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Gene: Bub1b (BUB1B, mitotic checkpoint serine/threonine kinase) Mus musculus
Symbol: Bub1b
Name: BUB1B, mitotic checkpoint serine/threonine kinase
RGD ID: 1316317
Description: Predicted to have protein kinase activity. Involved in metaphase/anaphase transition of mitotic cell cycle and protein localization to chromosome, centromeric region. Localizes to condensed chromosome outer kinetochore and condensed nuclear chromosome kinetochore. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study mosaic variegated aneuploidy syndrome 1. Human ortholog(s) of this gene implicated in colorectal cancer and mosaic variegated aneuploidy syndrome 1. Orthologous to human BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B); PARTICIPATES IN cell cycle pathway, mitotic; INTERACTS WITH 1,2-dimethylhydrazine; 1-chloro-2,4-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AU045529; BUBR; BUBR1; budding uninhibited by benzimidazoles 1 beta; budding uninhibited by benzimidazoles 1 homolog, beta; MAD3/BUB1-related protein kinase; MGC36092; mitotic checkpoint kinase MAD3L; mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392118,428,684 - 118,472,073 (+)NCBI
GRCm382118,598,202 - 118,641,592 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2118,598,211 - 118,641,591 (+)EnsemblGRCm38mm10GRCm38
MGSCv372118,423,947 - 118,467,328 (+)NCBIGRCm37mm9NCBIm37
MGSCv362118,289,697 - 118,333,032 (+)NCBImm8
Celera2119,745,153 - 119,796,040 (+)NCBICelera
Cytogenetic Map2E5NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Bub1b
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1316317
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.