Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Brca1 (breast cancer 1, early onset) Mus musculus
Analyze
Symbol: Brca1
Name: breast cancer 1, early onset
Description: Exhibits damaged DNA binding activity and transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including regulation of gene expression, epigenetic; regulation of histone modification; and regulation of nucleobase-containing compound metabolic process. Localizes to condensed nuclear chromosome and cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Used to study breast cancer. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia; cervix uteri carcinoma in situ; colon cancer; hereditary breast ovarian cancer syndrome; and reproductive organ cancer (multiple). Orthologous to human BRCA1 (BRCA1 DNA repair associated); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; forkhead class A signaling pathway; homologous recombination pathway of double-strand break repair; INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: breast cancer 1; breast cancer associated 1; breast cancer type 1 susceptibility protein homolog; RING-type E3 ubiquitin transferase BRCA1
Orthologs:
Homo sapiens (human) : BRCA1 (BRCA1 DNA repair associated)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Brca1 (BRCA1, DNA repair associated)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Brca1 (BRCA1 DNA repair associated)
Pan paniscus (bonobo/pygmy chimpanzee) : BRCA1 (BRCA1 DNA repair associated)
Canis lupus familiaris (dog) : BRCA1 (BRCA1 DNA repair associated)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Brca1 (BRCA1 DNA repair associated)
Sus scrofa (pig) : BRCA1 (BRCA1 DNA repair associated)
Chlorocebus sabaeus (African green monkey) : BRCA1 (BRCA1 DNA repair associated)
Heterocephalus glaber (naked mole-rat) : Brca1 (BRCA1 DNA repair associated)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl11101,488,764 - 101,551,955 (-)EnsemblGRCm38mm10GRCm38
GRCm3811101,488,761 - 101,551,955 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711101,350,078 - 101,413,269 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611101,304,854 - 101,365,210 (-)NCBImm8
Celera11113,175,987 - 113,239,169 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1165.18NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model