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Gene: Serpine1 (serine (or cysteine) peptidase inhibitor, clade E, member 1) Mus musculus
Symbol: Serpine1
Name: serine (or cysteine) peptidase inhibitor, clade E, member 1
Description: Exhibits serine-type endopeptidase inhibitor activity. Involved in several processes, including defense response to Gram-negative bacterium; negative regulation of plasminogen activation; and regulation of angiogenesis. Localizes to extracellular space. Is expressed in several structures, including aorta; extraembryonic component; liver; oocyte; and placenta. Used to study severe acute respiratory syndrome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune hypersensitivity disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1); PARTICIPATES IN fibrinolysis pathway; hypoxia inducible factor pathway; oxygen homeostasis pathway; INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; 1,1-dichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: endothelial plasminogen activator inhibitor; nexin, plasminogen activator inhibitor type 1; PAI; PAI-1; PAI1; Planh1; plasminogen activator inhibitor 1; plasminogen activator inhibitor, type I; Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI); serine (or cysteine) proteinase inhibitor, clade E, member 1; serpin E1
Homo sapiens (human) : SERPINE1 (serpin family E member 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Serpine1 (serpin family E member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Serpine1 (serpin family E member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SERPINE1 (serpin family E member 1)
Canis lupus familiaris (dog) : SERPINE1 (serpin family E member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Serpine1 (serpin family E member 1)
Sus scrofa (pig) : SERPINE1 (serpin family E member 1)
Chlorocebus sabaeus (African green monkey) : SERPINE1 (serpin family E member 1)
Heterocephalus glaber (naked mole-rat) : Serpine1 (serpin family E member 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl5137,061,504 - 137,072,268 (-)EnsemblGRCm38mm10GRCm38
GRCm385137,061,504 - 137,072,272 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375137,537,374 - 137,548,142 (-)NCBIGRCm37mm9NCBIm37
MGSCv365137,346,135 - 137,356,886 (-)NCBImm8
Celera5134,078,340 - 134,089,224 (-)NCBICelera
Cytogenetic Map5G2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Serpine1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11055
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.