Brca1 Mouse (+)-schisandrin B multiple interactions ISO Brca1 (Rattus norvegicus) 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of BRCA1 mRNA] CTD PMID:31150632 Brca1 Mouse (-)-alpha-phellandrene decreases expression EXP 6480464 alpha phellandrene results in decreased expression of BRCA1 protein CTD PMID:24861204 Brca1 Mouse (-)-epigallocatechin 3-gallate multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of BRCA1 mRNA CTD PMID:22079256 Brca1 Mouse (-)-epigallocatechin 3-gallate increases expression ISO BRCA1 (Homo sapiens) 6480464 epigallocatechin gallate results in increased expression of BRCA1 mRNA CTD PMID:25839702 Brca1 Mouse (S)-naringenin multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [naringenin co-treated with bisphenol A] results in increased expression of BRCA1 mRNA and [naringenin metabolite co-treated with bisphenol A] results in increased expression of BRCA1 mRNA CTD PMID:36235125 Brca1 Mouse (S)-nicotine decreases expression ISO BRCA1 (Homo sapiens) 6480464 Nicotine results in decreased expression of BRCA1 mRNA CTD PMID:18247414 Brca1 Mouse (S)-nicotine multiple interactions ISO BRCA1 (Homo sapiens) 6480464 Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of BRCA1 protein modified form] CTD PMID:23907605 Brca1 Mouse 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expression ISO BRCA1 (Homo sapiens) 6480464 o and p'-DDT results in increased expression of BRCA1 mRNA CTD PMID:20206645 Brca1 Mouse 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane multiple interactions ISO BRCA1 (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o more ... CTD PMID:20206645 Brca1 Mouse 1,1-dichloroethene increases expression EXP 6480464 vinylidene chloride results in increased expression of BRCA1 mRNA CTD PMID:26682919 Brca1 Mouse 1-naphthyl isothiocyanate increases expression ISO Brca1 (Rattus norvegicus) 6480464 1-Naphthylisothiocyanate results in increased expression of BRCA1 mRNA CTD PMID:30723492 Brca1 Mouse 1-nitropyrene decreases expression ISO BRCA1 (Homo sapiens) 6480464 1-nitropyrene results in decreased expression of BRCA1 mRNA CTD PMID:21540303 Brca1 Mouse 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of BRCA1 mRNA CTD PMID:25210133 Brca1 Mouse 17beta-estradiol decreases expression ISO BRCA1 (Homo sapiens) 6480464 Estradiol results in decreased expression of BRCA1 mRNA CTD PMID:23373633 Brca1 Mouse 17beta-estradiol increases expression ISO BRCA1 (Homo sapiens) 6480464 Estradiol results in increased expression of BRCA1 mRNA and Estradiol results in increased expression of BRCA1 protein CTD PMID:12473173 more ... Brca1 Mouse 17beta-estradiol affects localization ISO BRCA1 (Homo sapiens) 6480464 Estradiol affects the localization of BRCA1 protein CTD PMID:16061635 Brca1 Mouse 17beta-estradiol multiple interactions ISO BRCA1 (Homo sapiens) 6480464 2 more ... CTD PMID:11110848 more ... Brca1 Mouse 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases expression ISO BRCA1 (Homo sapiens) 6480464 Metribolone results in increased expression of BRCA1 mRNA CTD PMID:17010196 Brca1 Mouse 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO BRCA1 (Homo sapiens) 6480464 2 more ... CTD PMID:12473173 Brca1 Mouse 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO Brca1 (Rattus norvegicus) 6480464 2 more ... CTD PMID:20566336 Brca1 Mouse 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] promotes the reaction [AHR protein binds to BRCA1 promoter]] inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA] more ... CTD PMID:12473173 more ... Brca1 Mouse 2,3,7,8-tetrachlorodibenzodioxine increases methylation ISO BRCA1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in increased methylation of BRCA1 promoter CTD PMID:22197621 Brca1 Mouse 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO BRCA1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in decreased expression of BRCA1 mRNA and Tetrachlorodibenzodioxin results in decreased expression of BRCA1 protein CTD PMID:20631324 and PMID:22197621 Brca1 Mouse 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO BRCA1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin affects the expression of BRCA1 mRNA CTD PMID:22298810 and PMID:22574217 Brca1 Mouse 2,3,7,8-tetrachlorodibenzodioxine increases methylation ISO Brca1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in increased methylation of BRCA1 promoter CTD PMID:24136580 Brca1 Mouse 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Brca1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin affects the expression of BRCA1 mRNA CTD PMID:22298810 and PMID:32109520 Brca1 Mouse 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Brca1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of BRCA1 mRNA and Tetrachlorodibenzodioxin results in decreased expression of BRCA1 protein CTD PMID:24136580 and PMID:33387578 Brca1 Mouse 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of BRCA1 mRNA CTD PMID:21167638 Brca1 Mouse 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Brca1 (Rattus norvegicus) 6480464 BRCA1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] more ... CTD PMID:16567799 and PMID:24136580 Brca1 Mouse 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of BRCA1 mRNA CTD PMID:19465110 Brca1 Mouse 2-acetamidofluorene increases expression ISO Brca1 (Rattus norvegicus) 6480464 2-Acetylaminofluorene results in increased expression of BRCA1 mRNA CTD PMID:19167416 Brca1 Mouse 2-butoxyethanol increases expression EXP 6480464 n-butoxyethanol results in increased expression of BRCA1 mRNA CTD PMID:19812364 Brca1 Mouse 2-methylcholine affects expression ISO BRCA1 (Homo sapiens) 6480464 beta-methylcholine affects the expression of BRCA1 mRNA CTD PMID:21179406 Brca1 Mouse 2-naphthylamine decreases expression ISO BRCA1 (Homo sapiens) 6480464 2-Naphthylamine results in decreased expression of BRCA1 mRNA CTD PMID:18247414 Brca1 Mouse 3,3',4,4',5-pentachlorobiphenyl increases expression ISO Brca1 (Rattus norvegicus) 6480464 3 more ... CTD PMID:23196670 Brca1 Mouse 3-methylcholanthrene multiple interactions ISO BRCA1 (Homo sapiens) 6480464 Methylcholanthrene promotes the reaction [AHR protein binds to BRCA1 protein] CTD PMID:18259752 Brca1 Mouse 3-methylcholanthrene increases expression EXP 6480464 Methylcholanthrene results in increased expression of BRCA1 mRNA CTD PMID:20713471 Brca1 Mouse 4,4'-sulfonyldiphenol multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [bisphenol S co-treated with Fulvestrant] results in increased methylation of BRCA1 gene CTD PMID:31601247 Brca1 Mouse 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression EXP 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of BRCA1 mRNA CTD PMID:21167638 Brca1 Mouse 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of BRCA1 mRNA CTD PMID:21167638 Brca1 Mouse 5-aza-2'-deoxycytidine affects localization ISO BRCA1 (Homo sapiens) 6480464 Decitabine affects the localization of BRCA1 protein modified form CTD PMID:17991895 Brca1 Mouse 5-fluorouracil increases expression ISO BRCA1 (Homo sapiens) 6480464 Fluorouracil results in increased expression of BRCA1 mRNA CTD PMID:16101138 and PMID:16557594 Brca1 Mouse 5-fluorouracil decreases expression ISO BRCA1 (Homo sapiens) 6480464 Fluorouracil results in decreased expression of BRCA1 mRNA CTD PMID:15607317 and PMID:17982676 Brca1 Mouse 5-fluorouracil multiple interactions ISO BRCA1 (Homo sapiens) 6480464 TP53 protein inhibits the reaction [Fluorouracil results in decreased expression of BRCA1 mRNA] CTD PMID:17982676 Brca1 Mouse 7,12-dimethyltetraphene affects response to substance ISO BRCA1 (Homo sapiens) 6480464 BRCA1 protein affects the susceptibility to 9 more ... CTD PMID:21507987 Brca1 Mouse 7,12-dimethyltetraphene multiple interactions EXP 6480464 9 more ... CTD PMID:25448685 Brca1 Mouse 7,12-dimethyltetraphene increases expression EXP 6480464 9 more ... CTD PMID:25448685 Brca1 Mouse 7,12-dimethyltetraphene increases expression ISO Brca1 (Rattus norvegicus) 6480464 9 more ... CTD PMID:23969067 Brca1 Mouse 7,9-dihydro-1H-purine-2,6,8(3H)-trione decreases expression EXP 6480464 Uric Acid results in decreased expression of BRCA1 mRNA CTD PMID:23619996 Brca1 Mouse 7,9-dihydro-1H-purine-2,6,8(3H)-trione multiple interactions EXP 6480464 NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of BRCA1 mRNA] CTD PMID:23619996 Brca1 Mouse 8-hydroxy-2'-deoxyguanosine multiple interactions EXP 6480464 [BRCA1 gene mutant form results in increased susceptibility to Ethanol] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:26629949 Brca1 Mouse acetamide increases expression ISO Brca1 (Rattus norvegicus) 6480464 acetamide results in increased expression of BRCA1 mRNA CTD PMID:31881176 Brca1 Mouse acetylsalicylic acid decreases expression ISO BRCA1 (Homo sapiens) 6480464 Aspirin results in decreased expression of BRCA1 mRNA CTD PMID:20457246 and PMID:20514442 Brca1 Mouse acrolein multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of BRCA1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of BRCA1 mRNA CTD PMID:32699268 Brca1 Mouse acrylamide decreases expression ISO Brca1 (Rattus norvegicus) 6480464 Acrylamide results in decreased expression of BRCA1 mRNA CTD PMID:28606764 Brca1 Mouse Aflatoxin G1 increases activity ISO BRCA1 (Homo sapiens) 6480464 aflatoxin G1 results in increased activity of BRCA1 protein CTD PMID:23907605 Brca1 Mouse Aflatoxin G1 multiple interactions ISO BRCA1 (Homo sapiens) 6480464 Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of BRCA1 protein modified form] and Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of BRCA1 protein modified form] CTD PMID:23907605 Brca1 Mouse Aflatoxin G1 increases expression ISO BRCA1 (Homo sapiens) 6480464 aflatoxin G1 results in increased expression of BRCA1 protein modified form CTD PMID:23907605 Brca1 Mouse all-trans-retinoic acid increases expression ISO BRCA1 (Homo sapiens) 6480464 Tretinoin results in increased expression of BRCA1 mRNA CTD PMID:16054129 Brca1 Mouse all-trans-retinoic acid decreases expression ISO BRCA1 (Homo sapiens) 6480464 Tretinoin results in decreased expression of BRCA1 mRNA CTD PMID:15498508 and PMID:33167477 Brca1 Mouse all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of BRCA1 mRNA CTD PMID:17198874 Brca1 Mouse allethrin multiple interactions ISO Brca1 (Rattus norvegicus) 6480464 [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of BRCA1 protein CTD PMID:34896426 Brca1 Mouse alpha-naphthoflavone multiple interactions ISO BRCA1 (Homo sapiens) 6480464 alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased activity of BRCA1 protein] and alpha-naphthoflavone inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA] CTD PMID:16489025 and PMID:18259752 Brca1 Mouse alpha-phellandrene decreases expression EXP 6480464 alpha phellandrene results in decreased expression of BRCA1 protein CTD PMID:24861204 Brca1 Mouse alpha-pinene multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of BRCA1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of BRCA1 mRNA CTD PMID:32699268 Brca1 Mouse amiodarone increases expression EXP 6480464 Amiodarone results in increased expression of BRCA1 mRNA CTD PMID:24489787 Brca1 Mouse ammonium chloride affects expression ISO Brca1 (Rattus norvegicus) 6480464 Ammonium Chloride affects the expression of BRCA1 mRNA CTD PMID:16483693 Brca1 Mouse arecoline decreases expression ISO BRCA1 (Homo sapiens) 6480464 Arecoline results in decreased expression of BRCA1 mRNA CTD PMID:17682004 Brca1 Mouse arsane affects methylation ISO BRCA1 (Homo sapiens) 6480464 Arsenic affects the methylation of BRCA1 gene CTD PMID:25304211 Brca1 Mouse arsane increases expression ISO BRCA1 (Homo sapiens) 6480464 Arsenic results in increased expression of BRCA1 mRNA CTD PMID:36720308 Brca1 Mouse arsenic atom affects methylation ISO BRCA1 (Homo sapiens) 6480464 Arsenic affects the methylation of BRCA1 gene CTD PMID:25304211 Brca1 Mouse arsenic atom increases expression ISO BRCA1 (Homo sapiens) 6480464 Arsenic results in increased expression of BRCA1 mRNA CTD PMID:36720308 Brca1 Mouse arsenite(3-) decreases expression ISO BRCA1 (Homo sapiens) 6480464 arsenite results in decreased expression of BRCA1 mRNA CTD PMID:31646340 Brca1 Mouse arsenous acid increases expression ISO BRCA1 (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of BRCA1 mRNA CTD PMID:20458559 Brca1 Mouse asbestos affects response to substance ISO BRCA1 (Homo sapiens) 6480464 BRCA1 alternative form affects the susceptibility to Asbestos CTD PMID:28687356 Brca1 Mouse atrazine decreases expression ISO BRCA1 (Homo sapiens) 6480464 Atrazine results in decreased expression of BRCA1 mRNA CTD PMID:22378314 Brca1 Mouse benzo[a]pyrene multiple interactions ISO BRCA1 (Homo sapiens) 6480464 ARNT protein affects the reaction [BRCA1 protein affects the susceptibility to Benzo(a)pyrene] more ... CTD PMID:11782367 more ... Brca1 Mouse benzo[a]pyrene affects methylation ISO BRCA1 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of BRCA1 promoter CTD PMID:27901495 Brca1 Mouse benzo[a]pyrene increases expression ISO BRCA1 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of BRCA1 mRNA CTD PMID:28461126 more ... Brca1 Mouse benzo[a]pyrene decreases expression ISO BRCA1 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of BRCA1 mRNA CTD PMID:11782367 more ... Brca1 Mouse benzo[a]pyrene affects response to substance EXP 6480464 BRCA1 protein affects the susceptibility to Benzo(a)pyrene CTD PMID:21507987 Brca1 Mouse benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of BRCA1 mRNA CTD PMID:20713471 Brca1 Mouse benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of BRCA1 mRNA CTD PMID:17942131 Brca1 Mouse benzo[a]pyrene affects response to substance ISO BRCA1 (Homo sapiens) 6480464 BRCA1 protein affects the susceptibility to Benzo(a)pyrene CTD PMID:21507987 Brca1 Mouse benzo[a]pyrene diol epoxide I decreases expression ISO BRCA1 (Homo sapiens) 6480464 7 more ... CTD PMID:11782367 and PMID:20382639 Brca1 Mouse benzo[a]pyrene diol epoxide I affects expression ISO BRCA1 (Homo sapiens) 6480464 7 more ... CTD PMID:34454013 Brca1 Mouse benzo[a]pyrene diol epoxide I multiple interactions ISO BRCA1 (Homo sapiens) 6480464 TP53 protein promotes the reaction [7 more ... CTD PMID:11782367 Brca1 Mouse benzophenanthridine decreases expression ISO BRCA1 (Homo sapiens) 6480464 Benzophenanthridines analog results in decreased expression of BRCA1 mRNA CTD PMID:23117580 Brca1 Mouse beta-hexachlorocyclohexane multiple interactions ISO BRCA1 (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of BRCA1 mRNA] and fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of BRCA1 mRNA] CTD PMID:20206645 Brca1 Mouse beta-hexachlorocyclohexane increases expression ISO BRCA1 (Homo sapiens) 6480464 beta-hexachlorocyclohexane results in increased expression of BRCA1 mRNA CTD PMID:20206645 Brca1 Mouse bifenthrin affects binding ISO BRCA1 (Homo sapiens) 6480464 bifenthrin binds to BRCA1 protein CTD PMID:32278787 Brca1 Mouse biphenyl-4-amine decreases expression ISO BRCA1 (Homo sapiens) 6480464 4-biphenylamine results in decreased expression of BRCA1 mRNA CTD PMID:24857880 and PMID:32905825 Brca1 Mouse biphenyl-4-amine multiple interactions ISO BRCA1 (Homo sapiens) 6480464 TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BRCA1 mRNA] CTD PMID:32905825 Brca1 Mouse bis(2-chloroethyl) sulfide decreases expression ISO BRCA1 (Homo sapiens) 6480464 Mustard Gas results in decreased expression of BRCA1 mRNA CTD PMID:33491125 Brca1 Mouse bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of BRCA1 mRNA CTD PMID:36423848 Brca1 Mouse bisphenol A increases methylation ISO BRCA1 (Homo sapiens) 6480464 bisphenol A results in increased methylation of BRCA1 gene CTD PMID:22258036 Brca1 Mouse bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of BRCA1 promoter CTD PMID:27312807 Brca1 Mouse bisphenol A increases expression ISO Brca1 (Rattus norvegicus) 6480464 bisphenol A results in increased expression of BRCA1 mRNA CTD PMID:27208089 and PMID:32145629 Brca1 Mouse bisphenol A decreases expression ISO Brca1 (Rattus norvegicus) 6480464 bisphenol A results in decreased expression of BRCA1 mRNA CTD PMID:25181051 Brca1 Mouse bisphenol A increases expression ISO BRCA1 (Homo sapiens) 6480464 bisphenol A results in increased expression of BRCA1 mRNA and bisphenol A results in increased expression of BRCA1 protein CTD PMID:22576693 and PMID:25933419 Brca1 Mouse bisphenol A increases response to substance EXP 6480464 BRCA1 gene mutant form results in increased susceptibility to bisphenol A CTD PMID:20868731 Brca1 Mouse bisphenol A affects response to substance ISO BRCA1 (Homo sapiens) 6480464 BRCA1 protein affects the susceptibility to bisphenol A CTD PMID:20868731 Brca1 Mouse bisphenol A multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] results in increased methylation of BRCA1 gene more ... CTD PMID:20868731 more ... Brca1 Mouse bisphenol A decreases expression ISO BRCA1 (Homo sapiens) 6480464 bisphenol A results in decreased expression of BRCA1 mRNA CTD PMID:16029874 Brca1 Mouse bortezomib decreases expression ISO BRCA1 (Homo sapiens) 6480464 Bortezomib results in decreased expression of BRCA1 mRNA CTD PMID:21917757 Brca1 Mouse bortezomib multiple interactions EXP 6480464 BRCA1 protein inhibits the reaction [BRCA1 gene mutant form results in increased susceptibility to Bortezomib] CTD PMID:25522274 Brca1 Mouse bortezomib increases response to substance EXP 6480464 BRCA1 gene mutant form results in increased susceptibility to Bortezomib CTD PMID:25522274 Brca1 Mouse bortezomib multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in decreased expression of AKR7A2 mRNA more ... CTD PMID:25522274 Brca1 Mouse bortezomib decreases ubiquitination ISO BRCA1 (Homo sapiens) 6480464 Bortezomib results in decreased ubiquitination of BRCA1 protein CTD PMID:21917757 Brca1 Mouse bortezomib increases response to substance ISO BRCA1 (Homo sapiens) 6480464 BRCA1 mutant form results in increased susceptibility to Bortezomib CTD PMID:25522274 Brca1 Mouse bromoacetate decreases expression ISO BRCA1 (Homo sapiens) 6480464 bromoacetate results in decreased expression of BRCA1 mRNA CTD PMID:19753638 Brca1 Mouse cadmium atom decreases expression ISO BRCA1 (Homo sapiens) 6480464 Cadmium results in decreased expression of BRCA1 mRNA and Cadmium results in decreased expression of BRCA1 protein CTD PMID:20049202 and PMID:31646340 Brca1 Mouse cadmium dichloride decreases expression ISO BRCA1 (Homo sapiens) 6480464 Cadmium Chloride results in decreased expression of BRCA1 mRNA CTD PMID:26525392 Brca1 Mouse caffeine affects phosphorylation ISO BRCA1 (Homo sapiens) 6480464 Caffeine affects the phosphorylation of BRCA1 protein CTD PMID:35688186 Brca1 Mouse calcitriol multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of BRCA1 mRNA more ... CTD PMID:21592394 Brca1 Mouse calcitriol decreases expression ISO BRCA1 (Homo sapiens) 6480464 Calcitriol results in decreased expression of BRCA1 mRNA CTD PMID:21592394 Brca1 Mouse Calcium propionate affects response to substance ISO BRCA1 (Homo sapiens) 6480464 BRCA1 exon mutant form affects the susceptibility to calcium propionate CTD PMID:31333813 Brca1 Mouse camptothecin decreases response to substance ISO BRCA1 (Homo sapiens) 6480464 BRCA1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 Brca1 Mouse camptothecin decreases expression ISO BRCA1 (Homo sapiens) 6480464 Camptothecin results in decreased expression of BRCA1 mRNA CTD PMID:10344722 Brca1 Mouse cannabidiol decreases expression ISO BRCA1 (Homo sapiens) 6480464 Cannabidiol results in decreased expression of BRCA1 mRNA CTD PMID:33244087 and PMID:36519830 Brca1 Mouse cannabidiol increases expression ISO BRCA1 (Homo sapiens) 6480464 Cannabidiol results in increased expression of BRCA1 mRNA CTD PMID:27918106 Brca1 Mouse cannabidiol multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [Cannabidiol co-treated with moringin] results in increased expression of BRCA1 mRNA CTD PMID:30096889 Brca1 Mouse carboplatin decreases activity ISO BRCA1 (Homo sapiens) 6480464 Carboplatin results in decreased activity of BRCA1 protein CTD PMID:20878461 Brca1 Mouse carfilzomib increases response to substance ISO BRCA1 (Homo sapiens) 6480464 BRCA1 mutant form results in increased susceptibility to carfilzomib CTD PMID:25522274 Brca1 Mouse casticin increases expression ISO BRCA1 (Homo sapiens) 6480464 casticin results in increased expression of BRCA1 protein CTD PMID:29098808 Brca1 Mouse ceric oxide decreases expression ISO Brca1 (Rattus norvegicus) 6480464 ceric oxide results in decreased expression of BRCA1 mRNA CTD PMID:29463257 Brca1 Mouse CGP 52608 multiple interactions ISO BRCA1 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to BRCA1 gene] CTD PMID:28238834 Brca1 Mouse chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of BRCA1 mRNA CTD PMID:37019170 Brca1 Mouse choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BRCA1 mRNA CTD PMID:20938992 Brca1 Mouse cisplatin multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of BRCA1 mRNA more ... CTD PMID:20623183 more ... Brca1 Mouse cisplatin increases expression ISO BRCA1 (Homo sapiens) 6480464 Cisplatin results in increased expression of BRCA1 mRNA and Cisplatin results in increased expression of BRCA1 protein CTD PMID:20623183 and PMID:27594783 Brca1 Mouse cisplatin decreases response to substance ISO BRCA1 (Homo sapiens) 6480464 BRCA1 protein results in decreased susceptibility to Cisplatin and BRCA1 results in decreased susceptibility to Cisplatin CTD PMID:20603439 more ... Brca1 Mouse cisplatin increases phosphorylation EXP 6480464 Cisplatin results in increased phosphorylation of BRCA1 protein CTD PMID:22006019 Brca1 Mouse cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of BRCA1 mRNA CTD PMID:21151649 Brca1 Mouse cisplatin decreases response to substance EXP 6480464 BRCA1 results in decreased susceptibility to Cisplatin CTD PMID:21771338 Brca1 Mouse cisplatin decreases activity ISO BRCA1 (Homo sapiens) 6480464 Cisplatin results in decreased activity of BRCA1 protein CTD PMID:20878461 Brca1 Mouse cobalt dichloride decreases expression ISO BRCA1 (Homo sapiens) 6480464 cobaltous chloride results in decreased expression of BRCA1 mRNA CTD PMID:19376846 Brca1 Mouse copper atom multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in increased expression of BRCA1 mRNA CTD PMID:30911355 Brca1 Mouse copper(0) multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in increased expression of BRCA1 mRNA CTD PMID:30911355 Brca1 Mouse copper(II) sulfate affects expression ISO BRCA1 (Homo sapiens) 6480464 Copper Sulfate affects the expression of BRCA1 mRNA CTD PMID:19549813 Brca1 Mouse coumarin affects phosphorylation ISO BRCA1 (Homo sapiens) 6480464 coumarin affects the phosphorylation of BRCA1 protein CTD PMID:35688186 Brca1 Mouse coumestrol multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 Brca1 Mouse coumestrol increases expression ISO BRCA1 (Homo sapiens) 6480464 Coumestrol results in increased expression of BRCA1 mRNA CTD PMID:19167446 Brca1 Mouse crocidolite asbestos affects expression ISO BRCA1 (Homo sapiens) 6480464 Asbestos and Crocidolite affects the expression of BRCA1 mRNA CTD PMID:17331233 Brca1 Mouse curcumin multiple interactions ISO BRCA1 (Homo sapiens) 6480464 Curcumin inhibits the reaction [Furazolidone results in increased expression of BRCA1 protein] CTD PMID:27996348 Brca1 Mouse cycloheximide multiple interactions ISO BRCA1 (Homo sapiens) 6480464 Cycloheximide inhibits the reaction [Nitrogen Mustard Compounds results in decreased expression of BRCA1 mRNA] CTD PMID:10344722 Brca1 Mouse cycloheximide multiple interactions EXP 6480464 BAP1 inhibits the reaction [Cycloheximide results in increased degradation of BRCA1 protein] and Cycloheximide inhibits the reaction [Thapsigargin affects the localization of BRCA1 mRNA] CTD PMID:29576526 and PMID:37414201 Brca1 Mouse cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of BRCA1 mRNA CTD PMID:17942131 and PMID:19770486 Brca1 Mouse cyclosporin A decreases expression ISO BRCA1 (Homo sapiens) 6480464 Cyclosporine results in decreased expression of BRCA1 mRNA CTD PMID:21632981 and PMID:25562108 Brca1 Mouse cyhalothrin multiple interactions ISO Brca1 (Rattus norvegicus) 6480464 [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of BRCA1 protein CTD PMID:34896426 Brca1 Mouse cypermethrin decreases expression ISO BRCA1 (Homo sapiens) 6480464 cypermethrin results in decreased expression of BRCA1 protein CTD PMID:36063984 Brca1 Mouse cypermethrin multiple interactions ISO Brca1 (Rattus norvegicus) 6480464 [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of BRCA1 protein CTD PMID:34896426 Brca1 Mouse daidzein increases expression ISO BRCA1 (Homo sapiens) 6480464 daidzein results in increased expression of BRCA1 mRNA CTD PMID:17266178 Brca1 Mouse DDE increases expression ISO BRCA1 (Homo sapiens) 6480464 Dichlorodiphenyl Dichloroethylene results in increased expression of BRCA1 mRNA CTD PMID:20206645 and PMID:38568856 Brca1 Mouse DDE multiple interactions ISO BRCA1 (Homo sapiens) 6480464 fulvestrant inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of BRCA1 mRNA] CTD PMID:20206645 Brca1 Mouse Decamethylcyclopentasiloxane decreases expression ISO BRCA1 (Homo sapiens) 6480464 decamethylcyclopentasiloxane results in decreased expression of BRCA1 protein CTD PMID:27601420 Brca1 Mouse Decamethylcyclopentasiloxane affects expression ISO BRCA1 (Homo sapiens) 6480464 decamethylcyclopentasiloxane affects the expression of BRCA1 mRNA CTD PMID:27601420 Brca1 Mouse deguelin decreases expression ISO BRCA1 (Homo sapiens) 6480464 deguelin results in decreased expression of BRCA1 mRNA CTD PMID:22227970 Brca1 Mouse diamminedichloroplatinum decreases activity ISO BRCA1 (Homo sapiens) 6480464 transplatin results in decreased activity of BRCA1 protein CTD PMID:20878461 Brca1 Mouse diarsenic trioxide increases expression ISO BRCA1 (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of BRCA1 mRNA CTD PMID:20458559 Brca1 Mouse dibenzofuran decreases expression ISO Brca1 (Rattus norvegicus) 6480464 dibenzofuran analog results in decreased expression of BRCA1 mRNA CTD PMID:20566336 Brca1 Mouse dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of BRCA1 mRNA and Dibutyl Phthalate results in decreased expression of BRCA1 protein CTD PMID:21266533 and PMID:31318015 Brca1 Mouse diclofenac increases expression EXP 6480464 Diclofenac results in increased expression of BRCA1 mRNA CTD PMID:26934552 Brca1 Mouse dieldrin affects expression ISO Brca1 (Rattus norvegicus) 6480464 Dieldrin affects the expression of BRCA1 mRNA CTD PMID:22546817 Brca1 Mouse dinaciclib decreases expression ISO BRCA1 (Homo sapiens) 6480464 dinaciclib results in decreased expression of BRCA1 mRNA and dinaciclib results in decreased expression of BRCA1 protein CTD PMID:27880910 Brca1 Mouse dioxygen decreases expression ISO BRCA1 (Homo sapiens) 6480464 Oxygen deficiency results in decreased expression of BRCA1 mRNA and Oxygen deficiency results in decreased expression of BRCA1 protein CTD PMID:17599377 more ... Brca1 Mouse disodium selenite decreases expression ISO BRCA1 (Homo sapiens) 6480464 Sodium Selenite results in decreased expression of BRCA1 mRNA CTD PMID:10344722 Brca1 Mouse doxorubicin decreases expression ISO BRCA1 (Homo sapiens) 6480464 Doxorubicin results in decreased expression of BRCA1 mRNA CTD PMID:10344722 more ... Brca1 Mouse doxorubicin multiple interactions ISO BRCA1 (Homo sapiens) 6480464 Doxorubicin inhibits the reaction [[RBBP8 protein binds to BRCA1 protein binds to E2F1 protein] which results in increased expression of ATM mRNA] and Doxorubicin inhibits the reaction [BRCA1 protein binds to ATM promoter] CTD PMID:22832221 Brca1 Mouse emetine multiple interactions EXP 6480464 Emetine inhibits the reaction [Thapsigargin affects the localization of BRCA1 mRNA] CTD PMID:29576526 Brca1 Mouse endosulfan affects expression ISO BRCA1 (Homo sapiens) 6480464 Endosulfan affects the expression of BRCA1 mRNA CTD PMID:29705383 Brca1 Mouse endosulfan multiple interactions ISO BRCA1 (Homo sapiens) 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Endosulfan affects the expression of BRCA1 mRNA] CTD PMID:29705383 Brca1 Mouse Enterolactone multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of BRCA1 mRNA CTD PMID:19167446 Brca1 Mouse erlotinib hydrochloride multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [Erlotinib Hydrochloride results in decreased activity of EGFR protein] which results in decreased phosphorylation of BRCA1 protein CTD PMID:23548265 Brca1 Mouse ethanol multiple interactions EXP 6480464 [BRCA1 gene mutant form results in increased susceptibility to Ethanol] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine more ... CTD PMID:26629949 Brca1 Mouse ethanol increases response to substance EXP 6480464 BRCA1 gene mutant form results in increased susceptibility to Ethanol CTD PMID:26629949 Brca1 Mouse etoposide multiple interactions ISO BRCA1 (Homo sapiens) 6480464 BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of CDK2 protein] more ... CTD PMID:16417649 and PMID:26259609 Brca1 Mouse etoposide increases expression ISO BRCA1 (Homo sapiens) 6480464 Etoposide results in increased expression of BRCA1 protein CTD PMID:26259609 Brca1 Mouse etoposide decreases expression ISO BRCA1 (Homo sapiens) 6480464 Etoposide results in decreased expression of BRCA1 mRNA CTD PMID:15607317 Brca1 Mouse fenthion decreases expression ISO BRCA1 (Homo sapiens) 6480464 Fenthion results in decreased expression of BRCA1 mRNA CTD PMID:33221015 Brca1 Mouse fenvalerate affects binding ISO BRCA1 (Homo sapiens) 6480464 fenvalerate binds to BRCA1 protein CTD PMID:32278787 Brca1 Mouse fenvalerate multiple interactions ISO Brca1 (Rattus norvegicus) 6480464 [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of BRCA1 protein CTD PMID:34896426 Brca1 Mouse fenvalerate increases expression ISO Brca1 (Rattus norvegicus) 6480464 fenvalerate results in increased expression of BRCA1 mRNA CTD PMID:30307764 Brca1 Mouse flavonoids increases expression ISO Brca1 (Rattus norvegicus) 6480464 Flavonoids results in increased expression of BRCA1 mRNA CTD PMID:18035473 Brca1 Mouse folic acid multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BRCA1 mRNA CTD PMID:20938992 Brca1 Mouse folic acid multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of BRCA1 mRNA CTD PMID:24657277 Brca1 Mouse FR900359 affects phosphorylation ISO BRCA1 (Homo sapiens) 6480464 FR900359 affects the phosphorylation of BRCA1 protein CTD PMID:37730182 Brca1 Mouse fulvestrant decreases expression ISO BRCA1 (Homo sapiens) 6480464 Fulvestrant results in decreased expression of BRCA1 mRNA CTD PMID:20206645 and PMID:31646340 Brca1 Mouse fulvestrant multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] results in increased methylation of BRCA1 gene more ... CTD PMID:12473173 more ... Brca1 Mouse furan increases expression ISO Brca1 (Rattus norvegicus) 6480464 furan results in increased expression of BRCA1 mRNA CTD PMID:22079235 Brca1 Mouse furan decreases expression ISO Brca1 (Rattus norvegicus) 6480464 furan results in decreased expression of BRCA1 mRNA CTD PMID:25539665 Brca1 Mouse furazolidone multiple interactions ISO BRCA1 (Homo sapiens) 6480464 Curcumin inhibits the reaction [Furazolidone results in increased expression of BRCA1 protein] CTD PMID:27996348 Brca1 Mouse furazolidone increases expression ISO BRCA1 (Homo sapiens) 6480464 Furazolidone results in increased expression of BRCA1 protein CTD PMID:27996348 Brca1 Mouse gemcitabine decreases response to substance EXP 6480464 BRCA1 results in decreased susceptibility to Gemcitabine CTD PMID:21771338 Brca1 Mouse gemcitabine increases expression ISO BRCA1 (Homo sapiens) 6480464 Gemcitabine results in increased expression of BRCA1 mRNA CTD PMID:20103597 Brca1 Mouse genistein multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [indole-3-carbinol co-treated with Genistein] results in increased expression of BRCA1 protein and Genistein inhibits the reaction [sodium arsenite inhibits the reaction [Estradiol results in increased expression of BRCA1 protein]] CTD PMID:16434996 and PMID:30664189 Brca1 Mouse genistein increases expression ISO BRCA1 (Homo sapiens) 6480464 Genistein results in increased expression of BRCA1 mRNA and Genistein results in increased expression of BRCA1 protein CTD PMID:16434996 and PMID:17266178 Brca1 Mouse gentamycin decreases expression ISO Brca1 (Rattus norvegicus) 6480464 Gentamicins results in decreased expression of BRCA1 mRNA CTD PMID:33387578 Brca1 Mouse geraniol decreases expression ISO BRCA1 (Homo sapiens) 6480464 geraniol results in decreased expression of BRCA1 mRNA CTD PMID:27683099 Brca1 Mouse glyphosate decreases expression ISO BRCA1 (Homo sapiens) 6480464 Glyphosate results in decreased expression of BRCA1 mRNA CTD PMID:31295307 Brca1 Mouse gold atom multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of BRCA1 mRNA CTD PMID:28433809 Brca1 Mouse gold atom decreases expression ISO BRCA1 (Homo sapiens) 6480464 Gold analog results in decreased expression of BRCA1 mRNA CTD PMID:36057382 Brca1 Mouse gold(0) multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of BRCA1 mRNA CTD PMID:28433809 Brca1 Mouse gold(0) decreases expression ISO BRCA1 (Homo sapiens) 6480464 Gold analog results in decreased expression of BRCA1 mRNA CTD PMID:36057382 Brca1 Mouse hexamethylcyclotrisiloxane affects expression ISO BRCA1 (Homo sapiens) 6480464 hexamethylcyclotrisiloxane affects the expression of BRCA1 mRNA CTD PMID:27601420 Brca1 Mouse hexamethylcyclotrisiloxane decreases expression ISO BRCA1 (Homo sapiens) 6480464 hexamethylcyclotrisiloxane results in decreased expression of BRCA1 protein CTD PMID:27601420 Brca1 Mouse hydrogen peroxide decreases response to substance ISO BRCA1 (Homo sapiens) 6480464 BRCA1 protein results in decreased susceptibility to Hydrogen Peroxide CTD PMID:15520196 Brca1 Mouse hydrogen peroxide multiple interactions EXP 6480464 N-(oxo-5 more ... CTD PMID:31494107 Brca1 Mouse hydrogen peroxide increases expression ISO BRCA1 (Homo sapiens) 6480464 Hydrogen Peroxide results in increased expression of BRCA1 mRNA CTD PMID:22539617 Brca1 Mouse hydroquinone increases expression ISO BRCA1 (Homo sapiens) 6480464 hydroquinone results in increased expression of BRCA1 protein CTD PMID:29421518 Brca1 Mouse indole-3-methanol multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [indole-3-carbinol co-treated with Genistein] results in increased expression of BRCA1 protein more ... CTD PMID:11110848 more ... Brca1 Mouse indole-3-methanol increases expression ISO BRCA1 (Homo sapiens) 6480464 indole-3-carbinol results in increased expression of BRCA1 mRNA and indole-3-carbinol results in increased expression of BRCA1 protein CTD PMID:11110848 and PMID:16434996 Brca1 Mouse L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BRCA1 mRNA CTD PMID:20938992 Brca1 Mouse Lasiocarpine multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of BRCA1 mRNA CTD PMID:33884520 Brca1 Mouse Lasiocarpine increases expression ISO BRCA1 (Homo sapiens) 6480464 lasiocarpine results in increased expression of BRCA1 mRNA CTD PMID:32234424 Brca1 Mouse lead diacetate decreases expression EXP 6480464 lead acetate results in decreased expression of BRCA1 mRNA CTD PMID:22613225 Brca1 Mouse leptomycin B decreases expression ISO BRCA1 (Homo sapiens) 6480464 leptomycin B results in decreased expression of BRCA1 mRNA CTD PMID:20803015 Brca1 Mouse leptomycin B multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of BRCA1 mRNA CTD PMID:20803015 Brca1 Mouse lipopolysaccharide decreases expression EXP 6480464 Lipopolysaccharides results in decreased expression of BRCA1 protein CTD PMID:37414201 Brca1 Mouse lipopolysaccharide multiple interactions EXP 6480464 BAP1 inhibits the reaction [Lipopolysaccharides results in decreased expression of BRCA1 protein] and BAP1 protein inhibits the reaction [[Lipopolysaccharides results in decreased expression of BRCA1 protein] which results in increased phosphorylation of RELA protein] CTD PMID:37414201 Brca1 Mouse lucanthone decreases expression ISO BRCA1 (Homo sapiens) 6480464 Lucanthone results in decreased expression of BRCA1 mRNA CTD PMID:21148553 Brca1 Mouse methotrexate multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of BRCA1 mRNA and BRCA1 mutant form promotes the reaction [TP53 mutant form results in increased susceptibility to Methotrexate] CTD PMID:21875941 and PMID:24657277 Brca1 Mouse methotrexate increases expression ISO BRCA1 (Homo sapiens) 6480464 Methotrexate results in increased expression of BRCA1 mRNA CTD PMID:21678067 Brca1 Mouse methoxsalen multiple interactions ISO BRCA1 (Homo sapiens) 6480464 Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of BRCA1 protein modified form] CTD PMID:23907605 Brca1 Mouse methyl methanesulfonate increases expression ISO BRCA1 (Homo sapiens) 6480464 Methyl Methanesulfonate results in increased expression of BRCA1 mRNA CTD PMID:23649840 Brca1 Mouse mitomycin C increases response to substance ISO BRCA1 (Homo sapiens) 6480464 BRCA1 protein mutant form results in increased susceptibility to Mitomycin CTD PMID:26320175 Brca1 Mouse Monobutylphthalate affects expression ISO Brca1 (Rattus norvegicus) 6480464 monobutyl phthalate affects the expression of BRCA1 mRNA CTD PMID:20864626 Brca1 Mouse myristicin decreases expression ISO BRCA1 (Homo sapiens) 6480464 myristicin results in decreased expression of BRCA1 mRNA CTD PMID:24792648 Brca1 Mouse N-methyl-N'-nitro-N-nitrosoguanidine increases expression ISO BRCA1 (Homo sapiens) 6480464 Methylnitronitrosoguanidine results in increased expression of BRCA1 mRNA CTD PMID:12634122 Brca1 Mouse N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of BRCA1 mRNA CTD PMID:17854601 Brca1 Mouse N-nitrosodiethylamine multiple interactions EXP 6480464 RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of BRCA1 mRNA] CTD PMID:17854601 Brca1 Mouse nickel dichloride decreases expression ISO BRCA1 (Homo sapiens) 6480464 nickel chloride results in decreased expression of BRCA1 mRNA and nickel chloride results in decreased expression of BRCA1 protein CTD PMID:28472268 Brca1 Mouse nicotine decreases expression ISO BRCA1 (Homo sapiens) 6480464 Nicotine results in decreased expression of BRCA1 mRNA CTD PMID:18247414 Brca1 Mouse nicotine multiple interactions ISO BRCA1 (Homo sapiens) 6480464 Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of BRCA1 protein modified form] CTD PMID:23907605 Brca1 Mouse nitrogen mustard decreases expression ISO BRCA1 (Homo sapiens) 6480464 Nitrogen Mustard Compounds results in decreased expression of BRCA1 mRNA CTD PMID:10344722 Brca1 Mouse nitrogen mustard multiple interactions ISO BRCA1 (Homo sapiens) 6480464 Cycloheximide inhibits the reaction [Nitrogen Mustard Compounds results in decreased expression of BRCA1 mRNA] CTD PMID:10344722 Brca1 Mouse O-methyleugenol decreases expression ISO Brca1 (Rattus norvegicus) 6480464 methyleugenol results in decreased expression of BRCA1 mRNA CTD PMID:21659616 and PMID:26011634 Brca1 Mouse ochratoxin A increases expression ISO Brca1 (Rattus norvegicus) 6480464 ochratoxin A results in increased expression of BRCA1 mRNA CTD PMID:37162024 Brca1 Mouse octamethylcyclotetrasiloxane decreases expression ISO BRCA1 (Homo sapiens) 6480464 octamethylcyclotetrasiloxane results in decreased expression of BRCA1 protein CTD PMID:27601420 Brca1 Mouse octamethylcyclotetrasiloxane affects expression ISO BRCA1 (Homo sapiens) 6480464 octamethylcyclotetrasiloxane affects the expression of BRCA1 mRNA CTD PMID:27601420 Brca1 Mouse olaparib affects response to substance ISO BRCA1 (Homo sapiens) 6480464 BRCA1 affects the susceptibility to olaparib CTD PMID:21633166 Brca1 Mouse olaparib multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [BRD4 protein affects the susceptibility to olaparib] which affects the expression of BRCA1 protein more ... CTD PMID:29567272 Brca1 Mouse ouabain decreases expression ISO BRCA1 (Homo sapiens) 6480464 Ouabain results in decreased expression of BRCA1 protein CTD PMID:31436044 Brca1 Mouse oxaliplatin multiple interactions ISO Brca1 (Rattus norvegicus) 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of BRCA1 mRNA CTD PMID:25729387 Brca1 Mouse oxaliplatin decreases activity ISO BRCA1 (Homo sapiens) 6480464 oxaliplatin results in decreased activity of BRCA1 protein CTD PMID:20878461 Brca1 Mouse oxybenzone increases expression ISO BRCA1 (Homo sapiens) 6480464 oxybenzone results in increased expression of BRCA1 mRNA CTD PMID:36581016 Brca1 Mouse ozone decreases expression EXP 6480464 Ozone results in decreased expression of BRCA1 mRNA CTD PMID:24336422 Brca1 Mouse ozone increases expression ISO BRCA1 (Homo sapiens) 6480464 Ozone results in increased expression of BRCA1 mRNA CTD PMID:23033980 Brca1 Mouse ozone multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of BRCA1 mRNA more ... CTD PMID:32699268 Brca1 Mouse ozone multiple interactions EXP 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of BRCA1 mRNA more ... CTD PMID:25658374 more ... Brca1 Mouse paclitaxel decreases expression ISO BRCA1 (Homo sapiens) 6480464 Paclitaxel results in decreased expression of BRCA1 mRNA CTD PMID:15607317 Brca1 Mouse paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of BRCA1 mRNA CTD PMID:17562736 Brca1 Mouse paracetamol increases expression ISO Brca1 (Rattus norvegicus) 6480464 Acetaminophen results in increased expression of BRCA1 mRNA CTD PMID:33387578 Brca1 Mouse paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of BRCA1 protein CTD PMID:29540258 Brca1 Mouse paracetamol increases activity ISO Brca1 (Rattus norvegicus) 6480464 Acetaminophen results in increased activity of BRCA1 protein CTD PMID:25858767 Brca1 Mouse paracetamol increases expression ISO BRCA1 (Homo sapiens) 6480464 Acetaminophen results in increased expression of BRCA1 mRNA CTD PMID:22230336 Brca1 Mouse paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of BRCA1 mRNA CTD PMID:17942131 Brca1 Mouse paraquat decreases response to substance ISO BRCA1 (Homo sapiens) 6480464 BRCA1 protein results in decreased susceptibility to Paraquat CTD PMID:15520196 Brca1 Mouse paraquat multiple interactions EXP 6480464 [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of BRCA1 mRNA CTD PMID:28012437 Brca1 Mouse PCB138 multiple interactions ISO BRCA1 (Homo sapiens) 6480464 2 more ... CTD PMID:12473173 Brca1 Mouse phenobarbital affects expression ISO BRCA1 (Homo sapiens) 6480464 Phenobarbital affects the expression of BRCA1 mRNA CTD PMID:19159669 Brca1 Mouse phenobarbital affects expression EXP 6480464 Phenobarbital affects the expression of BRCA1 mRNA CTD PMID:23091169 Brca1 Mouse PhIP decreases expression ISO Brca1 (Rattus norvegicus) 6480464 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in decreased expression of BRCA1 protein CTD PMID:12203372 Brca1 Mouse phorbol 13-acetate 12-myristate multiple interactions EXP 6480464 [sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of BRCA1 mRNA CTD PMID:16368122 Brca1 Mouse phosphoramide mustard affects expression ISO Brca1 (Rattus norvegicus) 6480464 phosphoramide mustard affects the expression of BRCA1 mRNA CTD PMID:25497287 Brca1 Mouse phosphoramide mustard increases expression ISO Brca1 (Rattus norvegicus) 6480464 phosphoramide mustard results in increased expression of BRCA1 mRNA and phosphoramide mustard results in increased expression of BRCA1 protein CTD PMID:25497287 and PMID:26708502 Brca1 Mouse pifithrin-? multiple interactions ISO BRCA1 (Homo sapiens) 6480464 pifithrin inhibits the reaction [Etoposide results in increased expression of and affects the localization of BRCA1 protein] CTD PMID:26259609 Brca1 Mouse pirinixic acid multiple interactions EXP 6480464 PPARA protein promotes the reaction [pirinixic acid results in increased expression of BRCA1 mRNA] CTD PMID:17950772 Brca1 Mouse pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of BRCA1 mRNA CTD PMID:23811191 Brca1 Mouse pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of BRCA1 mRNA CTD PMID:17950772 Brca1 Mouse potassium bromate increases expression ISO BRCA1 (Homo sapiens) 6480464 potassium bromate results in increased expression of BRCA1 mRNA CTD PMID:22539617 Brca1 Mouse potassium chromate decreases expression ISO BRCA1 (Homo sapiens) 6480464 potassium chromate(VI) results in decreased expression of BRCA1 mRNA CTD PMID:22079256 Brca1 Mouse potassium chromate multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of BRCA1 mRNA CTD PMID:22079256 Brca1 Mouse pregnenolone 16alpha-carbonitrile multiple interactions EXP 6480464 [1 more ... CTD PMID:23626729 Brca1 Mouse procyanidin B2 increases expression ISO BRCA1 (Homo sapiens) 6480464 procyanidin B2 results in increased expression of BRCA1 mRNA CTD PMID:25839702 Brca1 Mouse promethazine decreases expression ISO Brca1 (Rattus norvegicus) 6480464 Promethazine results in decreased expression of BRCA1 mRNA CTD PMID:26011634 Brca1 Mouse propanal decreases expression ISO BRCA1 (Homo sapiens) 6480464 propionaldehyde results in decreased expression of BRCA1 mRNA CTD PMID:26079696 Brca1 Mouse pyrethrins decreases expression ISO Brca1 (Rattus norvegicus) 6480464 Pyrethrins results in decreased expression of BRCA1 protein CTD PMID:34896426 Brca1 Mouse quercetin increases expression ISO BRCA1 (Homo sapiens) 6480464 Quercetin results in increased expression of BRCA1 mRNA CTD PMID:14715546 and PMID:21632981 Brca1 Mouse quercetin decreases expression ISO BRCA1 (Homo sapiens) 6480464 Quercetin results in decreased expression of BRCA1 mRNA CTD PMID:36982678 Brca1 Mouse reactive oxygen species multiple interactions ISO BRCA1 (Homo sapiens) 6480464 BRCA1 inhibits the reaction [Benzo(a)pyrene results in increased abundance of Reactive Oxygen Species] and NFE2L2 protein inhibits the reaction [BRCA1 inhibits the reaction [Benzo(a)pyrene results in increased abundance of Reactive Oxygen Species]] CTD PMID:22192953 Brca1 Mouse resveratrol increases expression ISO BRCA1 (Homo sapiens) 6480464 resveratrol results in increased expression of BRCA1 mRNA and resveratrol results in increased expression of BRCA1 protein CTD PMID:15149879 and PMID:25533949 Brca1 Mouse resveratrol decreases expression ISO Brca1 (Rattus norvegicus) 6480464 Resveratrol results in decreased expression of BRCA1 mRNA CTD PMID:33775663 Brca1 Mouse resveratrol affects localization ISO BRCA1 (Homo sapiens) 6480464 resveratrol affects the localization of BRCA1 protein CTD PMID:19559722 Brca1 Mouse resveratrol multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [Coumestrol co-treated with Resveratrol] results in increased expression of BRCA1 mRNA more ... CTD PMID:19167446 more ... Brca1 Mouse resveratrol increases expression ISO Brca1 (Rattus norvegicus) 6480464 resveratrol results in increased expression of BRCA1 mRNA and resveratrol results in increased expression of BRCA1 protein CTD PMID:24136580 Brca1 Mouse resveratrol multiple interactions ISO Brca1 (Rattus norvegicus) 6480464 resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter]] more ... CTD PMID:24136580 Brca1 Mouse riddelliine multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRCA1 mRNA CTD PMID:33884520 Brca1 Mouse rotenone increases expression ISO BRCA1 (Homo sapiens) 6480464 Rotenone results in increased expression of BRCA1 mRNA CTD PMID:18191903 Brca1 Mouse rucaparib affects response to substance ISO BRCA1 (Homo sapiens) 6480464 BRCA1 protein affects the susceptibility to rucaparib CTD PMID:32927276 Brca1 Mouse silicon dioxide increases expression EXP 6480464 Silicon Dioxide results in increased expression of BRCA1 mRNA CTD PMID:29341224 Brca1 Mouse sodium arsenite affects expression EXP 6480464 sodium arsenite affects the expression of BRCA1 mRNA CTD PMID:16507464 Brca1 Mouse sodium arsenite decreases expression ISO BRCA1 (Homo sapiens) 6480464 sodium arsenite results in decreased expression of BRCA1 mRNA and sodium arsenite results in decreased expression of BRCA1 protein CTD PMID:30664189 and PMID:38568856 Brca1 Mouse sodium arsenite increases methylation ISO BRCA1 (Homo sapiens) 6480464 sodium arsenite results in increased methylation of BRCA1 gene CTD PMID:30664189 Brca1 Mouse sodium arsenite multiple interactions ISO BRCA1 (Homo sapiens) 6480464 Genistein inhibits the reaction [sodium arsenite inhibits the reaction [Estradiol results in increased expression of BRCA1 protein]] more ... CTD PMID:30664189 and PMID:36087615 Brca1 Mouse sodium arsenite multiple interactions EXP 6480464 [sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of BRCA1 mRNA CTD PMID:16368122 Brca1 Mouse sodium arsenite increases expression ISO BRCA1 (Homo sapiens) 6480464 sodium arsenite results in increased expression of BRCA1 mRNA CTD PMID:12760830 and PMID:29301061 Brca1 Mouse sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of BRCA1 mRNA CTD PMID:22155349 Brca1 Mouse succimer multiple interactions EXP 6480464 [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of BRCA1 mRNA and [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of BRCA1 mRNA CTD PMID:21641980 and PMID:26378955 Brca1 Mouse sulindac decreases expression ISO BRCA1 (Homo sapiens) 6480464 Sulindac results in decreased expression of BRCA1 mRNA CTD PMID:16273229 Brca1 Mouse talazoparib increases response to substance ISO BRCA1 (Homo sapiens) 6480464 BRCA1 gene mutant form results in increased susceptibility to talazoparib CTD PMID:30672063 Brca1 Mouse tamibarotene decreases expression ISO BRCA1 (Homo sapiens) 6480464 tamibarotene results in decreased expression of BRCA1 mRNA CTD PMID:15498508 Brca1 Mouse tamoxifen affects activity ISO BRCA1 (Homo sapiens) 6480464 BRCA1 affects the activity of Tamoxifen CTD PMID:15750629 Brca1 Mouse tamoxifen multiple interactions EXP 6480464 [Tamoxifen co-treated with BRCA1 protein mutant form] results in decreased expression of ESR1 protein CTD PMID:15750629 Brca1 Mouse tamoxifen increases response to substance ISO BRCA1 (Homo sapiens) 6480464 BRCA1 protein results in increased susceptibility to Tamoxifen CTD PMID:18997820 Brca1 Mouse tamoxifen multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [Tamoxifen co-treated with Estradiol] results in increased expression of BRCA1 protein more ... CTD PMID:18997820 and PMID:30664189 Brca1 Mouse terbufos decreases expression ISO BRCA1 (Homo sapiens) 6480464 terbufos results in decreased expression of BRCA1 mRNA CTD PMID:33221015 Brca1 Mouse testosterone multiple interactions ISO BRCA1 (Homo sapiens) 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of BRCA1 mRNA more ... CTD PMID:21592394 Brca1 Mouse testosterone decreases expression ISO BRCA1 (Homo sapiens) 6480464 Testosterone results in decreased expression of BRCA1 mRNA CTD PMID:21592394 Brca1 Mouse tetrachloromethane affects expression ISO Brca1 (Rattus norvegicus) 6480464 Carbon Tetrachloride affects the expression of BRCA1 mRNA CTD PMID:12734012 Brca1 Mouse tetrachloromethane multiple interactions ISO Brca1 (Rattus norvegicus) 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of BRCA1 mRNA] CTD PMID:31150632 Brca1 Mouse tetrachloromethane decreases expression ISO Brca1 (Rattus norvegicus) 6480464 Carbon Tetrachloride results in decreased expression of BRCA1 mRNA CTD PMID:31150632 Brca1 Mouse tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of BRCA1 mRNA CTD PMID:17484886 Brca1 Mouse tetramethrin affects binding ISO BRCA1 (Homo sapiens) 6480464 tetramethrin binds to BRCA1 protein CTD PMID:32278787 Brca1 Mouse thapsigargin increases expression ISO BRCA1 (Homo sapiens) 6480464 Thapsigargin results in increased expression of BRCA1 mRNA and Thapsigargin results in increased expression of BRCA1 protein CTD PMID:16434996 Brca1 Mouse thapsigargin affects localization EXP 6480464 Thapsigargin affects the localization of BRCA1 mRNA CTD PMID:29576526 Brca1 Mouse thapsigargin multiple interactions EXP 6480464 Cycloheximide inhibits the reaction [Thapsigargin affects the localization of BRCA1 mRNA] and Emetine inhibits the reaction [Thapsigargin affects the localization of BRCA1 mRNA] CTD PMID:29576526 Brca1 Mouse thioacetamide decreases expression ISO Brca1 (Rattus norvegicus) 6480464 Thioacetamide results in decreased expression of BRCA1 mRNA CTD PMID:26011634 Brca1 Mouse topotecan multiple interactions ISO Brca1 (Rattus norvegicus) 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of BRCA1 mRNA CTD PMID:25729387 Brca1 Mouse topotecan decreases expression ISO Brca1 (Rattus norvegicus) 6480464 Topotecan results in decreased expression of BRCA1 mRNA CTD PMID:25729387 Brca1 Mouse toxaphene increases expression ISO BRCA1 (Homo sapiens) 6480464 Toxaphene results in increased expression of BRCA1 mRNA CTD PMID:12473173 Brca1 Mouse transplatin decreases activity ISO BRCA1 (Homo sapiens) 6480464 transplatin results in decreased activity of BRCA1 protein CTD PMID:20878461 Brca1 Mouse Tributyltin oxide decreases expression EXP 6480464 bis(tri-n-butyltin)oxide results in decreased expression of BRCA1 mRNA CTD PMID:17942131 Brca1 Mouse trichostatin A decreases expression ISO BRCA1 (Homo sapiens) 6480464 trichostatin A results in decreased expression of BRCA1 mRNA CTD PMID:23770000 Brca1 Mouse triclosan decreases expression ISO BRCA1 (Homo sapiens) 6480464 Triclosan results in decreased expression of BRCA1 mRNA CTD PMID:30510588 Brca1 Mouse trimellitic anhydride increases expression EXP 6480464 trimellitic anhydride results in increased expression of BRCA1 mRNA CTD PMID:19042947 Brca1 Mouse troglitazone decreases expression ISO BRCA1 (Homo sapiens) 6480464 troglitazone results in decreased expression of BRCA1 mRNA CTD PMID:19140230 Brca1 Mouse trovafloxacin decreases expression EXP 6480464 trovafloxacin results in decreased expression of BRCA1 mRNA CTD PMID:35537566 Brca1 Mouse tungsten decreases expression EXP 6480464 Tungsten results in decreased expression of BRCA1 mRNA CTD PMID:30912803 Brca1 Mouse tunicamycin increases expression ISO BRCA1 (Homo sapiens) 6480464 Tunicamycin results in increased expression of BRCA1 protein CTD PMID:16434996 Brca1 Mouse urethane decreases expression ISO BRCA1 (Homo sapiens) 6480464 Urethane results in decreased expression of BRCA1 mRNA CTD PMID:28818685 Brca1 Mouse valproic acid decreases expression ISO BRCA1 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of BRCA1 mRNA CTD PMID:20585447 and PMID:28001369 Brca1 Mouse valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of BRCA1 mRNA CTD PMID:24913804 Brca1 Mouse valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of BRCA1 mRNA CTD PMID:24913804 Brca1 Mouse valproic acid increases methylation ISO BRCA1 (Homo sapiens) 6480464 Valproic Acid results in increased methylation of BRCA1 gene CTD PMID:29154799 Brca1 Mouse veliparib affects response to substance ISO BRCA1 (Homo sapiens) 6480464 BRCA1 affects the susceptibility to veliparib CTD PMID:21633166 Brca1 Mouse veliparib decreases response to substance ISO BRCA1 (Homo sapiens) 6480464 BRCA1 protein results in decreased susceptibility to veliparib CTD PMID:21707865 Brca1 Mouse vorinostat multiple interactions ISO BRCA1 (Homo sapiens) 6480464 vorinostat inhibits the reaction [BRCA1 results in decreased susceptibility to Cisplatin] CTD PMID:21854619 Brca1 Mouse vorinostat decreases expression ISO BRCA1 (Homo sapiens) 6480464 vorinostat results in decreased expression of BRCA1 protein CTD PMID:21854619 Brca1 Mouse zearalenone increases expression ISO BRCA1 (Homo sapiens) 6480464 Zearalenone results in increased expression of BRCA1 mRNA CTD PMID:28965971 Brca1 Mouse zearalenone increases expression EXP 6480464 Zearalenone results in increased expression of BRCA1 mRNA CTD PMID:28552778 Brca1 Mouse zinc atom affects binding ISO BRCA1 (Homo sapiens) 6480464 Zinc binds to BRCA1 protein CTD PMID:36087615 Brca1 Mouse zinc atom multiple interactions ISO BRCA1 (Homo sapiens) 6480464 sodium arsenite inhibits the reaction [Zinc binds to BRCA1 protein] CTD PMID:36087615 Brca1 Mouse zinc(0) affects binding ISO BRCA1 (Homo sapiens) 6480464 Zinc binds to BRCA1 protein CTD PMID:36087615 Brca1 Mouse zinc(0) multiple interactions ISO BRCA1 (Homo sapiens) 6480464 sodium arsenite inhibits the reaction [Zinc binds to BRCA1 protein] CTD PMID:36087615