Plk4 (polo like kinase 4) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Plk4 (polo like kinase 4) Mus musculus
Analyze
Symbol: Plk4
Name: polo like kinase 4
RGD ID: 1313393
MGI Page MGI
Description: Enables identical protein binding activity and protein serine/threonine kinase activity. Involved in centriole replication; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation; and trophoblast giant cell differentiation. Located in XY body; deuterosome; and nucleolus. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and musculoskeletal system. Human ortholog(s) of this gene implicated in microcephaly and chorioretinopathy 2. Orthologous to human PLK4 (polo like kinase 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1700028H20; AI385771; PLK-4; polo-like kinase 4; S; Sak; serine/threonine kinase 18; serine/threonine-protein kinase 18; serine/threonine-protein kinase PLK4; serine/threonine-protein kinase Sak; Stk1; Stk18
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm9742  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39340,754,463 - 40,771,318 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl340,754,454 - 40,771,318 (+)EnsemblGRCm39 Ensembl
GRCm38340,799,951 - 40,816,883 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl340,800,019 - 40,816,883 (+)EnsemblGRCm38mm10GRCm38
MGSCv37340,603,873 - 40,620,805 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36340,896,599 - 40,913,432 (+)NCBIMGSCv36mm8
Celera340,529,562 - 40,546,495 (+)NCBICelera
Cytogenetic Map3BNCBI
cM Map319.54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (EXP)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3-methylcholanthrene  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
chlorpyrifos  (EXP)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
Echimidine  (ISO)
Enterolactone  (ISO)
furan  (ISO)
genistein  (ISO)
glycidol  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (EXP,ISO)
lucanthone  (ISO)
methotrexate  (EXP)
monocrotaline  (ISO)
N-nitrosodiethylamine  (EXP)
nickel dichloride  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
progesterone  (EXP)
propanal  (ISO)
resveratrol  (ISO)
riddelliine  (ISO)
rotenone  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
succimer  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
Tiron  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trans-caffeic acid  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Loss of KLF14 triggers centrosome amplification and tumorigenesis. Fan G, etal., Nat Commun. 2015 Oct 6;6:8450. doi: 10.1038/ncomms9450.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Aberrant methylation of Polo-like kinase CpG islands in Plk4 heterozygous mice. Ward A, etal., BMC Cancer. 2011 Feb 15;11:71. doi: 10.1186/1471-2407-11-71.
9. MicroRNA‑126 suppresses the proliferation and migration of endothelial cells in experimental diabetic retinopathy by targeting polo‑like kinase 4. Zheng Y, etal., Int J Mol Med. 2021 Jan;47(1):151-160. doi: 10.3892/ijmm.2020.4775. Epub 2020 Oct 30.
Additional References at PubMed
PMID:8022793   PMID:8756623   PMID:10349636   PMID:10607900   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11301255   PMID:12352953   PMID:12477932   PMID:12520002   PMID:15489334  
PMID:15640847   PMID:15761153   PMID:16025114   PMID:16141072   PMID:16141073   PMID:17174311   PMID:17891141   PMID:18207742   PMID:19607708   PMID:20100909   PMID:20348415   PMID:20360068  
PMID:21267068   PMID:21677750   PMID:21791561   PMID:21873635   PMID:21987638   PMID:22024926   PMID:22258617   PMID:22349705   PMID:22456511   PMID:22840514   PMID:22854038   PMID:23666084  
PMID:24240477   PMID:24268700   PMID:24498222   PMID:25740542   PMID:26158450   PMID:26578791   PMID:26595384   PMID:26949938   PMID:28972102   PMID:32325033   PMID:34321999   PMID:35758262  
PMID:35772791   PMID:35969030   PMID:35981754   PMID:36067731   PMID:37738460  


Genomics

Comparative Map Data
Plk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39340,754,463 - 40,771,318 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl340,754,454 - 40,771,318 (+)EnsemblGRCm39 Ensembl
GRCm38340,799,951 - 40,816,883 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl340,800,019 - 40,816,883 (+)EnsemblGRCm38mm10GRCm38
MGSCv37340,603,873 - 40,620,805 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36340,896,599 - 40,913,432 (+)NCBIMGSCv36mm8
Celera340,529,562 - 40,546,495 (+)NCBICelera
Cytogenetic Map3BNCBI
cM Map319.54NCBI
PLK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384127,880,893 - 127,899,224 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4127,880,893 - 127,899,224 (+)EnsemblGRCh38hg38GRCh38
GRCh374128,802,048 - 128,820,379 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364129,021,495 - 129,039,803 (+)NCBINCBI36Build 36hg18NCBI36
Build 344129,159,705 - 129,177,532NCBI
Celera4126,180,969 - 126,199,332 (+)NCBICelera
Cytogenetic Map4q28.1NCBI
HuRef4124,529,792 - 124,548,157 (+)NCBIHuRef
CHM1_14128,778,476 - 128,796,837 (+)NCBICHM1_1
T2T-CHM13v2.04131,183,905 - 131,202,250 (+)NCBIT2T-CHM13v2.0
Plk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82125,730,480 - 125,748,894 (+)NCBIGRCr8
mRatBN7.22123,802,527 - 123,820,942 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2123,802,512 - 123,820,942 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2130,373,009 - 130,391,421 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02128,485,441 - 128,503,853 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02123,114,577 - 123,132,993 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02127,686,911 - 127,705,518 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2127,686,925 - 127,705,518 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02147,289,950 - 147,308,585 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42127,760,508 - 127,779,640 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12127,710,374 - 127,729,098 (+)NCBI
Celera2118,710,474 - 118,728,860 (+)NCBICelera
Cytogenetic Map2q26NCBI
Plk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542813,549,000 - 13,566,516 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542813,548,485 - 13,566,786 (-)NCBIChiLan1.0ChiLan1.0
PLK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23125,641,740 - 125,662,398 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14125,907,865 - 125,928,520 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04120,044,423 - 120,062,544 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14131,349,562 - 131,367,832 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4131,349,562 - 131,371,054 (+)Ensemblpanpan1.1panPan2
PLK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11913,041,739 - 13,060,300 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1913,041,742 - 13,060,072 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1913,230,516 - 13,249,086 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01913,131,767 - 13,150,342 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1913,131,770 - 13,150,336 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11913,104,502 - 13,123,557 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01913,390,106 - 13,408,959 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01913,852,450 - 13,871,021 (-)NCBIUU_Cfam_GSD_1.0
Plk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530161,544,655 - 61,562,496 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366422,837,022 - 2,855,103 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366422,837,041 - 2,855,369 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl896,991,847 - 97,013,461 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1896,989,011 - 97,013,324 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28103,855,622 - 103,876,526 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1775,005,468 - 75,023,768 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl775,006,431 - 75,023,730 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603754,141,868 - 54,160,207 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247778,804,593 - 8,825,257 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247778,804,372 - 8,825,669 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Plk4
544 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:542
Count of miRNA genes:308
Interacting mature miRNAs:342
Transcripts:ENSMUST00000026858, ENSMUST00000166936, ENSMUST00000167556, ENSMUST00000168287, ENSMUST00000168363, ENSMUST00000169566, ENSMUST00000170825, ENSMUST00000171538
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
14746977Manh53_mmandible shape 53 (mouse)33592528069925280Mouse
15039332Nmrs6_mNAFLD-associated magnetic resonance shift 6 (mouse)33417074168170741Mouse
1301585Cd4ts1_mCD4 T cell subset 1 (mouse)Not determined33970410273704231Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1024922183184946Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1024922183184946Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31024922183184946Mouse
11041901Lmr11b_mleishmaniasis resistance 11b (mouse)33970410273704231Mouse
15039336Nmrs2_mNAFLD-associated magnetic resonance shift 2 (mouse)33457610368576103Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31024922183184946Mouse
10755516Amzn1_manatomical modifier of Zfp423 1 (mouse)33970410273704231Mouse
1558925Hivan1_mHIV-associated nephropathy 1 (mouse)Not determined3758617468716946Mouse
9587784Afw13_mabdominal fat weight QTL 13 (mouse)Not determined33375204567752228Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31024922183184946Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1301114Ssial2_msusceptibility to sialadenitis 2 (mouse)Not determined32017486254180103Mouse
1357689Mdmsc1_mmodifier of muscularity 1 (mouse)Not determined33332720145916479Mouse
18337272Bmd46_mbone mineral density 46, males (mouse)33540742169407421Mouse
11039513Ltpr3a_mLeishmania tropica response 3a (mouse)33970410273704231Mouse
1300961Bh4p_mbar holding four paws (mouse)Not determined33183785465837997Mouse
4142092Tgq13_mtriglyceride QTL 13 (mouse)Not determined1828816852288168Mouse
10043882Bwtq13_mbody weight QTL 13 (mouse)Not determined33375204567752228Mouse
10412073Ssen2_msuseptibility to Sendai virus 2 (mouse)Not determined33353546567535615Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1024922183184946Mouse
12910781Pwgrq12_mpost-weaning growth rate QTL 12 (mouse)33263576058017363Mouse
1300587Aod2_mautoimmune ovarian dysgenesis 2 (mouse)Not determined33717974268716946Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301358Eae20_mexperimental allergic encephalomyelitis 20 (mouse)Not determined31163045345630591Mouse
12910778Pwgrq13_mpost-weaning growth rate QTL 13 (mouse)33263576058017363Mouse

Markers in Region
AU022933  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38340,799,602 - 40,799,829UniSTSGRCm38
MGSCv37340,603,524 - 40,603,751UniSTSGRCm37
Celera340,529,213 - 40,529,440UniSTS
Cytogenetic Map3BUniSTS
Whitehead/MRC_RH1958.64UniSTS
AI385771  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38340,816,612 - 40,816,745UniSTSGRCm38
MGSCv37340,620,534 - 40,620,667UniSTSGRCm37
Celera340,546,224 - 40,546,357UniSTS
Cytogenetic Map3BUniSTS
Stk18  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38340,805,751 - 40,805,938UniSTSGRCm38
MGSCv37340,609,673 - 40,609,860UniSTSGRCm37
Celera340,535,363 - 40,535,550UniSTS
Cytogenetic Map3BUniSTS
cM Map1313.0UniSTS
cM Map3 UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001410621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001410622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_173169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_045576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006500770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030252518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC146980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC160757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF046864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK006459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK006827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L29479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L29480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000026858   ⟹   ENSMUSP00000026858
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl340,754,454 - 40,771,318 (+)Ensembl
GRCm38.p6 Ensembl340,800,019 - 40,816,883 (+)Ensembl
Ensembl Acc Id: ENSMUST00000167556   ⟹   ENSMUSP00000126945
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl340,754,689 - 40,770,852 (+)Ensembl
GRCm38.p6 Ensembl340,800,254 - 40,816,417 (+)Ensembl
Ensembl Acc Id: ENSMUST00000203295   ⟹   ENSMUSP00000145277
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl340,754,489 - 40,771,318 (+)Ensembl
GRCm38.p6 Ensembl340,800,054 - 40,816,883 (+)Ensembl
Ensembl Acc Id: ENSMUST00000203320
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl340,754,485 - 40,760,500 (+)Ensembl
GRCm38.p6 Ensembl340,800,050 - 40,806,065 (+)Ensembl
Ensembl Acc Id: ENSMUST00000203895   ⟹   ENSMUSP00000145455
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl340,754,477 - 40,771,186 (+)Ensembl
GRCm38.p6 Ensembl340,800,042 - 40,816,751 (+)Ensembl
Ensembl Acc Id: ENSMUST00000204032   ⟹   ENSMUSP00000145201
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl340,767,173 - 40,771,317 (+)Ensembl
GRCm38.p6 Ensembl340,812,738 - 40,816,882 (+)Ensembl
Ensembl Acc Id: ENSMUST00000204289
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl340,754,477 - 40,756,058 (+)Ensembl
GRCm38.p6 Ensembl340,800,042 - 40,801,623 (+)Ensembl
Ensembl Acc Id: ENSMUST00000204473   ⟹   ENSMUSP00000144693
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl340,755,216 - 40,759,448 (+)Ensembl
GRCm38.p6 Ensembl340,800,781 - 40,805,013 (+)Ensembl
Ensembl Acc Id: ENSMUST00000204594
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl340,754,463 - 40,762,848 (+)Ensembl
GRCm38.p6 Ensembl340,800,028 - 40,808,413 (+)Ensembl
Ensembl Acc Id: ENSMUST00000205046
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl340,755,898 - 40,756,479 (+)Ensembl
GRCm38.p6 Ensembl340,801,463 - 40,802,044 (+)Ensembl
RefSeq Acc Id: NM_001410621   ⟹   NP_001397550
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39340,755,216 - 40,771,318 (+)NCBI
RefSeq Acc Id: NM_001410622   ⟹   NP_001397551
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39340,754,463 - 40,771,318 (+)NCBI
RefSeq Acc Id: NM_011495   ⟹   NP_035625
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39340,754,463 - 40,771,318 (+)NCBI
GRCm38340,799,951 - 40,816,883 (+)ENTREZGENE
MGSCv37340,603,873 - 40,620,805 (+)RGD
Celera340,529,562 - 40,546,495 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_173169   ⟹   NP_775261
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39340,754,463 - 40,771,318 (+)NCBI
GRCm38340,799,951 - 40,816,883 (+)ENTREZGENE
Celera340,529,562 - 40,546,495 (+)ENTREZGENE
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_045576
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39340,754,463 - 40,771,318 (+)NCBI
GRCm38340,799,951 - 40,816,883 (+)ENTREZGENE
Celera340,529,562 - 40,546,495 (+)ENTREZGENE
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006500770   ⟹   XP_006500833
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39340,754,465 - 40,771,318 (+)NCBI
GRCm38340,800,012 - 40,816,865 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030252518   ⟹   XP_030108378
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39340,754,748 - 40,771,318 (+)NCBI
GRCm38340,800,314 - 40,816,865 (+)NCBI
Sequence:
RefSeq Acc Id: NP_035625   ⟸   NM_011495
- Peptide Label: isoform 1
- UniProtKB: Q9CVR6 (UniProtKB/Swiss-Prot),   Q8R0I5 (UniProtKB/Swiss-Prot),   Q80UT6 (UniProtKB/Swiss-Prot),   Q78EG6 (UniProtKB/Swiss-Prot),   Q6PEP6 (UniProtKB/Swiss-Prot),   Q3UVA3 (UniProtKB/Swiss-Prot),   Q9CVU6 (UniProtKB/Swiss-Prot),   Q64702 (UniProtKB/Swiss-Prot),   E9PVH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_775261   ⟸   NM_173169
- Peptide Label: isoform 2
- UniProtKB: E9PVH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006500833   ⟸   XM_006500770
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_030108378   ⟸   XM_030252518
- Peptide Label: isoform X2
Ensembl Acc Id: ENSMUSP00000145201   ⟸   ENSMUST00000204032
Ensembl Acc Id: ENSMUSP00000145455   ⟸   ENSMUST00000203895
Ensembl Acc Id: ENSMUSP00000145277   ⟸   ENSMUST00000203295
Ensembl Acc Id: ENSMUSP00000026858   ⟸   ENSMUST00000026858
Ensembl Acc Id: ENSMUSP00000144693   ⟸   ENSMUST00000204473
Ensembl Acc Id: ENSMUSP00000126945   ⟸   ENSMUST00000167556
RefSeq Acc Id: NP_001397551   ⟸   NM_001410622
- Peptide Label: isoform 4
- UniProtKB: E9PVH4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001397550   ⟸   NM_001410621
- Peptide Label: isoform 3
- UniProtKB: E9PVH4 (UniProtKB/TrEMBL)
Protein Domains
Cryptic POLO box 1 (CPB1)   Cryptic POLO box 2 (CPB2)   POLO box   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64702-F1-model_v2 AlphaFold Q64702 1-925 view protein structure

Promoters
RGD ID:6834255
Promoter ID:MM_KWN:34188
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_011495,   UC008PBM.1,   UC008PBN.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36340,603,711 - 40,604,211 (+)MPROMDB
RGD ID:6880548
Promoter ID:EPDNEW_M3724
Type:multiple initiation site
Name:Plk4_1
Description:Mus musculus polo like kinase 4 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M3725  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38340,800,028 - 40,800,088EPDNEW
RGD ID:6880564
Promoter ID:EPDNEW_M3725
Type:multiple initiation site
Name:Plk4_2
Description:Mus musculus polo like kinase 4 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M3724  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38340,800,781 - 40,800,841EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:101783 AgrOrtholog
Ensembl Genes ENSMUSG00000025758 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000026858 ENTREZGENE
  ENSMUST00000026858.11 UniProtKB/Swiss-Prot
  ENSMUST00000167556.7 UniProtKB/TrEMBL
  ENSMUST00000203295 ENTREZGENE
  ENSMUST00000203295.3 UniProtKB/Swiss-Prot
  ENSMUST00000203895 ENTREZGENE
  ENSMUST00000203895.3 UniProtKB/TrEMBL
  ENSMUST00000204032.2 UniProtKB/TrEMBL
  ENSMUST00000204473.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.930 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.1120.120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.1120.130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aur-like UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Plk4-like_POLO_box_2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box_Plk4_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box_Plk4_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box_Plk4_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser_Thr-PK_POLO_box_1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20873 UniProtKB/Swiss-Prot
MGD MGI:101783 ENTREZGENE
NCBI Gene 20873 ENTREZGENE
PANTHER AURORA KINASE UniProtKB/TrEMBL
  PTHR24345:SF89 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE IAL-RELATED UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE PLK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Plk4_PB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Plk4_PB2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plk4 PhenoGen
PROSITE CPB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CPB2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_BOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Polo-box domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0N4SWB8_MOUSE UniProtKB/TrEMBL
  E9PVH4 ENTREZGENE, UniProtKB/TrEMBL
  E9Q4W7_MOUSE UniProtKB/TrEMBL
  F6QIM3_MOUSE UniProtKB/TrEMBL
  PLK4_MOUSE UniProtKB/Swiss-Prot
  Q3UVA3 ENTREZGENE
  Q3V382_MOUSE UniProtKB/TrEMBL
  Q64702 ENTREZGENE
  Q6PEP6 ENTREZGENE
  Q78EG6 ENTREZGENE
  Q80UT6 ENTREZGENE
  Q8C3W9_MOUSE UniProtKB/TrEMBL
  Q8R0I5 ENTREZGENE
  Q9CVR6 ENTREZGENE
  Q9CVU6 ENTREZGENE
UniProt Secondary Q3UVA3 UniProtKB/Swiss-Prot
  Q6PEP6 UniProtKB/Swiss-Prot
  Q78EG6 UniProtKB/Swiss-Prot
  Q80UT6 UniProtKB/Swiss-Prot
  Q8R0I5 UniProtKB/Swiss-Prot
  Q9CVR6 UniProtKB/Swiss-Prot
  Q9CVU6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-05 Plk4  polo like kinase 4  Plk4  polo-like kinase 4  Symbol and/or name change 5135510 APPROVED
2012-07-05 Plk4  polo-like kinase 4  Plk4  polo-like kinase 4 (Drosophila)  Symbol and/or name change 5135510 APPROVED