Brca1 (breast cancer 1, early onset) - Rat Genome Database

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Gene: Brca1 (breast cancer 1, early onset) Mus musculus
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Symbol: Brca1
Name: breast cancer 1, early onset
RGD ID: 10246
MGI Page MGI
Description: Enables damaged DNA binding activity and transcription cis-regulatory region binding activity. Involved in several processes, including regulation of gene expression by genomic imprinting; regulation of histone modification; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within several processes, including centrosome cycle; dosage compensation by inactivation of X chromosome; and mitotic G2/M transition checkpoint. Located in chromosome; cytoplasm; and male germ cell nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Used to study breast cancer; hereditary breast ovarian cancer syndrome; and ovarian cancer. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); hereditary breast ovarian cancer syndrome; and reproductive organ cancer (multiple). Orthologous to human BRCA1 (BRCA1 DNA repair associated).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: breast cancer 1; breast cancer associated 1; breast cancer type 1 susceptibility protein homolog; RING-type E3 ubiquitin transferase BRCA1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,379,587 - 101,442,808 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,379,590 - 101,442,781 (-)EnsemblGRCm39 Ensembl
GRCm3811101,488,761 - 101,551,955 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,488,764 - 101,551,955 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,350,078 - 101,413,269 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,304,854 - 101,365,210 (-)NCBIMGSCv36mm8
Celera11113,175,987 - 113,239,169 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1165.18NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-alpha-phellandrene  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (EXP)
2-methylcholine  (ISO)
2-naphthylamine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-methylcholanthrene  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
8-hydroxy-2'-deoxyguanosine  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
Aflatoxin G1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-naphthoflavone  (ISO)
alpha-phellandrene  (EXP)
alpha-pinene  (ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
arecoline  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzophenanthridine  (ISO)
beta-hexachlorocyclohexane  (ISO)
bifenthrin  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (EXP,ISO)
bromoacetate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
Calcium propionate  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
carboplatin  (ISO)
carfilzomib  (ISO)
casticin  (ISO)
ceric oxide  (ISO)
CGP 52608  (ISO)
choline  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
daidzein  (ISO)
DDE  (ISO)
Decamethylcyclopentasiloxane  (ISO)
deguelin  (ISO)
diamminedichloroplatinum  (ISO)
diarsenic trioxide  (ISO)
dibenzofuran  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP)
dieldrin  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
emetine  (EXP)
endosulfan  (ISO)
Enterolactone  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP)
etoposide  (ISO)
fenthion  (ISO)
fenvalerate  (ISO)
flavonoids  (ISO)
folic acid  (EXP,ISO)
fulvestrant  (ISO)
furan  (ISO)
gemcitabine  (EXP,ISO)
genistein  (ISO)
gentamycin  (ISO)
geraniol  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hexamethylcyclotrisiloxane  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
indole-3-methanol  (ISO)
L-methionine  (EXP)
Lasiocarpine  (ISO)
lead diacetate  (EXP)
leptomycin B  (ISO)
lucanthone  (ISO)
methotrexate  (ISO)
methoxsalen  (ISO)
methyl methanesulfonate  (ISO)
mitomycin C  (ISO)
Monobutylphthalate  (ISO)
myristicin  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
nickel dichloride  (ISO)
nicotine  (ISO)
nitrogen mustard  (ISO)
O-methyleugenol  (ISO)
octamethylcyclotetrasiloxane  (ISO)
olaparib  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PCB138  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphoramide mustard  (ISO)
pirinixic acid  (EXP)
potassium bromate  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
procyanidin B2  (ISO)
promethazine  (ISO)
propanal  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
riddelliine  (ISO)
rotenone  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
succimer  (EXP)
sulindac  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetramethrin  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (ISO)
topotecan  (ISO)
toxaphene  (ISO)
transplatin  (ISO)
Tributyltin oxide  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
troglitazone  (ISO)
tungsten  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
veliparib  (ISO)
vorinostat  (ISO)
zearalenone  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
brain development  (ISO)
cellular response to DNA damage stimulus  (IC,IMP)
cellular response to indole-3-methanol  (ISO)
cellular response to ionizing radiation  (ISO)
cellular response to tumor necrosis factor  (ISO)
centrosome cycle  (IGI)
centrosome duplication  (TAS)
chordate embryonic development  (IBA,IMP)
chromosome segregation  (ISO)
DNA recombination  (IEA)
DNA repair  (IC)
DNA strand resection involved in replication fork processing  (IC)
dosage compensation by inactivation of X chromosome  (IBA,IDA)
double-strand break repair  (IMP,ISO)
double-strand break repair via homologous recombination  (IBA,ISO)
fatty acid biosynthetic process  (IEA)
fatty acid metabolic process  (IEA)
histone H2A K63-linked deubiquitination  (IC)
histone H2A monoubiquitination  (IC)
homologous recombination  (IC)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
lipid metabolic process  (IEA)
localization  (ISO)
mitotic G2 DNA damage checkpoint signaling  (ISO)
mitotic G2/M transition checkpoint  (IC,IMP)
negative regulation of cell growth  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
negative regulation of fatty acid biosynthetic process  (IBA,ISO)
negative regulation of histone acetylation  (IBA,IMP)
negative regulation of histone H3-K4 methylation  (IMP)
negative regulation of histone H3-K9 methylation  (IMP,ISO)
negative regulation of intracellular estrogen receptor signaling pathway  (ISO)
negative regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of cell cycle  (IC)
positive regulation of DNA repair  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of histone acetylation  (IBA,IMP,ISO)
positive regulation of histone H3-K4 methylation  (IMP,ISO)
positive regulation of histone H3-K9 acetylation  (IMP,ISO)
positive regulation of histone H3-K9 methylation  (IMP)
positive regulation of histone H4-K16 acetylation  (IMP,ISO)
positive regulation of histone H4-K20 methylation  (IMP,ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IMP,ISO)
positive regulation of vascular endothelial growth factor production  (ISO)
postreplication repair  (ISO)
protein autoubiquitination  (IC,ISO)
protein K6-linked ubiquitination  (ISO)
protein polyubiquitination  (ISO)
protein ubiquitination  (ISO)
regulation of cell cycle  (ISO)
regulation of DNA damage checkpoint  (IC)
regulation of DNA methylation  (IMP)
regulation of DNA repair  (IC)
regulation of gene expression by genomic imprinting  (IMP)
regulation of transcription by RNA polymerase II  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to ionizing radiation  (ISO)
response to lipid  (ISO)
response to nutrient  (ISO)
response to organic substance  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal allantois morphology  (IAGP)
abnormal awl hair morphology  (IAGP)
abnormal axial mesoderm morphology  (IAGP)
abnormal bone structure  (IAGP)
abnormal branching of the mammary ductal tree  (IAGP)
abnormal cell adhesion  (IAGP)
abnormal cell cycle  (IAGP)
abnormal cell cycle checkpoint function  (IAGP)
abnormal cell death  (IAGP)
abnormal cell migration  (IAGP)
abnormal cell morphology  (IAGP)
abnormal centrosome morphology  (IAGP)
abnormal chromosome morphology  (IAGP)
abnormal chromosome number  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal coat/hair pigmentation  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal double-strand DNA break repair  (IAGP)
abnormal egg cylinder morphology  (IAGP)
abnormal embryonic neuroepithelial layer differentiation  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal embryonic-extraembryonic boundary morphology  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal esophageal epithelium morphology  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair growth  (IAGP)
abnormal heart development  (IAGP)
abnormal immune system organ morphology  (IAGP)
abnormal involution of the mammary gland  (IAGP)
abnormal male meiosis  (IAGP)
abnormal mammary gland development  (IAGP)
abnormal mammary gland duct morphology  (IAGP)
abnormal mammary gland epithelium morphology  (IAGP)
abnormal mammary gland growth during pregnancy  (IAGP)
abnormal mammary gland lobule morphology  (IAGP)
abnormal mammary gland morphology  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal oviduct morphology  (IAGP)
abnormal parietal endoderm morphology  (IAGP)
abnormal primitive streak formation  (IAGP)
abnormal skin pigmentation  (IAGP)
abnormal small intestinal villus morphology  (IAGP)
abnormal spermatid morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal stomach epithelium morphology  (IAGP)
abnormal T cell number  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal trophoblast layer morphology  (IAGP)
abnormal tumor morphology  (IAGP)
abnormal tumor pathology  (IAGP)
abnormal uterine cervix squamous epithelium morphology  (IAGP)
abnormal visceral endoderm morphology  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
absent amniotic folds  (IAGP)
absent egg cylinders  (IAGP)
absent mesoderm  (IAGP)
absent trophoblast giant cells  (IAGP)
aneuploidy  (IAGP)
arrest of male meiosis  (IAGP)
arrest of spermatogenesis  (IAGP)
azoospermia  (IAGP)
chromosomal instability  (IAGP)
chromosome breakage  (IAGP)
decreased body weight  (IAGP)
decreased cell proliferation  (IAGP)
decreased compact bone thickness  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased fibroblast proliferation  (IAGP)
decreased hair follicle number  (IAGP)
decreased mammary gland epithelial cell proliferation  (IAGP)
decreased mammary gland tumor incidence  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased skin tumor incidence  (IAGP)
decreased small intestinal villus height  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
decreased survivor rate  (IAGP)
decreased T cell proliferation  (IAGP)
decreased telomere length  (IAGP)
decreased thymocyte number  (IAGP)
decreased total body fat amount  (IAGP)
decreased tumor latency  (IAGP)
delayed hair regrowth  (IAGP)
dermatitis  (IAGP)
disorganized embryonic tissue  (IAGP)
disorganized extraembryonic tissue  (IAGP)
early cellular replicative senescence  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and placentation, complete penetrance  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
empty decidua capsularis  (IAGP)
endometrium hyperplasia  (IAGP)
enlarged tail bud  (IAGP)
enlarged thymus  (IAGP)
exencephaly  (IAGP)
failure of initiation of embryo turning  (IAGP)
failure of primitive streak formation  (IAGP)
hemorrhagic ascites  (IAGP)
hyperactivity  (IAGP)
impaired wound healing  (IAGP)
incomplete somite formation  (IAGP)
increased apoptosis  (IAGP)
increased body weight  (IAGP)
increased carcinoma incidence  (IAGP)
increased cell proliferation  (IAGP)
increased cellular sensitivity to gamma-irradiation  (IAGP)
increased double-negative T cell number  (IAGP)
increased embryonic tissue cell apoptosis  (IAGP)
increased fibroblast proliferation  (IAGP)
increased hepatoma incidence  (IAGP)
increased incidence of tumors by chemical induction  (IAGP)
increased incidence of tumors by ionizing radiation induction  (IAGP)
increased keratinocyte proliferation  (IAGP)
increased lipoma incidence  (IAGP)
increased liver tumor incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased male germ cell apoptosis  (IAGP)
increased mammary adenocarcinoma incidence  (IAGP)
increased mammary gland apoptosis  (IAGP)
increased mammary gland ductal carcinoma incidence  (IAGP)
increased mammary gland epithelial cell proliferation  (IAGP)
increased mammary gland tumor incidence  (IAGP)
increased metastatic potential  (IAGP)
increased mortality induced by gamma-irradiation  (IAGP)
increased mouth tumor incidence  (IAGP)
increased ovarian carcinoma incidence  (IAGP)
increased ovary tumor incidence  (IAGP)
increased papilloma incidence  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased reproductive system tumor incidence  (IAGP)
increased salivary adenocarcinoma incidence  (IAGP)
increased sensitivity to xenobiotic induced morbidity/mortality  (IAGP)
increased skin tumor incidence  (IAGP)
increased squamous cell carcinoma incidence  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased tumor incidence  (IAGP)
increased tumor latency  (IAGP)
kidney cyst  (IAGP)
kinked tail  (IAGP)
kyphosis  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
male infertility  (IAGP)
mammary gland alveolar hyperplasia  (IAGP)
mammary gland duct hyperplasia  (IAGP)
mammary gland hyperplasia  (IAGP)
meiotic nondisjunction  (IAGP)
muscular atrophy  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
open neural tube  (IAGP)
osteoporosis  (IAGP)
ovary cyst  (IAGP)
postnatal growth retardation  (IAGP)
premature aging  (IAGP)
premature death  (IAGP)
prenatal lethality  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preneoplasia  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
respiratory distress  (IAGP)
small testis  (IAGP)
spina bifida  (IAGP)
spontaneous chromosome breakage  (IAGP)
thin dermal layer  (IAGP)
ureter obstruction  (IAGP)
uterus hyperplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Retroviral transduction of splice variant Brca1-Delta11 or mutant Brca1-W1777Stop causes mouse epithelial mammary atypical duct hyperplasia. Bachelier R, etal., Virchows Arch. 2002 Mar;440(3):261-6. Epub 2001 Sep 22.
2. Transcriptional regulation by p53. Beckerman R and Prives C, Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a000935. doi: 10.1101/cshperspect.a000935. Epub 2010 Apr 28.
3. Localization of human BRCA1 and BRCA2 in non-inherited colorectal carcinomas and matched normal mucosas. Bernard-Gallon DJ, etal., Anticancer Res. 2001 May-Jun;21(3B):2011-20.
4. Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. Cao L, etal., Genes Dev. 2003 Jan 15;17(2):201-13.
5. Cloning, genetic mapping and expression studies of the rat Brca1 gene. Chen KS, etal., Carcinogenesis 1996 Aug;17(8):1561-6.
6. Allelic imbalance in BRCA1 and BRCA2 gene expression is associated with an increased breast cancer risk. Chen X, etal., Hum Mol Genet. 2008 May 1;17(9):1336-48. Epub 2008 Jan 19.
7. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. de Lecea L, etal., Proc Natl Acad Sci U S A 1998 Jan 6;95(1):322-7.
8. Low levels of BRCA1 protein expression predict a worse prognosis in stage I-II colon cancer. Du C, etal., Int J Biol Markers. 2021 Mar;36(1):47-53. doi: 10.1177/1724600820986572. Epub 2021 Feb 14.
9. Risks of cancer in BRCA1-mutation carriers. Breast Cancer Linkage Consortium. Ford D, etal., Lancet. 1994 Mar 19;343(8899):692-5.
10. Prevalent somatic BRCA1 mutations shape clinically relevant genomic patterns of nasopharyngeal carcinoma in Southeast Europe. Fountzilas G, etal., Int J Cancer. 2018 Jan 1;142(1):66-80. doi: 10.1002/ijc.31023. Epub 2017 Sep 30.
11. Correlation between BRCA1 expression and clinicopathological factors including brain metastases in patients with non-small-cell lung cancer. Gachechiladze M, etal., Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2013 Sep;157(3):227-32. doi: 10.5507/bp.2012.099. Epub 2012 Nov 1.
12. Expression of DNA double-strand break repair proteins ATM and BRCA1 predicts survival in colorectal cancer. Grabsch H, etal., Clin Cancer Res. 2006 Mar 1;12(5):1494-500. doi: 10.1158/1078-0432.CCR-05-2105.
13. Methylation of breast cancer susceptibility gene 1 (BRCA1) predicts recurrence in patients with curatively resected stage I non-small cell lung cancer. Harada H, etal., Cancer. 2013 Feb 15;119(4):792-8. doi: 10.1002/cncr.27754. Epub 2013 Jan 18.
14. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
15. Growth retardation and tumour inhibition by BRCA1. Holt JT, etal., Nat Genet. 1996 Mar;12(3):298-302. doi: 10.1038/ng0396-298.
16. Effects of BRCA1 transgene expression on murine mammary gland development and mutagen-induced mammary neoplasia. Hoshino A, etal., Int J Biol Sci. 2007 Apr 25;3(5):281-91.
17. Differing effects of adjuvant chemotherapy according to BRCA1 nuclear expression in gastric cancer. Kim JW, etal., Cancer Chemother Pharmacol. 2013 Jun;71(6):1435-43. doi: 10.1007/s00280-013-2141-x. Epub 2013 Apr 30.
18. Structural analysis and chromosomal localization of the mouse Psmb5 gene coding for the constitutively expressed beta-type proteasome subunit. Kohda K, etal., Immunogenetics 1997;47(1):77-87.
19. Evaluation of the protective effect of Nigella sativa extract and its primary active component thymoquinone against DMBA-induced breast cancer in female rats. Linjawi SA, etal., Arch Med Sci. 2015 Mar 16;11(1):220-9. doi: 10.5114/aoms.2013.33329. Epub 2013 Feb 28.
20. BRCA1 shields vascular smooth muscle cells from oxidative stress. Lovren F, etal., J Thorac Cardiovasc Surg. 2014 Jun;147(6):1946-55, 1955.e1. doi: 10.1016/j.jtcvs.2013.09.060. Epub 2013 Nov 13.
21. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
22. MGDs mouse GO annotations MGD data from the GO Consortium
23. MGD IEA MGD IEA
24. Prostate cancer in male BRCA1 and BRCA2 mutation carriers has a more aggressive phenotype. Mitra A, etal., Br J Cancer. 2008 Jan 29;98(2):502-7. Epub 2008 Jan 8.
25. Prostate cancer in male BRCA1 and BRCA2 mutation carriers has a more aggressive phenotype. Mitra A, etal., Br J Cancer. 2008 Jan 8;.
26. Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcome. Narayan G, etal., Mol Cancer. 2003 May 13;2:24.
27. Oral contraceptives and the risk of hereditary ovarian cancer. Hereditary Ovarian Cancer Clinical Study Group. Narod SA, etal., N Engl J Med 1998 Aug 13;339(7):424-8.
28. Common mutations in BRCA1 and BRCA2 do not contribute to early prostate cancer in Jewish men. Nastiuk KL, etal., Prostate 1999 Aug 1;40(3):172-7.
29. Pathology of familial breast cancer: differences between breast cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases. Breast Cancer Linkage Consortium. NO_AUTHOR Lancet 1997 May 24;349(9064):1505-10.
30. Reduced Brca1 protein expression in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary carcinomas. Okochi E, etal., Mol Carcinog. 2002 Aug;34(4):211-8.
31. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
32. Double-strand break repair: 53BP1 comes into focus. Panier S and Boulton SJ, Nat Rev Mol Cell Biol. 2014 Jan;15(1):7-18. doi: 10.1038/nrm3719. Epub 2013 Dec 11.
33. Denaturing gradient gel electrophoresis screening of the BRCA1 gene in cells from precancerous cervical lesions. Park SJ, etal., J Reprod Med. 1999 Jul;44(7):575-80.
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
36. ERCC1 and BRCA1 mRNA expressions are associated with clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy. Qin X, etal., Tumour Biol. 2014 May;35(5):4697-704. doi: 10.1007/s13277-014-1615-8. Epub 2014 Jan 18.
37. Expression of BRCA1 protein in breast cancer and its prognostic significance. Rakha EA, etal., Hum Pathol. 2008 Apr 7;.
38. Mouse MP Annotation Import Pipeline RGD automated import pipeline
39. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Molecular characterization, homology modeling and docking studies of the R2787H missense variation in BRCA2 gene: Association with breast cancer. Riahi A, etal., J Theor Biol. 2016 Aug 21;403:188-196. doi: 10.1016/j.jtbi.2016.05.013. Epub 2016 May 19.
42. BRCA1-Associated Protein 1 (BAP1) Immunohistochemical Expression as a Diagnostic Tool in Malignant Pleural Mesothelioma Classification: A Large Retrospective Study. Righi L, etal., J Thorac Oncol. 2016 Nov;11(11):2006-2017. doi: 10.1016/j.jtho.2016.06.020. Epub 2016 Jul 13.
43. The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression. Shakya R, etal., Proc Natl Acad Sci U S A. 2008 May 13;105(19):7040-5. Epub 2008 Apr 28.
44. High incidence of mutations in BRCA1 and BRCA2 genes in ovarian cancer. Smirnova TY, etal., Bull Exp Biol Med. 2007 Jul;144(1):83-5.
45. BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with a BRCA1 tumour phenotype. Snell C, etal., Breast Cancer Res. 2008;10(1):R12. Epub 2008 Feb 12.
46. BRCA1 mutations and colorectal cancer in Poland. Suchy J, etal., Fam Cancer. 2010 Dec;9(4):541-4. doi: 10.1007/s10689-010-9378-x.
47. The functional BRCA1 rs799917 genetic polymorphism is associated with gastric cancer risk in a Chinese Han population. Wang K, etal., Tumour Biol. 2015 Jan;36(1):393-7. doi: 10.1007/s13277-014-2655-9. Epub 2014 Sep 30.
48. DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis. Xu Y Nat Rev Immunol. 2006 Apr;6(4):261-70.
49. A novel set of DNA methylation markers in urine sediments for sensitive/specific detection of bladder cancer. Yu J, etal., Clin Cancer Res. 2007 Dec 15;13(24):7296-304.
50. BRCA1a has antitumor activity in TN breast, ovarian and prostate cancers. Yuli C, etal., Oncogene. 2007 Sep 6;26(41):6031-7. doi: 10.1038/sj.onc.1210420. Epub 2007 Mar 26.
51. [Relationship between the protein expression of ERCC1, BRCA, β-tubulin and K-ras and the efficacy and prognosis in advanced non-small cell lung cancer]. Zhang L, etal., Zhonghua Zhong Liu Za Zhi. 2011 Mar;33(3):212-6.
52. A functional BRCA1 coding sequence genetic variant contributes to risk of esophageal squamous cell carcinoma. Zhang X, etal., Carcinogenesis. 2013 Oct;34(10):2309-13. doi: 10.1093/carcin/bgt213. Epub 2013 Jun 8.
53. Loss of BRCA1 expression leads to worse survival in patients with gastric carcinoma. Zhang ZZ, etal., World J Gastroenterol. 2013 Mar 28;19(12):1968-74. doi: 10.3748/wjg.v19.i12.1968.
Additional References at PubMed
PMID:1598904   PMID:1676470   PMID:2270482   PMID:7501018   PMID:7545954   PMID:7550308   PMID:7590247   PMID:8563759   PMID:8566965   PMID:8575748   PMID:8589722   PMID:8634697  
PMID:8634698   PMID:8637708   PMID:8673121   PMID:8674108   PMID:8698242   PMID:8760307   PMID:8833256   PMID:8872468   PMID:8889551   PMID:8917547   PMID:8975707   PMID:8982467  
PMID:9063750   PMID:9096121   PMID:9121124   PMID:9133444   PMID:9171368   PMID:9171369   PMID:9177778   PMID:9207798   PMID:9218537   PMID:9467943   PMID:9774970   PMID:9798686  
PMID:9799267   PMID:9838122   PMID:9872327   PMID:9892727   PMID:9917000   PMID:9950212   PMID:10087300   PMID:10195418   PMID:10198641   PMID:10319859   PMID:10349636   PMID:10433968  
PMID:10441734   PMID:10500182   PMID:10713690   PMID:10855792   PMID:10881179   PMID:10910057   PMID:10918303   PMID:10942534   PMID:10962568   PMID:11013085   PMID:11042159   PMID:11076861  
PMID:11077440   PMID:11156526   PMID:11156530   PMID:11170347   PMID:11172592   PMID:11181458   PMID:11217851   PMID:11353511   PMID:11358863   PMID:11376699   PMID:11420664   PMID:11431698  
PMID:11477095   PMID:11704837   PMID:11709723   PMID:11711534   PMID:11832208   PMID:11879563   PMID:11921186   PMID:11934988   PMID:12039951   PMID:12140760   PMID:12214252   PMID:12242698  
PMID:12360400   PMID:12419249   PMID:12466851   PMID:12477932   PMID:12483515   PMID:12485996   PMID:12520002   PMID:12531920   PMID:12555066   PMID:12557227   PMID:12573259   PMID:12637547  
PMID:12640109   PMID:12642502   PMID:12668603   PMID:12684687   PMID:12792649   PMID:12802282   PMID:12832489   PMID:12904583   PMID:12913077   PMID:12915453   PMID:12915465   PMID:12934101  
PMID:14560035   PMID:14610273   PMID:14612409   PMID:14636569   PMID:14654789   PMID:14681479   PMID:14729266   PMID:15033636   PMID:15123655   PMID:15131084   PMID:15159397   PMID:15175241  
PMID:15187254   PMID:15232000   PMID:15254237   PMID:15485900   PMID:15485917   PMID:15563594   PMID:15574597   PMID:15589157   PMID:15618518   PMID:15701640   PMID:15782115   PMID:15797026  
PMID:16108063   PMID:16109739   PMID:16141072   PMID:16141073   PMID:16179389   PMID:16204043   PMID:16211273   PMID:16446309   PMID:16522651   PMID:16585167   PMID:16651405   PMID:16675955  
PMID:16782705   PMID:16807234   PMID:16843262   PMID:16849561   PMID:16914727   PMID:16943438   PMID:16951165   PMID:16982732   PMID:16998503   PMID:17024228   PMID:17070800   PMID:17138902  
PMID:17145961   PMID:17212342   PMID:17318223   PMID:17363841   PMID:17397913   PMID:17420720   PMID:17493263   PMID:17496925   PMID:17626182   PMID:17626183   PMID:17653086   PMID:17656716  
PMID:17700520   PMID:17804718   PMID:18095153   PMID:18171670   PMID:18230721   PMID:18287559   PMID:18313945   PMID:18343216   PMID:18375767   PMID:18394172   PMID:18451150   PMID:18461147  
PMID:18588899   PMID:18596218   PMID:18663141   PMID:18678890   PMID:18765304   PMID:18799693   PMID:18809582   PMID:18851829   PMID:18974875   PMID:19015238   PMID:19048111   PMID:19067158  
PMID:19079346   PMID:19088202   PMID:19244116   PMID:19403657   PMID:19531582   PMID:19709408   PMID:19716796   PMID:19770520   PMID:19996295   PMID:20007691   PMID:20028858   PMID:20038817  
PMID:20046869   PMID:20046879   PMID:20059953   PMID:20080676   PMID:20145144   PMID:20175908   PMID:20211142   PMID:20230796   PMID:20362325   PMID:20473725   PMID:20484223   PMID:20551173  
PMID:20616007   PMID:20631063   PMID:20656689   PMID:20724228   PMID:20804975   PMID:20807817   PMID:20820192   PMID:20979543   PMID:21113097   PMID:21132007   PMID:21187397   PMID:21217819  
PMID:21267068   PMID:21396117   PMID:21459848   PMID:21478856   PMID:21501420   PMID:21507987   PMID:21677750   PMID:21680703   PMID:21709021   PMID:21737879   PMID:21765473   PMID:21846369  
PMID:21873635   PMID:21901007   PMID:21933912   PMID:22034435   PMID:22172724   PMID:22186889   PMID:22262859   PMID:22346761   PMID:22369660   PMID:22396490   PMID:22445450   PMID:22445484  
PMID:22488153   PMID:22492723   PMID:22539352   PMID:22549958   PMID:22560297   PMID:22580959   PMID:22617326   PMID:22665067   PMID:22666314   PMID:22767648   PMID:22777348   PMID:22789542  
PMID:22915751   PMID:22988430   PMID:23039116   PMID:23103855   PMID:23173005   PMID:23204224   PMID:23243027   PMID:23246963   PMID:23271346   PMID:23317938   PMID:23319656   PMID:23408054  
PMID:23415688   PMID:23436574   PMID:23447579   PMID:23509290   PMID:23624935   PMID:23657012   PMID:23664366   PMID:23712259   PMID:23727112   PMID:23850973   PMID:23857982   PMID:23863842  
PMID:23880761   PMID:23892456   PMID:23901102   PMID:24013561   PMID:24120138   PMID:24220145   PMID:24332043   PMID:24565757   PMID:24567396   PMID:24569637   PMID:24639535   PMID:24748377  
PMID:24776801   PMID:24829461   PMID:24842372   PMID:24913804   PMID:24914237   PMID:24966277   PMID:25016020   PMID:25066119   PMID:25079327   PMID:25176624   PMID:25239453   PMID:25400280  
PMID:25483082   PMID:25522274   PMID:25582120   PMID:25703348   PMID:25943777   PMID:26100884   PMID:26123487   PMID:26227626   PMID:26363031   PMID:26365490   PMID:26443207   PMID:26490168  
PMID:26496610   PMID:26509798   PMID:26575024   PMID:26615780   PMID:26629949   PMID:26644450   PMID:26658019   PMID:26774285   PMID:26903517   PMID:26916217   PMID:26941120   PMID:27073218  
PMID:27107135   PMID:27220670   PMID:27292187   PMID:27295426   PMID:27322743   PMID:27340177   PMID:27402769   PMID:27454287   PMID:27550455   PMID:27625309   PMID:27653681   PMID:27670884  
PMID:27694478   PMID:27739607   PMID:27760317   PMID:27798604   PMID:27811360   PMID:27815389   PMID:27869163   PMID:27923913   PMID:27943283   PMID:28115467   PMID:28122244   PMID:28190767  
PMID:28278054   PMID:28283467   PMID:28297660   PMID:28552778   PMID:28592566   PMID:28608929   PMID:28649985   PMID:28659469   PMID:29109428   PMID:29120748   PMID:29168504   PMID:29203461  
PMID:29401626   PMID:29426838   PMID:29497033   PMID:29632206   PMID:29709199   PMID:29718910   PMID:29739757   PMID:29768208   PMID:29877575   PMID:29894693   PMID:29938573   PMID:29996906  
PMID:30014904   PMID:30017478   PMID:30022158   PMID:30036938   PMID:30174241   PMID:30244837   PMID:30257212   PMID:30289697   PMID:30352856   PMID:30393076   PMID:30416390   PMID:30443181  
PMID:30445628   PMID:30456390   PMID:30484104   PMID:30530501   PMID:30540933   PMID:30556208   PMID:30590041   PMID:30652068   PMID:30657944   PMID:30674894   PMID:30704900   PMID:30733279  
PMID:30995416   PMID:31233030   PMID:31242413   PMID:31251913   PMID:31367040   PMID:31446616   PMID:31453335   PMID:31541646   PMID:31653568   PMID:31839538   PMID:31877165   PMID:31911557  
PMID:31916095   PMID:32051414   PMID:32053991   PMID:32139898   PMID:32325033   PMID:32359443   PMID:32513774   PMID:32580962   PMID:32591500   PMID:32758484   PMID:32840210   PMID:32978388  
PMID:32989256   PMID:33441637   PMID:33686070   PMID:33798452   PMID:33854442   PMID:33857404   PMID:33882298   PMID:33953351   PMID:33969421   PMID:34090924   PMID:34329741   PMID:34421362  
PMID:34548335   PMID:34555355   PMID:34607954   PMID:34746147   PMID:34815798   PMID:35236825   PMID:35310947   PMID:35393420   PMID:35409089   PMID:35601919   PMID:35648791  


Genomics

Comparative Map Data
Brca1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,379,587 - 101,442,808 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,379,590 - 101,442,781 (-)EnsemblGRCm39 Ensembl
GRCm3811101,488,761 - 101,551,955 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,488,764 - 101,551,955 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,350,078 - 101,413,269 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,304,854 - 101,365,210 (-)NCBIMGSCv36mm8
Celera11113,175,987 - 113,239,169 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1165.18NCBI
BRCA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381743,044,295 - 43,125,364 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1743,044,295 - 43,170,245 (-)EnsemblGRCh38hg38GRCh38
GRCh371741,196,312 - 41,277,381 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,449,840 - 38,530,994 (-)NCBINCBI36Build 36hg18NCBI36
Build 341738,449,843 - 38,530,934NCBI
Celera1737,853,171 - 37,934,354 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1736,962,663 - 37,043,809 (-)NCBIHuRef
CHM1_11741,431,851 - 41,513,018 (-)NCBICHM1_1
T2T-CHM13v2.01743,902,857 - 43,983,996 (-)NCBIT2T-CHM13v2.0
Brca1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21086,417,441 - 86,477,762 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,418,000 - 86,477,304 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,454,623 - 91,513,795 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01090,930,035 - 90,990,102 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01086,323,338 - 86,383,395 (-)NCBIRnor_WKY
Rnor_6.01089,394,821 - 89,455,093 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,394,803 - 89,454,681 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,192,653 - 89,252,760 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,513,630 - 90,572,676 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,527,999 - 90,587,046 (-)NCBI
Celera1085,140,052 - 85,200,670 (-)NCBICelera
Cytogenetic Map10q31NCBI
Brca1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,819,023 - 16,855,528 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,819,463 - 16,870,780 (-)NCBIChiLan1.0ChiLan1.0
BRCA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11714,429,601 - 14,506,815 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,428,526 - 14,506,815 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01714,197,946 - 14,279,064 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
BRCA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,958,941 - 20,025,494 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,958,391 - 20,025,494 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,422,566 - 19,486,083 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,677,057 - 20,743,989 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,677,128 - 20,743,989 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,464,421 - 19,527,988 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0919,730,981 - 19,794,752 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0919,833,116 - 19,896,786 (+)NCBIUU_Cfam_GSD_1.0
Brca1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,272,096 - 19,340,929 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493649017,735,444 - 17,801,456 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRCA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1219,786,020 - 19,854,668 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11219,788,087 - 19,854,515 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,028,878 - 20,093,800 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BRCA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,162,827 - 63,243,928 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607733,932,799 - 34,042,352 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Brca1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,188,136 - 1,241,964 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,186,043 - 1,238,986 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
U36475  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,489,545 - 101,489,696UniSTSGRCm38
MGSCv3711101,350,859 - 101,351,010UniSTSGRCm37
Celera11113,176,768 - 113,176,919UniSTS
Cytogenetic Map11DUniSTS
cM Map1160.5UniSTS
Whitehead/MRC_RH111352.0UniSTS
Whitehead_YAC11 UniSTS
D11Mit200  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,545,590 - 101,545,714UniSTSGRCm38
MGSCv3711101,406,904 - 101,407,028UniSTSGRCm37
Celera11113,232,802 - 113,232,928UniSTS
Cytogenetic Map11DUniSTS
cM Map1162.0UniSTS
Whitehead Genetic1163.4UniSTS
Whitehead_YAC11 UniSTS
Brca1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11DUniSTS
cM Map1160.5UniSTS
Brca1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,535,822 - 101,536,190UniSTSGRCm38
MGSCv3711101,397,136 - 101,397,504UniSTSGRCm37
Celera11113,223,034 - 113,223,402UniSTS
Cytogenetic Map11DUniSTS
cM Map1160.5UniSTS
Brca1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11DUniSTS
cM Map1160.5UniSTS
U36475  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,489,609 - 101,489,731UniSTSGRCm38
MGSCv3711101,350,923 - 101,351,045UniSTSGRCm37
Celera11113,176,832 - 113,176,954UniSTS
Cytogenetic Map11DUniSTS
Whitehead/MRC_RH111352.0UniSTS
Brca1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11DUniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse
13513919Heal56_mwound healing/ regeneration 56 (mouse)11101156468101540293Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir17mmu-miR-17-5pOncomiRDBexternal_infoNANA19048628
Mir182mmu-miR-182-5pOncomiRDBexternal_infoNANA21195000
Mir146mmu-miR-146a-5pOncomiRDBexternal_infoNANA21472990
Mir146bmmu-miR-146b-5pOncomiRDBexternal_infoNANA21472990

Predicted Target Of
Summary Value
Count of predictions:632
Count of miRNA genes:450
Interacting mature miRNAs:522
Transcripts:ENSMUST00000017290, ENSMUST00000131460, ENSMUST00000142086, ENSMUST00000156843
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_009764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004936704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB221610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB221611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF080589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL590996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB662609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC068303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU349657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ497232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ589202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC124947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN228637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U31625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U32446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U32585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U33835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U35641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U36475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U68174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U73040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000017290   ⟹   ENSMUSP00000017290
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,379,590 - 101,442,705 (-)Ensembl
GRCm38.p6 Ensembl11101,488,764 - 101,551,879 (-)Ensembl
RefSeq Acc Id: ENSMUST00000131460
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,403,337 - 101,413,285 (-)Ensembl
GRCm38.p6 Ensembl11101,512,511 - 101,522,459 (-)Ensembl
RefSeq Acc Id: ENSMUST00000142086   ⟹   ENSMUSP00000139813
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,416,333 - 101,442,781 (-)Ensembl
GRCm38.p6 Ensembl11101,525,507 - 101,551,955 (-)Ensembl
RefSeq Acc Id: ENSMUST00000156843
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,387,141 - 101,399,004 (-)Ensembl
GRCm38.p6 Ensembl11101,496,315 - 101,508,178 (-)Ensembl
RefSeq Acc Id: ENSMUST00000188168
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,415,033 - 101,416,032 (-)Ensembl
GRCm38.p6 Ensembl11101,524,207 - 101,525,206 (-)Ensembl
RefSeq Acc Id: ENSMUST00000190862   ⟹   ENSMUSP00000139599
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,422,909 - 101,442,408 (-)Ensembl
GRCm38.p6 Ensembl11101,532,083 - 101,551,582 (-)Ensembl
RefSeq Acc Id: ENSMUST00000191198   ⟹   ENSMUSP00000139737
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,415,019 - 101,415,684 (-)Ensembl
GRCm38.p6 Ensembl11101,524,193 - 101,524,858 (-)Ensembl
RefSeq Acc Id: NM_009764   ⟹   NP_033894
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,379,590 - 101,442,781 (-)NCBI
GRCm3811101,488,764 - 101,551,955 (-)NCBI
MGSCv3711101,350,078 - 101,413,269 (-)RGD
Celera11113,175,987 - 113,239,169 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006532064   ⟹   XP_006532127
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,379,587 - 101,442,808 (-)NCBI
GRCm3811101,488,761 - 101,551,952 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006532068   ⟹   XP_006532131
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,379,587 - 101,442,808 (-)NCBI
GRCm3811101,488,761 - 101,551,952 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030245495   ⟹   XP_030101355
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,379,590 - 101,441,841 (-)NCBI
GRCm3811101,489,354 - 101,551,016 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036156253   ⟹   XP_036012146
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,379,590 - 101,442,774 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004936704
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,379,587 - 101,442,808 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_033894 (Get FASTA)   NCBI Sequence Viewer  
  XP_006532127 (Get FASTA)   NCBI Sequence Viewer  
  XP_006532131 (Get FASTA)   NCBI Sequence Viewer  
  XP_030101355 (Get FASTA)   NCBI Sequence Viewer  
  XP_036012146 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA96393 (Get FASTA)   NCBI Sequence Viewer  
  AAA99742 (Get FASTA)   NCBI Sequence Viewer  
  AAB17113 (Get FASTA)   NCBI Sequence Viewer  
  AAB17114 (Get FASTA)   NCBI Sequence Viewer  
  AAC52323 (Get FASTA)   NCBI Sequence Viewer  
  AAD00168 (Get FASTA)   NCBI Sequence Viewer  
  AAH03248 (Get FASTA)   NCBI Sequence Viewer  
  AAH68303 (Get FASTA)   NCBI Sequence Viewer  
  ABY60627 (Get FASTA)   NCBI Sequence Viewer  
  ACK87008 (Get FASTA)   NCBI Sequence Viewer  
  ACM24793 (Get FASTA)   NCBI Sequence Viewer  
  BAE26023 (Get FASTA)   NCBI Sequence Viewer  
  BAV56142 (Get FASTA)   NCBI Sequence Viewer  
  EDL34053 (Get FASTA)   NCBI Sequence Viewer  
  P48754 (Get FASTA)   NCBI Sequence Viewer  
  QJW38966 (Get FASTA)   NCBI Sequence Viewer  
  QJW38967 (Get FASTA)   NCBI Sequence Viewer  
  QJW38968 (Get FASTA)   NCBI Sequence Viewer  
  QJW38969 (Get FASTA)   NCBI Sequence Viewer  
  QJW38970 (Get FASTA)   NCBI Sequence Viewer  
  QJW38971 (Get FASTA)   NCBI Sequence Viewer  
  QJW38972 (Get FASTA)   NCBI Sequence Viewer  
  QJW38973 (Get FASTA)   NCBI Sequence Viewer  
  QJW38974 (Get FASTA)   NCBI Sequence Viewer  
  QJW38975 (Get FASTA)   NCBI Sequence Viewer  
  QJW38976 (Get FASTA)   NCBI Sequence Viewer  
  QJW38977 (Get FASTA)   NCBI Sequence Viewer  
  QJW38978 (Get FASTA)   NCBI Sequence Viewer  
  QJW38979 (Get FASTA)   NCBI Sequence Viewer  
  QJW38980 (Get FASTA)   NCBI Sequence Viewer  
  QJW38981 (Get FASTA)   NCBI Sequence Viewer  
  QJW38982 (Get FASTA)   NCBI Sequence Viewer  
  QJW38983 (Get FASTA)   NCBI Sequence Viewer  
  QJW38984 (Get FASTA)   NCBI Sequence Viewer  
  QJW38985 (Get FASTA)   NCBI Sequence Viewer  
  QJW38986 (Get FASTA)   NCBI Sequence Viewer  
  QJW38987 (Get FASTA)   NCBI Sequence Viewer  
  QJW38988 (Get FASTA)   NCBI Sequence Viewer  
  QJW38989 (Get FASTA)   NCBI Sequence Viewer  
  QJW38990 (Get FASTA)   NCBI Sequence Viewer  
  QJW38991 (Get FASTA)   NCBI Sequence Viewer  
  QJW38992 (Get FASTA)   NCBI Sequence Viewer  
  QJW38993 (Get FASTA)   NCBI Sequence Viewer  
  QJW38994 (Get FASTA)   NCBI Sequence Viewer  
  QJW38995 (Get FASTA)   NCBI Sequence Viewer  
  QJW38996 (Get FASTA)   NCBI Sequence Viewer  
  QJW38997 (Get FASTA)   NCBI Sequence Viewer  
  QJW38998 (Get FASTA)   NCBI Sequence Viewer  
  QJW38999 (Get FASTA)   NCBI Sequence Viewer  
  QJW39000 (Get FASTA)   NCBI Sequence Viewer  
  QJW39001 (Get FASTA)   NCBI Sequence Viewer  
  QJW39002 (Get FASTA)   NCBI Sequence Viewer  
  QJW39003 (Get FASTA)   NCBI Sequence Viewer  
  QJW39004 (Get FASTA)   NCBI Sequence Viewer  
  QJW39005 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_033894   ⟸   NM_009764
- UniProtKB: Q60983 (UniProtKB/Swiss-Prot),   P48754 (UniProtKB/Swiss-Prot),   Q6NV63 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006532127   ⟸   XM_006532064
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006532131   ⟸   XM_006532068
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_030101355   ⟸   XM_030245495
- Peptide Label: isoform X1
- UniProtKB: Q60983 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSMUSP00000139737   ⟸   ENSMUST00000191198
RefSeq Acc Id: ENSMUSP00000139599   ⟸   ENSMUST00000190862
RefSeq Acc Id: ENSMUSP00000017290   ⟸   ENSMUST00000017290
RefSeq Acc Id: ENSMUSP00000139813   ⟸   ENSMUST00000142086
RefSeq Acc Id: XP_036012146   ⟸   XM_036156253
- Peptide Label: isoform X3
Protein Domains
BRCT   BRCT_assoc   RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48754-F1-model_v2 AlphaFold P48754 1-1812 view protein structure

Promoters
RGD ID:6820501
Promoter ID:MM_KWN:9905
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000103098,   ENSMUST00000103099,   ENSMUST00000107208,   ENSMUST00000107212,   ENSMUST00000107213,   NM_009764,   OTTMUST00000005870,   OTTMUST00000005877,   OTTMUST00000005883,   OTTMUST00000005887,   OTTMUST00000005889,   UC007LPE.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611101,413,476 - 101,414,637 (-)MPROMDB
RGD ID:8676812
Promoter ID:EPDNEW_M16436
Type:initiation region
Name:Brca1_1
Description:Mus musculus breast cancer 1, early onset , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811101,551,862 - 101,551,922EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104537 AgrOrtholog
Ensembl Genes ENSMUSG00000017146 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000017290 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000139599.2 UniProtKB/TrEMBL
  ENSMUSP00000139737.2 UniProtKB/TrEMBL
  ENSMUSP00000139813.2 UniProtKB/TrEMBL