Ranbp2 (RAN binding protein 2) - Rat Genome Database

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Gene: Ranbp2 (RAN binding protein 2) Mus musculus
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Symbol: Ranbp2
Name: RAN binding protein 2
RGD ID: 1558482
MGI Page MGI
Description: Exhibits SUMO transferase activity. Is predicted to contribute to GTPase activator activity. Involved in positive regulation of glucokinase activity and regulation of gluconeogenesis. Localizes to mitochondrion. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; hemolymphoid system; and nervous system. Human ortholog(s) of this gene implicated in brain disease and inflammatory myofibroblastic tumor. Orthologous to several human genes including RANBP2 (RAN binding protein 2); PARTICIPATES IN CRM1 export pathway; mitochondria transport pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A430087B05Rik; AI256741; E3 SUMO-protein ligase RanBP2; E3 SUMO-protein transferase RanBP2; NUP358; ran-binding protein 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Related Pseudogenes: Ranbp2-ps2  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391058,282,674 - 58,329,977 (+)NCBIGRCm39mm39
GRCm39 Ensembl1058,282,742 - 58,330,178 (+)Ensembl
GRCm381058,446,852 - 58,494,155 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1058,446,920 - 58,494,356 (+)EnsemblGRCm38mm10GRCm38
MGSCv371057,909,600 - 57,956,903 (+)NCBIGRCm37mm9NCBIm37
MGSCv361057,842,209 - 57,889,512 (+)NCBImm8
Celera1059,184,895 - 59,203,874 (+)NCBICelera
Celera712,211,992 - 12,212,429 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1029.34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7559465   PMID:8603673   PMID:8857542   PMID:8889548   PMID:9037092   PMID:9733766   PMID:10349636   PMID:10601307   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11353387  
PMID:11553612   PMID:12191015   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:14697343   PMID:16141072   PMID:16141073   PMID:16332688   PMID:16452087   PMID:17372272  
PMID:17887960   PMID:18394993   PMID:18949001   PMID:20360068   PMID:20682751   PMID:21205196   PMID:21267068   PMID:21670213   PMID:21677750   PMID:21859863   PMID:21873635   PMID:22262462  
PMID:22922362   PMID:23536549   PMID:23818861   PMID:23892456   PMID:24194600   PMID:24403063   PMID:24457600   PMID:25187515   PMID:26365490   PMID:26496610   PMID:26632511   PMID:27412403  
PMID:27626380   PMID:27746211   PMID:28100513   PMID:28378742   PMID:28671696   PMID:28745977   PMID:28877029   PMID:30196744   PMID:30457570   PMID:30944974   PMID:31077711   PMID:31427429  
PMID:32325033  


Genomics

Comparative Map Data
Ranbp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391058,282,674 - 58,329,977 (+)NCBIGRCm39mm39
GRCm39 Ensembl1058,282,742 - 58,330,178 (+)Ensembl
GRCm381058,446,852 - 58,494,155 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1058,446,920 - 58,494,356 (+)EnsemblGRCm38mm10GRCm38
MGSCv371057,909,600 - 57,956,903 (+)NCBIGRCm37mm9NCBIm37
MGSCv361057,842,209 - 57,889,512 (+)NCBImm8
Celera1059,184,895 - 59,203,874 (+)NCBICelera
Celera712,211,992 - 12,212,429 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1029.34NCBI
RANBP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2108,719,482 - 108,785,809 (+)EnsemblGRCh38hg38GRCh38
GRCh382108,719,446 - 108,785,809 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372109,335,938 - 109,402,265 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362108,702,369 - 108,768,699 (+)NCBINCBI36hg18NCBI36
Build 342108,794,454 - 108,859,768NCBI
Celera2103,645,916 - 103,712,243 (+)NCBI
Cytogenetic Map2q13NCBI
HuRef2102,934,349 - 103,000,733 (+)NCBIHuRef
CHM1_12109,340,280 - 109,406,595 (+)NCBICHM1_1
Ranbp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22026,442,156 - 26,493,481 (+)NCBI
Rnor_6.0 Ensembl2028,365,988 - 28,375,791 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl2028,027,054 - 28,076,664 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02028,027,054 - 28,076,664 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.02028,365,538 - 28,375,676 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02030,181,409 - 30,191,111 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02029,846,539 - 29,896,149 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42037,271,467 - 37,322,723 (-)NCBIRGSC3.4rn4RGSC3.4
Celera2027,892,535 - 27,943,825 (+)NCBICelera
Cytogenetic Map20q11NCBI
Ranbp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547012,180,544 - 12,249,555 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547012,180,426 - 12,247,737 (+)NCBIChiLan1.0ChiLan1.0
LOC100989340
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A110,010,961 - 110,039,769 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v02A94,961,024 - 95,029,437 (+)NCBIMhudiblu_PPA_v0panPan3
RANBP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11035,088,175 - 35,181,248 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1035,088,872 - 35,181,129 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1035,010,394 - 35,103,514 (-)NCBI
ROS_Cfam_1.01035,940,061 - 36,033,454 (-)NCBI
UMICH_Zoey_3.11035,669,581 - 35,762,815 (-)NCBI
UNSW_CanFamBas_1.01035,952,703 - 36,045,859 (-)NCBI
UU_Cfam_GSD_1.01036,144,312 - 36,238,211 (-)NCBI
Ranbp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629292,063,973 - 92,136,842 (-)NCBI
SpeTri2.0NW_004936829261,017 - 333,910 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100511376
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl347,531,358 - 47,601,379 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1347,531,362 - 47,601,328 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2349,693,982 - 49,735,050 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RANBP2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11412,250,986 - 12,318,801 (+)NCBI
ChlSab1.1 Ensembl1412,251,007 - 12,319,735 (+)Ensembl

Position Markers
RH136086  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381058,493,067 - 58,493,784UniSTSGRCm38
MGSCv371057,955,815 - 57,956,532UniSTSGRCm37
Cytogenetic Map10B4UniSTS
cM Map1030.0UniSTS
Ranbp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381058,475,308 - 58,476,792UniSTSGRCm38
MGSCv371057,938,056 - 57,939,540UniSTSGRCm37
Cytogenetic Map10B4UniSTS
cM Map1030.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302092Ath11_matherosclerosis 11 (mouse)Not determined10620194558857699Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108359714116355075Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101023252187565233Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101282830784243920Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101282830784243920Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101282830784243920Mouse
1357893Lvrq4_mliver weight QTL 4 (mouse)Not determined101282830784243920Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1282830784243920Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1282830784243920Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1282830784243920Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1282830784243920Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101282830784243920Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018383585125739363Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1019000000129800000Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021532255114381325Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102171529368255809Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102300000091200000Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024800000121200000Mouse
1300898Cfid_mcystic fibrosis intestinal distress (mouse)Not determined102984430763844387Mouse
10045632Heal16_mwound healing/regeneration 16 (mouse)Not determined103109840365098534Mouse
1357558Bmch4_mbone mechanical trait 4 (mouse)Not determined103170104065701188Mouse
27095920Pglq9_mpelvic girdle length QTL 9, 10 week (mouse)103390000071000000Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039300000129800000Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039300000129800000Mouse
4141070Ltgq1_mliver triglyceride QTL 1 (mouse)Not determined4140150475401504Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1045000000116100000Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045600000120800000Mouse
26884421Cvht5_mcranial vault height 5, 10 week (mouse)104570000069300000Mouse
26884400Huml5_mhumerus length 5, 16 week (mouse)104640000069400000Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4684430782655287Mouse
4141159Phl2_mprogressive hearing loss 2 (mouse)Not determined104809840370276821Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104950223383502378Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined105001240884012633Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined105001240884012633Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined105001240884012633Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined105001244384012618Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined105001244384012618Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105125566085255809Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105125566085255809Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105161730482655287Mouse
14746991Manh68_mmandible shape 68 (mouse)105244466786444667Mouse
12904011Cfq11_mconditioned fear QTL 11 (mouse)105660406061105062Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:41
Interacting mature miRNAs:43
Transcripts:ENSMUST00000003310
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000003310   ⟹   ENSMUSP00000003310
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1058,446,922 - 58,494,356 (+)Ensembl
RefSeq Acc Id: ENSMUST00000219332
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1058,446,920 - 58,458,999 (+)Ensembl
RefSeq Acc Id: ENSMUST00000220131
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1058,447,195 - 58,460,973 (+)Ensembl
RefSeq Acc Id: NM_011240   ⟹   NP_035370
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391058,282,674 - 58,329,977 (+)NCBI
GRCm381058,446,852 - 58,494,155 (+)ENTREZGENE
MGSCv371057,909,600 - 57,956,903 (+)RGD
Celera1059,184,895 - 59,203,869 (+)ENTREZGENE
cM Map10 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035370   ⟸   NM_011240
- UniProtKB: Q9ERU9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000003310   ⟸   ENSMUST00000003310
Promoters
RGD ID:6819786
Promoter ID:MM_KWN:4195
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000003310,   UC007FDE.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361057,908,851 - 57,909,777 (+)MPROMDB
RGD ID:8672016
Promoter ID:EPDNEW_M14039
Type:initiation region
Name:Ranbp2_1
Description:Mus musculus RAN binding protein 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381058,446,892 - 58,446,952EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:894323 AgrOrtholog
Ensembl Genes ENSMUSG00000003226 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000003310 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000003310 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.100.10 UniProtKB/Swiss-Prot
InterPro Cyclophilin-like_dom_sf UniProtKB/Swiss-Prot
  Cyclophilin-type_PPIase_CS UniProtKB/Swiss-Prot
  Cyclophilin-type_PPIase_dom UniProtKB/Swiss-Prot
  IR1-M UniProtKB/Swiss-Prot
  Nucleoporin UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ran_bind_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR-contain_dom UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
  TPR_repeat UniProtKB/Swiss-Prot
  Znf_RanBP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RanBP2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19386 UniProtKB/Swiss-Prot
MGD MGI:894323 ENTREZGENE
NCBI Gene 19386 ENTREZGENE
PANTHER PTHR23193 UniProtKB/TrEMBL
Pfam IR1-M UniProtKB/Swiss-Prot
  Pro_isomerase UniProtKB/Swiss-Prot
  Ran_BP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-RanBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ranbp2 PhenoGen
PRINTS CSAPPISMRASE UniProtKB/Swiss-Prot
PROSITE CSA_PPIASE_1 UniProtKB/Swiss-Prot
  CSA_PPIASE_2 UniProtKB/Swiss-Prot
  RANBD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR UniProtKB/Swiss-Prot
  TPR_REGION UniProtKB/Swiss-Prot
  ZF_RANBP2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RANBP2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RanBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR UniProtKB/Swiss-Prot
  ZnF_RBZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot
  SSF50891 UniProtKB/Swiss-Prot
  SSF90209 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q3TYW0_MOUSE UniProtKB/TrEMBL
  Q8BQK6_MOUSE UniProtKB/TrEMBL
  Q9ERU9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary E9QM01 UniProtKB/Swiss-Prot
  Q61992 UniProtKB/Swiss-Prot
  Q8C9K9 UniProtKB/Swiss-Prot