Slit2 (slit guidance ligand 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Slit2 (slit guidance ligand 2) Mus musculus
Analyze
Symbol: Slit2
Name: slit guidance ligand 2
RGD ID: 735484
MGI Page MGI
Description: Enables chemorepellent activity. Involved in aortic valve morphogenesis; pulmonary valve morphogenesis; and ventricular septum morphogenesis. Acts upstream of or within several processes, including mammary duct terminal end bud growth; negative regulation of axon extension; and nervous system development. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Kartagener syndrome; cystic kidney disease; primary ciliary dyskinesia; and visceral heterotaxy. Orthologous to human SLIT2 (slit guidance ligand 2).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: b2b1200.1Clo; downregulated during adipocyte differentiation-1; Drad; Drad-1; E030015M03Rik; E130320P19Rik; KIAA4141; mKIAA4141; neurogenic extracellular slit protein; S; Slil3; slit homolog 2 (Drosophila); slit homolog 2 protein; slit-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39548,138,633 - 48,465,077 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl548,140,480 - 48,465,075 (+)EnsemblGRCm39 Ensembl
GRCm38547,981,291 - 48,307,735 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl547,983,138 - 48,307,733 (+)EnsemblGRCm38mm10GRCm38
MGSCv37548,374,394 - 48,697,017 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36548,273,041 - 48,593,759 (+)NCBIMGSCv36mm8
Celera545,381,658 - 45,708,133 (+)NCBICelera
Cytogenetic Map5B3NCBI
cM Map526.05NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-methylcholanthrene  (EXP)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
acetaldehyde  (EXP)
acetamide  (ISO)
acrylamide  (EXP,ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
choline  (EXP)
chromium(6+)  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
cyproconazole  (EXP)
cytarabine  (ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (EXP)
dimethylarsinous acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enniatin  (ISO)
ethanol  (EXP)
fenvalerate  (ISO)
flusilazole  (EXP)
folic acid  (EXP,ISO)
fulvestrant  (ISO)
furan  (ISO)
gentamycin  (ISO)
hexaconazole  (EXP)
iron dichloride  (ISO)
ketoconazole  (ISO)
L-methionine  (EXP)
lithium atom  (ISO)
lithium hydride  (ISO)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
mifepristone  (ISO)
Muraglitazar  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
nickel sulfate  (ISO)
nitrofen  (ISO)
O-methyleugenol  (ISO)
oxaliplatin  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
PD 0325901  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
pyrimidifen  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
sulfadimethoxine  (ISO)
temozolomide  (ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve morphogenesis  (IMP)
apoptotic process involved in luteolysis  (ISO)
axon extension involved in axon guidance  (ISO)
axon guidance  (IDA,IGI,IMP,ISO)
axonogenesis  (IDA,IMP)
branching morphogenesis of an epithelial tube  (ISO)
cell migration involved in sprouting angiogenesis  (ISO)
cell-cell adhesion  (IGI,IMP)
cellular response to heparin  (ISO)
cellular response to hormone stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration  (ISO)
chemorepulsion involved in postnatal olfactory bulb interneuron migration  (ISO)
corticospinal neuron axon guidance through spinal cord  (ISO)
dorsal/ventral axon guidance  (IGI,IMP)
in utero embryonic development  (IMP)
induction of negative chemotaxis  (ISO)
kidney development  (IMP)
mammary duct terminal end bud growth  (IMP)
mammary gland duct morphogenesis  (IGI,IMP)
metanephros development  (IMP)
motor neuron axon guidance  (ISO)
negative chemotaxis  (IBA,IMP,ISO)
negative regulation of actin filament polymerization  (ISO)
negative regulation of axon extension  (IDA)
negative regulation of cell growth  (IBA,ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (IGI)
negative regulation of cellular response to growth factor stimulus  (ISO)
negative regulation of chemokine-mediated signaling pathway  (ISO)
negative regulation of endothelial cell migration  (ISO)
negative regulation of gene expression  (IGI)
negative regulation of lamellipodium assembly  (ISO)
negative regulation of leukocyte chemotaxis  (ISO)
negative regulation of monocyte chemotaxis  (ISO)
negative regulation of mononuclear cell migration  (ISO)
negative regulation of neutrophil chemotaxis  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of retinal ganglion cell axon guidance  (ISO)
negative regulation of small GTPase mediated signal transduction  (ISO)
negative regulation of smooth muscle cell chemotaxis  (ISO)
negative regulation of smooth muscle cell migration  (ISO)
negative regulation of vascular permeability  (ISO)
neuron projection extension  (ISO)
neuron projection morphogenesis  (IGI,IMP)
olfactory bulb development  (IGI)
positive regulation of apoptotic process  (ISO)
positive regulation of synapse assembly  (ISO)
pulmonary valve morphogenesis  (IMP)
response to cortisol  (ISO)
response to nutrient levels  (ISO)
retinal ganglion cell axon guidance  (IBA,IGI,IMP,ISO)
Roundabout signaling pathway  (ISO)
spinal cord development  (ISO)
synapse maturation  (ISO)
telencephalon cell migration  (IGI)
ureteric bud development  (ISO)
ventricular septum morphogenesis  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A Study Based on the Correlation Between Slit2/Robo1 Signaling Pathway Proteins and Polymyositis/Dermatomyositis. Chai KX, etal., Curr Mol Med. 2020;20(9):717-722. doi: 10.2174/1566524020666200326102837.
2. Upregulation of Slit-2 and Slit-3 gene expressions in the nitrofen-induced hypoplastic lung. Doi T, etal., J Pediatr Surg. 2009 Nov;44(11):2092-5. doi: 10.1016/j.jpedsurg.2009.02.068.
3. Increased Expression of Slit2 and its Robo Receptors During Astroglial Scar Formation After Transient Focal Cerebral Ischemia in Rats. Jin X, etal., Neurochem Res. 2016 Dec;41(12):3373-3385. doi: 10.1007/s11064-016-2072-0. Epub 2016 Sep 29.
4. Modulation of inflammation by slit protein in vivo in experimental crescentic glomerulonephritis. Kanellis J, etal., Am J Pathol. 2004 Jul;165(1):341-52.
5. Recombinant Slit2 attenuates neuronal apoptosis via the Robo1-srGAP1 pathway in a rat model of neonatal HIE. Kaur H, etal., Neuropharmacology. 2019 Nov 1;158:107727. doi: 10.1016/j.neuropharm.2019.107727. Epub 2019 Jul 26.
6. Slit2/Robo1 Mediation of Synaptic Plasticity Contributes to Bone Cancer Pain. Ke C, etal., Mol Neurobiol. 2017 Jan;54(1):295-307. doi: 10.1007/s12035-015-9564-9. Epub 2016 Jan 6.
7. Slit2/Robo1 promotes synaptogenesis and functional recovery of spinal cord injury. Li Y, etal., Neuroreport. 2017 Jan 18;28(2):75-81. doi: 10.1097/WNR.0000000000000715.
8. Potential Role of Axonal Chemorepellent Slit2 in Modulating Adventitial Inflammation in a Rat Carotid Artery Balloon Injury Model. Liu D, etal., J Cardiovasc Pharmacol. 2016 May;67(5):433-41. doi: 10.1097/FJC.0000000000000369.
9. Expression of Slit2 and Robo1 after traumatic lesions of the rat spinal cord. Liu JB, etal., Acta Histochem. 2009 Sep 22.
10. Crosstalk between the activated Slit2-Robo1 pathway and TGF-β1 signalling promotes cardiac fibrosis. Liu Y, etal., ESC Heart Fail. 2021 Feb;8(1):447-460. doi: 10.1002/ehf2.13095. Epub 2020 Nov 24.
11. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
12. MGDs mouse GO annotations MGD data from the GO Consortium
13. MGD IEA MGD IEA
14. Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves. Mommersteeg MT, etal., Cardiovasc Res. 2015 Apr 1;106(1):55-66. doi: 10.1093/cvr/cvv040. Epub 2015 Feb 17.
15. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
16. Increased expression of Slit2 and its receptors Robo1 and Robo4 in reactive astrocytes of the rat hippocampus after transient forebrain ischemia. Park JH, etal., Brain Res. 2016 Mar 1;1634:45-56. doi: 10.1016/j.brainres.2015.12.056. Epub 2016 Jan 4.
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system. Plump AS, etal., Neuron 2002 Jan 17;33(2):219-32.
19. Mouse MP Annotation Import Pipeline RGD automated import pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Recombinant Slit2 attenuates neuroinflammation after surgical brain injury by inhibiting peripheral immune cell infiltration via Robo1-srGAP1 pathway in a rat model. Sherchan P, etal., Neurobiol Dis. 2016 Jan;85:164-173. doi: 10.1016/j.nbd.2015.11.003. Epub 2015 Nov 10.
23. The expression of the Slit-Robo signal in the retina of diabetic rats and the vitreous or fibrovascular retinal membranes of patients with proliferative diabetic retinopathy. Zhou W, etal., PLoS One. 2017 Oct 3;12(10):e0185795. doi: 10.1371/journal.pone.0185795. eCollection 2017.
Additional References at PubMed
PMID:8889548   PMID:9323794   PMID:9490702   PMID:10349621   PMID:10349636   PMID:10433822   PMID:10842075   PMID:10864954   PMID:10864955   PMID:10922068   PMID:11042159   PMID:11076861  
PMID:11217851   PMID:11306627   PMID:11520671   PMID:11748150   PMID:11804571   PMID:11830575   PMID:12023301   PMID:12051827   PMID:12097499   PMID:12141424   PMID:12477932   PMID:12488830  
PMID:12514217   PMID:12515855   PMID:12609596   PMID:12642493   PMID:12654290   PMID:12655597   PMID:12702769   PMID:12879062   PMID:12954717   PMID:12954881   PMID:14507778   PMID:14605369  
PMID:14662852   PMID:14681479   PMID:14960623   PMID:15091338   PMID:15130495   PMID:15162513   PMID:15226823   PMID:15489334   PMID:15509772   PMID:15632069   PMID:16141072   PMID:16141073  
PMID:16226035   PMID:16284245   PMID:16291793   PMID:16309667   PMID:16319112   PMID:16410488   PMID:16439476   PMID:16540508   PMID:16602821   PMID:16715082   PMID:16774856   PMID:16828733  
PMID:16854408   PMID:16870172   PMID:16885222   PMID:17329426   PMID:17360927   PMID:17392456   PMID:17496152   PMID:17581972   PMID:17715346   PMID:18054781   PMID:18159948   PMID:18287559  
PMID:18345009   PMID:18417704   PMID:18547144   PMID:18562598   PMID:18617019   PMID:18701067   PMID:18829537   PMID:18842816   PMID:19033678   PMID:19048120   PMID:19115401   PMID:19303107  
PMID:19463158   PMID:19515977   PMID:19592574   PMID:19700621   PMID:19727199   PMID:19759280   PMID:19782674   PMID:19859539   PMID:19906969   PMID:19906978   PMID:19961580   PMID:20231872  
PMID:20375003   PMID:20436479   PMID:20438712   PMID:20498081   PMID:20606719   PMID:20631173   PMID:20696379   PMID:20941780   PMID:20944010   PMID:20947829   PMID:21118670   PMID:21135133  
PMID:21307234   PMID:21421844   PMID:21435555   PMID:21485009   PMID:21508241   PMID:21664580   PMID:21688288   PMID:21743013   PMID:21873635   PMID:21880902   PMID:21949750   PMID:21986575  
PMID:22000108   PMID:22076636   PMID:22306607   PMID:22307612   PMID:22313734   PMID:22349628   PMID:22365545   PMID:22399681   PMID:22627285   PMID:22696295   PMID:22789544   PMID:22806432  
PMID:22840396   PMID:22865890   PMID:22875847   PMID:22912413   PMID:22981605   PMID:23042737   PMID:23083737   PMID:23161783   PMID:23217742   PMID:23255421   PMID:23292680   PMID:23307742  
PMID:23320558   PMID:23328398   PMID:23396189   PMID:23438940   PMID:23534961   PMID:23811810   PMID:23814012   PMID:23821580   PMID:23884932   PMID:24006456   PMID:24065825   PMID:24607227  
PMID:24673457   PMID:24741061   PMID:24790087   PMID:24840330   PMID:24891614   PMID:24952961   PMID:25030704   PMID:25056828   PMID:25264302   PMID:25336744   PMID:25366972   PMID:25456121  
PMID:25485759   PMID:25490006   PMID:25490618   PMID:25504371   PMID:25530182   PMID:25605242   PMID:25807483   PMID:25838543   PMID:25843547   PMID:25894826   PMID:25904499   PMID:26026792  
PMID:26047956   PMID:26071364   PMID:26102480   PMID:26116176   PMID:26156498   PMID:26159615   PMID:26166575   PMID:26244297   PMID:26257608   PMID:26282852   PMID:26297762   PMID:26395479  
PMID:26416771   PMID:26520399   PMID:26659946   PMID:26743624   PMID:26876562   PMID:26975850   PMID:27002738   PMID:27223325   PMID:27466379   PMID:27503415   PMID:27521753   PMID:27770832  
PMID:27819291   PMID:27984743   PMID:28071719   PMID:28164238   PMID:28219675   PMID:28234971   PMID:28676569   PMID:28986144   PMID:29031500   PMID:29062064   PMID:29343636   PMID:29459093  
PMID:29660433   PMID:29961574   PMID:30177526   PMID:30470893   PMID:30504829   PMID:30550785   PMID:30617207   PMID:30881290   PMID:31008488   PMID:31040226   PMID:31084928   PMID:31356769  
PMID:31545977   PMID:31624071   PMID:31812516   PMID:32325033   PMID:32398956   PMID:32499648   PMID:32561725   PMID:32707082   PMID:32807784   PMID:32999457   PMID:33347679   PMID:33574432  
PMID:33932339   PMID:34230480   PMID:34249921   PMID:34321999   PMID:34341180   PMID:34490644   PMID:35340430   PMID:35343246   PMID:35377797   PMID:35462405   PMID:35927240   PMID:35951416  
PMID:36074819   PMID:36266461   PMID:36792623   PMID:37497580   PMID:37566909   PMID:37707834   PMID:37773612   PMID:37816598   PMID:38355793   PMID:38450283   PMID:38657443   PMID:38937814  
PMID:39159057   PMID:39353435   PMID:39366945  


Genomics

Comparative Map Data
Slit2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39548,138,633 - 48,465,077 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl548,140,480 - 48,465,075 (+)EnsemblGRCm39 Ensembl
GRCm38547,981,291 - 48,307,735 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl547,983,138 - 48,307,733 (+)EnsemblGRCm38mm10GRCm38
MGSCv37548,374,394 - 48,697,017 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36548,273,041 - 48,593,759 (+)NCBIMGSCv36mm8
Celera545,381,658 - 45,708,133 (+)NCBICelera
Cytogenetic Map5B3NCBI
cM Map526.05NCBI
SLIT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38420,251,905 - 20,620,561 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl420,251,905 - 20,620,561 (+)EnsemblGRCh38hg38GRCh38
GRCh37420,253,528 - 20,622,184 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36419,864,333 - 20,229,886 (+)NCBINCBI36Build 36hg18NCBI36
Build 34419,931,503 - 20,297,057NCBI
Celera420,712,350 - 21,077,291 (+)NCBICelera
Cytogenetic Map4p15.31NCBI
HuRef419,604,199 - 19,969,514 (+)NCBIHuRef
CHM1_1420,253,276 - 20,618,733 (+)NCBICHM1_1
T2T-CHM13v2.0420,234,597 - 20,602,238 (+)NCBIT2T-CHM13v2.0
Slit2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81466,829,661 - 67,168,517 (-)NCBIGRCr8
mRatBN7.21462,616,337 - 62,955,934 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1462,617,067 - 62,955,948 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1467,016,997 - 67,353,404 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01468,330,637 - 68,667,055 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01464,727,393 - 65,063,822 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01466,831,848 - 67,171,491 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1466,831,848 - 67,170,361 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01466,864,065 - 67,202,691 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41467,546,283 - 67,891,840 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11467,624,799 - 67,894,206 (-)NCBI
Celera1461,665,582 - 62,001,006 (-)NCBICelera
Cytogenetic Map14q11NCBI
Slit2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554803,984,586 - 4,313,908 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554803,982,977 - 4,314,160 (-)NCBIChiLan1.0ChiLan1.0
SLIT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2320,490,764 - 20,869,771 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1420,698,666 - 21,066,091 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0414,654,448 - 15,023,708 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1419,946,369 - 20,314,656 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl420,158,952 - 20,314,656 (+)Ensemblpanpan1.1panPan2
SLIT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1388,964,707 - 89,311,817 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl388,966,232 - 89,312,955 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha391,423,926 - 91,773,328 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0389,948,981 - 90,297,465 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl389,948,988 - 90,298,073 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1389,094,518 - 89,443,898 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0389,179,097 - 89,528,769 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0389,562,948 - 89,912,569 (-)NCBIUU_Cfam_GSD_1.0
Slit2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528554,409,516 - 54,746,912 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364778,109,228 - 8,446,653 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364778,111,212 - 8,448,567 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLIT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl814,758,335 - 15,148,133 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1814,758,426 - 15,149,515 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2814,998,769 - 15,257,500 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLIT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12729,650,589 - 30,020,105 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2729,650,337 - 29,803,612 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604776,267,556 - 76,654,726 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slit2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475511,472,377 - 11,819,266 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475511,470,810 - 11,819,800 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slit2
16680 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:7552
Count of miRNA genes:994
Interacting mature miRNAs:1511
Transcripts:ENSMUST00000033967, ENSMUST00000170109, ENSMUST00000172484, ENSMUST00000172493, ENSMUST00000172561, ENSMUST00000172824, ENSMUST00000172998, ENSMUST00000173107, ENSMUST00000173303, ENSMUST00000173646, ENSMUST00000173671, ENSMUST00000173686, ENSMUST00000173702, ENSMUST00000173774, ENSMUST00000173926, ENSMUST00000174061, ENSMUST00000174313, ENSMUST00000174421, ENSMUST00000174487, ENSMUST00000174658
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
10043995Hbnr9_mHeligmosomoides bakeri nematode resistance 9 (mouse)Not determined53348866767488876Mouse
1301776Skts3_mskin tumor susceptibility 3 (mouse)Not determined52166729555667403Mouse
1300951Gbvq1_mgallstone bladder volume QTL 1 (mouse)Not determined53811168172111798Mouse
14746981Manh57_mmandible shape 57 (mouse)54716974281169742Mouse
1301845Lxw4_mlupus BXSB x NZW 4 (mouse)Not determined53569446269694594Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
1301403Alcp9_malcohol preference locus 9 (mouse)Not determined53102427565024480Mouse
1300701Cd8ts1_mCD8 T cell subset 1 (mouse)Not determined52721534861215451Mouse
11353827Hplq1_mhot plate latency 1 (mouse)53157045865570458Mouse
1301698Pcfm4_mperiosteal circumference and femur length 4 (mouse)Not determined54458584378585965Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
1301555Alcp10_malcohol preference locus 10 (mouse)Not determined53102427565024480Mouse
1301170Lith13_mlithogenic gene 13 (mouse)Not determined53649448670494598Mouse
1301685Estq2_mestradiol regulated response QTL 2 (mouse)Not determined51563408449634190Mouse
11537367Hmtb11_mhemostasis and thrombosis 11 (mouse)52210082364806579Mouse
11537368Hmtb10_mhemostasis and thrombosis 10 (mouse)52210082354500318Mouse
13207584Mwmlpt4_mMorris water maze latency to platform, training, 4 (mouse)54632260680322606Mouse
1300926Hpi2_mhepatic PMN infiltration 2 (mouse)Not determined53758148864806579Mouse
13207588Mwmlpa4_mMorris water maze latency to platform, all, 4 (mouse)54632260680322606Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
4141647Hrvhf1_mheart rate variability, high frequency 1 (mouse)Not determined3643342370433423Mouse
11049561Lmr24e_mleishmaniasis resistance 24e (mouse)53569446269694594Mouse
13464252Ahl10_mage related hearing loss, early onset 10 (mouse)53585456869854714Mouse
1301223Hdlq7_mHDL QTL 7 (mouse)Not determined53585456869854714Mouse
13464245Ahl12_mage related hearing loss, early onset 12 (mouse)53811168172111798Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
13464246Ahl11_mage related hearing loss, early onset 11 (mouse)53764377771643896Mouse
1300719Iba5_minduction of brown adipocytes 5 (mouse)Not determined52068699354687134Mouse
11049558Lmr24b_mleishmaniasis resistance 24b (mouse)53569446269694594Mouse
11049559Lmr24c_mleishmaniasis resistance 24c (mouse)53569446269694594Mouse

Markers in Region
Slit2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5B3UniSTS
cM Map5 UniSTS
Slit2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5B3UniSTS
cM Map5 UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001291227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001291228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_178804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_111900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006503813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006503814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006503815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006503816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC101004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC113542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC157351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF074960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF144628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK033292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK038807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW556809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC150779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE944330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF471608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D67077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KX232631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000033967   ⟹   ENSMUSP00000033967
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl548,140,496 - 48,461,738 (+)Ensembl
GRCm38.p6 Ensembl547,983,154 - 48,304,396 (+)Ensembl
Ensembl Acc Id: ENSMUST00000170109   ⟹   ENSMUSP00000127615
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl548,140,496 - 48,462,853 (+)Ensembl
GRCm38.p6 Ensembl547,983,154 - 48,305,511 (+)Ensembl
Ensembl Acc Id: ENSMUST00000172484
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl548,388,832 - 48,440,290 (+)Ensembl
GRCm38.p6 Ensembl548,231,490 - 48,282,948 (+)Ensembl
Ensembl Acc Id: ENSMUST00000172493   ⟹   ENSMUSP00000134655
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl548,395,843 - 48,416,939 (+)Ensembl
GRCm38.p6 Ensembl548,238,501 - 48,259,597 (+)Ensembl
Ensembl Acc Id: ENSMUST00000172561
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl548,413,915 - 48,416,893 (+)Ensembl
GRCm38.p6 Ensembl548,256,573 - 48,259,551 (+)Ensembl
Ensembl Acc Id: ENSMUST00000172824
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl548,380,813 - 48,395,794 (+)Ensembl
GRCm38.p6 Ensembl548,223,471 - 48,238,452 (+)Ensembl
Ensembl Acc Id: ENSMUST00000172998
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl548,140,496 - 48,340,499 (+)Ensembl
GRCm38.p6 Ensembl547,983,154 - 48,183,157 (+)Ensembl
Ensembl Acc Id: ENSMUST00000173107   ⟹   ENSMUSP00000133840
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl548,140,480 - 48,465,075 (+)Ensembl
GRCm38.p6 Ensembl547,983,138 - 48,307,733 (+)Ensembl
Ensembl Acc Id: ENSMUST00000173303
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl548,339,444 - 48,377,050 (+)Ensembl
GRCm38.p6 Ensembl548,182,102 - 48,219,708 (+)Ensembl
Ensembl Acc Id: ENSMUST00000173646
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl548,432,583 - 48,439,141 (+)Ensembl
GRCm38.p6 Ensembl548,275,241 - 48,281,799 (+)Ensembl
Ensembl Acc Id: ENSMUST00000173671
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl548,405,985 - 48,420,007 (+)Ensembl
GRCm38.p6 Ensembl548,248,643 - 48,262,665 (+)Ensembl
Ensembl Acc Id: ENSMUST00000173686   ⟹   ENSMUSP00000133382
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl548,439,120 - 48,459,854 (+)Ensembl
GRCm38.p6 Ensembl548,281,778 - 48,302,512 (+)Ensembl
Ensembl Acc Id: ENSMUST00000173774
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl548,326,533 - 48,349,551 (+)Ensembl
GRCm38.p6 Ensembl548,169,191 - 48,192,209 (+)Ensembl
Ensembl Acc Id: ENSMUST00000173926
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl548,142,336 - 48,330,535 (+)Ensembl
GRCm38.p6 Ensembl547,984,994 - 48,173,193 (+)Ensembl
Ensembl Acc Id: ENSMUST00000174061
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl548,140,496 - 48,147,674 (+)Ensembl
GRCm38.p6 Ensembl547,983,154 - 47,990,332 (+)Ensembl
Ensembl Acc Id: ENSMUST00000174313   ⟹   ENSMUSP00000133912
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl548,140,496 - 48,462,853 (+)Ensembl
GRCm38.p6 Ensembl547,983,154 - 48,305,511 (+)Ensembl
Ensembl Acc Id: ENSMUST00000174421   ⟹   ENSMUSP00000134263
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl548,140,496 - 48,462,853 (+)Ensembl
GRCm38.p6 Ensembl547,983,154 - 48,305,511 (+)Ensembl
Ensembl Acc Id: ENSMUST00000174487
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl548,346,809 - 48,387,463 (+)Ensembl
GRCm38.p6 Ensembl548,189,467 - 48,230,121 (+)Ensembl
Ensembl Acc Id: ENSMUST00000174658   ⟹   ENSMUSP00000134359
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl548,145,184 - 48,348,347 (+)Ensembl
GRCm38.p6 Ensembl547,987,842 - 48,191,005 (+)Ensembl
Ensembl Acc Id: ENSMUST00000196024
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl548,140,519 - 48,143,010 (+)Ensembl
GRCm38.p6 Ensembl547,983,177 - 47,985,668 (+)Ensembl
Ensembl Acc Id: ENSMUST00000197400
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl548,140,500 - 48,241,873 (+)Ensembl
GRCm38.p6 Ensembl547,983,158 - 48,084,531 (+)Ensembl
Ensembl Acc Id: ENSMUST00000197737
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl548,331,576 - 48,336,373 (+)Ensembl
GRCm38.p6 Ensembl548,174,234 - 48,179,031 (+)Ensembl
Ensembl Acc Id: ENSMUST00000199024
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl548,402,544 - 48,405,420 (+)Ensembl
GRCm38.p6 Ensembl548,245,202 - 48,248,078 (+)Ensembl
RefSeq Acc Id: NM_001291227   ⟹   NP_001278156
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39548,140,497 - 48,465,077 (+)NCBI
GRCm38547,983,155 - 48,307,735 (+)NCBI
Celera545,381,658 - 45,708,637 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001291228   ⟹   NP_001278157
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39548,140,497 - 48,465,077 (+)NCBI
GRCm38547,983,155 - 48,307,735 (+)NCBI
Celera545,381,658 - 45,708,637 (+)NCBI
Sequence:
RefSeq Acc Id: NM_178804   ⟹   NP_848919
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39548,140,497 - 48,465,077 (+)NCBI
GRCm38547,983,155 - 48,307,735 (+)NCBI
MGSCv37548,374,394 - 48,697,017 (+)RGD
Celera545,381,658 - 45,708,637 (+)NCBI
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_111900
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39548,140,497 - 48,465,077 (+)NCBI
GRCm38547,983,155 - 48,307,735 (+)NCBI
Celera545,381,658 - 45,708,637 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006503813   ⟹   XP_006503876
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39548,138,633 - 48,464,090 (+)NCBI
GRCm38547,981,291 - 48,306,748 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006503814   ⟹   XP_006503877
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39548,138,633 - 48,464,090 (+)NCBI
GRCm38547,981,291 - 48,306,748 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006503815   ⟹   XP_006503878
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39548,138,633 - 48,464,090 (+)NCBI
GRCm38547,981,291 - 48,306,748 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006503816   ⟹   XP_006503879
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39548,138,633 - 48,464,090 (+)NCBI
GRCm38547,981,291 - 48,306,748 (+)NCBI
Sequence:
RefSeq Acc Id: NP_848919   ⟸   NM_178804
- Peptide Label: isoform c precursor
- UniProtKB: E9QKB4 (UniProtKB/Swiss-Prot),   Q9Z166 (UniProtKB/Swiss-Prot),   Q9R1B9 (UniProtKB/Swiss-Prot),   B7ZNW9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006503877   ⟸   XM_006503814
- Peptide Label: isoform X2
- UniProtKB: B2RX05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006503876   ⟸   XM_006503813
- Peptide Label: isoform X1
- UniProtKB: B2RX05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006503878   ⟸   XM_006503815
- Peptide Label: isoform X3
- UniProtKB: A0A140T8T2 (UniProtKB/TrEMBL),   B7ZNW9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006503879   ⟸   XM_006503816
- Peptide Label: isoform X4
- UniProtKB: B7ZNW9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001278156   ⟸   NM_001291227
- Peptide Label: isoform a precursor
- UniProtKB: G3UYX7 (UniProtKB/TrEMBL),   B2RX05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001278157   ⟸   NM_001291228
- Peptide Label: isoform b precursor
- UniProtKB: G3UY21 (UniProtKB/TrEMBL),   B7ZNW9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000127615   ⟸   ENSMUST00000170109
Ensembl Acc Id: ENSMUSP00000134655   ⟸   ENSMUST00000172493
Ensembl Acc Id: ENSMUSP00000033967   ⟸   ENSMUST00000033967
Ensembl Acc Id: ENSMUSP00000134359   ⟸   ENSMUST00000174658
Ensembl Acc Id: ENSMUSP00000133912   ⟸   ENSMUST00000174313
Ensembl Acc Id: ENSMUSP00000134263   ⟸   ENSMUST00000174421
Ensembl Acc Id: ENSMUSP00000133840   ⟸   ENSMUST00000173107
Ensembl Acc Id: ENSMUSP00000133382   ⟸   ENSMUST00000173686
Protein Domains
CTCK   EGF-like   Laminin G   Laminin G-like   LRRCT   LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R1B9-F1-model_v2 AlphaFold Q9R1B9 1-1521 view protein structure

Promoters
RGD ID:6886656
Promoter ID:EPDNEW_M6779
Type:single initiation site
Name:Slit2_1
Description:Mus musculus slit guidance ligand 2 , transcript variant 4, non-codingRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38547,983,155 - 47,983,215EPDNEW
RGD ID:6838388
Promoter ID:MM_KWN:42217
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   ES_Cell,   Kidney,   MEF_B4,   MEF_B6
Transcripts:NM_178804,   UC008XJM.1,   UC008XJN.1,   UC008XJP.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36548,374,311 - 48,376,357 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1315205 AgrOrtholog
Ensembl Genes ENSMUSG00000031558 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000170109 ENTREZGENE
  ENSMUST00000173107 ENTREZGENE
  ENSMUST00000173107.8 UniProtKB/Swiss-Prot
  ENSMUST00000174313 ENTREZGENE
  ENSMUST00000174421 ENTREZGENE
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot
  3.80.10.10 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot
  Cys-rich_flank_reg_C UniProtKB/Swiss-Prot
  Cys_knot_C UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_CS UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  Fol_N UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  Laminin_G UniProtKB/Swiss-Prot
  Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
  Notch/Slit_guidance UniProtKB/Swiss-Prot
KEGG Report mmu:20563 UniProtKB/Swiss-Prot
MGD MGI:1315205 ENTREZGENE
NCBI Gene 20563 ENTREZGENE
PANTHER SLIT HOMOLOG UniProtKB/Swiss-Prot
  SLIT HOMOLOG 2 PROTEIN UniProtKB/Swiss-Prot
Pfam EGF UniProtKB/Swiss-Prot
  hEGF UniProtKB/Swiss-Prot
  Laminin_G_1 UniProtKB/Swiss-Prot
  LRR_1 UniProtKB/Swiss-Prot
  LRR_8 UniProtKB/Swiss-Prot
  LRRCT UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
PhenoGen Slit2 PhenoGen
PROSITE CTCK_1 UniProtKB/Swiss-Prot
  CTCK_2 UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  LAM_G_DOMAIN UniProtKB/Swiss-Prot
  LRR UniProtKB/Swiss-Prot
SMART EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  FOLN UniProtKB/Swiss-Prot
  LamG UniProtKB/Swiss-Prot
  LRR_SD22 UniProtKB/Swiss-Prot
  LRR_TYP UniProtKB/Swiss-Prot
  LRRCT UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
  SM00041 UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  L domain-like UniProtKB/Swiss-Prot
  SSF49899 UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
UniProt A0A140T8T2 ENTREZGENE, UniProtKB/TrEMBL
  B2RX05 ENTREZGENE, UniProtKB/TrEMBL
  B7ZNW9 ENTREZGENE, UniProtKB/TrEMBL
  E9QKB4 ENTREZGENE
  G3UWQ3_MOUSE UniProtKB/TrEMBL
  G3UY21 ENTREZGENE, UniProtKB/TrEMBL
  G3UYX7 ENTREZGENE, UniProtKB/TrEMBL
  G3UZ61_MOUSE UniProtKB/TrEMBL
  G3UZW0_MOUSE UniProtKB/TrEMBL
  G3X909_MOUSE UniProtKB/TrEMBL
  Q5DTL5_MOUSE UniProtKB/TrEMBL
  Q8BPJ0_MOUSE UniProtKB/TrEMBL
  Q9R1B9 ENTREZGENE
  Q9Z166 ENTREZGENE
  SLIT2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary E9QKB4 UniProtKB/Swiss-Prot
  Q9Z166 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-31 Slit2  slit guidance ligand 2    slit homolog 2 (Drosophila)  Symbol and/or name change 5135510 APPROVED