Srsf1 (serine and arginine-rich splicing factor 1) - Rat Genome Database

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Gene: Srsf1 (serine and arginine-rich splicing factor 1) Mus musculus
Analyze
Symbol: Srsf1
Name: serine and arginine-rich splicing factor 1
RGD ID: 1621394
MGI Page MGI
Description: Enables RS domain binding activity and mRNA binding activity. Involved in interleukin-17-mediated signaling pathway; protein localization to organelle; and regulation of gene expression. Acts upstream of or within RNA splicing; cardiac muscle contraction; and in utero embryonic development. Located in nuclear speck. Is expressed in several structures, including alimentary system; central nervous system; liver; sensory organ; and thymus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with dysmorphic facies and behavioral abnormalities. Orthologous to human SRSF1 (serine and arginine rich splicing factor 1).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 1110054N12Rik; 5730507C05Rik; 6330415C05Rik; AI482334; Asf; ASF/SF2; AW491331; pre-mRNA-splicing factor SRp30a; serine/arginine-rich splicing factor 1; Sf; Sf2; Sfrs1; splicing factor, arginine/serine-rich 1; splicing factor, arginine/serine-rich 1 (ASF/SF2)
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391187,937,325 - 87,944,583 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1187,938,199 - 87,944,581 (+)EnsemblGRCm39 Ensembl
GRCm381188,046,499 - 88,053,757 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1188,047,373 - 88,053,755 (+)EnsemblGRCm38mm10GRCm38
MGSCv371187,861,173 - 87,867,259 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361187,863,972 - 87,867,844 (+)NCBIMGSCv36mm8
Celera1187,395,560 - 87,401,471 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1152.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic UMP  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-nitrophenol  (EXP)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
AM-251  (ISO)
amitrole  (ISO)
antimony(0)  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
biochanin A  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Brodifacoum  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
choline  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (EXP)
diallyl trisulfide  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (ISO)
glyphosate  (EXP)
hydrogen cyanide  (EXP)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
leflunomide  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mitomycin C  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-nitrosodimethylamine  (ISO)
ochratoxin A  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
phenol  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
potassium cyanide  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (EXP)
selenium atom  (ISO)
silicon dioxide  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
trovafloxacin  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
2. Mitogenic insulin receptor-A is overexpressed in human hepatocellular carcinoma due to EGFR-mediated dysregulation of RNA splicing factors. Chettouh H, etal., Cancer Res. 2013 Jul 1;73(13):3974-86. doi: 10.1158/0008-5472.CAN-12-3824. Epub 2013 Apr 30.
3. The oncoprotein SF2/ASF promotes non-small cell lung cancer survival by enhancing survivin expression. Ezponda T, etal., Clin Cancer Res. 2010 Aug 15;16(16):4113-25. doi: 10.1158/1078-0432.CCR-10-0076. Epub 2010 Aug 3.
4. Abnormal expression of the pre-mRNA splicing regulators SRSF1, SRSF2, SRPK1 and SRPK2 in non small cell lung carcinoma. Gout S, etal., PLoS One. 2012;7(10):e46539. doi: 10.1371/journal.pone.0046539. Epub 2012 Oct 10.
5. Involvement of the dual-specificity tyrosine phosphorylation-regulated kinase 1A-alternative splicing factor-calcium/calmodulin-dependent protein kinase IIdelta signaling pathway in myocardial infarction-induced heart failure of rats. He J, etal., J Card Fail. 2015 Sep;21(9):751-60. doi: 10.1016/j.cardfail.2015.05.015. Epub 2015 Jun 9.
6. Alterations in expression pattern of splicing factors in epithelial ovarian cancer and its clinical impact. Iborra S, etal., Int J Gynecol Cancer. 2013 Jul;23(6):990-6. doi: 10.1097/IGC.0b013e31829783e3.
7. The gene encoding the splicing factor SF2/ASF is a proto-oncogene. Karni R, etal., Nat Struct Mol Biol. 2007 Mar;14(3):185-93. Epub 2007 Feb 18.
8. RNA splicing factors regulated by HPV16 during cervical tumour progression. Mole S, etal., J Pathol. 2009 Nov;219(3):383-91. doi: 10.1002/path.2608.
9. Alternative splicing of iodothyronine deiodinases in pituitary adenomas. Regulation by oncoprotein SF2/ASF. Piekielko-Witkowska A, etal., Biochim Biophys Acta. 2013 Jun;1832(6):763-72. doi: 10.1016/j.bbadis.2013.02.013. Epub 2013 Feb 24.
10. Disturbed expression of splicing factors in renal cancer affects alternative splicing of apoptosis regulators, oncogenes, and tumor suppressors. Piekielko-Witkowska A, etal., PLoS One. 2010 Oct 27;5(10):e13690. doi: 10.1371/journal.pone.0013690.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Alternative splicing of SLC39A14 in colorectal cancer is regulated by the Wnt pathway. Thorsen K, etal., Mol Cell Proteomics. 2011 Jan;10(1):M110.002998. doi: 10.1074/mcp.M110.002998. Epub 2010 Oct 11.
15. The spliceosome: design principles of a dynamic RNP machine. Wahl MC, etal., Cell. 2009 Feb 20;136(4):701-18. doi: 10.1016/j.cell.2009.02.009.
16. Alternative splicing factor ASF/SF2 is down regulated in inflamed muscle. Xiong Z, etal., J Clin Pathol. 2006 Aug;59(8):855-61. Epub 2006 Mar 30.
17. Dyrk1A-ASF-CaMKIIδ Signaling Is Involved in Valsartan Inhibition of Cardiac Hypertrophy in Renovascular Hypertensive Rats. Yao J, etal., Cardiology. 2016;133(3):198-204. doi: 10.1159/000441695. Epub 2015 Dec 1.
18. Relative amounts of antagonistic splicing factors, hnRNP A1 and ASF/SF2, change during neoplastic lung growth: implications for pre-mRNA processing. Zerbe LK, etal., Mol Carcinog. 2004 Dec;41(4):187-96.
19. Alternative expression of TCRzeta related genes in patients with chronic myeloid leukemia. Zha X, etal., J Hematol Oncol. 2012 Dec 10;5:74. doi: 10.1186/1756-8722-5-74.
Additional References at PubMed
PMID:1437571   PMID:2030943   PMID:8530103   PMID:8617202   PMID:8798720   PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11544199  
PMID:11925564   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15306695   PMID:15356259   PMID:15489334   PMID:15615787   PMID:15652482   PMID:15782199   PMID:15798186   PMID:16033648  
PMID:16107646   PMID:16141072   PMID:16141073   PMID:16285923   PMID:16602821   PMID:18799693   PMID:18987029   PMID:19218444   PMID:19379695   PMID:19729518   PMID:20477871   PMID:20516191  
PMID:20558599   PMID:20657585   PMID:20729808   PMID:20923760   PMID:21135118   PMID:21191184   PMID:21267068   PMID:21677750   PMID:21822258   PMID:21873635   PMID:21984414   PMID:22354994  
PMID:22718948   PMID:22855529   PMID:23042150   PMID:23478443   PMID:23562324   PMID:23604122   PMID:23663783   PMID:23843040   PMID:24457600   PMID:24552714   PMID:26336360   PMID:26370502  
PMID:26496610   PMID:27022105   PMID:27496889   PMID:27616424   PMID:28378742   PMID:28444861   PMID:28671696   PMID:28785060   PMID:28799539   PMID:29055695   PMID:29120871   PMID:29233683  
PMID:29262322   PMID:29563620   PMID:30457570   PMID:30550785   PMID:31077711   PMID:31138677   PMID:31487268   PMID:32325033   PMID:32338600   PMID:32810232   PMID:32888503   PMID:32964995  
PMID:33452620   PMID:33607522   PMID:33863728   PMID:33981019   PMID:34195277   PMID:34233194   PMID:34338635   PMID:34522020   PMID:34839165   PMID:35012549   PMID:35154164   PMID:35202586  
PMID:36114006   PMID:36189299   PMID:36280202   PMID:36293380   PMID:36368121   PMID:36759613   PMID:36882745   PMID:37098965   PMID:37179228   PMID:37697438   PMID:37907803   PMID:38200098  
PMID:38271475  


Genomics

Comparative Map Data
Srsf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391187,937,325 - 87,944,583 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1187,938,199 - 87,944,581 (+)EnsemblGRCm39 Ensembl
GRCm381188,046,499 - 88,053,757 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1188,047,373 - 88,053,755 (+)EnsemblGRCm38mm10GRCm38
MGSCv371187,861,173 - 87,867,259 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361187,863,972 - 87,867,844 (+)NCBIMGSCv36mm8
Celera1187,395,560 - 87,401,471 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1152.4NCBI
SRSF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381757,989,038 - 58,007,246 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1758,000,919 - 58,007,346 (-)EnsemblGRCh38hg38GRCh38
GRCh371756,078,280 - 56,084,607 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361753,433,279 - 53,439,706 (-)NCBINCBI36Build 36hg18NCBI36
Build 341753,435,853 - 53,439,587NCBI
Celera1752,540,069 - 52,546,497 (-)NCBICelera
Cytogenetic Map17q22NCBI
HuRef1751,439,237 - 51,445,664 (-)NCBIHuRef
CHM1_11756,143,411 - 56,149,838 (-)NCBICHM1_1
T2T-CHM13v2.01758,863,040 - 58,881,254 (-)NCBIT2T-CHM13v2.0
Srsf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81073,335,519 - 73,342,549 (+)NCBIGRCr8
mRatBN7.21072,838,926 - 72,859,066 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1072,839,274 - 72,845,336 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1077,449,632 - 77,455,683 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01076,954,574 - 76,960,625 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01072,419,074 - 72,425,125 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01075,334,200 - 75,341,197 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1075,335,146 - 75,341,197 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01074,759,412 - 74,765,821 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41076,339,824 - 76,344,552 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1071,749,406 - 71,755,457 (+)NCBICelera
Cytogenetic Map10q26NCBI
Srsf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554514,992,634 - 4,999,029 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554514,992,634 - 4,996,619 (+)NCBIChiLan1.0ChiLan1.0
SRSF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21974,179,536 - 74,185,632 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11778,975,993 - 78,996,573 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01752,083,676 - 52,087,454 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11756,937,295 - 56,944,874 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1756,937,295 - 56,944,425 (-)Ensemblpanpan1.1panPan2
SRSF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1932,692,517 - 32,696,325 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl932,694,073 - 32,696,285 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha931,930,816 - 31,934,636 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0933,500,269 - 33,504,092 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl933,500,274 - 33,504,046 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1932,284,909 - 32,288,729 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0932,568,190 - 32,572,012 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0932,651,906 - 32,655,725 (-)NCBIUU_Cfam_GSD_1.0
Srsf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560232,015,932 - 32,019,748 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364905,055,253 - 5,059,116 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364905,055,258 - 5,059,118 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRSF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1234,272,956 - 34,282,162 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11234,278,363 - 34,282,164 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21235,278,498 - 35,284,062 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRSF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11635,392,573 - 35,396,815 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1635,392,873 - 35,394,982 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660776,208,339 - 6,216,079 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Srsf1
51 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2474
Count of miRNA genes:808
Interacting mature miRNAs:1061
Transcripts:ENSMUST00000079866, ENSMUST00000107920, ENSMUST00000132983, ENSMUST00000134824, ENSMUST00000139129, ENSMUST00000171976, ENSMUST00000172186
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
15092057Lgrme3_mlate growth rate, maternal effect 3 (mouse)118487732496629512Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
15092049Wsigrme3_mweek six growth rate, maternal effect 3 (mouse)118487732496629512Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse

Markers in Region
AW491331  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381188,053,122 - 88,053,262UniSTSGRCm38
MGSCv371187,866,624 - 87,866,764UniSTSGRCm37
Celera1197,653,575 - 97,653,715UniSTS
Celera1187,395,884 - 87,396,024UniSTS
Cytogenetic Map11CUniSTS
cM Map1149.0UniSTS
Whitehead/MRC_RH111138.11UniSTS
2010015M23Rik  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381188,046,843 - 88,047,382UniSTSGRCm38
MGSCv371187,860,345 - 87,860,884UniSTSGRCm37
Celera1187,401,761 - 87,402,304UniSTS
Cytogenetic Map11CUniSTS
cM Map11 UniSTS
Sfrs1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11CUniSTS
cM Map1149.0UniSTS
AI482334  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381188,053,511 - 88,053,642UniSTSGRCm38
MGSCv371187,867,013 - 87,867,144UniSTSGRCm37
Celera1197,653,964 - 97,654,095UniSTS
Cytogenetic Map11CUniSTS
cM Map1149.0UniSTS
Whitehead/MRC_RH111138.06UniSTS
UniSTS:236692  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381188,053,279 - 88,053,579UniSTSGRCm38
MGSCv371187,866,781 - 87,867,081UniSTSGRCm37
Celera1197,653,732 - 97,654,032UniSTS
Celera1187,395,567 - 87,395,867UniSTS
Cytogenetic Map11CUniSTS
cM Map1149.0UniSTS
UniSTS:236695  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381188,052,303 - 88,052,389UniSTSGRCm38
MGSCv371187,865,805 - 87,865,891UniSTSGRCm37
Celera1187,396,759 - 87,396,846UniSTS
Cytogenetic Map11CUniSTS
cM Map1149.0UniSTS
MARC_12219-12220:1004719985:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381188,050,490 - 88,050,903UniSTSGRCm38
MGSCv371187,863,992 - 87,864,405UniSTSGRCm37
Celera1187,398,239 - 87,398,652UniSTS
Cytogenetic Map11CUniSTS
cM Map1149.0UniSTS
PMC310730P5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Celera1187,399,031 - 87,399,226UniSTS
Cytogenetic Map11CUniSTS
cM Map1149.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001078167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_173374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_388324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK004255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK018176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK027960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL593853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY743476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF739274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU406964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DS033270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X66091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000079866   ⟹   ENSMUSP00000133517
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1187,938,544 - 87,942,316 (+)Ensembl
GRCm38.p6 Ensembl1188,047,718 - 88,051,490 (+)Ensembl
RefSeq Acc Id: ENSMUST00000107920   ⟹   ENSMUSP00000103553
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1187,938,629 - 87,941,236 (+)Ensembl
GRCm38.p6 Ensembl1188,047,803 - 88,050,410 (+)Ensembl
RefSeq Acc Id: ENSMUST00000132983
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1187,940,238 - 87,941,877 (+)Ensembl
GRCm38.p6 Ensembl1188,049,412 - 88,051,051 (+)Ensembl
RefSeq Acc Id: ENSMUST00000134824   ⟹   ENSMUSP00000114549
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1187,939,393 - 87,942,298 (+)Ensembl
GRCm38.p6 Ensembl1188,048,567 - 88,051,472 (+)Ensembl
RefSeq Acc Id: ENSMUST00000139129   ⟹   ENSMUSP00000120595
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1187,938,199 - 87,944,581 (+)Ensembl
GRCm38.p6 Ensembl1188,047,373 - 88,053,755 (+)Ensembl
RefSeq Acc Id: ENSMUST00000171976
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1187,938,551 - 87,939,652 (+)Ensembl
GRCm38.p6 Ensembl1188,047,725 - 88,048,826 (+)Ensembl
RefSeq Acc Id: ENSMUST00000172186   ⟹   ENSMUSP00000128190
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1187,939,415 - 87,941,948 (+)Ensembl
GRCm38.p6 Ensembl1188,048,589 - 88,051,122 (+)Ensembl
RefSeq Acc Id: NM_001078167   ⟹   NP_001071635
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391187,938,199 - 87,944,583 (+)NCBI
GRCm381188,047,373 - 88,053,757 (+)NCBI
MGSCv371187,861,173 - 87,867,259 (+)RGD
Celera1187,395,560 - 87,401,770 (-)NCBI
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_173374   ⟹   NP_775550
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391187,938,199 - 87,944,583 (+)NCBI
GRCm381188,047,373 - 88,053,757 (+)NCBI
MGSCv371187,861,173 - 87,867,259 (+)RGD
Celera1187,395,560 - 87,401,770 (-)NCBI
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_388324
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391187,937,325 - 87,944,583 (+)NCBI
GRCm381188,046,499 - 88,053,757 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001071635   ⟸   NM_001078167
- Peptide Label: isoform 2
- UniProtKB: Q6PDM2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_775550   ⟸   NM_173374
- Peptide Label: isoform 1
- UniProtKB: Q8BJV3 (UniProtKB/Swiss-Prot),   Q5SXC5 (UniProtKB/Swiss-Prot),   Q3UCH2 (UniProtKB/Swiss-Prot),   B2KGJ5 (UniProtKB/Swiss-Prot),   Q8C1H9 (UniProtKB/Swiss-Prot),   Q6PDM2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000120595   ⟸   ENSMUST00000139129
RefSeq Acc Id: ENSMUSP00000133517   ⟸   ENSMUST00000079866
RefSeq Acc Id: ENSMUSP00000128190   ⟸   ENSMUST00000172186
RefSeq Acc Id: ENSMUSP00000103553   ⟸   ENSMUST00000107920
RefSeq Acc Id: ENSMUSP00000114549   ⟸   ENSMUST00000134824
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6PDM2-F1-model_v2 AlphaFold Q6PDM2 1-248 view protein structure

Promoters
RGD ID:6822152
Promoter ID:MM_KWN:9113
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:AK041907_2010015M23RIK,   NM_001078167,   OTTMUST00000002908
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361187,860,876 - 87,861,376 (+)MPROMDB
RGD ID:6822107
Promoter ID:MM_KWN:9115
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   MEF_B6
Transcripts:OTTMUST00000002909,   OTTMUST00000002911
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361187,861,721 - 87,862,682 (+)MPROMDB
RGD ID:8676092
Promoter ID:EPDNEW_M16076
Type:initiation region
Name:Srsf1_1
Description:Mus musculus serine/arginine-rich splicing factor 1 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381188,047,721 - 88,047,781EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98283 AgrOrtholog
Ensembl Genes ENSMUSG00000018379 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000079866 ENTREZGENE
  ENSMUST00000079866.11 UniProtKB/Swiss-Prot
  ENSMUST00000107920.10 UniProtKB/TrEMBL
  ENSMUST00000134824.9 UniProtKB/TrEMBL
  ENSMUST00000139129 ENTREZGENE
  ENSMUST00000139129.9 UniProtKB/Swiss-Prot
  ENSMUST00000172186.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRSF1_RRM1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRSF1_RRM2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:110809 UniProtKB/Swiss-Prot
MGD MGI:98283 ENTREZGENE
NCBI Gene 110809 ENTREZGENE
PANTHER NUCLEOLAR PROTEIN 3-RELATED UniProtKB/TrEMBL
  RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE_ARGININE-RICH SPLICING FACTOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Srsf1 PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2KGJ5 ENTREZGENE
  F6QXN3_MOUSE UniProtKB/TrEMBL
  F7AI47_MOUSE UniProtKB/TrEMBL
  H7BX95_MOUSE UniProtKB/TrEMBL
  Q3UCH2 ENTREZGENE
  Q5SXC5 ENTREZGENE
  Q6PDM2 ENTREZGENE
  Q8BJV3 ENTREZGENE
  Q8C1H9 ENTREZGENE
  SRSF1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary B2KGJ5 UniProtKB/Swiss-Prot
  Q3UCH2 UniProtKB/Swiss-Prot
  Q5SXC5 UniProtKB/Swiss-Prot
  Q8BJV3 UniProtKB/Swiss-Prot
  Q8C1H9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-27 Srsf1  serine and arginine-rich splicing factor 1  Srsf1  serine/arginine-rich splicing factor 1  Symbol and/or name change 5135510 APPROVED
2011-07-27 Srsf1  serine/arginine-rich splicing factor 1  Sfrs1  splicing factor, arginine/serine-rich 1 (ASF/SF2)  Symbol and/or name change 5135510 APPROVED