Hhip (Hedgehog-interacting protein) - Rat Genome Database
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Gene: Hhip (Hedgehog-interacting protein) Mus musculus
Analyze
Symbol: Hhip
Name: Hedgehog-interacting protein
RGD ID: 1557623
MGI Page MGI
Description: Predicted to have hedgehog family protein binding activity and zinc ion binding activity. Involved in several processes, including animal organ morphogenesis; neuroblast proliferation; and regulation of signal transduction. Localizes to cell surface and integral component of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; limb; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease. Orthologous to human HHIP (hedgehog interacting protein); PARTICIPATES IN Hedgehog signaling pathway; basal cell carcinoma pathway; INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: H; Hhi; Hhip1; Hi
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39880,692,479 - 80,784,691 (-)NCBIGRCm39mm39
GRCm38879,965,850 - 80,058,060 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl879,965,851 - 80,058,006 (-)EnsemblGRCm38mm10GRCm38
MGSCv37882,489,750 - 82,581,907 (-)NCBIGRCm37mm9NCBIm37
MGSCv36882,867,946 - 82,954,065 (-)NCBImm8
Celera884,241,203 - 84,333,109 (-)NCBICelera
Cytogenetic Map8C2NCBI
cM Map837.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
bromobenzene  (ISO)
calciol  (EXP)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chloroprene  (ISO)
choline  (EXP)
chromium atom  (ISO)
chromium(6+)  (EXP)
cobalt dichloride  (ISO)
cocaine  (ISO)
crocidolite asbestos  (EXP)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (EXP,ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
folic acid  (EXP)
fonofos  (ISO)
genistein  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (ISO)
L-methionine  (EXP)
methylisothiazolinone  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
panobinostat  (ISO)
parathion  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pioglitazone  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
sulforaphane  (EXP)
terbufos  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vismodegib  (EXP)
vorinostat  (ISO)
XL147  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10050855   PMID:10349636   PMID:10981962   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12403705   PMID:12421714   PMID:12477932   PMID:12569124   PMID:12617826  
PMID:12917290   PMID:14610273   PMID:14980515   PMID:15013801   PMID:15019948   PMID:15075292   PMID:15151988   PMID:15294024   PMID:15489334   PMID:15533830   PMID:15576403   PMID:15590741  
PMID:15611179   PMID:15944188   PMID:16059910   PMID:16141072   PMID:16141073   PMID:16168717   PMID:16272887   PMID:16439469   PMID:17182001   PMID:17442700   PMID:17631878   PMID:18287559  
PMID:18367557   PMID:18417110   PMID:18434416   PMID:18832395   PMID:19000842   PMID:19252479   PMID:19574535   PMID:19906978   PMID:20430747   PMID:21267068   PMID:21795282   PMID:21820362  
PMID:21873635   PMID:21911092   PMID:22330336   PMID:22402963   PMID:22496664   PMID:23077214   PMID:23123965   PMID:23153495   PMID:23177959   PMID:23383321   PMID:23645682   PMID:23677168  
PMID:23900540   PMID:24076664   PMID:24726283   PMID:24738827   PMID:24952961   PMID:25150496   PMID:25224227   PMID:25356765   PMID:25448692   PMID:26056142   PMID:26238476   PMID:26256211  
PMID:26329601   PMID:26930384   PMID:26932670   PMID:27444019   PMID:28052872   PMID:28127049   PMID:28248572   PMID:28323616   PMID:28344083   PMID:28432216   PMID:28566717   PMID:28688895  
PMID:28722118   PMID:28794157   PMID:28797033   PMID:28859094   PMID:28943241   PMID:28963460   PMID:29654303   PMID:30111653   PMID:30254141   PMID:30352852   PMID:30685387   PMID:31202927  
PMID:31371780   PMID:31486675   PMID:31719045   PMID:32747435  


Genomics

Comparative Map Data
Hhip
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39880,692,479 - 80,784,691 (-)NCBIGRCm39mm39
GRCm38879,965,850 - 80,058,060 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl879,965,851 - 80,058,006 (-)EnsemblGRCm38mm10GRCm38
MGSCv37882,489,750 - 82,581,907 (-)NCBIGRCm37mm9NCBIm37
MGSCv36882,867,946 - 82,954,065 (-)NCBImm8
Celera884,241,203 - 84,333,109 (-)NCBICelera
Cytogenetic Map8C2NCBI
cM Map837.95NCBI
HHIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4144,646,156 - 144,745,271 (+)EnsemblGRCh38hg38GRCh38
GRCh384144,646,154 - 144,745,271 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374145,567,148 - 145,662,542 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364145,786,623 - 145,879,331 (+)NCBINCBI36hg18NCBI36
Build 344145,924,777 - 146,017,486NCBI
Celera4142,895,050 - 142,987,336 (+)NCBI
Cytogenetic Map4q31.21NCBI
HuRef4141,298,063 - 141,390,789 (+)NCBIHuRef
CHM1_14145,543,638 - 145,636,362 (+)NCBICHM1_1
Hhip
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01931,525,134 - 31,614,487 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1931,524,671 - 31,614,246 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01942,430,120 - 42,518,700 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41929,752,595 - 29,840,439 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1927,371,896 - 27,460,078 (+)NCBICelera
Cytogenetic Map19q11NCBI
Hhip
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955428657,900 - 745,250 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955428657,918 - 745,255 (+)NCBIChiLan1.0ChiLan1.0
HHIP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14148,651,597 - 148,743,933 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4148,651,597 - 148,744,619 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04136,989,818 - 137,085,407 (+)NCBIMhudiblu_PPA_v0panPan3
HHIP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1543,431,650 - 43,520,861 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11543,432,464 - 43,525,973 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Hhip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365354,210,305 - 4,305,930 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HHIP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl883,583,737 - 83,679,136 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1883,583,735 - 83,678,368 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2888,870,182 - 88,941,146 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103236317
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1791,216,874 - 91,311,392 (+)NCBI
ChlSab1.1 Ensembl791,216,955 - 91,310,387 (+)Ensembl
Hhip
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248533,649,974 - 3,739,344 (+)NCBI

Position Markers
Hhip  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38880,051,494 - 80,051,612UniSTSGRCm38
MGSCv37882,575,393 - 82,575,511UniSTSGRCm37
Celera884,326,579 - 84,326,697UniSTS
Cytogenetic Map8C3UniSTS
cM Map8 UniSTS
cM Map840.0UniSTS
D8Mit134  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38880,032,536 - 80,032,655UniSTSGRCm38
MGSCv37882,556,435 - 82,556,554UniSTSGRCm37
Celera884,307,774 - 84,307,895UniSTS
Cytogenetic Map8C3UniSTS
cM Map837.0UniSTS
Whitehead Genetic838.3UniSTS
Whitehead_YAC8 UniSTS
Hhip  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38879,970,424 - 79,970,640UniSTSGRCm38
MGSCv37882,494,323 - 82,494,539UniSTSGRCm37
Celera884,245,776 - 84,245,992UniSTS
Cytogenetic Map8C3UniSTS
cM Map8 UniSTS
Hhip  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C3UniSTS
Hhip  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:704
Count of miRNA genes:447
Interacting mature miRNAs:537
Transcripts:ENSMUST00000079038, ENSMUST00000155850
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000079038   ⟹   ENSMUSP00000078047
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl879,965,853 - 80,058,006 (-)Ensembl
RefSeq Acc Id: ENSMUST00000155850
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl879,965,851 - 79,990,349 (-)Ensembl
RefSeq Acc Id: NM_020259   ⟹   NP_064655
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39880,692,480 - 80,784,637 (-)NCBI
GRCm38879,965,851 - 80,058,008 (-)NCBI
MGSCv37882,489,750 - 82,581,907 (-)RGD
Celera884,241,203 - 84,333,109 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006530702   ⟹   XP_006530765
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39880,692,479 - 80,784,691 (-)NCBI
GRCm38879,965,850 - 80,058,060 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_064655   ⟸   NM_020259
- Peptide Label: precursor
- UniProtKB: Q7TN16 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006530765   ⟸   XM_006530702
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000078047   ⟸   ENSMUST00000079038
Protein Domains
EGF-like

Promoters
RGD ID:8667583
Promoter ID:EPDNEW_M11810
Type:multiple initiation site
Name:Hhip_1
Description:Mus musculus Hedgehog-interacting protein , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38880,058,008 - 80,058,068EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1341847 AgrOrtholog
Ensembl Genes ENSMUSG00000064325 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000078047 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000079038 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  Folate_rcpt-like UniProtKB/Swiss-Prot
  Glc/Sorbosone_DH UniProtKB/Swiss-Prot
  Quinoprot_gluc/sorb_DH UniProtKB/Swiss-Prot
KEGG Report mmu:15245 UniProtKB/Swiss-Prot
MGD MGI:1341847 ENTREZGENE
NCBI Gene 15245 ENTREZGENE
Pfam Folate_rec UniProtKB/Swiss-Prot
  GSDH UniProtKB/Swiss-Prot
PhenoGen Hhip PhenoGen
PROSITE EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
SMART EGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50952 UniProtKB/Swiss-Prot
UniGene Mm.254493 ENTREZGENE
UniProt HHIP_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q8C0B0 UniProtKB/Swiss-Prot
  Q9WU59 UniProtKB/Swiss-Prot