q32	NCBI

Siva1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955538	3,197,983 - 3,202,782 (+)	NCBI	ChiLan1.0	ChiLan1.0

SIVA1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	14	105,196,118 - 105,202,678 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	105,196,118 - 105,202,678 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	14	85,404,148 - 85,408,254 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

SIVA1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	8	72,309,447 - 72,313,640 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	8	72,309,400 - 72,313,726 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Siva1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936621	641,456 - 650,067 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SIVA1
(Sus scrofa - pig)

No map positions available.

SIVA1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	82,689,233 - 82,695,073 (+)	NCBI
ChlSab1.1 Ensembl	24	82,689,254 - 82,695,146 (+)	Ensembl

Siva1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624734	530,711 - 535,281 (-)	NCBI

Position Markers

UniSTS:236127

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	12	112,646,933 - 112,647,863	UniSTS	GRCm38
GRCm38	9	53,884,295 - 53,884,433	UniSTS	GRCm38
MGSCv37	12	113,885,144 - 113,886,074	UniSTS	GRCm37
MGSCv37	9	53,732,102 - 53,732,240	UniSTS	GRCm37
Celera	9	51,137,595 - 51,137,733	UniSTS
Celera	12	113,860,560 - 113,861,490	UniSTS
Cytogenetic Map	12	F2	UniSTS
Cytogenetic Map	9	A5.3	UniSTS

QTLs in Region (GRCm38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
27226793	Feml10_m	femur length 10, 5 week (mouse)					12	68300000	113400000	Mouse
4142401	Egq10_m	early growth QTL 10 (mouse)			Not determined			80909934	113419913	Mouse
4141335	W6q10_m	weight 6 weeks QTL 10 (mouse)			Not determined			80909934	113419913	Mouse
4141610	Tailaq1_m	tail length adjusted QTL 1 (mouse)			Not determined			80909934	113419913	Mouse
1357701	Lvrq10_m	liver weight QTL 10 (mouse)			Not determined		12	80909934	113419913	Mouse
39128213	Lwq23_m	liver weight QTL 10 (mouse)					12	80909934	113419913	Mouse
13524849	Ppiq11a_m	prepulse inhibition QTL 11a (mouse)					12	81022884	115022884	Mouse
13524846	Ppiq11_m	prepulse inhibition QTL 11 (mouse)					12	82700137	116700137	Mouse
1301879	Insq10_m	insulin QTL 10 (mouse)			Not determined		12	83565816	117565965	Mouse
1301492	Dbsty3_m	diabesity 3 (mouse)			Not determined		12	83565816	117565965	Mouse
1300883	Ath21_m	atherosclerosis 21 (mouse)			Not determined		12	85995320	119995424	Mouse
10412156	Nociq3_m	nociceptive sensitivity inflammatory QTL 3 (mouse)			Not determined		12	86349301	114868033	Mouse
4142007	Chlq17_m	circulating hormone level QTL 17 (mouse)			Not determined		12	88086615	120129022	Mouse
1300545	Lifespan3_m	life span 3 (mouse)			Not determined		12	88086615	120129022	Mouse
1301308	Prdt4_m	prion disease incubation time 4 (mouse)			Not determined		12	88342095	120129022	Mouse
5491194	Mobq3_m	multigenic obesity QTL 3 (mouse)			Not determined		12	89697812	120129022	Mouse
1301836	Heal5_m	wound healing/regeneration 5 (mouse)			Not determined		12	89972772	120129022	Mouse
1301922	Bbaa6_m	B.burgdorferi-associated arthritis 6 (mouse)			Not determined		12	90342009	120129022	Mouse
10402491	Dipa4_m	drug induced psychomotor activation 4 (mouse)			Not determined		12	91256256	120129022	Mouse
12910532	Nrq10a_m	noise-induced hearing loss resistant QTL 10a (mouse)					12	92783591	120129022	Mouse
12910533	Nrq10_m	noise-induced hearing loss resistant QTL 10 (mouse)					12	92783591	120129022	Mouse
1357463	Vtbt14_m	vertebral trabecular bone trait 14 (mouse)			Not determined		12	92969663	120129022	Mouse
1300973	Abmm_m	antibody mediated myocarditis (mouse)			Not determined		12	93298027	120129022	Mouse
1302177	Dps2_m	delta power in slow-wave sleep 2 (mouse)			Not determined		12	94179630	120129022	Mouse
1302138	Im6_m	immunoregulatory 6 (mouse)			Not determined		12	96896717	120129022	Mouse
1301269	Sluc12_m	susceptibility to lung cancer 12 (mouse)			Not determined		12	96896717	120129022	Mouse
10412075	Nils1_m	neointima lesion size 1 (mouse)			Not determined		12	102060930	120129022	Mouse
4141297	Plyid_m	Polymeric IgA dominance (mouse)			Not determined			109217459	115921502	Mouse
1558957	Igan4_m	IgA nephropathy 4 (mouse)			Not determined		12	109783591	119061214	Mouse
15092085	Igly2_m	IgG glycosylation 2, GP14 (mouse)					12	111770863	121233193	Mouse

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	136
Count of miRNA genes:	60
Interacting mature miRNAs:	67
Transcripts:	ENSMUST00000021728, ENSMUST00000109755
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001161737	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_013929	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC124373	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF033112	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF033113	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF033114	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF033115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK010562	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK017570	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK153115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK169200	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK184852	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK194303	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK207814	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK209128	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK212226	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK213981	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK218153	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AW060433	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC012279	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB524656	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466549	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000021728 ⟹ ENSMUSP00000021728

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	12	112,644,679 - 112,649,145 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000109755 ⟹ ENSMUSP00000105377

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	12	112,644,967 - 112,649,037 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000222353

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	12	112,646,418 - 112,646,985 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000222368

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	12	112,647,751 - 112,649,149 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000222729

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	12	112,647,832 - 112,649,148 (+)	Ensembl

RefSeq Acc Id:

NM_001161737 ⟹ NP_001155209

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	12	112,611,262 - 112,615,586 (+)	NCBI
GRCm38	12	112,644,828 - 112,649,152 (+)	ENTREZGENE
MGSCv37	12	113,883,039 - 113,887,363 (+)	RGD
Celera	12	113,858,455 - 113,862,779 (+)	RGD
cM Map	12		ENTREZGENE

Sequence:

show sequence

GCCCCCAGCCTTTCTCCGGCCTATTGGGCGCCGCGCCCTCGTCGGCTCGGGCCTCCGCCGCGGT
CCGAGGGCGCCGTGACGTGTGCTCGGCGCGCGGCGCGCTGCGCGCTGCTGAAGGCTGTGTCTGG
TACCCGCTACCATGCCCAAGCGGAGCTGCCCGTTCGCAGACGCAGCCCCGCTCCAACTCAAAGT
CCACGTGGGCCTGAAAGAGCTGAGCCACGGTGTGTTCGCCGAGCGCTACTCACGCGAGGTCTTC
GGCCTTCCCAGGACAGCGCCCATCGCTTGTTCATCGTGCATGAGATCTGTGGATGGGAAGGCGG
TCTGCAGCCAGTGCGAGCGGGCCCTGTGTGGGCAGTGTGTATACACCTGCTGGGGCTGCGGTGC
TTTGGCCTGTGTGCTGTGTGGCCTTGCAGACTATGCCGACGATGGTGAGAAGACACTGTGCACC
AGCTGTGCTATGTTTGAAGCCTGAGGTGGCCACAGACAGCACAAGATGTTCACACTAAAGAGAG
AGAAGGTGGCTTTTTATATGTTATGTTTTATACCCAGTAACAAGTGAATAAACCTCTTTATATT
TGCACAAGGAC

hide sequence

RefSeq Acc Id:

NM_013929 ⟹ NP_038957

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	12	112,611,262 - 112,615,586 (+)	NCBI
GRCm38	12	112,644,828 - 112,649,152 (+)	ENTREZGENE
MGSCv37	12	113,883,039 - 113,887,363 (+)	RGD
Celera	12	113,858,455 - 113,862,779 (+)	RGD
cM Map	12		ENTREZGENE

Sequence:

show sequence

GCCCCCAGCCTTTCTCCGGCCTATTGGGCGCCGCGCCCTCGTCGGCTCGGGCCTCCGCCGCGGT
CCGAGGGCGCCGTGACGTGTGCTCGGCGCGCGGCGCGCTGCGCGCTGCTGAAGGCTGTGTCTGG
TACCCGCTACCATGCCCAAGCGGAGCTGCCCGTTCGCAGACGCAGCCCCGCTCCAACTCAAAGT
CCACGTGGGCCTGAAAGAGCTGAGCCACGGTGTGTTCGCCGAGCGCTACTCACGCGAGGTCTTC
GAAAGAACCAAGCAGCTCCTTTTCCAAGGGGCTCGGGCCTATAGAGATCACATATCGAGCGAAG
ATTGTTCCGTGAACCACCTGCAGGAGTCACTGAAGTCTGGTGTGGTAGGAGCCCCTCAACCTGC
GAGGGGACAGATGTTGATTGGACCTGATGGCCGACTGACACGGTGCCAAGCTCAGGCCTCAGAA
GGTGGCCTTCCCAGGACAGCGCCCATCGCTTGTTCATCGTGCATGAGATCTGTGGATGGGAAGG
CGGTCTGCAGCCAGTGCGAGCGGGCCCTGTGTGGGCAGTGTGTATACACCTGCTGGGGCTGCGG
TGCTTTGGCCTGTGTGCTGTGTGGCCTTGCAGACTATGCCGACGATGGTGAGAAGACACTGTGC
ACCAGCTGTGCTATGTTTGAAGCCTGAGGTGGCCACAGACAGCACAAGATGTTCACACTAAAGA
GAGAGAAGGTGGCTTTTTATATGTTATGTTTTATACCCAGTAACAAGTGAATAAACCTCTTTAT
ATTTGCACAAGGAC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001155209	(Get FASTA)	NCBI Sequence Viewer
	NP_038957	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC04706	(Get FASTA)	NCBI Sequence Viewer
	AAD50058	(Get FASTA)	NCBI Sequence Viewer
	AAD50059	(Get FASTA)	NCBI Sequence Viewer
	AAD50060	(Get FASTA)	NCBI Sequence Viewer
	AAH12279	(Get FASTA)	NCBI Sequence Viewer
	BAB27029	(Get FASTA)	NCBI Sequence Viewer
	BAB30811	(Get FASTA)	NCBI Sequence Viewer
	BAE31732	(Get FASTA)	NCBI Sequence Viewer
	BAE40975	(Get FASTA)	NCBI Sequence Viewer
	EDL18588	(Get FASTA)	NCBI Sequence Viewer
	EDL18589	(Get FASTA)	NCBI Sequence Viewer
	O54926	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_038957 ⟸ NM_013929
- Peptide Label:	isoform 1
- UniProtKB:	O54926 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MPKRSCPFADAAPLQLKVHVGLKELSHGVFAERYSREVFERTKQLLFQGARAYRDHISSEDCSV NHLQESLKSGVVGAPQPARGQMLIGPDGRLTRCQAQASEGGLPRTAPIACSSCMRSVDGKAVCS QCERALCGQCVYTCWGCGALACVLCGLADYADDGEKTLCTSCAMFEA hide sequence

RefSeq Acc Id:	NP_001155209 ⟸ NM_001161737
- Peptide Label:	isoform 2
- UniProtKB:	O54926 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MPKRSCPFADAAPLQLKVHVGLKELSHGVFAERYSREVFGLPRTAPIACSSCMRSVDGKAVCSQ CERALCGQCVYTCWGCGALACVLCGLADYADDGEKTLCTSCAMFEA hide sequence

RefSeq Acc Id:

ENSMUSP00000105377 ⟸ ENSMUST00000109755

RefSeq Acc Id:

ENSMUSP00000021728 ⟸ ENSMUST00000021728

Promoters

RGD ID:

8679384

Promoter ID:

EPDNEW_M17723

Type:

initiation region

Name:

Siva1_1

Description:

Mus musculus SIVA1, apoptosis-inducing factor , transcript variant2, mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	12	112,644,935 - 112,644,995	EPDNEW

RGD ID:

6823413

Promoter ID:

MM_KWN:12874

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day1, BoneMarrow_0Hour, BoneMarrow_2Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

NM_001161737, NM_013929

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	12	113,882,616 - 113,883,302 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1353606	AgrOrtholog
Ensembl Genes	ENSMUSG00000064326	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSMUSP00000021728	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUSP00000105377	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000021728	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUST00000109755	ENTREZGENE, UniProtKB/Swiss-Prot
InterPro	Siva	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:30954	UniProtKB/Swiss-Prot
MGD	MGI:1353606	ENTREZGENE
NCBI Gene	30954	ENTREZGENE
PANTHER	PTHR14365	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Siva	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Siva1	PhenoGen
PIRSF	Siva_cd27_bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	O54926	ENTREZGENE
	Q3TFC3_MOUSE	UniProtKB/TrEMBL
	SIVA_MOUSE	UniProtKB/Swiss-Prot
UniProt Secondary	Q3U6J2	UniProtKB/Swiss-Prot
	Q921I8	UniProtKB/Swiss-Prot
	Q9CWL1	UniProtKB/Swiss-Prot
	Q9R1Q0	UniProtKB/Swiss-Prot
	Q9R1Q1	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD