Mmp1b (matrix metallopeptidase 1b (interstitial collagenase)) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Mmp1b (matrix metallopeptidase 1b (interstitial collagenase)) Mus musculus
Analyze
Symbol: Mmp1b
Name: matrix metallopeptidase 1b (interstitial collagenase)
RGD ID: 1315688
MGI Page MGI
Description: Enables peptidase activity. Predicted to be involved in several processes, including cellular response to UV-A; collagen catabolic process; and extracellular matrix organization. Predicted to be located in extracellular matrix and extracellular region. Is expressed in embryo; placenta; and trophoblast giant cell. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); female reproductive organ cancer (multiple); intrinsic cardiomyopathy (multiple); obstructive lung disease (multiple); and urinary system cancer (multiple). Orthologous to human MMP1 (matrix metallopeptidase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: collagenase-like B; interstitial collagenase B; matrix metalloproteinase 1b (interstitial collagenase); matrix metalloproteinase-1b; Mcol; Mcol-B; Mcolb; MMP-1b
RGD Orthologs
Human
Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,367,670 - 7,388,026 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,368,239 - 7,388,047 (-)EnsemblGRCm39 Ensembl
GRCm3897,367,670 - 7,388,026 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,368,239 - 7,388,047 (-)EnsemblGRCm38mm10GRCm38
MGSCv3797,367,670 - 7,388,026 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,368,237 - 7,387,993 (-)NCBIMGSCv36mm8
Celera94,767,814 - 4,788,756 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 108 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mmp1bMouseabdominal aortic aneurysm  ISORGD:13173889068941 RGDPMID:16293969|REF_RGD_ID:1582519
Mmp1bMouseAdult Cerebral Astrocytoma susceptibilityISORGD:13173889068941DNA:insertion:promoter:g.-1607insG (human)RGDPMID:17502998|REF_RGD_ID:7207034
Mmp1bMouseAirway Obstruction  ISORGD:13173889068941associated with Asthma; DNA:insertion:promoter:g.-1607insG (human)RGDPMID:19191136|REF_RGD_ID:4890372
Mmp1bMouseAmaurosis Fugax  ISORGD:13173889068941 RGDPMID:15073384|REF_RGD_ID:1582361
Mmp1bMouseamyotrophic lateral sclerosis  ISORGD:13173889068941protein:increased expression:serum (human)RGDPMID:19796283|REF_RGD_ID:7207054
Mmp1bMouseaortic valve stenosis  ISORGD:13173889068941 RGDPMID:15780799|REF_RGD_ID:1582522
Mmp1bMousearteriosclerosis  ISORGD:13173889068941 RGDPMID:15621056|REF_RGD_ID:1582525
Mmp1bMouseatherosclerosis susceptibilityISORGD:13173889068941human gene in mouse modelRGDPMID:11375412|REF_RGD_ID:7207025
Mmp1bMouseatrial fibrillation  ISORGD:13173889068941 RGDPMID:20935575|REF_RGD_ID:8693675
Mmp1bMouseatrial fibrillation  ISORGD:13173889068941protein:increased expression:papillary muscle of left ventricle RGDPMID:19734590|REF_RGD_ID:8549736
Mmp1bMouseautosomal dominant polycystic kidney disease  ISORGD:13173889068941protein:increased expression:serum (human)RGDPMID:10644865|REF_RGD_ID:7207194
Mmp1bMouseBarrett's esophagus  ISORGD:13173889068941DNA:insertion:promoter:g.-1607insG (rs1799750) (human)RGDPMID:19321798|REF_RGD_ID:7207058
Mmp1bMousebreast cancer susceptibilityISORGD:13173889068941DNA:insertion:promoter:g.-1607insG (human)RGDPMID:12473595|REF_RGD_ID:7207138
Mmp1bMousebreast cancer  ISORGD:13173889068941protein:decreased expression:plasmaRGDPMID:18366705|REF_RGD_ID:2298552
Mmp1bMousebreast cancer disease_progressionISORGD:13173889068941protein:increased expression:breast, stromal cell (human)RGDPMID:21835023|REF_RGD_ID:7207143
Mmp1bMousecarotid artery disease severityISORGD:13173889068941 RGDPMID:15073384|REF_RGD_ID:1582361
Mmp1bMousecarotid stenosis  ISORGD:13173889068941DNA:insertion, haplotype:promoter:g.-1607insG (human)RGDPMID:12364729|REF_RGD_ID:1580553
Mmp1bMousecervical cancer disease_progressionISORGD:13173889068941DNA:insertion:promoter:g.-1607insG (human)RGDPMID:14550952|REF_RGD_ID:7207024
Mmp1bMousecholesteatoma of middle ear  ISORGD:13173889068941protein:increased expression:skinRGDPMID:12768791|REF_RGD_ID:7794712
Mmp1bMouseChronic Periodontitis  ISORGD:13173889068941mRNA:increased expression:gingiva (human)RGDPMID:22401717|REF_RGD_ID:7206856
1 to 20 of 108 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mmp1bMouseasphyxiating thoracic dystrophy  ISORGD:13173888554872ClinVar Annotator: match by term: Jeune thoracic dystrophyClinVarPMID:23339108|PMID:24781753|PMID:28492532|PMID:31413057|PMID:32753734
Mmp1bMouseataxia telangiectasia  ISORGD:13173888554872ClinVar Annotator: match by term: Ataxia-telangiectasia syndromeClinVarPMID:23807571|PMID:25614872|PMID:28492532
Mmp1bMousechronic obstructive pulmonary disease  ISORGD:13173888554872ClinVar Annotator: match by term: PULMONARY DISEASE, CHRONIC OBSTRUCTIVE, RATE OF DECLINE OF LUNG FUNCTION more ...ClinVarPMID:11741975|PMID:11875051|PMID:18030675|PMID:25741868|PMID:28492532|PMID:9850057
Mmp1bMouseepidermolysis bullosa dystrophica  ISORGD:13173888554872ClinVar Annotator: match by term: EPIDERMOLYSIS BULLOSA DYSTROPHICA, GENERALIZED SEVERE, AUTOSOMAL RECESSIVEClinVarPMID:25741868|PMID:28492532
Mmp1bMouseintellectual disability  ISORGD:13173888554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
Mmp1bMouseinterstitial lung disease 2  ISORGD:13173888554872ClinVar Annotator: match by term: Interstitial lung disease 2ClinVar 
Mmp1bMousepreterm premature rupture of the membranes  ISORGD:13173888554872ClinVar Annotator: match by term: Preterm premature rupture of the membranesClinVar 
Mmp1bMouserecessive dystrophic epidermolysis bullosa  ISORGD:13173888554872ClinVar Annotator: match by term: Recessive dystrophic epidermolysis bullosaClinVarPMID:25741868|PMID:28492532
1 to 13 of 13 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mmp1bMouseAneurysm  ISORGD:131738811554173CTD Direct Evidence: marker/mechanismCTDPMID:21742783
Mmp1bMouseasthma  ISORGD:131738811554173CTD Direct Evidence: marker/mechanismCTDPMID:24469321
Mmp1bMouseatherosclerosis  ISORGD:131738811554173CTD Direct Evidence: marker/mechanismCTDPMID:21742783
Mmp1bMouseBreast Neoplasms  ISORGD:131738811554173CTD Direct Evidence: marker/mechanismCTDPMID:23548910
Mmp1bMouseColorectal Neoplasms  ISORGD:131738811554173CTD Direct Evidence: marker/mechanismCTDPMID:23548910
Mmp1bMouseExperimental Liver Cirrhosis  ISORGD:131738811554173CTD Direct Evidence: therapeuticCTDPMID:12557150
Mmp1bMouseLung Neoplasms  ISORGD:131738811554173CTD Direct Evidence: marker/mechanismCTDPMID:23548910
Mmp1bMouselung non-small cell carcinoma  ISORGD:131738811554173CTD Direct Evidence: marker/mechanismCTDPMID:20471133
Mmp1bMousemetabolic dysfunction-associated steatotic liver disease  ISORGD:131738811554173CTD Direct Evidence: marker/mechanismCTDPMID:21664615
Mmp1bMouseNeoplasm Invasiveness  ISORGD:131738811554173CTD Direct Evidence: marker/mechanismCTDPMID:22580338
Mmp1bMouseNeoplasm Metastasis  ISORGD:131738811554173CTD Direct Evidence: marker/mechanismCTDPMID:12538496|PMID:19487542|PMID:22580338|PMID:23548910
Mmp1bMouseocular hypertension  ISORGD:131738811554173CTD Direct Evidence: therapeuticCTDPMID:20089869
Mmp1bMouseoral submucous fibrosis  ISORGD:131738811554173CTD Direct Evidence: marker/mechanismCTDPMID:16311067
1 to 13 of 13 rows

1 to 20 of 380 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mmp1bMouse(-)-epigallocatechin 3-gallate multiple interactionsISORGD:13173886480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of MMP1 mRNA; epigallocatechin gallate more ...CTDPMID:22079256|PMID:31252129
Mmp1bMouse(S)-nicotine increases expressionISORGD:13173886480464Nicotine results in increased expression of MMP1 mRNA; Nicotine results in increased expression of MMP1 more ...CTDPMID:17151781|PMID:18986645
Mmp1bMouse(S)-nicotine multiple interactionsISORGD:13173886480464lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 mRNA]; more ...CTDPMID:17151781|PMID:18986645
Mmp1bMouse1-chloro-2,4-dinitrobenzene increases expressionISORGD:13173886480464Dinitrochlorobenzene results in increased expression of MMP1 mRNACTDPMID:20146380
Mmp1bMouse15-deoxy-Delta(12,14)-prostaglandin J2 increases expressionISORGD:1317388648046415-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 mRNACTDPMID:19136476
Mmp1bMouse15-deoxy-Delta(12,14)-prostaglandin J2 multiple interactionsISORGD:1317388648046415-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of MMP1 protein; more ...CTDPMID:19136476
Mmp1bMouse17beta-estradiol decreases expressionISORGD:13173886480464Estradiol results in decreased expression of MMP1 mRNACTDPMID:21795739
Mmp1bMouse17beta-estradiol increases expressionISORGD:13173886480464Estradiol results in increased expression of MMP1 mRNACTDPMID:20106945|PMID:32844545
Mmp1bMouse17beta-estradiol multiple interactionsISORGD:13173886480464[Estradiol co-treated with Progesterone] results in decreased expression of MMP1 mRNA; [Progesterone co-treated with Estradiol] more ...CTDPMID:17157789|PMID:17404688|PMID:20600708|PMID:20660070|PMID:22219637|PMID:32844545
Mmp1bMouse17beta-hydroxy-17-methylestra-4,9,11-trien-3-one multiple interactionsISORGD:13173886480464Metribolone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP1 mRNA]CTDPMID:8798622
Mmp1bMouse17beta-hydroxy-5alpha-androstan-3-one multiple interactionsISORGD:13173886480464Dihydrotestosterone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP1 mRNA]CTDPMID:8798622
Mmp1bMouse2,2',4,4'-Tetrabromodiphenyl ether increases secretionISORGD:131738864804642,2',4,4'-tetrabromodiphenyl ether results in increased secretion of MMP1 proteinCTDPMID:32142752
Mmp1bMouse2,2',4,4'-Tetrabromodiphenyl ether increases expressionISORGD:131738864804642,2',4,4'-tetrabromodiphenyl ether results in increased expression of MMP1 mRNA; 2,2',4,4'-tetrabromodiphenyl ether results in increased expression more ...CTDPMID:30202865|PMID:31675489|PMID:32142752
Mmp1bMouse2,2',5,5'-tetrachlorobiphenyl increases expressionISORGD:131738864804642,5,2',5'-tetrachlorobiphenyl results in increased expression of MMP1 mRNACTDPMID:36804509
Mmp1bMouse2,2',5,5'-tetrachlorobiphenyl decreases expressionISORGD:131738864804642,5,2',5'-tetrachlorobiphenyl analog results in decreased expression of MMP1 mRNACTDPMID:36804509
Mmp1bMouse2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:13173886480464Tetrachlorodibenzodioxin results in increased expression of MMP1; Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNA; more ...CTDPMID:12377990|PMID:15075337|PMID:15531779|PMID:15982688|PMID:17003102|PMID:18061397|PMID:19755661|PMID:20106945|PMID:21632981|PMID:23152189|PMID:23625689|PMID:24469321
Mmp1bMouse2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:13079176480464Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNACTDPMID:34747641
Mmp1bMouse2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORGD:131738864804641,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP1 more ...CTDPMID:15075337|PMID:15982688|PMID:23625689|PMID:24469321
Mmp1bMouse2,4,6-tribromophenol increases expressionISORGD:131738864804642,4,6-tribromophenol results in increased expression of MMP1 mRNACTDPMID:31675489
Mmp1bMouse2,4,6-trinitrobenzenesulfonic acid increases expressionISORGD:13079176480464Trinitrobenzenesulfonic Acid results in increased expression of MMP1 mRNA; Trinitrobenzenesulfonic Acid results in increased expression more ...CTDPMID:18837084

1 to 20 of 380 rows

Biological Process
1 to 20 of 24 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mmp1bMousecellular response to alkaloid  ISORGD:13079179068941berberineRGDPMID:21108488|REF_RGD_ID:7207365
Mmp1bMousecellular response to fluid shear stress  ISORGD:13079179068941 RGDPMID:19880665|REF_RGD_ID:7207384
Mmp1bMousecellular response to interleukin-1  ISORGD:13079179068941Il1-alphaRGDPMID:22410640|REF_RGD_ID:7207278
Mmp1bMousecellular response to iron(III) ion  ISORGD:13079179068941 RGDPMID:21683124|REF_RGD_ID:7207286
Mmp1bMousecellular response to lipopolysaccharide  ISORGD:13079179068941 RGDPMID:21683124|REF_RGD_ID:7207286
Mmp1bMousecellular response to peptide hormone stimulus  ISORGD:13079179068941adiponectinRGDPMID:20564215|REF_RGD_ID:7207371
Mmp1bMousecellular response to tumor necrosis factor  ISORGD:13079179068941 RGDPMID:22410640|REF_RGD_ID:7207278
Mmp1bMousecellular response to UV-A involved_inISOUniProtKB:P039562290270 GO_CentralGO_REF:0000119
Mmp1bMousecellular response to vitamin D  ISORGD:13079179068941 RGDPMID:22064970|REF_RGD_ID:7207281
Mmp1bMousecellular response to xenobiotic stimulus  ISORGD:13079179068941ibuprophenRGDPMID:19847888|REF_RGD_ID:7207385
Mmp1bMousecollagen catabolic process involved_inIEAUniProtKB-KW:KW-01772290270 UniProtGO_REF:0000043
Mmp1bMousecollagen catabolic process involved_inIBAPANTHER:PTN001303987|MGI:97011|RGD:621316|UniProtKB:P45452|MGI:1340026|MGI:1276107|MGI:101900|MGI:97008|RGD:621320|MGI:970092290270 GO_CentralGO_REF:0000033
Mmp1bMouseextracellular matrix organization involved_inIBAPANTHER:PTN001303987|ZFIN:ZDB-GENE-040426-2132|MGI:1353466|FB:FBgn0033438|MGI:97008|MGI:1340026|MGI:97011|UniProtKB:P45452|FB:FBgn00350492290270 GO_CentralGO_REF:0000033
Mmp1bMouseluteinization  ISORGD:13079179068941 RGDPMID:8835383|REF_RGD_ID:7207087
Mmp1bMouseluteolysis  ISORGD:13079179068941 RGDPMID:8835383|REF_RGD_ID:7207087
Mmp1bMousepositive regulation of fibroblast migration  ISORGD:13079179068941 RGDPMID:19465549|REF_RGD_ID:7207389
Mmp1bMousepositive regulation of protein-containing complex assembly involved_inISOUniProtKB:P039562290270 GO_CentralGO_REF:0000119
Mmp1bMousepositive regulation of smooth muscle cell migration  ISORGD:13079179068941 RGDPMID:19465549|REF_RGD_ID:7207389
Mmp1bMouseproteolysis involved_inISOUniProtKB:P039562290270 GO_CentralGO_REF:0000119
Mmp1bMouseproteolysis involved_inIEAUniProtKB-KW:KW-06452290270 UniProtGO_REF:0000043
1 to 20 of 24 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mmp1bMouseextracellular matrix located_inIEAInterPro:IPR001818|InterPro:IPR0211582290270 InterProGO_REF:0000002
Mmp1bMouseextracellular region located_inIEAUniProtKB-KW:KW-09642290270 UniProtGO_REF:0000043
Mmp1bMouseextracellular space  ISORGD:13079179068941 RGDPMID:22410640|REF_RGD_ID:7207278

Molecular Function
1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mmp1bMouseendopeptidase activity enablesISOUniProtKB:P039562290270 GO_CentralGO_REF:0000119
Mmp1bMousemetalloendopeptidase activity enablesIBAPANTHER:PTN001303987|MGI:97011|UniProtKB:O60882|UniProtKB:P14780|MGI:1340026|MGI:101900|UniProtKB:O75900|UniProtKB:P03956|UniProtKB:Q99542|TAIR:locus:2025891|TAIR:locus:2020548|UniProtKB:P50281|UniProtKB:P45452|FB:FBgn0035049|RGD:620196|TAIR:locus:2130928|TAIR:locus:2032467|MGI:1341867|UniProtKB:P51512|MGI:97009|UniProtKB:Q90611|FB:FBgn0033438|UniProtKB:P39900|TAIR:locus:20556052290270 GO_CentralGO_REF:0000033
Mmp1bMousemetalloendopeptidase activity enablesIEAEC:3.4.24.72290270 UniProtGO_REF:0000003
Mmp1bMousemetalloendopeptidase activity enablesISOUniProtKB:P039562290270 GO_CentralGO_REF:0000119
Mmp1bMousepeptidase activity enablesISOUniProtKB:P039562290270 GO_CentralGO_REF:0000119
Mmp1bMousepeptidase activity enablesIDA 2290270 PMID:11113146MGIPMID:11113146
Mmp1bMousepeptidase activity  ISORGD:13079179068941collagenaseRGDPMID:8531210|REF_RGD_ID:7207198
Mmp1bMouseprotein binding  ISORGD:6216759068941 RGDPMID:21846328|REF_RGD_ID:7207284
Mmp1bMousezinc ion binding enablesIEAInterPro:IPR001818|InterPro:IPR006026|InterPro:IPR021158|InterPro:IPR021190|InterPro:IPR0337392290270 InterProGO_REF:0000002
1 to 9 of 9 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mmp1bMouseatherosclerosis pathway  ISORGD:13173889068941 RGDPMID:15662225|REF_RGD_ID:1582524

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mmp1bMouserheumatoid arthritis pathway  IEA 6907045 KEGGmmu:05323
Mmp1bMouseurinary bladder cancer pathway  IEA 6907045 KEGGmmu:05219

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mmp1bMouseendothelin signaling pathway  ISORGD:13173889068941 PIDPID:200005
Mmp1bMousesyndecan signaling pathway  ISORGD:13173889068941 PIDPID:200156

#
Reference Title
Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:11113146   PMID:11544199   PMID:12815621   PMID:16236725   PMID:17307908   PMID:18267097   PMID:19853894   PMID:21873635   PMID:23421805   PMID:25964075   PMID:37701782  



Mmp1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,367,670 - 7,388,026 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,368,239 - 7,388,047 (-)EnsemblGRCm39 Ensembl
GRCm3897,367,670 - 7,388,026 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,368,239 - 7,388,047 (-)EnsemblGRCm38mm10GRCm38
MGSCv3797,367,670 - 7,388,026 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,368,237 - 7,387,993 (-)NCBIMGSCv36mm8
Celera94,767,814 - 4,788,756 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
MMP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,789,919 - 102,798,160 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,789,401 - 102,798,160 (-)EnsemblGRCh38hg38GRCh38
GRCh3711102,660,650 - 102,668,891 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611102,165,861 - 102,174,104 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411102,165,860 - 102,174,104NCBI
Celera1199,822,300 - 99,830,624 (-)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,588,616 - 98,596,940 (-)NCBIHuRef
CHM1_111102,543,487 - 102,551,813 (-)NCBICHM1_1
T2T-CHM13v2.011102,793,739 - 102,801,980 (-)NCBIT2T-CHM13v2.0
Mmp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8812,943,453 - 12,963,966 (+)NCBIGRCr8
mRatBN7.284,658,588 - 4,679,099 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,658,588 - 4,679,097 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,618,256 - 8,638,758 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.086,916,028 - 6,936,530 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.084,918,249 - 4,938,764 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.085,703,206 - 5,723,593 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,703,206 - 5,723,591 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,706,054 - 5,726,441 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,333,773 - 4,354,284 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,333,814 - 4,353,725 (+)NCBI
Celera86,218,410 - 6,238,921 (+)NCBICelera
Cytogenetic Map8q11NCBI

.

.
Variants in Mmp1b
368 total Variants

1 to 10 of 113 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 20p13(chr20:89939-1360110)x1 copy number loss See cases [RCV000050841] Chr20:89939..1360110 [GRCh38]
Chr20:70580..1340754 [GRCh37]
Chr20:18580..1288754 [NCBI36]
Chr20:20p13		 pathogenic
GRCh38/hg38 20p13(chr20:89939-1028206)x3 copy number gain See cases [RCV000050986] Chr20:89939..1028206 [GRCh38]
Chr20:70580..1008849 [GRCh37]
Chr20:18580..956849 [NCBI36]
Chr20:20p13		 pathogenic
GRCh38/hg38 20p13(chr20:89939-1852477)x1 copy number loss See cases [RCV000050373] Chr20:89939..1852477 [GRCh38]
Chr20:70580..1833123 [GRCh37]
Chr20:18580..1781123 [NCBI36]
Chr20:20p13		 pathogenic
GRCh38/hg38 20p13-11.21(chr20:89939-25697564)x3 copy number gain See cases [RCV000051227] Chr20:89939..25697564 [GRCh38]
Chr20:70580..25678200 [GRCh37]
Chr20:18580..25626200 [NCBI36]
Chr20:20p13-11.21		 pathogenic
GRCh38/hg38 20p13-11.23(chr20:89939-19146279)x3 copy number gain See cases [RCV000051041] Chr20:89939..19146279 [GRCh38]
Chr20:70580..19126923 [GRCh37]
Chr20:18580..19074923 [NCBI36]
Chr20:20p13-11.23		 pathogenic
GRCh38/hg38 20p13(chr20:89939-975656)x1 copy number loss See cases [RCV000052733] Chr20:89939..975656 [GRCh38]
Chr20:70580..956299 [GRCh37]
Chr20:18580..904299 [NCBI36]
Chr20:20p13		 pathogenic
GRCh38/hg38 20p13(chr20:89939-1939218)x1 copy number loss See cases [RCV000052735] Chr20:89939..1939218 [GRCh38]
Chr20:70580..1919864 [GRCh37]
Chr20:18580..1867864 [NCBI36]
Chr20:20p13		 pathogenic
GRCh38/hg38 20p13(chr20:89939-1770567)x1 copy number loss See cases [RCV000052736] Chr20:89939..1770567 [GRCh38]
Chr20:70580..1751213 [GRCh37]
Chr20:18580..1699213 [NCBI36]
Chr20:20p13		 pathogenic
GRCh38/hg38 20p13(chr20:89939-1668795)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052737]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052737]|See cases [RCV000052737] Chr20:89939..1668795 [GRCh38]
Chr20:70580..1649441 [GRCh37]
Chr20:18580..1597441 [NCBI36]
Chr20:20p13		 pathogenic
GRCh38/hg38 20p13(chr20:121781-2290194)x1 copy number loss See cases [RCV000052738] Chr20:121781..2290194 [GRCh38]
Chr20:102422..2270840 [GRCh37]
Chr20:50422..2218840 [NCBI36]
Chr20:20p13		 pathogenic
1 to 10 of 113 rows

Predicted Target Of
Summary Value
Count of predictions:31
Count of miRNA genes:31
Interacting mature miRNAs:31
Transcripts:ENSMUST00000047888
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300899Chol6_mcholesterol 6 (mouse)Not determined9129902913Mouse
13434920Dcollq1_mdifferential colonization level QTL 1 (mouse)9130341840Mouse
4142326Tgq19_mtriglyceride QTL 19 (mouse)Not determined121060750Mouse

UniSTS:225085  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3897,368,638 - 7,368,811UniSTSGRCm38
MGSCv3797,368,638 - 7,368,811UniSTSGRCm37
Celera94,768,782 - 4,768,955UniSTS
Cytogenetic Map9A1UniSTS







Ensembl Acc Id: ENSMUST00000047888   ⟹   ENSMUSP00000047261
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl97,368,239 - 7,388,047 (-)Ensembl
GRCm38.p6 Ensembl97,368,239 - 7,388,047 (-)Ensembl
RefSeq Acc Id: NM_032007   ⟹   NP_114396
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3997,367,670 - 7,388,026 (-)NCBI
GRCm3897,367,670 - 7,388,026 (-)NCBI
MGSCv3797,367,670 - 7,388,026 (-)RGD
Celera94,767,814 - 4,788,756 (-)RGD
cM Map9 ENTREZGENE
Sequence:
Protein RefSeqs NP_114396 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAC18879 (Get FASTA)   NCBI Sequence Viewer  
  EDL24934 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000047261
GenBank Protein Q9EPL6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_114396   ⟸   NM_032007
- Peptide Label: preproprotein
- UniProtKB: Q9EPL6 (UniProtKB/Swiss-Prot),   G5E8A9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000047261   ⟸   ENSMUST00000047888
Peptidase metallopeptidase

Name Modeler Protein Id AA Range Protein Structure
AF-Q9EPL6-F1-model_v2 AlphaFold Q9EPL6 1-463 view protein structure



1 to 37 of 37 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000041620 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000047888 ENTREZGENE
Gene3D-CATH 2.110.10.10 UniProtKB/Swiss-Prot
  3.40.390.10 UniProtKB/Swiss-Prot
InterPro Hemopexin-like_dom UniProtKB/Swiss-Prot
  Hemopexin-like_dom_sf UniProtKB/Swiss-Prot
  Hemopexin-like_repeat UniProtKB/Swiss-Prot
  Hemopexin_CS UniProtKB/Swiss-Prot
  M10A_MMP UniProtKB/Swiss-Prot
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot
  Pept_M10_metallopeptidase UniProtKB/Swiss-Prot
  Pept_M10A UniProtKB/Swiss-Prot
  Pept_M10A_Zn_BS UniProtKB/Swiss-Prot
  Peptidase_Metallo UniProtKB/Swiss-Prot
  Peptidoglycan-bd-like UniProtKB/Swiss-Prot
  PGBD-like_sf UniProtKB/Swiss-Prot
MGD MGI:1933847 ENTREZGENE
NCBI Gene 83996 ENTREZGENE
PANTHER INTERSTITIAL COLLAGENASE UniProtKB/Swiss-Prot
  MATRIX METALLOPROTEINASE UniProtKB/Swiss-Prot
Pfam Hemopexin UniProtKB/Swiss-Prot
  Peptidase_M10 UniProtKB/Swiss-Prot
  PG_binding_1 UniProtKB/Swiss-Prot
PhenoGen Mmp1b PhenoGen
PIRSF Peptidase_M10A_matrix UniProtKB/Swiss-Prot
PRINTS MATRIXIN UniProtKB/Swiss-Prot
PROSITE CYSTEINE_SWITCH UniProtKB/Swiss-Prot
  HEMOPEXIN UniProtKB/Swiss-Prot
  HEMOPEXIN_2 UniProtKB/Swiss-Prot
  ZINC_PROTEASE UniProtKB/Swiss-Prot
SMART SM00120 UniProtKB/Swiss-Prot
  ZnMc UniProtKB/Swiss-Prot
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot
  SSF47090 UniProtKB/Swiss-Prot
  SSF50923 UniProtKB/Swiss-Prot
UniProt G5E8A9 ENTREZGENE, UniProtKB/TrEMBL
  MMP1B_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
1 to 37 of 37 rows