Tbx3 (T-box 3) - Rat Genome Database

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Gene: Tbx3 (T-box 3) Mus musculus
Analyze
Symbol: Tbx3
Name: T-box 3
RGD ID: 1557562
MGI Page MGI
Description: Enables DNA-binding transcription factor activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in atrioventricular canal morphogenesis. Acts upstream of or within several processes, including animal organ development; embryonic limb morphogenesis; and regulation of transcription, DNA-templated. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study ulnar-mammary syndrome. Human ortholog(s) of this gene implicated in ulnar-mammary syndrome. Orthologous to human TBX3 (T-box transcription factor 3); INTERACTS WITH 1,1-dichloroethene; 1,2-dichloroethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D5Ertd189; D5Ertd189e; T-box protein 3; T-box transcription factor TBX3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395119,808,600 - 119,822,789 (+)NCBIGRCm39mm39
GRCm39 Ensembl5119,808,734 - 119,822,789 (+)Ensembl
GRCm385119,670,534 - 119,684,724 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5119,670,669 - 119,684,724 (+)EnsemblGRCm38mm10GRCm38
MGSCv375120,120,678 - 120,134,610 (+)NCBIGRCm37mm9NCBIm37
MGSCv365119,931,286 - 119,945,218 (+)NCBImm8
Celera5116,764,719 - 116,778,686 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map560.34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
afimoxifene  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (ISO)
amitrole  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
bisphenol F  (EXP)
bromobenzene  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP)
carmustine  (ISO)
cefaloridine  (ISO)
chlordecone  (EXP)
ciguatoxin CTX1B  (EXP)
clofibrate  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cylindrospermopsin  (ISO)
cyproconazole  (EXP)
dexamethasone  (ISO)
diclofenac  (EXP)
dicrotophos  (ISO)
dimethoate  (ISO)
disodium selenite  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
enzacamene  (ISO)
fenvalerate  (ISO)
folic acid  (EXP)
fonofos  (ISO)
furan  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
Iopanoic acid  (ISO)
leflunomide  (ISO)
metformin  (ISO)
methimazole  (ISO)
methoxychlor  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide  (EXP)
nickel atom  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
parathion  (ISO)
PD 0325901  (ISO)
PD173074  (ISO)
pentanal  (ISO)
phenformin  (ISO)
phenobarbital  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propanal  (ISO)
propiconazole  (EXP)
Ptaquiloside  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
ritodrine  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
titanium dioxide  (EXP)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
anterior/posterior axis specification, embryo  (ISO)
atrioventricular bundle cell differentiation  (IMP)
atrioventricular canal development  (IGI)
atrioventricular canal morphogenesis  (IGI)
blood vessel development  (IMP)
branching involved in mammary gland duct morphogenesis  (IMP)
cardiac chamber development  (IBA)
cardiac epithelial to mesenchymal transition  (ISO)
cardiac jelly development  (ISO)
cardiac muscle cell differentiation  (IMP)
cardiac muscle cell fate commitment  (IMP)
cell aging  (IDA,ISO)
cell fate specification  (IBA)
cellular senescence  (ISO)
central nervous system development  (IBA)
embryonic digit morphogenesis  (IMP,ISO)
embryonic forelimb morphogenesis  (ISO)
embryonic heart tube development  (IMP)
embryonic hindlimb morphogenesis  (IMP)
endocardial cushion formation  (ISO)
female genitalia development  (ISO)
follicle-stimulating hormone secretion  (ISO)
forelimb morphogenesis  (ISO)
heart looping  (IBA,IMP)
heart morphogenesis  (IMP)
in utero embryonic development  (IMP)
limb morphogenesis  (IMP)
limbic system development  (IMP)
luteinizing hormone secretion  (ISO)
male genitalia development  (ISO)
mammary gland development  (IMP,ISO)
mammary placode formation  (IDA,IGI)
mesoderm morphogenesis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell proliferation involved in heart morphogenesis  (ISO)
negative regulation of epithelial cell differentiation  (IMP)
negative regulation of myoblast differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (IDA,IMP,ISO)
outflow tract morphogenesis  (IMP)
positive regulation of cell cycle  (ISO)
positive regulation of cell population proliferation  (IBA,ISO)
positive regulation of stem cell proliferation  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (IMP)
regulation of cell population proliferation  (IMP)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription, DNA-templated  (IEA)
roof of mouth development  (IGI)
sinoatrial node cell development  (IMP,ISO)
skeletal system development  (ISO)
smooth muscle cell differentiation  (IGI)
specification of animal organ position  (IDA)
stem cell population maintenance  (IMP)
ureteric peristalsis  (IGI)
ventricular septum morphogenesis  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cardiac jelly morphology  (IAGP)
abnormal cardiovascular development  (IAGP)
abnormal clitoris morphology  (IAGP)
abnormal digit morphology  (IAGP)
abnormal embryonic autopod plate morphology  (IAGP)
abnormal female reproductive system morphology  (IAGP)
abnormal fetal atrioventricular canal morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart looping  (IAGP)
abnormal hindlimb morphology  (IAGP)
abnormal hindlimb zeugopod morphology  (IAGP)
abnormal impulse conducting system conduction  (IAGP)
abnormal inferior vena cava morphology  (IAGP)
abnormal limb development  (IAGP)
abnormal limb morphology  (IAGP)
abnormal mammary gland bud morphology  (IAGP)
abnormal mammary gland development  (IAGP)
abnormal mammary gland embryonic development  (IAGP)
abnormal P wave  (IAGP)
abnormal palatal shelf fusion at midline  (IAGP)
abnormal pelvic girdle bone morphology  (IAGP)
abnormal QRS complex  (IAGP)
abnormal sinoatrial node morphology  (IAGP)
abnormal sinus arrhythmia  (IAGP)
abnormal ulna morphology  (IAGP)
abnormal vagina orifice morphology  (IAGP)
abnormal visceral yolk sac endoderm morphology  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent atrioventricular cushions  (IAGP)
absent carpal bone  (IAGP)
absent fibula  (IAGP)
absent mammary gland  (IAGP)
absent metacarpal bones  (IAGP)
absent P wave  (IAGP)
absent PR interval  (IAGP)
absent tarsus bones  (IAGP)
absent ulna  (IAGP)
absent vitelline blood vessels  (IAGP)
atrioventricular block  (IAGP)
cleft secondary palate  (IAGP)
decreased body size  (IAGP)
decreased heart rate  (IAGP)
delayed heart looping  (IAGP)
edema  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
embryonic lethality, incomplete penetrance  (IAGP)
failure of heart looping  (IAGP)
increased cardiac muscle contractility  (IAGP)
increased heart rate variability  (IAGP)
irregular heartbeat  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
oligodactyly  (IAGP)
pale yolk sac  (IAGP)
pericardial edema  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
prolonged QRS complex duration  (IAGP)
reduced female fertility  (IAGP)
reduced male fertility  (IAGP)
shortened PR interval  (IAGP)
sinus bradycardia  (IAGP)
small hindlimb buds  (IAGP)
small liver  (IAGP)
thin apical ectodermal ridge  (IAGP)
ventricular septal defect  (IAGP)
References

Additional References at PubMed
PMID:1375456   PMID:7688225   PMID:7920656   PMID:8798150   PMID:8853987   PMID:8878690   PMID:8889548   PMID:8954725   PMID:9169414   PMID:9196325   PMID:9337408   PMID:10072792  
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11726608   PMID:11748239   PMID:12032820   PMID:12376101   PMID:12477932   PMID:12668638   PMID:12736212   PMID:14610273  
PMID:14723846   PMID:15136151   PMID:15158141   PMID:15255957   PMID:15297379   PMID:15385444   PMID:15459098   PMID:15618518   PMID:15843407   PMID:15901664   PMID:16140987   PMID:16141072  
PMID:16141073   PMID:16207751   PMID:16222716   PMID:16380715   PMID:16556915   PMID:16556916   PMID:16602821   PMID:16632597   PMID:16870172   PMID:16989801   PMID:17028893   PMID:17071745  
PMID:17173667   PMID:17199044   PMID:17234970   PMID:17239249   PMID:17265068   PMID:17460765   PMID:17473172   PMID:17519333   PMID:17588959   PMID:17609113   PMID:17668378   PMID:17698011  
PMID:18285513   PMID:18287559   PMID:18292603   PMID:18356246   PMID:18410737   PMID:18444963   PMID:18467625   PMID:18534921   PMID:18723448   PMID:18799693   PMID:18832392   PMID:19096026  
PMID:19115250   PMID:19140222   PMID:19166829   PMID:19498200   PMID:19576202   PMID:19592579   PMID:19765559   PMID:19769959   PMID:19877281   PMID:20025935   PMID:20059953   PMID:20110338  
PMID:20139965   PMID:20159597   PMID:20185795   PMID:20386744   PMID:20412781   PMID:20457925   PMID:20596014   PMID:20732316   PMID:20941780   PMID:21143873   PMID:21189255   PMID:21256124  
PMID:21266775   PMID:21267068   PMID:21282332   PMID:21304516   PMID:21454626   PMID:21455926   PMID:21538160   PMID:21589869   PMID:21640717   PMID:21731673   PMID:21757651   PMID:21795542  
PMID:21867776   PMID:21873635   PMID:21924257   PMID:21983003   PMID:22039763   PMID:22116619   PMID:22116936   PMID:22130515   PMID:22164283   PMID:22174793   PMID:22203979   PMID:22223620  
PMID:22419669   PMID:22438573   PMID:22522080   PMID:22535523   PMID:22543974   PMID:22706305   PMID:22711520   PMID:22921202   PMID:22988430   PMID:23201021   PMID:23283339   PMID:23341776  
PMID:23369715   PMID:23473983   PMID:23506836   PMID:23584530   PMID:23624936   PMID:23633963   PMID:23661717   PMID:23674600   PMID:23743334   PMID:23844108   PMID:23936153   PMID:24068957  
PMID:24143284   PMID:24146773   PMID:24260306   PMID:24319661   PMID:24336466   PMID:24394418   PMID:24425205   PMID:24449835   PMID:24472544   PMID:24623077   PMID:24680892   PMID:24705356  
PMID:24859004   PMID:24876127   PMID:24924197   PMID:24927531   PMID:24963028   PMID:25053429   PMID:25166052   PMID:25336743   PMID:25343378   PMID:25389758   PMID:25453830   PMID:25487574  
PMID:25488669   PMID:25552398   PMID:25599332   PMID:25792196   PMID:25859222   PMID:26095607   PMID:26138475   PMID:26193633   PMID:26238476   PMID:26243870   PMID:26321631   PMID:26417040  
PMID:26459221   PMID:26493106   PMID:26581094   PMID:26651606   PMID:26764381   PMID:26988119   PMID:27046536   PMID:27076431   PMID:27180262   PMID:27491074   PMID:27518902   PMID:27720610  
PMID:27856909   PMID:28069742   PMID:28205312   PMID:28361920   PMID:28807898   PMID:28894084   PMID:29031500   PMID:29107716   PMID:29409032   PMID:29420474   PMID:29853617   PMID:30042181  
PMID:30201295   PMID:30291164   PMID:30292786   PMID:30478225   PMID:30595499   PMID:30630509   PMID:30840660   PMID:30936179   PMID:31077711   PMID:31175693   PMID:31306714   PMID:31320323  
PMID:31578032   PMID:31591643   PMID:31688894   PMID:31836710   PMID:31896583   PMID:32098917   PMID:32290757   PMID:32672536   PMID:32675240   PMID:32694784   PMID:32808927   PMID:33443158  
PMID:33545088   PMID:33577921   PMID:33600763   PMID:33795231   PMID:33869166   PMID:33887179  


Genomics

Comparative Map Data
Tbx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395119,808,600 - 119,822,789 (+)NCBIGRCm39mm39
GRCm39 Ensembl5119,808,734 - 119,822,789 (+)Ensembl
GRCm385119,670,534 - 119,684,724 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5119,670,669 - 119,684,724 (+)EnsemblGRCm38mm10GRCm38
MGSCv375120,120,678 - 120,134,610 (+)NCBIGRCm37mm9NCBIm37
MGSCv365119,931,286 - 119,945,218 (+)NCBImm8
Celera5116,764,719 - 116,778,686 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map560.34NCBI
TBX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12114,670,255 - 114,684,175 (-)EnsemblGRCh38hg38GRCh38
GRCh3812114,670,255 - 114,684,175 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712115,108,060 - 115,121,980 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612113,592,442 - 113,606,352 (-)NCBINCBI36hg18NCBI36
Build 3412113,570,778 - 113,584,689NCBI
Celera12114,735,560 - 114,749,458 (-)NCBI
Cytogenetic Map12q24.21NCBI
HuRef12112,116,904 - 112,130,825 (-)NCBIHuRef
CHM1_112115,075,996 - 115,089,899 (-)NCBICHM1_1
Tbx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21236,879,924 - 36,894,849 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1236,881,445 - 36,893,708 (-)Ensembl
Rnor_6.01242,479,518 - 42,494,588 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1242,480,560 - 42,492,526 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01244,326,928 - 44,342,670 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41238,155,494 - 38,166,670 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11238,018,881 - 38,030,058 (-)NCBI
Celera1238,555,497 - 38,566,664 (-)NCBICelera
Cytogenetic Map12q16NCBI
Tbx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545515,988,663 - 16,000,063 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545515,988,153 - 16,000,156 (+)NCBIChiLan1.0ChiLan1.0
TBX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112115,618,420 - 115,632,327 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12115,620,002 - 115,631,316 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012112,240,050 - 112,254,299 (-)NCBIMhudiblu_PPA_v0panPan3
TBX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12611,694,885 - 11,709,594 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2611,696,565 - 11,708,918 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2611,753,296 - 11,767,965 (-)NCBI
ROS_Cfam_1.02611,953,157 - 11,967,841 (-)NCBI
UMICH_Zoey_3.12611,914,521 - 11,929,199 (-)NCBI
UNSW_CanFamBas_1.02611,977,110 - 11,991,787 (-)NCBI
UU_Cfam_GSD_1.02612,026,728 - 12,041,404 (-)NCBI
Tbx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118152,235,738 - 152,248,370 (-)NCBI
SpeTri2.0NW_0049365587,230,361 - 7,243,651 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1437,582,822 - 37,596,767 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11437,582,704 - 37,596,767 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21440,012,569 - 40,026,314 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TBX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111109,952,100 - 109,966,328 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl11109,952,054 - 109,965,065 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037135,142,552 - 135,156,757 (+)NCBIVero_WHO_p1.0
Tbx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474718,128,003 - 18,142,366 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
UniSTS:235919  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385119,675,771 - 119,675,861UniSTSGRCm38
MGSCv375120,125,780 - 120,125,870UniSTSGRCm37
Celera5116,769,819 - 116,769,909UniSTS
Cytogenetic Map5FUniSTS
cM Map565.0UniSTS
D5Ertd189e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385119,683,739 - 119,683,955UniSTSGRCm38
MGSCv375120,133,748 - 120,133,964UniSTSGRCm37
Celera5116,777,831 - 116,778,045UniSTS
Cytogenetic Map5FUniSTS
cM Map565.0UniSTS
Tbx3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv375120,124,230 - 120,125,665UniSTSGRCm37
Celera5116,768,272 - 116,769,704UniSTS
Cytogenetic Map5FUniSTS
cM Map565.0UniSTS
Tbx3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385119,674,221 - 119,675,656UniSTSGRCm38
MGSCv375120,124,230 - 120,125,665UniSTSGRCm37
Celera5116,768,272 - 116,769,704UniSTS
Cytogenetic Map5FUniSTS
Tbx3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5FUniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526236236138457140Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554342835126924008Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)569900000132500000Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572700000140000000Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574300000132500000Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574300000132500000Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575154687119880564Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587239005121239199Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587239005121239199Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587239005121239199Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587239005121239199Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587239005121239199Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589271017124100176Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589271017146851125Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590173096124173175Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590413140124413285Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590413140124413285Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592682300126682419Mouse
1301974Chab7_mcholesterol absorption 7 (mouse)Not determined595085348129085464Mouse
1357644Egrd1_mearly growth rate, direct effect 1 (mouse)Not determined595286714129286920Mouse
1558774Lith17_mlithogenic gene 17 (mouse)Not determined595317683129317856Mouse
10402486Dipa1_mdrug induced psychomotor activation 1 (mouse)Not determined595317683129317856Mouse
13464244Ahl19_mage related hearing loss, early onset 19 (mouse)595317683129317856Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596172519130172667Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined596883692130883925Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined596883692130883925Mouse
4141519Hmtb5_mhemostasis and thrombosis bleeding time 5 (mouse)Not determined99801563126805880Mouse
12904945Tammq2_mtibialis anterior muscle mass QTL 2 (mouse)5100527900134527900Mouse
12904959Smmq1_msoleus muscle mass QTL 1 (mouse)5100527900134527900Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101194514135194514Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101725767135725963Mouse
14746986Manh58_mmandible shape 58 (mouse)5102308218136308218Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102806972136807131Mouse
11528550Sluc33_msusceptibility to lung cancer 33 (mouse)5104239005120573921Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104435822138557193Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104567876138567876Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107829235141829348Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107829235141829348Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107829235141829348Mouse
4141139Hmtb4_mhemostasis and thrombosis rebleeding time 4 (mouse)Not determined108614643126805880Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109090176143090317Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109090176143090317Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109090758139133150Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109362284143362395Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113172519138557193Mouse
1357662Lprq4_mlipoprotein QTL 4 (mouse)Not determined5113883692129555542Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115128044149128176Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115128044149128176Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118920110151834684Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir153mmu-miR-153-3pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//qRT-PCRFunctional MTI21256124
Mir137mmu-miR-137-3pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//qRT-PCRFunctional MTI21256124

Predicted Target Of
Summary Value
Count of predictions:1803
Count of miRNA genes:531
Interacting mature miRNAs:655
Transcripts:ENSMUST00000018748, ENSMUST00000079719, ENSMUST00000121021, ENSMUST00000145647, ENSMUST00000154680
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_198052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006530276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA543734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC140675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF429310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK031708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK087128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB054411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB694449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB728182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ216213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U15567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U57328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000018748   ⟹   ENSMUSP00000018748
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5119,809,083 - 119,822,789 (+)Ensembl
GRCm38.p6 Ensembl5119,671,018 - 119,684,724 (+)Ensembl
RefSeq Acc Id: ENSMUST00000079719   ⟹   ENSMUSP00000078657
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5119,808,734 - 119,822,626 (+)Ensembl
GRCm38.p6 Ensembl5119,670,669 - 119,684,561 (+)Ensembl
RefSeq Acc Id: ENSMUST00000121021   ⟹   ENSMUSP00000112519
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5119,808,927 - 119,822,789 (+)Ensembl
GRCm38.p6 Ensembl5119,670,862 - 119,684,724 (+)Ensembl
RefSeq Acc Id: ENSMUST00000145647
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5119,813,510 - 119,818,695 (+)Ensembl
GRCm38.p6 Ensembl5119,675,445 - 119,680,630 (+)Ensembl
RefSeq Acc Id: ENSMUST00000154680
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5119,818,314 - 119,818,897 (+)Ensembl
GRCm38.p6 Ensembl5119,680,249 - 119,680,832 (+)Ensembl
RefSeq Acc Id: ENSMUST00000202034
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5119,808,734 - 119,811,728 (+)Ensembl
GRCm38.p6 Ensembl5119,670,669 - 119,673,663 (+)Ensembl
RefSeq Acc Id: NM_011535   ⟹   NP_035665
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395119,809,298 - 119,822,789 (+)NCBI
GRCm385119,671,233 - 119,684,724 (+)NCBI
MGSCv375120,120,678 - 120,134,610 (+)RGD
Celera5116,764,912 - 116,778,809 (+)NCBI
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_198052   ⟹   NP_932169
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395119,808,927 - 119,822,789 (+)NCBI
GRCm385119,670,862 - 119,684,724 (+)NCBI
MGSCv375120,120,678 - 120,134,610 (+)RGD
Celera5116,764,912 - 116,778,809 (+)NCBI
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006530276   ⟹   XP_006530339
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395119,808,600 - 119,822,789 (+)NCBI
GRCm385119,670,534 - 119,684,724 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035665   ⟸   NM_011535
- Peptide Label: isoform 1
- UniProtKB: P70324 (UniProtKB/Swiss-Prot),   Q3ULL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_932169   ⟸   NM_198052
- Peptide Label: isoform 2
- UniProtKB: Q4VA43 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006530339   ⟸   XM_006530276
- Peptide Label: isoform X1
- UniProtKB: P70324 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000078657   ⟸   ENSMUST00000079719
RefSeq Acc Id: ENSMUSP00000112519   ⟸   ENSMUST00000121021
RefSeq Acc Id: ENSMUSP00000018748   ⟸   ENSMUST00000018748
Protein Domains
TBX

Promoters
RGD ID:6887840
Promoter ID:EPDNEW_M7371
Type:initiation region
Name:Tbx3_1
Description:Mus musculus T-box 3 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M7372  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385119,671,018 - 119,671,078EPDNEW
RGD ID:6887842
Promoter ID:EPDNEW_M7372
Type:multiple initiation site
Name:Tbx3_2
Description:Mus musculus T-box 3 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M7371  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385119,671,693 - 119,671,753EPDNEW
RGD ID:6838478
Promoter ID:MM_KWN:43796
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000121021,   NM_198052,   OTTMUST00000073569
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365120,119,931 - 120,122,307 (+)MPROMDB
RGD ID:6838479
Promoter ID:MM_KWN:43798
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:OTTMUST00000073571
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365120,124,706 - 120,125,206 (+)MPROMDB
RGD ID:6838480
Promoter ID:MM_KWN:43799
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000073572
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365120,130,361 - 120,130,861 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98495 AgrOrtholog
Ensembl Genes ENSMUSG00000018604 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000018748 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000078657 UniProtKB/Swiss-Prot
  ENSMUSP00000112519 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000018748 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000079719 UniProtKB/Swiss-Prot
  ENSMUST00000121021 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-box_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_Brachyury UniProtKB/TrEMBL
  TF_T-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_T-box_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21386 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98495 ENTREZGENE
NCBI Gene 21386 ENTREZGENE
PANTHER PTHR11267 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam T-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tbx3 PhenoGen
PRINTS BRACHYURY UniProtKB/TrEMBL
  TBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBOX_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P70324 ENTREZGENE
  Q3U043_MOUSE UniProtKB/TrEMBL
  Q3ULL3 ENTREZGENE, UniProtKB/TrEMBL
  Q4VA43 ENTREZGENE, UniProtKB/TrEMBL
  Q8BG45_MOUSE UniProtKB/TrEMBL
  Q8BJW3_MOUSE UniProtKB/TrEMBL
  Q8BU76_MOUSE UniProtKB/TrEMBL
  Q8CJ82_MOUSE UniProtKB/TrEMBL
  TBX3_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary E9QM97 UniProtKB/Swiss-Prot
  Q60708 UniProtKB/Swiss-Prot
  Q8BWH7 UniProtKB/Swiss-Prot