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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1322141
Species: Mus musculus
RGD Object: Gene
Symbol: Sos1
Name: SOS Ras/Rac guanine nucleotide exchange factor 1
Acc ID: CHEBI:34342
Term: 3-methylcholanthrene
Definition: A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Chemical ID: MESH:D008748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sos1increases expressionISOSOS1 (Homo sapiens)6480464CTDMethylcholanthrene results in increased expression of SOS1 mRNAPMID:16619036
Sos1multiple interactionsISOSOS1 (Homo sapiens)6480464CTDMethylcholanthrene promotes the reaction [AHR protein binds to SOS1 promoter]PMID:20348232
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