Brca1 (breast cancer 1, early onset) - Rat Genome Database

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Gene: Brca1 (breast cancer 1, early onset) Mus musculus
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Symbol: Brca1
Name: breast cancer 1, early onset
RGD ID: 10246
MGI Page MGI
Description: Enables DNA-binding transcription activator activity; damaged DNA binding activity; and transcription cis-regulatory region binding activity. Involved in double-strand break repair and positive regulation of transcription by RNA polymerase II. Acts upstream of with a positive effect on negative regulation of gene expression via chromosomal CpG island methylation. Acts upstream of or within several processes, including centrosome cycle; mitotic G2/M transition checkpoint; and random inactivation of X chromosome. Located in chromosome; cytoplasm; and male germ cell nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Used to study breast cancer; hereditary breast ovarian cancer syndrome; and ovarian cancer. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia complementation group S; breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human BRCA1 (BRCA1 DNA repair associated).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: breast cancer 1; breast cancer associated 1; breast cancer type 1 susceptibility protein homolog; RING-type E3 ubiquitin transferase BRCA1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,379,587 - 101,442,808 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,379,590 - 101,442,781 (-)EnsemblGRCm39 Ensembl
GRCm3811101,488,761 - 101,551,955 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,488,764 - 101,551,955 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,350,078 - 101,413,269 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,304,854 - 101,365,210 (-)NCBIMGSCv36mm8
Celera11113,175,987 - 113,239,169 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1165.18NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenoid cystic carcinoma  (ISO)
Animal Mammary Neoplasms  (ISO)
bilateral breast cancer  (ISO)
breast adenocarcinoma  (ISO)
breast cancer  (IAGP,ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
breast ductal carcinoma  (ISO)
Breast Neoplasms  (ISO)
Burkitt lymphoma  (ISO)
carcinoma  (ISO)
cervical cancer  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chromosome Breakage  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
disease of cellular proliferation  (ISO)
ductal carcinoma in situ  (ISO)
dysgerminoma  (ISO)
endometrial carcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Mammary Neoplasms  (IAGP,ISO)
Familial Prostate Cancer  (ISO)
Fanconi anemia complementation group A  (ISO)
Fanconi anemia complementation group S  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
hereditary mixed polyposis syndrome 1  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Hyperplasia  (IMP)
hypertension  (ISO)
infant-type hemispheric glioma  (ISO)
invasive ductal carcinoma  (ISO)
lung non-small cell carcinoma  (ISO)
mouth disease  (ISO)
nasopharynx carcinoma  (ISO)
Neoplastic Cell Transformation  (ISO)
ovarian cancer  (ISO)
ovarian carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
ovary serous adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
peritoneum cancer  (ISO)
periventricular nodular heterotopia  (ISO)
Premature Aging  (IMP)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
punctate palmoplantar keratoderma type II  (ISO)
rhabdomyosarcoma  (ISO)
stomach cancer  (ISO)
stomach carcinoma  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)
uterine corpus cancer  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-alpha-phellandrene  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (EXP)
2-methylcholine  (ISO)
2-naphthylamine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-methylcholanthrene  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
8-hydroxy-2'-deoxyguanosine  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
Aflatoxin G1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (ISO)
alpha-naphthoflavone  (ISO)
alpha-phellandrene  (EXP)
alpha-pinene  (ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
arecoline  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzophenanthridine  (ISO)
beta-hexachlorocyclohexane  (ISO)
bifenthrin  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bortezomib  (EXP,ISO)
bromoacetate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
Calcium propionate  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
carboplatin  (ISO)
carfilzomib  (ISO)
casticin  (ISO)
ceric oxide  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
daidzein  (ISO)
DDE  (ISO)
Decamethylcyclopentasiloxane  (ISO)
deguelin  (ISO)
diamminedichloroplatinum  (ISO)
diarsenic trioxide  (ISO)
dibenzofuran  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP)
dieldrin  (ISO)
dinaciclib  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
emetine  (EXP)
endosulfan  (ISO)
Enterolactone  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP)
etoposide  (ISO)
fenthion  (ISO)
fenvalerate  (ISO)
flavonoids  (ISO)
folic acid  (EXP,ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (ISO)
furazolidone  (ISO)
gemcitabine  (EXP,ISO)
genistein  (ISO)
gentamycin  (ISO)
geraniol  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hexamethylcyclotrisiloxane  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
indole-3-methanol  (ISO)
L-methionine  (EXP)
Lasiocarpine  (ISO)
lead diacetate  (EXP)
leptomycin B  (ISO)
lipopolysaccharide  (EXP)
lucanthone  (ISO)
methotrexate  (ISO)
methoxsalen  (ISO)
methyl methanesulfonate  (ISO)
mitomycin C  (ISO)
Monobutylphthalate  (ISO)
myristicin  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
nickel dichloride  (ISO)
nicotine  (ISO)
nitrogen mustard  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
octamethylcyclotetrasiloxane  (ISO)
olaparib  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PCB138  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphoramide mustard  (ISO)
pifithrin-?  (ISO)
pirinixic acid  (EXP)
potassium bromate  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
procyanidin B2  (ISO)
promethazine  (ISO)
propanal  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
riddelliine  (ISO)
rotenone  (ISO)
rucaparib  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
succimer  (EXP)
sulindac  (ISO)
talazoparib  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetramethrin  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (ISO)
topotecan  (ISO)
toxaphene  (ISO)
transplatin  (ISO)
Tributyltin oxide  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
troglitazone  (ISO)
trovafloxacin  (EXP)
tungsten  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
veliparib  (ISO)
vorinostat  (ISO)
zearalenone  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to indole-3-methanol  (IEA,ISO)
cellular response to ionizing radiation  (ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
centrosome cycle  (IGI)
centrosome duplication  (TAS)
chordate embryonic development  (IBA,IMP)
chromosome segregation  (IEA,ISO)
DNA damage response  (IMP,NAS)
DNA repair  (NAS)
DNA strand resection involved in replication fork processing  (NAS)
double-strand break repair  (IMP,ISO)
double-strand break repair via homologous recombination  (IBA,IEA,ISO)
fatty acid biosynthetic process  (IEA)
homologous recombination  (NAS)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
mitotic G2 DNA damage checkpoint signaling  (IBA,IEA,ISO)
mitotic G2/M transition checkpoint  (IMP,NAS)
negative regulation of cell growth  (IEA,ISO)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
negative regulation of fatty acid biosynthetic process  (ISO,ISS)
negative regulation of gene expression via chromosomal CpG island methylation  (IDA,ISO)
negative regulation of intracellular estrogen receptor signaling pathway  (IEA,ISO)
negative regulation of reactive oxygen species metabolic process  (IEA,ISO)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of cell cycle  (NAS)
positive regulation of DNA repair  (IEA,ISO)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of gene expression  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IMP,ISO)
positive regulation of vascular endothelial growth factor production  (IEA,ISO)
postreplication repair  (IEA,ISO)
protein autoubiquitination  (ISO,ISS)
protein K6-linked ubiquitination  (ISO,ISS)
protein ubiquitination  (ISO)
random inactivation of X chromosome  (IGI)
regulation of cell cycle  (ISO)
regulation of DNA damage checkpoint  (NAS)
regulation of DNA repair  (NAS)
regulation of transcription by RNA polymerase II  (ISO,ISS)
response to estradiol  (ISO)
response to genistein  (ISO)
response to ionizing radiation  (ISO)
response to lipid  (ISO)
response to nutrient  (ISO)
sex-chromosome dosage compensation  (IBA)