Brca1 (breast cancer 1, early onset) - Rat Genome Database

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Gene: Brca1 (breast cancer 1, early onset) Mus musculus
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Symbol: Brca1
Name: breast cancer 1, early onset
RGD ID: 10246
MGI Page MGI
Description: Enables damaged DNA binding activity and transcription cis-regulatory region binding activity. Involved in several processes, including regulation of gene expression by genetic imprinting; regulation of histone modification; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within several processes, including centrosome cycle; dosage compensation by inactivation of X chromosome; and mitotic G2/M transition checkpoint. Located in condensed nuclear chromosome and cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Used to study breast cancer. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); hereditary breast ovarian cancer syndrome; and reproductive organ cancer (multiple). Orthologous to human BRCA1 (BRCA1 DNA repair associated); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; forkhead class A signaling pathway; homologous recombination pathway of double-strand break repair; INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: breast cancer 1; breast cancer associated 1; breast cancer type 1 susceptibility protein homolog; RING-type E3 ubiquitin transferase BRCA1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,379,587 - 101,442,808 (-)NCBIGRCm39mm39
GRCm39 Ensembl11101,379,590 - 101,442,781 (-)Ensembl
GRCm3811101,488,761 - 101,551,955 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,488,764 - 101,551,955 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,350,078 - 101,413,269 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611101,304,854 - 101,365,210 (-)NCBImm8
Celera11113,175,987 - 113,239,169 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1165.18NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model