thiopurine - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	thiopurine	go back to main search page
Accession:	CHEBI:35666	browse the term
Synonyms:	related_synonym:	mercaptopurines; sulfanylpurines; thiopurines
	alt_id:	CHEBI:26974; CHEBI:35665; CHEBI:9563

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Rat (639) Mouse (642) Human (658) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (639)

6-methylthioinosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 29 member 1

affects transport

SLC29A1 mRNA affects the transport of Methylthioinosine

NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203

azathioprine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases expression

Azathioprine results in decreased expression of ABCB11 mRNA

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

affects response to substance

ABCB1 gene polymorphism affects the susceptibility to Azathioprine

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily B member 4

increases expression

Azathioprine results in increased expression of ABCB4 mRNA

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily C member 2

increases expression

Azathioprine results in increased expression of ABCC2 mRNA

PMID:22623647 PMID:27765674

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

increases expression

Azathioprine results in increased expression of ABCC3 mRNA

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 4

increases expression

Azathioprine results in increased expression of ABCC4 mRNA

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily G member 2

decreases expression

Azathioprine results in decreased expression of ABCG2 mRNA

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ATP binding cassette subfamily G member 5

decreases expression

Azathioprine results in decreased expression of ABCG5 mRNA

NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563

G

abhydrolase domain containing 4, N-acyl phospholipase B

increases expression

Azathioprine results in increased expression of ABHD4 mRNA

NCBI chr15:27,697,384...27,716,013
Ensembl chr15:27,704,113...27,716,966

G

acetyl-CoA acetyltransferase 2

decreases expression

Azathioprine results in decreased expression of ACAT2 mRNA

NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821

G

angiotensin converting enzyme 2

increases expression

Azathioprine results in increased expression of ACE2 mRNA

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

atypical chemokine receptor 3

decreases expression

Azathioprine results in decreased expression of ACKR3 mRNA

NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237

G

acyl-CoA synthetase long-chain family member 5

increases expression

Azathioprine results in increased expression of ACSL5 mRNA

NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607

G

adrenomedullin

increases expression

Azathioprine results in increased expression of ADM mRNA

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

adenosine A2a receptor

decreases expression

Azathioprine results in decreased expression of ADORA2A mRNA

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

advanced glycosylation end product-specific receptor

increases expression

Azathioprine results in increased expression of AGER mRNA

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

aldo-keto reductase family 1 member B10

increases expression

Azathioprine results in increased expression of AKR1B10 mRNA

PMID:22623647 PMID:26198647

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

G

aldo-keto reductase family 1, member C1

increases expression

Azathioprine results in increased expression of AKR1C1 mRNA

NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326

G

aldo-keto reductase family 1, member C2

increases expression

Azathioprine results in increased expression of AKR1C2 mRNA

PMID:22623647 PMID:26198647

NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764

G

aldo-keto reductase family 1, member D1

decreases expression

Azathioprine results in decreased expression of AKR1D1 mRNA

NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372

G

AKT serine/threonine kinase 1

multiple interactions

Azathioprine inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

multiple interactions

[Carbon Tetrachloride co-treated with Azathioprine] results in decreased expression of ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 18 family, member A1

decreases expression

Azathioprine results in decreased expression of ALDH18A1 mRNA

NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890

G

aldehyde dehydrogenase 1 family, member A1

increases expression

Azathioprine results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 1 family, member L1

increases expression

Azathioprine results in increased expression of ALDH1L1 mRNA

NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465

G

aldehyde dehydrogenase 7 family, member A1

decreases expression

Azathioprine results in decreased expression of ALDH7A1 mRNA

NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193

G

aldehyde dehydrogenase 8 family, member A1

decreases expression

Azathioprine results in decreased expression of ALDH8A1 mRNA

NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385

G

adhesion molecule with Ig like domain 2

decreases expression

Azathioprine results in decreased expression of AMIGO2 mRNA

NCBI chr 7:128,391,493...128,394,589
Ensembl chr 7:128,390,412...128,394,695

G

angiogenin

decreases expression

Azathioprine results in decreased expression of ANG mRNA

NCBI chr15:24,312,711...24,323,361

G

ankyrin repeat domain 40

increases expression

Azathioprine results in increased expression of TMPRSS2 mRNA

NCBI chr10:79,282,075...79,295,322
Ensembl chr10:79,282,075...79,295,320

G

anillin, actin binding protein

decreases expression

Azathioprine results in decreased expression of ANLN mRNA

NCBI chr 8:20,858,227...20,921,602
Ensembl chr 8:20,858,228...20,921,538

G

ANTXR cell adhesion molecule 1

increases expression

Azathioprine results in increased expression of ANTXR1 mRNA

NCBI chr 4:119,590,770...119,778,232
Ensembl chr 4:119,590,771...119,778,232

G

ANTXR cell adhesion molecule 2

increases expression

Azathioprine results in increased expression of ANTXR2 mRNA

NCBI chr14:11,541,718...11,682,110
Ensembl chr14:11,541,772...11,682,094

G

aldehyde oxidase 1

increases expression

Azathioprine results in increased expression of AOX1 mRNA

NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770

G

apolipoprotein C3

decreases expression

Azathioprine results in decreased expression of APOC3 mRNA

NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583

G

aquaporin 11

decreases expression

Azathioprine results in decreased expression of AQP11 mRNA

NCBI chr 1:152,046,515...152,056,675
Ensembl chr 1:152,046,517...152,056,725

G

aquaporin 3 (Gill blood group)

increases expression

Azathioprine results in increased expression of AQP3 mRNA

NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720

G

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

increases expression

Azathioprine results in increased expression of ARAP2 mRNA

NCBI chr14:46,717,657...46,917,326
Ensembl chr14:46,718,760...46,917,154

G

Rho GTPase activating protein 11A

decreases expression

Azathioprine results in decreased expression of ARHGAP11A mRNA

NCBI chr 3:100,590,865...100,607,146
Ensembl chr 3:100,590,865...100,607,559

G

Rho GTPase activating protein 27

increases expression

Azathioprine results in increased expression of ARHGAP27 mRNA

NCBI chr10:88,280,470...88,313,225
Ensembl chr10:88,280,455...88,313,185

G

arrestin domain containing 2

increases expression

Azathioprine results in increased expression of ARRDC2 mRNA

NCBI chr16:18,601,897...18,606,029
Ensembl chr16:18,601,897...18,606,029

G

ankyrin repeat and SOCS box-containing 9

decreases expression

Azathioprine results in decreased expression of ASB9 mRNA

NCBI chr X:29,956,576...30,001,436
Ensembl chr X:29,956,576...30,001,105

G

asparagine synthetase (glutamine-hydrolyzing)

decreases expression

Azathioprine results in decreased expression of ASNS mRNA

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

assembly factor for spindle microtubules

decreases expression

Azathioprine results in decreased expression of ASPM mRNA

NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755

G

ATPase family, AAA domain containing 2

decreases expression

Azathioprine results in decreased expression of ATAD2 mRNA

NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738

G

autophagy related 2A

increases expression

Azathioprine results in increased expression of ATG2A mRNA

NCBI chr 1:203,542,559...203,562,242
Ensembl chr 1:203,542,559...203,562,242

G

ATPase, H+ transporting V0 subunit e2

decreases expression

Azathioprine results in decreased expression of ATP6V0E2 mRNA

NCBI chr 4:77,484,868...77,488,016
Ensembl chr 4:77,482,226...77,488,777

G

aurora kinase A

decreases expression

Azathioprine results in decreased expression of AURKA mRNA

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

aurora kinase B

decreases expression

Azathioprine results in decreased expression of AURKB mRNA

NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837

G

BAR/IMD domain containing adaptor protein 2 like 1

increases expression

Azathioprine results in increased expression of BAIAP2L1 mRNA

NCBI chr12:10,250,434...10,339,937
Ensembl chr12:10,250,473...10,339,928

G

BRCA1 associated RING domain 1

decreases expression

Azathioprine results in decreased expression of BARD1 mRNA

NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265

G

BCAR1 scaffold protein, Cas family member

increases expression

Azathioprine results in increased expression of BCAR1 mRNA

NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907

G

BCL2-related protein A1

decreases expression

Azathioprine results in decreased expression of BCL2A1 mRNA

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

G

Bcl2-like 1

decreases expression

Azathioprine results in decreased expression of BCL2L1 mRNA; Azathioprine results in decreased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

baculoviral IAP repeat-containing 5

decreases expression

Azathioprine results in decreased expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

bora, aurora kinase A activator

decreases expression

Azathioprine results in decreased expression of BORA mRNA

NCBI chr15:75,797,624...75,835,599
Ensembl chr15:75,797,891...75,821,322

G

BRCA2, DNA repair associated

decreases expression

Azathioprine results in decreased expression of BRCA2 mRNA

NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567

G

bone marrow stromal cell antigen 2

decreases expression

Azathioprine results in decreased expression of BST2 mRNA

NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979

G

BUB1 mitotic checkpoint serine/threonine kinase

decreases expression

Azathioprine results in decreased expression of BUB1 mRNA

NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650

G

BUB1 mitotic checkpoint serine/threonine kinase B

decreases expression

Azathioprine results in decreased expression of BUB1B mRNA

NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547

G

similar to human chromosome 3 open reading frame 70

decreases expression

Azathioprine results in decreased expression of C3ORF70 mRNA

NCBI chr11:79,345,857...79,396,140
Ensembl chr11:79,345,304...79,396,142

G

similar to human chromosome 4 open reading frame 46

decreases expression

Azathioprine results in decreased expression of C4ORF46 mRNA

NCBI chr 2:164,762,994...164,766,126
Ensembl chr 2:164,762,960...164,766,128

G

similar to human chromosome 5 open reading frame 34

decreases expression

Azathioprine results in decreased expression of C5ORF34 mRNA

NCBI chr 2:51,553,223...51,577,090
Ensembl chr 2:51,555,432...51,577,085

G

similar to human chromosome 11 open reading frame 96

increases expression

Azathioprine results in increased expression of C11ORF96 mRNA

NCBI chr 3:79,920,125...79,921,368
Ensembl chr 3:79,920,129...79,921,523

G

cell adhesion molecule 1

decreases expression

Azathioprine results in decreased expression of CADM1 mRNA

NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833

G

carbonic anhydrase 2

increases expression

Azathioprine results in increased expression of CA2 mRNA

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

caveolae associated protein 2

decreases expression

Azathioprine results in decreased expression of CAVIN2 mRNA

NCBI chr 9:50,302,079...50,314,096
Ensembl chr 9:50,301,206...50,314,147

G

coiled-coil domain containing 138

decreases expression

Azathioprine results in decreased expression of CCDC138 mRNA

NCBI chr20:26,493,624...26,572,367
Ensembl chr20:26,495,235...26,572,376

G

coiled-coil domain containing 15

decreases expression

Azathioprine results in decreased expression of CCDC15 mRNA

NCBI chr 8:36,991,147...37,068,849
Ensembl chr 8:36,998,867...37,068,919

G

coiled-coil domain containing 18

decreases expression

Azathioprine results in decreased expression of CCDC18 mRNA

NCBI chr14:1,501,749...1,607,672
Ensembl chr14:1,501,784...1,607,711

G

coiled-coil domain containing 34

decreases expression

Azathioprine results in decreased expression of CCDC34 mRNA

NCBI chr 3:96,553,074...96,588,310
Ensembl chr 3:96,552,992...96,588,146

G

coiled-coil domain containing 77

decreases expression

Azathioprine results in decreased expression of CCDC77 mRNA

NCBI chr 4:153,534,184...153,566,059
Ensembl chr 4:153,534,187...153,566,545

G

C-C motif chemokine ligand 2

multiple interactions

Azathioprine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 20

decreases expression

Azathioprine results in decreased expression of CCL20 mRNA; Azathioprine results in decreased expression of CCL20 protein

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

G

C-C motif chemokine ligand 3

multiple interactions

Azathioprine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL3 protein]

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 9

increases expression

Azathioprine results in increased expression of CCL15 mRNA

NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369

G

cellular communication network factor 1

increases expression

Azathioprine results in increased expression of CCN1 mRNA

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

G

cyclin A2

decreases expression

Azathioprine results in decreased expression of CCNA2 mRNA

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

decreases expression

Azathioprine results in decreased expression of CCNB1 mRNA

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin E2

decreases expression

Azathioprine results in decreased expression of CCNE2 mRNA

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

CD14 molecule

increases expression

Azathioprine results in increased expression of CD14 mRNA

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

CD36 molecule

increases expression

Azathioprine results in increased expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

cell division cycle 20

decreases expression

Azathioprine results in decreased expression of CDC20 mRNA

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

cell division cycle 25A

decreases expression

Azathioprine results in decreased expression of CDC25A mRNA

NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701

G

cell division cycle 25C

decreases expression

Azathioprine results in decreased expression of CDC25C mRNA

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

G

cell division cycle 45

decreases expression

Azathioprine results in decreased expression of CDC45 mRNA

NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619

G

cell division cycle 6

decreases expression

Azathioprine results in decreased expression of CDC6 mRNA

NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011

G

cell division cycle 7

decreases expression

Azathioprine results in decreased expression of CDC7 mRNA

NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,804,661...2,824,778

G

cell division cycle associated 2

decreases expression

Azathioprine results in decreased expression of CDCA2 mRNA

NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611

G

cell division cycle associated 3

decreases expression

Azathioprine results in decreased expression of CDCA3 mRNA

NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799

G

cell division cycle associated 5

decreases expression

Azathioprine results in decreased expression of CDCA5 mRNA

NCBI chr 1:203,378,550...203,392,027
Ensembl chr 1:203,378,577...203,392,023

G

cell division cycle associated 7

decreases expression

Azathioprine results in decreased expression of CDCA7 mRNA

NCBI chr 3:57,322,718...57,333,353
Ensembl chr 3:57,322,708...57,333,353

G

cell division cycle associated 7 like

decreases expression

Azathioprine results in decreased expression of CDCA7L mRNA

NCBI chr 6:138,793,953...138,839,889
Ensembl chr 6:138,794,228...138,839,888

G

cell division cycle associated 8

decreases expression

Azathioprine results in decreased expression of CDCA8 mRNA

NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629

G

cyclin-dependent kinase 1

decreases expression

Azathioprine results in decreased expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase inhibitor 1A

increases expression

Azathioprine results in increased expression of CDKN1A mRNA; Azathioprine results in increased expression of CDKN1A protein

PMID:22623647 PMID:27358234

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2B

increases expression

Azathioprine results in increased expression of CDKN2B mRNA

NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050

G

cyclin-dependent kinase inhibitor 3

decreases expression

Azathioprine results in decreased expression of CDKN3 mRNA

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945

G

centromere protein A

decreases expression

Azathioprine results in decreased expression of CENPA mRNA

NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675

G

centromere protein E

decreases expression

Azathioprine results in decreased expression of CENPE mRNA

NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669

G

centromere protein F

decreases expression

Azathioprine results in decreased expression of CENPF mRNA

NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669

G

centromere protein H

decreases expression

Azathioprine results in decreased expression of CENPH mRNA

NCBI chr 2:31,896,675...31,910,179
Ensembl chr 2:31,894,667...31,910,154

G

centromere protein K

decreases expression

Azathioprine results in decreased expression of CENPK mRNA

NCBI chr 2:35,360,390...35,421,372
Ensembl chr 2:35,360,132...35,385,706

G

centromere protein U

decreases expression

Azathioprine results in decreased expression of CENPU mRNA

NCBI chr16:45,715,821...45,739,038
Ensembl chr16:45,714,294...45,738,823

G

centrosomal protein 152

decreases expression

Azathioprine results in decreased expression of CEP152 mRNA

NCBI chr 3:112,803,185...112,878,298
Ensembl chr 3:112,810,425...112,878,458
Ensembl chr 3:112,810,425...112,878,458

G

centrosomal protein 192

decreases expression

Azathioprine results in decreased expression of CEP192 mRNA

NCBI chr18:61,373,937...61,458,405
Ensembl chr18:61,332,158...61,458,379

G

centrosomal protein 55

decreases expression

Azathioprine results in decreased expression of CEP55 mRNA

NCBI chr 1:235,832,823...235,848,401
Ensembl chr 1:235,832,878...235,848,394

G

complement factor I

decreases expression

Azathioprine results in decreased expression of CFI mRNA

NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561

G

checkpoint kinase 1

decreases expression

Azathioprine results in decreased expression of CHEK1 mRNA

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

carbohydrate sulfotransferase 9

decreases expression

Azathioprine results in decreased expression of CHST9 mRNA

NCBI chr18:6,576,391...6,851,078
Ensembl chr18:6,577,348...6,850,868

G

citron rho-interacting serine/threonine kinase

decreases expression

Azathioprine results in decreased expression of CIT mRNA

NCBI chr12:40,603,073...40,764,846
Ensembl chr12:40,605,563...40,763,860

G

cytoskeleton associated protein 2

decreases expression

Azathioprine results in decreased expression of CKAP2 mRNA

NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913

G

creatine kinase B

decreases expression

Azathioprine results in decreased expression of CKB mRNA

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

calmegin

decreases expression

Azathioprine results in decreased expression of CLGN mRNA

NCBI chr19:24,695,140...24,728,542
Ensembl chr19:24,696,875...24,728,758

G

CAP-GLY domain containing linker protein 2

increases expression

Azathioprine results in increased expression of CLIP2 mRNA

NCBI chr12:22,163,044...22,227,023
Ensembl chr12:22,163,218...22,227,023

G

collagen type I alpha 1 chain

increases expression

Azathioprine results in increased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collectin sub-family member 12

increases expression

Azathioprine results in increased expression of COLEC12 mRNA

NCBI chr18:732,950...920,620
Ensembl chr18:732,950...920,618

G

carboxypeptidase B2

decreases expression

Azathioprine results in decreased expression of CPB2 mRNA

NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556

G

cytoplasmic polyadenylation element binding protein 4

increases expression

Azathioprine results in increased expression of CPEB4 mRNA

NCBI chr10:15,717,794...15,780,482
Ensembl chr10:15,717,794...15,780,603

G

cAMP responsive element binding protein 5

increases expression

Azathioprine results in increased expression of CREB5 mRNA

NCBI chr 4:82,393,091...82,794,320
Ensembl chr 4:82,393,730...82,790,325

G

crystallin beta-gamma domain containing 1

decreases expression

Azathioprine results in decreased expression of CRYBG1 mRNA

NCBI chr20:47,425,030...47,496,918
Ensembl chr20:47,426,183...47,621,392

G

colony stimulating factor 3

decreases expression

Azathioprine results in decreased expression of CSF3 mRNA

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

cystatin A

increases expression

Azathioprine results in increased expression of CSTA mRNA

NCBI chr11:64,620,483...64,631,488
Ensembl chr11:64,620,483...64,631,488

G

cathepsin B

increases expression

Azathioprine results in increased expression of CTSB mRNA

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin L

increases expression

Azathioprine results in increased expression of CTSL mRNA

NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548

G

C-X-C motif chemokine ligand 2

increases expression

Azathioprine results in increased expression of CXCL2 mRNA

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine receptor 4

decreases expression

Azathioprine results in decreased expression of CXCR4 mRNA

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome P450, family 2, subfamily s, polypeptide 1

increases expression

Azathioprine results in increased expression of CYP2S1 mRNA

NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303

G

doublecortin domain containing 2

decreases expression

Azathioprine results in decreased expression of DCDC2 mRNA

NCBI chr17:39,845,952...40,031,781
Ensembl chr17:39,845,952...40,030,743

G

deoxycytidine kinase

decreases expression

Azathioprine results in decreased expression of DCK mRNA

NCBI chr14:19,305,218...19,326,247
Ensembl chr14:19,305,218...19,326,247

G

dopa decarboxylase

decreases expression

Azathioprine results in decreased expression of DDC mRNA

NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208

G

DNA-damage inducible transcript 3

increases expression

Azathioprine results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DEAD-box helicase 10

increases expression

Azathioprine results in increased expression of DDX10 mRNA

NCBI chr 8:53,488,656...53,643,373
Ensembl chr 8:53,488,656...53,643,373

G

DEP domain containing 1

decreases expression

Azathioprine results in decreased expression of DEPDC1 mRNA

NCBI chr 2:248,684,508...248,717,951
Ensembl chr 2:248,684,523...248,717,951

G

DEP domain containing 1B

decreases expression

Azathioprine results in decreased expression of DEPDC1B mRNA

NCBI chr 2:39,891,163...39,963,779
Ensembl chr 2:39,891,481...39,963,779

G

diaphanous-related formin 3

decreases expression

Azathioprine results in decreased expression of DIAPH3 mRNA

NCBI chr15:62,543,375...63,013,060
Ensembl chr15:62,543,375...63,012,975

G

iodothyronine deiodinase 1

decreases expression

Azathioprine results in decreased expression of DIO1 mRNA

NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970

G

dickkopf WNT signaling pathway inhibitor 1

decreases expression

Azathioprine results in decreased expression of DKK1 mRNA

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

DLG associated protein 5

decreases expression

Azathioprine results in decreased expression of DLGAP5 mRNA

NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518

G

DNA methyltransferase 3 beta

decreases expression

Azathioprine results in decreased expression of DNMT3B mRNA

NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124

G

dipeptidylpeptidase 4

decreases expression

Azathioprine results in decreased expression of DPP4 mRNA

NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901

G

dihydropyrimidine dehydrogenase

decreases expression

Azathioprine results in decreased expression of DPYD mRNA

NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982

G

DNA replication and sister chromatid cohesion 1

decreases expression

Azathioprine results in decreased expression of DSCC1 mRNA

NCBI chr 7:86,482,588...86,498,212
Ensembl chr 7:86,482,588...86,498,212

G

DSN1 component of MIS12 kinetochore complex

decreases expression

Azathioprine results in decreased expression of DSN1 mRNA

NCBI chr 3:145,652,741...145,668,025
Ensembl chr 3:145,652,737...145,665,856

G

denticleless E3 ubiquitin protein ligase homolog

decreases expression

Azathioprine results in decreased expression of DTL mRNA

NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890

G

deltex E3 ubiquitin ligase 4

decreases expression

Azathioprine results in decreased expression of DTX4 mRNA

NCBI chr 1:209,457,719...209,545,163
Ensembl chr 1:209,460,735...209,492,818

G

dual specificity phosphatase 1

increases expression

Azathioprine results in increased expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 5

increases expression

Azathioprine results in increased expression of DUSP5 mRNA

NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818

G

DAZ interacting zinc finger protein 1

decreases expression

Azathioprine results in decreased expression of DZIP1 mRNA

NCBI chr15:95,956,329...96,009,994
Ensembl chr15:95,956,398...96,010,066

G

E2F transcription factor 5

decreases expression

Azathioprine results in decreased expression of E2F5 mRNA

NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990

G

E2F transcription factor 7

decreases expression

Azathioprine results in decreased expression of E2F7 mRNA

NCBI chr 7:46,150,533...46,192,739
Ensembl chr 7:46,151,293...46,192,734

G

E2F transcription factor 8

decreases expression

Azathioprine results in decreased expression of E2F8 mRNA

NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098

G

EF-hand calcium binding domain 11

decreases expression

Azathioprine results in decreased expression of EFCAB11 mRNA

NCBI chr 6:119,008,908...119,162,994
Ensembl chr 6:119,008,919...119,162,046

G

EGF containing fibulin extracellular matrix protein 1

increases expression

Azathioprine results in increased expression of EFEMP1 mRNA

NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018

G

early growth response 1

increases expression

Azathioprine results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

early growth response 2

increases expression

Azathioprine results in increased expression of EGR2 mRNA

NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

decreases expression

Azathioprine results in decreased expression of EHHADH mRNA

NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188

G

EP300 interacting inhibitor of differentiation 3

increases expression

Azathioprine results in increased expression of EID3 mRNA

NCBI chr 7:20,860,073...20,861,395

G

epithelial membrane protein 3

increases expression

Azathioprine results in increased expression of EMP3 mRNA

NCBI chr 1:96,388,651...96,391,946
Ensembl chr 1:96,388,652...96,391,988

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

increases expression

Azathioprine results in increased expression of ENPP2 mRNA

NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827

G

ectonucleotide pyrophosphatase/phosphodiesterase 3

decreases expression

Azathioprine results in decreased expression of ENPP3 mRNA

NCBI chr 1:20,563,700...20,635,044
Ensembl chr 1:20,563,697...20,635,041

G

ectonucleoside triphosphate diphosphohydrolase 3

increases expression

Azathioprine results in increased expression of ENTPD3 mRNA

NCBI chr 8:120,246,412...120,277,943
Ensembl chr 8:120,247,121...120,277,943

G

erythrocyte membrane protein band 4.1-like 2

decreases expression

Azathioprine results in decreased expression of EPB41L2 mRNA

NCBI chr 1:19,863,010...20,037,795
Ensembl chr 1:19,863,009...20,037,721

G

epoxide hydrolase 1

increases expression

Azathioprine results in increased expression of EPHX1 mRNA

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

ERCC excision repair 1, endonuclease non-catalytic subunit

increases expression

Azathioprine results in increased expression of ERCC1 mRNA

NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963

G

endoplasmic reticulum protein 27

decreases expression

Azathioprine results in decreased expression of ERP27 mRNA

NCBI chr 4:169,804,656...169,821,660
Ensembl chr 4:169,804,658...169,821,660

G

establishment of sister chromatid cohesion N-acetyltransferase 2

decreases expression

Azathioprine results in decreased expression of ESCO2 mRNA

NCBI chr15:40,034,566...40,052,295
Ensembl chr15:40,034,568...40,055,306

G

extra spindle pole bodies like 1, separase

decreases expression

Azathioprine results in decreased expression of ESPL1 mRNA

NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984

G

exonuclease 1

decreases expression

Azathioprine results in decreased expression of EXO1 mRNA

NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

decreases expression

Azathioprine results in decreased expression of EZH2 mRNA

NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362

G

fatty acid binding protein 1

decreases expression

Azathioprine results in decreased expression of FABP1 mRNA

NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788

G

FAM161 centrosomal protein A

decreases expression

Azathioprine results in decreased expression of FAM161A mRNA

NCBI chr14:97,009,449...97,027,865
Ensembl chr14:97,009,491...97,028,588

G

FAM3 metabolism regulating signaling molecule B

decreases expression

Azathioprine results in decreased expression of FAM3B mRNA

NCBI chr11:36,831,532...36,863,902
Ensembl chr11:36,831,532...36,869,713

G

family with sequence similarity 43, member A

increases expression

Azathioprine results in increased expression of FAM43A mRNA

NCBI chr11:70,128,253...70,131,401
Ensembl chr11:70,128,253...70,131,401

G

family with sequence similarity 83, member D

decreases expression

Azathioprine results in decreased expression of FAM83D mRNA

NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192

G

FA complementation group I

decreases expression

Azathioprine results in decreased expression of FANCI mRNA

NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640

G

fibulin 1

increases expression

Azathioprine results in increased expression of FBLN1 mRNA

NCBI chr 7:116,310,582...116,390,075
Ensembl chr 7:116,310,582...116,390,075

G

F-box protein 30

increases expression

Azathioprine results in increased expression of FBXO30 mRNA

NCBI chr 1:5,655,341...5,671,558
Ensembl chr 1:5,655,339...5,672,441

G

F-box protein 5

decreases expression

Azathioprine results in decreased expression of FBXO5 mRNA

NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437

G

flap structure-specific endonuclease 1

decreases expression

Azathioprine results in decreased expression of FEN1 mRNA

NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003

G

fibrinogen alpha chain

decreases expression

Azathioprine results in decreased expression of FGA mRNA

NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528

G

fibroblast growth factor 7

increases expression

Azathioprine results in increased expression of FGF7 mRNA

NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929

G

four and a half LIM domains 3

increases expression

Azathioprine results in increased expression of FHL3 mRNA

NCBI chr 5:136,953,947...136,961,317
Ensembl chr 5:136,950,411...136,961,317

G

FIGNL1 interacting regulator of recombination and mitosis

decreases expression

Azathioprine results in decreased expression of FIRRM mRNA

NCBI chr13:76,301,914...76,345,842
Ensembl chr13:76,301,918...76,345,804

G

flavin containing dimethylaniline monoxygenase 2

increases expression

Azathioprine results in increased expression of FMO2 mRNA

NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308

G

flavin containing dimethylaniline monoxygenase 5

decreases expression

Azathioprine results in decreased expression of FMO5 mRNA

NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Azathioprine results in increased expression of FOS mRNA

PMID:22623647 PMID:23958494

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FOS like 1, AP-1 transcription factor subunit

increases expression

Azathioprine results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

forkhead box A1

decreases expression

Azathioprine results in decreased expression of FOXA1 mRNA

NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188

G

forkhead box M1

decreases expression

Azathioprine results in decreased expression of FOXM1 mRNA

NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684

G

forkhead box O1

multiple interactions

Azathioprine inhibits the reaction [IGF1 protein results in increased phosphorylation of FOXO1 protein]

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

40S small subunit processome assembly factor 1

decreases expression

Azathioprine results in decreased expression of FSAF1 mRNA

NCBI chr19:52,807,932...52,822,259
Ensembl chr19:52,807,934...52,822,267

G

follistatin

increases expression

Azathioprine results in increased expression of FST mRNA

NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571

G

gamma-aminobutyric acid type A receptor subunit epsilon

increases expression

Azathioprine results in increased expression of GABRE mRNA

NCBI chr X:150,060,035...150,078,773
Ensembl chr X:150,060,040...150,078,693

G

growth arrest and DNA-damage-inducible, beta

increases expression

Azathioprine results in increased expression of GADD45B mRNA

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

G

growth arrest-specific 2 like 3

decreases expression

Azathioprine results in decreased expression of GAS2L3 mRNA

NCBI chr 7:23,803,578...23,836,816
Ensembl chr 7:23,806,310...23,836,411

G

guanylate binding protein 1

decreases expression

Azathioprine results in decreased expression of GBP1 mRNA

NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131

G

grancalcin

decreases expression

Azathioprine results in decreased expression of GCA mRNA

NCBI chr 3:47,297,320...47,329,913
Ensembl chr 3:47,297,383...47,328,581

G

glucokinase regulator

increases expression

Azathioprine results in increased expression of GCKR mRNA

NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654

G

glutamate-cysteine ligase, catalytic subunit

increases expression

Azathioprine results in increased expression of GCLC mRNA

PMID:22623647 PMID:26198647

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

increases expression

Azathioprine results in increased expression of GCLM mRNA

PMID:18222062 PMID:22623647 PMID:26198647

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glucosaminyl (N-acetyl) transferase 3, mucin type

increases expression

Azathioprine results in increased expression of GCNT3 mRNA

PMID:22623647 PMID:26198647

NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562

G

growth differentiation factor 15

increases expression

Azathioprine results in increased expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

glycerophosphodiester phosphodiesterase domain containing 5

decreases expression

Azathioprine results in decreased expression of GDPD5 mRNA

NCBI chr 1:153,679,718...153,761,452
Ensembl chr 1:153,679,718...153,761,446

G

gamma-glutamyl hydrolase

decreases expression

Azathioprine results in decreased expression of GGH mRNA

NCBI chr 5:33,529,880...33,552,790
Ensembl chr 5:33,529,880...33,552,787

G

GINS complex subunit 1

decreases expression

Azathioprine results in decreased expression of GINS1 mRNA

NCBI chr 3:139,724,513...139,745,930
Ensembl chr 3:139,724,490...139,745,936

G

GINS complex subunit 2

decreases expression

Azathioprine results in decreased expression of GINS2 mRNA

NCBI chr19:48,626,770...48,639,523
Ensembl chr19:48,626,770...48,639,339

G

GINS complex subunit 3

decreases expression

Azathioprine results in decreased expression of GINS3 mRNA

NCBI chr19:9,420,085...9,428,621
Ensembl chr19:9,420,086...9,428,687

G

GIPC PDZ domain containing family, member 2

decreases expression

Azathioprine results in decreased expression of GIPC2 mRNA

NCBI chr 2:241,030,764...241,110,236
Ensembl chr 2:241,030,770...241,110,236

G

glutaredoxin

increases expression

Azathioprine results in increased expression of GLRX mRNA

NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680

G

glutamate dehydrogenase 1

decreases expression

Azathioprine results in decreased expression of GLUD1 mRNA

NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957

G

geminin, DNA replication inhibitor

decreases expression

Azathioprine results in decreased expression of GMNN mRNA

NCBI chr17:40,301,771...40,310,054
Ensembl chr17:40,301,808...40,310,054

G

golgi membrane protein 1

increases expression

Azathioprine results in increased expression of GOLM1 mRNA

NCBI chr17:4,995,925...5,044,329
Ensembl chr17:4,996,104...5,034,057

G

golgi transport 1A

increases expression

Azathioprine results in increased expression of GOLT1A mRNA

NCBI chr13:44,760,356...44,773,123
Ensembl chr13:44,760,380...44,773,122

G

glycerol-3-phosphate acyltransferase 3

increases expression

Azathioprine results in increased expression of GPAT3 mRNA

NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490

G

glycoprotein m6b

increases expression

Azathioprine results in increased expression of GPM6B mRNA

NCBI chr X:28,057,788...28,204,409
Ensembl chr X:28,059,450...28,204,211

G

G protein-coupled receptor 137B

increases expression

Azathioprine results in increased expression of GPR137B mRNA

NCBI chr17:86,003,635...86,041,841
Ensembl chr17:85,966,921...86,041,835

G

glutamic--pyruvic transaminase

increases expression
multiple interactions

Azathioprine results in increased expression of GPT protein
eritoran inhibits the reaction [Azathioprine results in increased expression of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 2

increases expression

Azathioprine results in increased expression of GPX2 mRNA

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutathione peroxidase 3

increases expression

Azathioprine results in increased expression of GPX3 mRNA

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

growth factor receptor bound protein 10

increases expression

Azathioprine results in increased expression of GRB10 mRNA

NCBI chr14:86,495,051...86,602,800
Ensembl chr14:86,495,054...86,602,806

G

growth factor receptor bound protein 14

decreases expression

Azathioprine results in decreased expression of GRB14 mRNA

NCBI chr 3:49,568,210...49,683,805
Ensembl chr 3:49,568,210...49,683,889

G

gasdermin E

decreases expression

Azathioprine results in decreased expression of GSDME mRNA

NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806

G

glutathione-disulfide reductase

increases expression

Azathioprine results in increased expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione synthetase

increases expression

Azathioprine results in increased expression of GSS mRNA

NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198

G

glutathione S-transferase alpha 1

affects metabolic processing

GSTA1 protein affects the metabolism of Azathioprine

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase alpha 2

affects response to substance
affects metabolic processing

GSTA2 gene polymorphism affects the susceptibility to Azathioprine
GSTA2 protein affects the metabolism of Azathioprine

PMID:18155239 PMID:20434437

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase mu 1

affects metabolic processing
affects response to substance

GSTM1 protein affects the metabolism of Azathioprine
GSTM1 gene polymorphism affects the susceptibility to Azathioprine

PMID:17206640 PMID:18155239 PMID:20434437

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

G-2 and S-phase expressed 1

decreases expression

Azathioprine results in decreased expression of GTSE1 mRNA

NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806

G

H2A.X variant histone

decreases expression

Azathioprine results in decreased expression of H2AX mRNA

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

H2A.Z variant histone 1

decreases expression

Azathioprine results in decreased expression of H2AZ1 mRNA

NCBI chr 2:226,355,668...226,357,984
Ensembl chr 2:226,355,708...226,358,485

G

H2A.Z variant histone 2

decreases expression

Azathioprine results in decreased expression of H2AZ2 mRNA

NCBI chr14:81,293,304...81,312,209
Ensembl chr14:81,293,299...81,312,144

G

hydroxyacyl-CoA dehydrogenase

decreases expression

Azathioprine results in decreased expression of HADH mRNA

NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353

G

HAUS augmin like complex subunit 6

decreases expression

Azathioprine results in decreased expression of HAUS6 mRNA

NCBI chr 5:101,116,532...101,156,396
Ensembl chr 5:101,119,300...101,153,124

G

helicase, lymphoid specific

decreases expression

Azathioprine results in decreased expression of HELLS mRNA

NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844

G

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6

decreases expression

Azathioprine results in decreased expression of HERC6 mRNA

NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744

G

hes-related family bHLH transcription factor with YRPW motif 1

increases expression

Azathioprine results in increased expression of HEY1 mRNA

NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312

G

hematopoietically expressed homeobox

decreases expression

Azathioprine results in decreased expression of HHEX mRNA

NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042

G

HHIP like 2

increases expression

Azathioprine results in increased expression of HHIPL2 mRNA

NCBI chr13:95,054,685...95,074,609
Ensembl chr13:95,054,694...95,074,608

G

hypoxia inducible lipid droplet-associated

decreases expression

Azathioprine results in decreased expression of HILPDA mRNA

NCBI chr 4:57,871,088...57,874,048
Ensembl chr 4:57,871,110...57,874,557

G

histone cluster 1, H2bc

increases expression

Azathioprine results in increased expression of H2BC21 mRNA

NCBI chr17:42,692,335...42,696,601
Ensembl chr17:42,694,723...42,696,642

G

histone cluster 1 H2B family member D

increases expression

Azathioprine results in increased expression of H2BC5 mRNA

NCBI chr17:42,792,887...42,793,268

G

hexokinase 1

increases expression

Azathioprine results in increased expression of HK1 mRNA

NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131

G

hexokinase 2

decreases expression

Azathioprine results in decreased expression of HK2 mRNA

NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530

G

high mobility group box 1

increases expression

Azathioprine results in increased expression of HMGB1 protein

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

high mobility group box 2

decreases expression

Azathioprine results in decreased expression of HMGB2 mRNA

NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140

G

3-hydroxy-3-methylglutaryl-CoA reductase

decreases expression

Azathioprine results in decreased expression of HMGCR mRNA

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

high mobility group nucleosomal binding domain 3

decreases expression

Azathioprine results in decreased expression of HMGN3 mRNA

NCBI chr 8:84,022,493...84,059,329
Ensembl chr 8:84,022,495...84,062,976

G

hyaluronan-mediated motility receptor

decreases expression

Azathioprine results in decreased expression of HMMR mRNA

NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060

G

homeo box D1

decreases expression

Azathioprine results in decreased expression of HOXD1 mRNA

NCBI chr 3:59,665,629...59,667,769
Ensembl chr 3:59,665,629...59,667,769

G

haptoglobin

multiple interactions

[Carbon Tetrachloride co-treated with Azathioprine] results in increased expression of HP protein

NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523

G

hypoxanthine phosphoribosyltransferase 1

increases mutagenesis

Azathioprine results in increased mutagenesis of HPRT1 gene

NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154

G

hydroxysteroid 11-beta dehydrogenase 1

decreases expression

Azathioprine results in decreased expression of HSD11B1 mRNA

NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687

G

hydroxysteroid 11-beta dehydrogenase 2

decreases expression

Azathioprine results in decreased expression of HSD11B2 mRNA

NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899

G

hydroxysteroid dehydrogenase like 2

decreases expression

Azathioprine results in decreased expression of HSDL2 mRNA

NCBI chr 5:74,443,933...74,479,104
Ensembl chr 5:74,443,872...74,479,839

G

heat shock transcription factor 1

increases activity

Azathioprine results in increased activity of HSF1 protein

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

G

inhibitor of DNA binding 3

increases expression

Azathioprine results in increased expression of ID3 mRNA

NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349

G

isocitrate dehydrogenase (NADP(+)) 1

decreases expression

Azathioprine results in decreased expression of IDH1 mRNA

NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708

G

isopentenyl-diphosphate delta isomerase 1

decreases expression

Azathioprine results in decreased expression of IDI1 mRNA

NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357

G

immediate early response 2

increases expression

Azathioprine results in increased expression of IER2 mRNA

NCBI chr19:23,494,551...23,496,075
Ensembl chr19:23,494,184...23,499,211

G

immediate early response 3

increases expression

Azathioprine results in increased expression of IER3 mRNA

NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583

G

immediate early response 5

increases expression

Azathioprine results in increased expression of IER5 mRNA

NCBI chr13:67,270,134...67,272,226
Ensembl chr13:67,270,135...67,272,227

G

immediate early response 5-like

increases expression

Azathioprine results in increased expression of IER5L mRNA

NCBI chr 3:13,744,056...13,745,647
Ensembl chr 3:13,744,078...13,745,647

G

interferon, alpha-inducible protein 27

decreases expression

Azathioprine results in decreased expression of IFI27 mRNA

NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294

G

interferon-induced protein 35

decreases expression

Azathioprine results in decreased expression of IFI35 mRNA

NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,381,010...86,389,952

G

interferon-induced protein 44

decreases expression

Azathioprine results in decreased expression of IFI44 mRNA

NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844

G

interferon-induced protein 44-like

decreases expression

Azathioprine results in decreased expression of IFI44L mRNA

NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359

G

interferon induced with helicase C domain 1

decreases expression

Azathioprine results in decreased expression of IFIH1 mRNA

PMID:19192274 PMID:22623647

NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456

G

interferon-induced protein with tetratricopeptide repeats 3

decreases expression

Azathioprine results in decreased expression of IFIT3 mRNA

NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307

G

interferon beta 1

decreases expression

Azathioprine results in decreased expression of IFNB1 mRNA

NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523

G

interferon gamma

multiple interactions

[Azathioprine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

immunoglobulin superfamily, DCC subclass, member 3

decreases expression

Azathioprine results in decreased expression of IGDCC3 mRNA

NCBI chr 8:65,661,165...65,707,961
Ensembl chr 8:65,661,196...65,707,959

G

insulin-like growth factor 1

multiple interactions

Azathioprine inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; Azathioprine inhibits the reaction [IGF1 protein results in increased phosphorylation of FOXO1 protein]; Azathioprine inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 1 receptor

decreases expression
multiple interactions

Azathioprine results in decreased expression of IGF1R protein
Azathioprine inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

insulin-like growth factor binding protein 3

increases expression

Azathioprine results in increased expression of IGFBP3 mRNA

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

interleukin 11

increases expression

Azathioprine results in increased expression of IL11 mRNA

NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129

G

interleukin 12A

multiple interactions

Azathioprine results in increased expression of [IL12A protein binds to IL12B protein]

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 12B

multiple interactions

Azathioprine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL12B protein]; Azathioprine results in increased expression of [IL12A protein binds to IL12B protein]

PMID:19584951 PMID:36416909

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 1 alpha

multiple interactions

[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Azathioprine

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression

Azathioprine results in increased expression of IL1B mRNA

PMID:24184165 PMID:29594315

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor antagonist

decreases expression

Azathioprine results in decreased expression of IL1RN mRNA

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 23 subunit alpha

decreases expression

Azathioprine results in decreased expression of IL23A mRNA

NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923

G

interleukin 4

decreases expression

Azathioprine results in decreased expression of IL4 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions
decreases expression

[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Azathioprine
Azathioprine results in decreased expression of IL6 mRNA; Azathioprine results in decreased expression of IL6 protein

PMID:19192274 PMID:19362101

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 receptor

increases expression

Azathioprine results in increased expression of IL6R mRNA

NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536

G

interleukin 7

decreases expression

Azathioprine results in decreased expression of IL7 mRNA

NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075

G

inositol monophosphatase 2

decreases expression

Azathioprine results in decreased expression of IMPA2 mRNA

NCBI chr18:60,834,206...60,867,575
Ensembl chr18:60,834,246...60,865,641

G

inosine monophosphate dehydrogenase 1

affects response to substance

IMPDH1 promoter mutant form affects the susceptibility to Azathioprine

NCBI chr 4:57,801,842...57,817,434
Ensembl chr 4:57,801,831...57,819,076

G

inosine monophosphate dehydrogenase 2

increases expression

Azathioprine results in increased expression of IMPDH2 mRNA

NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359

G

interleukin-1 receptor-associated kinase 1 binding protein 1

decreases expression

Azathioprine results in decreased expression of IRAK1BP1 mRNA

NCBI chr 8:83,731,512...83,748,289
Ensembl chr 8:83,731,507...83,748,289

G

interferon regulatory factor 1

decreases expression

Azathioprine results in decreased expression of IRF1 mRNA

NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166

G

interferon regulatory factor 7

decreases expression

Azathioprine results in decreased expression of IRF7 mRNA

NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832

G

insulin receptor substrate 1

multiple interactions

Azathioprine results in increased phosphorylation of and results in decreased expression of IRS1 protein

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

iroquois homeobox 3

decreases expression

Azathioprine results in decreased expression of IRX3 mRNA

NCBI chr19:15,211,882...15,215,317
Ensembl chr19:15,211,878...15,215,317

G

ISG15 ubiquitin-like modifier

decreases expression

Azathioprine results in decreased expression of ISG15 mRNA

NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435

G

interferon stimulated exonuclease gene 20

decreases expression

Azathioprine results in decreased expression of ISG20 mRNA

NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027

G

inosine triphosphatase

affects response to substance

ITPA gene polymorphism affects the susceptibility to Azathioprine; ITPA protein affects the susceptibility to Azathioprine

PMID:15167706 PMID:15571265 PMID:16431304 PMID:19129747 PMID:19214663 More...

NCBI chr 3:117,885,464...117,897,247
Ensembl chr 3:117,885,099...117,897,249

G

inositol 1,4,5-trisphosphate receptor interacting protein

increases expression

Azathioprine results in increased expression of ITPRIP mRNA

NCBI chr 1:246,762,804...246,786,379
Ensembl chr 1:246,762,472...246,786,408

G

jagged canonical Notch ligand 1

increases expression

Azathioprine results in increased expression of JAG1 mRNA

NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

Azathioprine results in increased expression of JUN mRNA

PMID:22623647 PMID:23958494

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

KN motif and ankyrin repeat domains 4

decreases expression

Azathioprine results in decreased expression of KANK4 mRNA

NCBI chr 5:113,401,491...113,465,526
Ensembl chr 5:113,402,468...113,465,555

G

kelch repeat and BTB domain containing 7

decreases expression

Azathioprine results in decreased expression of KBTBD7 mRNA

NCBI chr15:54,806,878...54,811,457
Ensembl chr15:54,806,873...54,811,687

G

potassium channel tetramerization domain containing 3

decreases expression

Azathioprine results in decreased expression of KCTD3 mRNA

NCBI chr13:100,510,193...100,548,765
Ensembl chr13:100,510,195...100,548,718

G

Kelch-like ECH-associated protein 1

affects response to substance

KEAP1 protein affects the susceptibility to Azathioprine

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

kinesin family member 11

decreases expression

Azathioprine results in decreased expression of KIF11 mRNA

NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766

G

kinesin family member 15

decreases expression

Azathioprine results in decreased expression of KIF15 mRNA

NCBI chr 8:122,601,888...122,672,750
Ensembl chr 8:122,601,897...122,672,750

G

kinesin family member 18A

decreases expression

Azathioprine results in decreased expression of KIF18A mRNA

NCBI chr 3:95,764,388...95,824,756
Ensembl chr 3:95,764,388...95,824,582

G

kinesin family member 20A

decreases expression

Azathioprine results in decreased expression of KIF20A mRNA

NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780

G

kinesin family member 20B

decreases expression

Azathioprine results in decreased expression of KIF20B mRNA

NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787

G

kinesin family member 23

decreases expression

Azathioprine results in decreased expression of KIF23 mRNA

NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072

G

kinesin family member 2C

decreases expression

Azathioprine results in decreased expression of KIF2C mRNA

NCBI chr 5:130,637,347...130,662,680
Ensembl chr 5:130,637,347...130,662,637

G

KLF transcription factor 5

increases expression

Azathioprine results in increased expression of KLF5 mRNA

NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445

G

KLF transcription factor 6

increases expression

Azathioprine results in increased expression of KLF6 mRNA

NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570

G

kelch-like family member 14

decreases expression

Azathioprine results in decreased expression of KLHL14 mRNA

NCBI chr18:12,804,253...12,917,828
Ensembl chr18:12,804,253...12,917,828

G

kinetochore associated 1

decreases expression

Azathioprine results in decreased expression of KNTC1 mRNA

NCBI chr12:32,769,020...32,839,617
Ensembl chr12:32,769,020...32,839,561

G

kynureninase

increases expression

Azathioprine results in increased expression of KYNU mRNA

NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488

G

laminin subunit beta 3

decreases expression

Azathioprine results in decreased expression of LAMB3 mRNA

NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405

G

liver enriched antimicrobial peptide 2

decreases expression

Azathioprine results in decreased expression of LEAP2 mRNA

NCBI chr10:37,580,172...37,581,244
Ensembl chr10:37,577,855...37,581,244

G

lipoic acid synthetase

increases expression

Azathioprine results in increased expression of LIAS mRNA

NCBI chr14:42,876,699...42,893,824
Ensembl chr14:42,876,699...42,893,783

G

LIF, interleukin 6 family cytokine

increases expression

Azathioprine results in increased expression of LIF mRNA

PMID:22623647 PMID:26198647

NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482

G

lamin B1

decreases expression

Azathioprine results in decreased expression of LMNB1 mRNA

NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502

G

lysophosphatidic acid receptor 6

decreases expression

Azathioprine results in decreased expression of LPAR6 mRNA

NCBI chr15:48,416,548...48,418,357
Ensembl chr15:48,416,544...48,422,331

G

LDL receptor related protein 10

increases expression

Azathioprine results in increased expression of LRP10 mRNA

NCBI chr15:27,921,335...27,927,507
Ensembl chr15:27,920,259...27,927,505

G

leucine rich repeat protein 1

decreases expression

Azathioprine results in decreased expression of LRR1 mRNA

NCBI chr 6:87,643,195...87,651,894
Ensembl chr 6:87,643,217...87,651,894

G

leucine rich repeat containing 8 VRAC subunit A

increases expression

Azathioprine results in increased expression of LRRC8A mRNA

NCBI chr 3:13,509,577...13,537,174
Ensembl chr 3:13,510,513...13,536,202

G

lactotransferrin

decreases expression

Azathioprine results in decreased expression of LTF mRNA

NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795

G

leucine rich adaptor protein 1-like

increases expression

Azathioprine results in increased expression of LURAP1L mRNA

NCBI chr 5:95,362,005...95,409,439
Ensembl chr 5:95,362,005...95,409,438

G

latexin

increases expression

Azathioprine results in increased expression of LXN mRNA

NCBI chr 2:151,727,556...151,733,426
Ensembl chr 2:151,727,102...151,733,460

G

lymphocyte antigen 6 family member E

decreases expression

Azathioprine results in decreased expression of LY6E mRNA

NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689

G

lymphocyte antigen 96

increases expression

Azathioprine results in increased expression of LY96 mRNA

NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386

G

lysozyme 2

decreases expression

Azathioprine results in decreased expression of LYZ mRNA

NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106

G

mitotic arrest deficient 2 like 1

decreases expression

Azathioprine results in decreased expression of MAD2L1 mRNA

NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470

G

MAF bZIP transcription factor F

increases expression

Azathioprine results in increased expression of MAFF mRNA

NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851

G

MAGE family member D1

decreases expression

Azathioprine results in decreased expression of MAGED1 mRNA

NCBI chr X:59,422,715...59,429,381
Ensembl chr X:59,422,717...59,429,364

G

mal, T-cell differentiation protein 2

decreases expression

Azathioprine results in decreased expression of MAL2 mRNA

NCBI chr 7:85,900,453...85,933,433
Ensembl chr 7:85,900,453...85,933,429

G

microtubule-associated protein 1B

increases expression

Azathioprine results in increased expression of MAP1B mRNA

NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317

G

mitogen activated protein kinase kinase 1

decreases phosphorylation

Azathioprine results in decreased phosphorylation of MAP2K1 protein

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen-activated protein kinase kinase 6

decreases expression

Azathioprine results in decreased expression of MAP2K6 mRNA

NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Azathioprine promotes the reaction [MAPK1 protein binds to TSC2 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Azathioprine results in increased phosphorylation of MAPK1 protein]; Azathioprine promotes the reaction [MAPK1 protein binds to TSC2 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 13

increases expression

Azathioprine results in increased expression of MAPK13 mRNA

NCBI chr20:6,835,277...6,845,500
Ensembl chr20:6,835,320...6,844,222

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Azathioprine promotes the reaction [MAPK3 protein binds to TSC2 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Azathioprine results in increased phosphorylation of MAPK3 protein]; Azathioprine promotes the reaction [MAPK3 protein binds to TSC2 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

myristoylated alanine rich protein kinase C substrate

decreases expression

Azathioprine results in decreased expression of MARCKS mRNA

NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012

G

microtubule associated serine/threonine kinase-like

decreases expression

Azathioprine results in decreased expression of MASTL mRNA

NCBI chr17:85,250,512...85,287,479
Ensembl chr17:85,251,997...85,287,353

G

matrilin 3

decreases expression

Azathioprine results in decreased expression of MATN3 mRNA

NCBI chr 6:31,748,517...31,768,564
Ensembl chr 6:31,748,474...31,768,101

G

mannose binding lectin 2

decreases expression

Azathioprine results in decreased expression of MBL2 mRNA

NCBI chr 1:228,016,439...228,024,736

G

minichromosome maintenance 10 replication initiation factor

decreases expression

Azathioprine results in decreased expression of MCM10 mRNA

NCBI chr17:73,263,788...73,288,346
Ensembl chr17:73,266,095...73,287,364

G

minichromosome maintenance complex component 2

decreases expression

Azathioprine results in decreased expression of MCM2 mRNA

NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847

G

minichromosome maintenance complex component 3

decreases expression

Azathioprine results in decreased expression of MCM3 mRNA

NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314

G

minichromosome maintenance complex component 4

decreases expression

Azathioprine results in decreased expression of MCM4 mRNA

NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144

G

minichromosome maintenance complex component 5

decreases expression

Azathioprine results in decreased expression of MCM5 mRNA

NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389

G

minichromosome maintenance complex component 6

decreases expression

Azathioprine results in decreased expression of MCM6 mRNA

NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960

G

Mdm1 nuclear protein

decreases expression

Azathioprine results in decreased expression of MDM1 mRNA

NCBI chr 7:53,729,603...53,766,034
Ensembl chr 7:53,729,610...53,766,034

G

maternal embryonic leucine zipper kinase

decreases expression

Azathioprine results in decreased expression of MELK mRNA

NCBI chr 5:58,540,393...58,600,562
Ensembl chr 5:58,540,449...58,600,937

G

MET proto-oncogene, receptor tyrosine kinase

decreases expression

Azathioprine results in decreased expression of MET mRNA

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

meteorin-like, glial cell differentiation regulator

increases expression

Azathioprine results in increased expression of METRNL mRNA

NCBI chr10:106,963,880...106,977,875
Ensembl chr10:106,963,880...106,977,869

G

MIS18 kinetochore protein A

decreases expression

Azathioprine results in decreased expression of MIS18A mRNA

NCBI chr11:29,968,030...29,981,058
Ensembl chr11:29,967,701...29,981,062

G

MIS18 binding protein 1

decreases expression

Azathioprine results in decreased expression of MIS18BP1 mRNA

NCBI chr 6:83,182,497...83,231,978
Ensembl chr 6:83,182,499...83,231,383

G

Mix paired-like homeobox 1

decreases expression

Azathioprine results in decreased expression of MIXL1 mRNA

NCBI chr13:92,422,031...92,426,065
Ensembl chr13:92,422,031...92,426,065

G

marker of proliferation Ki-67

decreases expression

Azathioprine results in decreased expression of MKI67 mRNA

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

mixed lineage kinase domain like pseudokinase

decreases expression

Azathioprine results in decreased expression of MLKL mRNA

NCBI chr19:39,277,526...39,304,555
Ensembl chr19:39,276,785...39,304,502

G

matrix metallopeptidase 10

decreases expression

Azathioprine results in decreased expression of MMP10 mRNA

NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748

G

matrix metallopeptidase 12

decreases expression

Azathioprine results in decreased expression of MMP12 mRNA

NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611

G

matrix metallopeptidase 3

increases expression

Azathioprine results in increased expression of MMP3 mRNA

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

meiotic nuclear divisions 1

decreases expression

Azathioprine results in decreased expression of MND1 mRNA

NCBI chr 2:169,433,523...169,496,081
Ensembl chr 2:169,433,540...169,496,096

G

meiosis-specific nuclear structural 1

decreases expression

Azathioprine results in decreased expression of MNS1 mRNA

NCBI chr 8:73,148,877...73,169,570
Ensembl chr 8:73,148,877...73,176,925

G

molybdenum cofactor sulfurase

multiple interactions

MOCOS gene SNP results in decreased metabolism of and affects the susceptibility to Azathioprine

NCBI chr18:15,931,659...15,977,415
Ensembl chr18:15,931,654...15,977,187

G

mitochondrial pyruvate carrier 1

decreases expression

Azathioprine results in decreased expression of MPC1 mRNA

NCBI chr 1:52,437,745...52,449,399
Ensembl chr 1:52,437,741...52,449,400

G

mutS homolog 2

affects response to substance
decreases expression

MSH2 gene mutant form affects the susceptibility to Azathioprine
Azathioprine results in decreased expression of MSH2 mRNA

PMID:20923998 PMID:22623647

NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938

G

mutS homolog 6

decreases expression

Azathioprine results in decreased expression of MSH6 mRNA

NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956

G

methylsterol monooxygenase 1

decreases expression

Azathioprine results in decreased expression of MSMO1 mRNA

NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016

G

mitochondrial amidoxime reducing component 1

decreases expression

Azathioprine results in decreased expression of MTARC1 mRNA

NCBI chr13:96,324,377...96,362,677
Ensembl chr13:96,339,757...96,397,796

G

mitochondrial fission regulator 2

decreases expression

Azathioprine results in decreased expression of MTFR2 mRNA

NCBI chr 1:15,123,232...15,138,632
Ensembl chr 1:15,070,894...15,148,832

G

mechanistic target of rapamycin kinase

increases phosphorylation

Azathioprine results in increased phosphorylation of MTOR protein

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

mucin 20, cell surface associated

increases expression

Azathioprine results in increased expression of MUC20 mRNA

NCBI chr11:67,987,816...68,001,496
Ensembl chr11:67,987,800...68,001,495

G

MX dynamin like GTPase 1

decreases expression

Azathioprine results in decreased expression of MX1 mRNA

NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507

G

max dimerization protein 1

increases expression

Azathioprine results in increased expression of MXD1 mRNA

NCBI chr 4:119,097,353...119,118,080
Ensembl chr 4:119,097,353...119,117,751

G

MYB proto-oncogene like 1

decreases expression

Azathioprine results in decreased expression of MYBL1 mRNA

NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183

G

myosin VC

decreases expression

Azathioprine results in decreased expression of MYO5C mRNA

NCBI chr 8:75,989,497...76,066,485
Ensembl chr 8:75,989,528...76,066,483

G

nucleic acid binding protein 1

increases expression

Azathioprine results in increased expression of NABP1 mRNA

NCBI chr 9:50,098,552...50,133,982
Ensembl chr 9:50,126,726...50,134,107

G

N-acetylglutamate synthase

increases expression

Azathioprine results in increased expression of NAGS mRNA

NCBI chr10:87,098,330...87,102,465
Ensembl chr10:87,098,330...87,102,465

G

nuclear autoantigenic sperm protein

decreases expression

Azathioprine results in decreased expression of NASP mRNA

NCBI chr 5:130,057,363...130,083,003
Ensembl chr 5:130,057,363...130,082,928

G

non-SMC condensin I complex, subunit G

decreases expression

Azathioprine results in decreased expression of NCAPG mRNA

NCBI chr14:65,403,930...65,432,902
Ensembl chr14:65,404,163...65,432,902

G

non-SMC condensin II complex, subunit G2

decreases expression

Azathioprine results in decreased expression of NCAPG2 mRNA

NCBI chr 6:137,342,449...137,418,083
Ensembl chr 6:137,342,943...137,415,159

G

non-SMC condensin I complex, subunit H

decreases expression

Azathioprine results in decreased expression of NCAPH mRNA

NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180

G

neutrophil cytosolic factor 2

increases expression

Azathioprine results in increased expression of NCF2 mRNA

NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277

G

NDC80 kinetochore complex component

decreases expression

Azathioprine results in decreased expression of NDC80 mRNA

NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924

G

N-myc downstream regulated 1

increases expression

Azathioprine results in increased expression of NDRG1 mRNA

NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880

G

NDUFA4, mitochondrial complex associated like 2

decreases expression

Azathioprine results in decreased expression of NDUFA4L2 mRNA

NCBI chr 7:63,351,021...63,359,010
Ensembl chr 7:63,356,883...63,359,010

G

NIMA-related kinase 2

decreases expression

Azathioprine results in decreased expression of NEK2 mRNA

NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051

G

NFE2 like bZIP transcription factor 2

multiple interactions

NFE2L2 protein affects the reaction [Azathioprine results in increased activity of NQO1 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFE2 like bZIP transcription factor 3

decreases expression

Azathioprine results in decreased expression of NFE2L3 mRNA

NCBI chr 4:80,506,756...80,534,629
Ensembl chr 4:80,506,756...80,534,629

G

nidogen 2

increases expression

Azathioprine results in increased expression of NID2 mRNA

NCBI chr15:4,458,082...4,513,808
Ensembl chr15:4,458,084...4,513,843

G

NLR family, pyrin domain containing 3

increases expression

Azathioprine results in increased expression of NLRP3 mRNA

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

neuromedin B

decreases expression

Azathioprine results in decreased expression of NMB mRNA

NCBI chr 1:134,869,446...134,875,507
Ensembl chr 1:134,869,446...134,872,190

G

nitric oxide synthase 2

decreases expression

Azathioprine results in decreased expression of NOS2 mRNA; Azathioprine results in decreased expression of NOS2 protein

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nephronectin

decreases expression

Azathioprine results in decreased expression of NPNT mRNA

NCBI chr 2:221,391,151...221,459,527
Ensembl chr 2:221,391,153...221,459,401

G

NAD(P)H quinone dehydrogenase 1

increases activity
multiple interactions

Azathioprine results in increased activity of NQO1 protein
NFE2L2 protein affects the reaction [Azathioprine results in increased activity of NQO1 protein]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 2, group F, member 2

decreases expression

Azathioprine results in decreased expression of NR2F2 mRNA

NCBI chr 1:124,008,282...124,022,521
Ensembl chr 1:124,009,181...124,022,031

G

nuclear receptor subfamily 4, group A, member 3

decreases expression

Azathioprine results in decreased expression of NR4A3 mRNA

NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733

G

NUF2 component of NDC80 kinetochore complex

decreases expression

Azathioprine results in decreased expression of NUF2 mRNA

NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766

G

nucleolar and spindle associated protein 1

decreases expression

Azathioprine results in decreased expression of NUSAP1 mRNA

NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624

G

2'-5' oligoadenylate synthetase 1A

decreases expression

Azathioprine results in decreased expression of OAS1 mRNA

NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517

G

2'-5'-oligoadenylate synthetase 3

decreases expression

Azathioprine results in decreased expression of OAS3 mRNA

NCBI chr12:35,779,028...35,802,781
Ensembl chr12:35,779,022...35,802,781

G

odontogenic, ameloblast associated

decreases expression

Azathioprine results in decreased expression of ODAM mRNA

NCBI chr14:20,193,286...20,202,517
Ensembl chr14:20,193,302...20,202,517

G

Opa interacting protein 5

decreases expression

Azathioprine results in decreased expression of OIP5 mRNA

NCBI chr 3:106,593,746...106,603,281
Ensembl chr 3:106,593,760...106,603,250

G

olfactomedin-like 2B

increases expression

Azathioprine results in increased expression of OLFML2B mRNA

NCBI chr13:82,869,414...82,906,607
Ensembl chr13:82,869,433...82,906,607

G

origin recognition complex, subunit 1

decreases expression

Azathioprine results in decreased expression of ORC1 mRNA

NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375

G

origin recognition complex, subunit 6

decreases expression

Azathioprine results in decreased expression of ORC6 mRNA

NCBI chr19:21,757,867...21,765,638
Ensembl chr19:21,757,866...21,765,662

G

orosomucoid 1

multiple interactions

[Carbon Tetrachloride co-treated with Azathioprine] results in decreased expression of ORM1 protein

NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154

G

oxidative stress induced growth inhibitor 1

increases expression

Azathioprine results in increased expression of OSGIN1 mRNA

NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516

G

progestagen associated endometrial protein

increases expression

Azathioprine results in increased expression of PAEP mRNA

NCBI chr 3:8,531,136...8,534,430
Ensembl chr 3:8,531,138...8,534,430

G

phenylalanine hydroxylase

decreases expression

Azathioprine results in decreased expression of PAH mRNA

NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130

G

palladin, cytoskeletal associated protein

increases expression

Azathioprine results in increased expression of PALLD mRNA

NCBI chr16:28,228,006...28,621,349
Ensembl chr16:27,981,354...28,621,337

G

pantothenate kinase 1

decreases expression

Azathioprine results in decreased expression of PANK1 mRNA

NCBI chr 1:232,324,718...232,395,445
Ensembl chr 1:232,328,430...232,396,829

G

progestin and adipoQ receptor family member 5

increases expression

Azathioprine results in increased expression of PAQR5 mRNA

NCBI chr 8:62,431,867...62,513,688
Ensembl chr 8:62,431,867...62,513,688

G

progestin and adipoQ receptor family member 9

decreases expression

Azathioprine results in decreased expression of PAQR9 mRNA

NCBI chr 8:96,114,249...96,116,546

G

PARP1 binding protein

decreases expression

Azathioprine results in decreased expression of PARPBP mRNA

NCBI chr 7:22,511,427...22,580,834
Ensembl chr 7:22,511,427...22,573,695

G

PAS domain containing serine/threonine kinase

decreases expression

Azathioprine results in decreased expression of PASK mRNA

NCBI chr 9:93,844,275...93,886,036
Ensembl chr 9:93,844,278...93,885,111

G

PDZ binding kinase

decreases expression

Azathioprine results in decreased expression of PBK mRNA

NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014

G

PBX homeobox 3

decreases expression

Azathioprine results in decreased expression of PBX3 mRNA

NCBI chr 3:17,488,691...17,682,412
Ensembl chr 3:17,488,693...17,682,791

G

phosphoenolpyruvate carboxykinase 1

decreases expression

Azathioprine results in decreased expression of PCK1 mRNA

NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191

G

PCNA clamp associated factor

decreases expression

Azathioprine results in decreased expression of PCLAF mRNA

NCBI chr 8:66,420,606...66,432,994
Ensembl chr 8:66,420,587...66,432,994
Ensembl chr 8:66,420,587...66,432,994

G

proliferating cell nuclear antigen

decreases expression

Azathioprine results in decreased expression of PCNA mRNA

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

platelet derived growth factor subunit A

increases expression

Azathioprine results in increased expression of PDGFA mRNA

NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497

G

paternally expressed 10

decreases expression

Azathioprine results in decreased expression of PEG10 mRNA

NCBI chr 4:32,842,441...32,855,639
Ensembl chr 4:32,848,493...32,852,621

G

phosphoglycerate dehydrogenase

decreases expression

Azathioprine results in decreased expression of PHGDH mRNA

NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944

G

pleckstrin homology-like domain, family A, member 2

increases expression

Azathioprine results in increased expression of PHLDA2 mRNA

NCBI chr 1:198,696,897...198,699,292
Ensembl chr 1:198,696,897...198,697,836

G

PIF1 5'-to-3' DNA helicase

decreases expression

Azathioprine results in decreased expression of PIF1 mRNA

NCBI chr 8:66,110,641...66,120,202
Ensembl chr 8:66,111,072...66,120,200

G

phosphatidylinositol glycan anchor biosynthesis, class A

affects mutagenesis

Azathioprine affects the mutagenesis of PIGA

NCBI chr X:30,043,033...30,055,861
Ensembl chr X:30,042,343...30,055,804

G

paired immunoglobin-like type 2 receptor alpha

decreases expression

Azathioprine results in decreased expression of PILRA mRNA

NCBI chr12:17,787,169...17,798,149
Ensembl chr12:17,787,127...17,798,094

G

Pim-1 proto-oncogene, serine/threonine kinase

increases expression

Azathioprine results in increased expression of PIM1 mRNA

NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174

G

PICALM interacting mitotic regulator

decreases expression

Azathioprine results in decreased expression of PIMREG mRNA

NCBI chr10:56,669,603...56,674,540
Ensembl chr10:56,669,675...56,674,791

G

phosphatidylinositol-4-phosphate 5-kinase type 1 beta

decreases expression

Azathioprine results in decreased expression of PIP5K1B mRNA

NCBI chr 1:221,907,220...222,183,672
Ensembl chr 1:221,914,159...222,183,672

G

polo-like kinase 3

increases expression

Azathioprine results in increased expression of PLK3 mRNA

NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317

G

phospholipid phosphatase 3

decreases expression

Azathioprine results in decreased expression of PLPP3 mRNA

NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205

G

phospholipid phosphatase related 1

decreases expression

Azathioprine results in decreased expression of LPPR1 mRNA

NCBI chr 5:63,437,457...63,725,286
Ensembl chr 5:63,437,816...63,763,835

G

patatin-like phospholipase domain containing 3

decreases expression

Azathioprine results in decreased expression of PNPLA3 mRNA

NCBI chr 7:115,293,538...115,314,077
Ensembl chr 7:115,293,538...115,314,077

G

protein O-glucosyltransferase 3

decreases expression

Azathioprine results in decreased expression of POGLUT3 mRNA

NCBI chr 8:53,777,614...53,795,404
Ensembl chr 8:53,777,785...53,795,399

G

DNA polymerase alpha 1, catalytic subunit

decreases expression

Azathioprine results in decreased expression of POLA1 mRNA

NCBI chr X:58,034,617...58,348,612
Ensembl chr X:58,034,619...58,348,536

G

DNA polymerase delta 3, accessory subunit

decreases expression

Azathioprine results in decreased expression of POLD3 mRNA

NCBI chr 1:154,417,893...154,456,687
Ensembl chr 1:154,418,084...154,456,665

G

DNA polymerase delta 4, accessory subunit

increases expression

Azathioprine results in increased expression of POLD4 mRNA

NCBI chr 1:201,526,591...201,528,406
Ensembl chr 1:201,526,665...201,528,401

G

DNA polymerase epsilon 2, accessory subunit

decreases expression

Azathioprine results in decreased expression of POLE2 mRNA

NCBI chr 6:87,674,702...87,712,723
Ensembl chr 6:87,674,702...87,699,305

G

periplakin

increases expression

Azathioprine results in increased expression of PPL mRNA

NCBI chr10:10,450,919...10,496,575
Ensembl chr10:10,450,919...10,496,575

G

protein phosphatase, Mg2+/Mn2+ dependent, 1H

decreases expression

Azathioprine results in decreased expression of PPM1H mRNA

NCBI chr 7:58,338,661...58,599,547
Ensembl chr 7:58,338,661...58,599,547

G

protein phosphatase 1, regulatory subunit 15A

increases expression

Azathioprine results in increased expression of PPP1R15A mRNA

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171

G

protein phosphatase 1, regulatory subunit 18

increases expression

Azathioprine results in increased expression of PPP1R18 mRNA

NCBI chr20:2,877,567...2,887,526
Ensembl chr20:2,877,567...2,891,802

G

protein phosphatase 1, regulatory subunit 3C

decreases expression

Azathioprine results in decreased expression of PPP1R3C mRNA

NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961

G

protein phosphatase 4, regulatory subunit 2

increases expression

Azathioprine results in increased expression of PPP4R2 mRNA

NCBI chr 4:133,454,555...133,495,486
Ensembl chr 4:133,454,555...133,495,486

G

PEAK1 related kinase activating pseudokinase 1

increases expression

Azathioprine results in increased expression of PRAG1 mRNA

NCBI chr16:56,087,885...56,141,153
Ensembl chr16:56,087,885...56,141,153

G

protein regulator of cytokinesis 1

decreases expression

Azathioprine results in decreased expression of PRC1 mRNA

NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765

G

DNA primase subunit 1

decreases expression

Azathioprine results in decreased expression of PRIM1 mRNA

NCBI chr 7:446,342...462,526
Ensembl chr 7:431,805...462,526

G

prominin 1

decreases expression

Azathioprine results in decreased expression of PROM1 mRNA

NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527

G

proteasome 20S subunit beta 9

decreases expression

Azathioprine results in decreased expression of PSMB9 mRNA

NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512

G

proline and serine rich coiled-coil 1

decreases expression

Azathioprine results in decreased expression of PSRC1 mRNA

NCBI chr 2:196,022,361...196,026,874
Ensembl chr 2:196,022,361...196,026,874

G

patched 1

affects mutagenesis

Azathioprine affects the mutagenesis of PTCH1 gene

NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333

G

prostaglandin reductase 1

increases expression

Azathioprine results in increased expression of PTGR1 mRNA

NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666

G

prostaglandin-endoperoxide synthase 2

decreases expression

Azathioprine results in decreased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

PX domain containing 1

increases expression

Azathioprine results in increased expression of PXDC1 mRNA

NCBI chr17:30,275,998...30,304,971
Ensembl chr17:30,276,377...30,304,973

G

2-phosphoxylose phosphatase 1

decreases expression

Azathioprine results in decreased expression of PXYLP1 mRNA

NCBI chr 8:97,419,766...97,485,163
Ensembl chr 8:97,419,776...97,485,064

G

RAB11 family interacting protein 4

decreases expression

Azathioprine results in decreased expression of RAB11FIP4 mRNA

NCBI chr10:64,550,109...64,658,123
Ensembl chr10:64,550,177...64,654,759

G

Rac family small GTPase 1

multiple interactions
affects response to substance
affects binding
decreases activity

Azathioprine inhibits the reaction [RAC1 protein binds to STAT3 protein]
RAC1 gene polymorphism affects the susceptibility to Azathioprine
Azathioprine metabolite binds to RAC1 protein
Azathioprine results in decreased activity of RAC1 protein

PMID:12697733 PMID:21372752

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

Rac GTPase-activating protein 1

decreases expression

Azathioprine results in decreased expression of RACGAP1 mRNA

NCBI chr 7:130,750,936...130,780,891
Ensembl chr 7:130,750,936...130,780,831

G

RAD51 associated protein 1

decreases expression

Azathioprine results in decreased expression of RAD51AP1 mRNA

NCBI chr 4:159,759,454...159,772,473
Ensembl chr 4:159,759,459...159,772,524

G

RAD54 homolog B

decreases expression

Azathioprine results in decreased expression of RAD54B mRNA

NCBI chr 5:25,032,112...25,104,630
Ensembl chr 5:25,032,066...25,104,616

G

Rap1 GTPase-activating protein

increases expression

Azathioprine results in increased expression of RAP1GAP mRNA

NCBI chr 5:149,873,987...149,939,254
Ensembl chr 5:149,892,019...149,939,253

G

retinoic acid receptor responder 1

increases expression

Azathioprine results in increased expression of RARRES1 mRNA

NCBI chr 2:151,749,715...151,783,975
Ensembl chr 2:151,749,715...151,783,978

G

ras related dexamethasone induced 1

increases expression

Azathioprine results in increased expression of RASD1 mRNA

NCBI chr10:44,766,451...44,775,773
Ensembl chr10:44,766,455...44,768,186

G

RNA binding motif protein 24

increases expression

Azathioprine results in increased expression of RBM24 mRNA

NCBI chr17:18,275,681...18,288,231
Ensembl chr17:18,275,688...18,288,102

G

RNA binding protein, mRNA processing factor 2

increases expression

Azathioprine results in increased expression of RBPMS2 mRNA

NCBI chr 8:66,153,169...66,184,278
Ensembl chr 8:66,153,593...66,184,268

G

reversion-inducing-cysteine-rich protein with kazal motifs

decreases expression

Azathioprine results in decreased expression of RECK mRNA

NCBI chr 5:58,102,961...58,169,516
Ensembl chr 5:58,102,981...58,169,502

G

replication factor C subunit 3

decreases expression

Azathioprine results in decreased expression of RFC3 mRNA

NCBI chr12:1,000,987...1,011,778
Ensembl chr12:1,000,994...1,011,778

G

replication factor C subunit 5

decreases expression

Azathioprine results in decreased expression of RFC5 mRNA

NCBI chr12:39,207,484...39,217,041
Ensembl chr12:39,207,484...39,217,312

G

regulator of cell cycle

increases expression

Azathioprine results in increased expression of RGCC mRNA

NCBI chr15:54,662,483...54,675,320
Ensembl chr15:54,662,483...54,681,141

G

regulator of G-protein signaling 4

decreases expression

Azathioprine results in decreased expression of RGS4 mRNA

NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068

G

rhomboid domain containing 1

increases expression

Azathioprine results in increased expression of RHBDD1 mRNA

NCBI chr 9:83,630,037...83,748,690
Ensembl chr 9:83,630,063...83,748,689

G

RAD9-HUS1-RAD1 interacting nuclear orphan 1

decreases expression

Azathioprine results in decreased expression of RHNO1 mRNA

NCBI chr 4:161,634,047...161,639,437
Ensembl chr 4:161,634,048...161,639,371

G

Rho-related BTB domain containing 1

decreases expression

Azathioprine results in decreased expression of RHOBTB1 mRNA

NCBI chr20:19,327,142...19,456,121
Ensembl chr20:19,327,155...19,403,012

G

ras homolog family member C

increases expression

Azathioprine results in increased expression of RHOC mRNA

NCBI chr 2:192,287,065...192,293,292
Ensembl chr 2:192,287,130...192,295,306

G

reactive intermediate imine deaminase A homolog

decreases expression

Azathioprine results in decreased expression of RIDA mRNA

NCBI chr 7:65,691,429...65,705,257
Ensembl chr 7:65,691,435...65,705,716

G

RNA sensor RIG-1

decreases expression

Azathioprine results in decreased expression of RIGI mRNA

NCBI chr 5:55,321,351...55,369,947
Ensembl chr 5:55,321,235...55,370,819

G

Ras and Rab interactor 2

increases expression

Azathioprine results in increased expression of RIN2 mRNA

NCBI chr 3:133,086,858...133,303,604
Ensembl chr 3:133,086,749...133,303,604

G

receptor-interacting serine-threonine kinase 2

decreases expression

Azathioprine results in decreased expression of RIPK2 mRNA

NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657

G

Ras-like without CAAX 1

increases expression

Azathioprine results in increased expression of RIT1 mRNA

NCBI chr 2:174,180,742...174,195,455
Ensembl chr 2:174,180,848...174,195,455

G

RecQ mediated genome instability 2

decreases expression

Azathioprine results in decreased expression of RMI2 mRNA

NCBI chr10:4,829,333...4,837,264
Ensembl chr10:4,830,553...4,837,235

G

ribonuclease A family member 4

decreases expression

Azathioprine results in decreased expression of RNASE4 mRNA

NCBI chr15:24,312,765...24,330,112
Ensembl chr15:24,312,464...24,330,117

G

ring finger protein 144A

decreases expression

Azathioprine results in decreased expression of RNF144A mRNA

NCBI chr 6:42,899,767...43,019,769
Ensembl chr 6:42,903,174...43,020,012

G

ring finger protein 19B

decreases expression

Azathioprine results in decreased expression of RNF19B mRNA

NCBI chr 5:141,406,085...141,431,376
Ensembl chr 5:141,406,118...141,431,380

G

ribosomal protein S6 kinase B1

multiple interactions
increases phosphorylation
decreases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Azathioprine results in increased phosphorylation of RPS6KB1 protein]
Azathioprine results in decreased phosphorylation of RPS6KB1 protein

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

RAS related 2

increases expression

Azathioprine results in increased expression of RRAS2 mRNA

NCBI chr 1:168,233,693...168,303,111
Ensembl chr 1:168,233,693...168,303,111

G

ribonucleotide reductase catalytic subunit M1

decreases expression

Azathioprine results in decreased expression of RRM1 mRNA

NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261

G

ribonucleotide reductase regulatory subunit M2

decreases expression

Azathioprine results in decreased expression of RRM2 mRNA

NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773

G

radical S-adenosyl methionine domain containing 2

decreases expression

Azathioprine results in decreased expression of RSAD2 mRNA

NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699

G

RT1 class II, locus Ba

affects response to substance

HLA-DQA1 gene polymorphism affects the susceptibility to Azathioprine

NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744

G

RT1 class II, locus Db1

affects response to substance

HLA-DRB1 gene polymorphism affects the susceptibility to Azathioprine

NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258

G

S100 calcium binding protein A11

increases expression

Azathioprine results in increased expression of S100A11 mRNA

NCBI chr 2:179,191,688...179,197,098
Ensembl chr 2:179,191,715...179,197,044

G

S100 calcium binding protein A8

increases expression

Azathioprine results in increased expression of S100A8 mRNA

NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643

G

S100 calcium binding protein A9

increases expression

Azathioprine results in increased expression of S100A9 mRNA

NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230

G

spalt-like transcription factor 1

decreases expression

Azathioprine results in decreased expression of SALL1 mRNA

NCBI chr19:18,005,782...18,022,705
Ensembl chr19:18,007,503...18,022,705

G

suppressor APC domain containing 2

decreases expression

Azathioprine results in decreased expression of SAPCD2 mRNA

NCBI chr 3:8,186,089...8,195,119
Ensembl chr 3:8,187,266...8,192,546

G

Scm polycomb group protein like 1

decreases expression

Azathioprine results in decreased expression of SCML1 mRNA

NCBI chr X:32,893,100...32,912,686
Ensembl chr X:32,894,327...32,911,366

G

sodium voltage-gated channel alpha subunit 1

decreases expression

Azathioprine results in decreased expression of SCN1A mRNA

NCBI chr 3:50,952,790...51,071,804
Ensembl chr 3:50,952,791...51,071,699

G

SEL1L family member 3

increases expression

Azathioprine results in increased expression of SEL1L3 mRNA

NCBI chr14:57,775,515...57,882,076
Ensembl chr14:57,775,501...57,882,644

G

serine incorporator 2

increases expression

Azathioprine results in increased expression of SERINC2 mRNA

NCBI chr 5:142,592,308...142,614,628
Ensembl chr 5:142,592,309...142,618,364

G

serine incorporator 3

increases expression

Azathioprine results in increased expression of SERINC3 mRNA

NCBI chr 3:152,301,882...152,321,327
Ensembl chr 3:152,301,772...152,321,808

G

serpin family A member 1

multiple interactions

[Carbon Tetrachloride co-treated with Azathioprine] results in increased expression of SERPINA1 protein

NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339

G

serpin family A member 7

decreases expression

Azathioprine results in decreased expression of SERPINA7 mRNA

NCBI chr X:102,663,242...102,722,319
Ensembl chr X:102,663,405...102,669,040

G

serpin family E member 1

increases expression

Azathioprine results in increased expression of SERPINE1 mRNA

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

serpin family E member 2

increases expression

Azathioprine results in increased expression of SERPINE2 mRNA

NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826

G

SERTA domain containing 1

increases expression

Azathioprine results in increased expression of SERTAD1 mRNA

NCBI chr 1:82,775,692...82,778,961
Ensembl chr 1:82,775,252...82,779,091

G

sestrin 2

increases expression

Azathioprine results in increased expression of SESN2 mRNA

NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260

G

stratifin

increases expression

Azathioprine results in increased expression of SFN mRNA

NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314

G

serum/glucocorticoid regulated kinase 1

decreases expression

Azathioprine results in decreased expression of SGK1 mRNA

NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283

G

shugoshin 2

decreases expression

Azathioprine results in decreased expression of SGO2 mRNA

NCBI chr 9:59,548,605...59,573,229
Ensembl chr 9:59,548,683...59,573,229

G

SH2 domain containing 5

increases expression

Azathioprine results in increased expression of SH2D5 mRNA

NCBI chr 5:150,469,738...150,480,615
Ensembl chr 5:150,467,728...150,479,955

G

SH3 domain containing ring finger 1

increases expression

Azathioprine results in increased expression of SH3RF1 mRNA

NCBI chr16:28,735,522...28,901,261
Ensembl chr16:28,735,440...28,901,644

G

SH2 domain containing adaptor protein B

increases expression

Azathioprine results in increased expression of SHB mRNA

NCBI chr 5:59,678,066...59,785,443
Ensembl chr 5:59,678,216...59,785,538

G

SHC binding and spindle associated 1

decreases expression

Azathioprine results in decreased expression of SHCBP1 mRNA

NCBI chr16:84,672,277...84,703,843
Ensembl chr16:84,672,321...84,703,844

G

serine hydroxymethyltransferase 1

decreases expression

Azathioprine results in decreased expression of SHMT1 mRNA

NCBI chr10:45,468,698...45,490,833
Ensembl chr10:45,468,700...45,497,820

G

spindle and kinetochore associated complex subunit 1

decreases expression

Azathioprine results in decreased expression of SKA1 mRNA

NCBI chr18:67,794,722...67,805,037
Ensembl chr18:67,794,725...67,805,037

G

S-phase kinase associated protein 2

decreases expression

Azathioprine results in decreased expression of SKP2 mRNA

NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338

G

stem-loop histone mRNA binding protein

decreases expression

Azathioprine results in decreased expression of SLBP mRNA

NCBI chr14:77,071,441...77,081,911
Ensembl chr14:77,071,632...77,081,906

G

solute carrier family 10 member 1

decreases expression

Azathioprine results in decreased expression of SLC10A1 mRNA

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 15 member 1

decreases expression

Azathioprine results in decreased expression of SLC15A1 mRNA

NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545

G

solute carrier family 16 member 10

decreases expression

Azathioprine results in decreased expression of SLC16A10 mRNA

NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839

G

solute carrier family 16, member 6

increases expression

Azathioprine results in increased expression of SLC16A6 mRNA

NCBI chr10:94,424,377...94,447,482
Ensembl chr10:94,426,244...94,448,779

G

solute carrier family 20 member 1

increases expression

Azathioprine results in increased expression of SLC20A1 mRNA

NCBI chr 3:116,427,095...116,441,049
Ensembl chr 3:116,427,098...116,441,051

G

solute carrier family 22, member 15

increases expression

Azathioprine results in increased expression of SLC22A15 mRNA

NCBI chr 2:189,298,836...189,359,902
Ensembl chr 2:189,298,832...189,358,792

G

solute carrier family 22, member 18

increases expression

Azathioprine results in increased expression of SLC22A18 mRNA

NCBI chr 1:198,670,626...198,694,977
Ensembl chr 1:198,671,731...198,694,975

G

solute carrier family 2 member 10

decreases expression

Azathioprine results in decreased expression of SLC2A10 mRNA

NCBI chr 3:154,240,395...154,252,690
Ensembl chr 3:154,240,391...154,252,690

G

solute carrier family 2 member 2

decreases expression

Azathioprine results in decreased expression of SLC2A2 mRNA

NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933

G

solute carrier family 30, member 10

decreases expression

Azathioprine results in decreased expression of SLC30A10 mRNA

NCBI chr13:96,998,143...97,048,076
Ensembl chr13:96,998,143...97,009,103

G

solute carrier family 38, member 11

decreases expression

Azathioprine results in decreased expression of SLC38A11 mRNA

NCBI chr 3:49,987,119...50,033,615
Ensembl chr 3:49,987,124...50,033,615

G

solute carrier family 3 member 2

increases expression

Azathioprine results in increased expression of SLC3A2 mRNA

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

G

solute carrier family 40 member 1

increases expression

Azathioprine results in increased expression of SLC40A1 mRNA

NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481

G

solute carrier family 44, member 3

decreases expression

Azathioprine results in decreased expression of SLC44A3 mRNA

NCBI chr 2:209,552,138...209,628,182
Ensembl chr 2:209,552,144...209,629,044

G

solute carrier family 5 member 9

decreases expression

Azathioprine results in decreased expression of SLC5A9 mRNA

NCBI chr 5:126,709,762...126,733,468
Ensembl chr 5:126,709,769...126,733,468

G

solute carrier family 66 member 1

increases expression

Azathioprine results in increased expression of SLC66A1 mRNA

NCBI chr 5:151,537,870...151,552,259
Ensembl chr 5:151,542,376...151,552,259

G

solute carrier family 6 member 14

decreases expression

Azathioprine results in decreased expression of SLC6A14 mRNA

NCBI chr X:112,314,643...112,375,412
Ensembl chr X:112,314,691...112,375,096

G

solute carrier family 6 member 6

increases expression

Azathioprine results in increased expression of SLC6A6 mRNA

NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875

G

solute carrier family 7 member 11

decreases expression
increases expression

Azathioprine results in decreased expression of SLC7A11 mRNA
Azathioprine results in increased expression of SLC7A11 mRNA

PMID:19192274 PMID:22623647 PMID:26198647

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

solute carrier organic anion transporter family, member 4C1

decreases expression

Azathioprine results in decreased expression of SLCO4C1 mRNA

NCBI chr 9:97,177,497...97,229,161
Ensembl chr 9:97,178,861...97,229,715

G

SMC5-SMC6 complex localization factor 1

decreases expression

Azathioprine results in decreased expression of SLF1 mRNA

NCBI chr 2:6,767,015...6,874,428
Ensembl chr 2:6,767,015...6,867,149

G

structural maintenance of chromosomes 2

decreases expression

Azathioprine results in decreased expression of SMC2 mRNA

NCBI chr 5:66,806,882...66,853,478
Ensembl chr 5:66,807,011...66,853,242

G

structural maintenance of chromosomes 4

decreases expression

Azathioprine results in decreased expression of SMC4 mRNA

NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571

G

spermine oxidase

increases expression

Azathioprine results in increased expression of SMOX mRNA

NCBI chr 3:118,731,814...118,767,242
Ensembl chr 3:118,731,900...118,765,710

G

spermine synthase

decreases expression

Azathioprine results in decreased expression of SMS mRNA

NCBI chr X:37,516,949...37,572,657
Ensembl chr X:37,516,931...37,570,822

G

superoxide dismutase 2

increases expression
decreases expression

Azathioprine results in increased expression of SOD2 mRNA
Azathioprine results in decreased expression of SOD2 mRNA

PMID:18222062 PMID:19192274

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

sorbin and SH3 domain containing 2

decreases expression

Azathioprine results in decreased expression of SORBS2 mRNA

NCBI chr16:46,435,220...46,748,743
Ensembl chr16:46,435,237...46,626,514

G

Sp5 transcription factor

decreases expression

Azathioprine results in decreased expression of SP5 mRNA

NCBI chr 3:55,274,931...55,277,733
Ensembl chr 3:55,274,931...55,277,733

G

sperm associated antigen 5

decreases expression

Azathioprine results in decreased expression of SPAG5 mRNA

NCBI chr10:63,198,717...63,216,746
Ensembl chr10:63,198,768...63,216,745

G

SPC25 component of NDC80 kinetochore complex

decreases expression

Azathioprine results in decreased expression of SPC25 mRNA

NCBI chr 3:53,930,013...53,988,940
Ensembl chr 3:53,975,704...53,988,959

G

spindle apparatus coiled-coil protein 1

decreases expression

Azathioprine results in decreased expression of SPDL1 mRNA

NCBI chr10:19,269,125...19,294,213
Ensembl chr10:19,269,127...19,294,127

G

spindlin family, member 4

decreases expression

Azathioprine results in decreased expression of SPIN4 mRNA

NCBI chr X:59,888,728...59,892,817
Ensembl chr X:59,891,581...59,892,330

G

serine peptidase inhibitor, Kazal type 1

increases expression

Azathioprine results in increased expression of SPINK1 mRNA

NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642

G

spondin 1

increases expression

Azathioprine results in increased expression of SPON1 mRNA

NCBI chr 1:167,929,049...168,228,239
Ensembl chr 1:167,928,972...168,228,226

G

sprouty RTK signaling antagonist 4

increases expression

Azathioprine results in increased expression of SPRY4 mRNA

NCBI chr18:30,436,513...30,451,426
Ensembl chr18:30,436,443...30,453,004

G

splA/ryanodine receptor domain and SOCS box containing 1

increases expression

Azathioprine results in increased expression of SPSB1 mRNA

NCBI chr 5:160,358,292...160,418,541
Ensembl chr 5:160,358,308...160,418,468

G

serine palmitoyltransferase, long chain base subunit 3

decreases expression

Azathioprine results in decreased expression of SPTLC3 mRNA

NCBI chr 3:126,847,878...126,978,010
Ensembl chr 3:126,847,878...126,978,010

G

squalene epoxidase

decreases expression

Azathioprine results in decreased expression of SQLE mRNA

NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618

G

sequestosome 1

increases expression

Azathioprine results in increased expression of SQSTM1 mRNA

PMID:22623647 PMID:26198647

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

sulfiredoxin 1

increases expression

Azathioprine results in increased expression of SRXN1 mRNA
Azathioprine results in increased expression of SRXN1 protein

PMID:22623647 PMID:26198647 PMID:27358234

NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448

G

signal transducer and activator of transcription 1

decreases expression

Azathioprine results in decreased expression of STAT1 mRNA

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

multiple interactions

Azathioprine inhibits the reaction [RAC1 protein binds to STAT3 protein]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

STIL, centriolar assembly protein

decreases expression

Azathioprine results in decreased expression of STIL mRNA

NCBI chr 5:128,520,837...128,573,732
Ensembl chr 5:128,520,953...128,573,730

G

stathmin 1

decreases expression

Azathioprine results in decreased expression of STMN1 mRNA

NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154

G

steroid sulfatase

increases expression

Azathioprine results in increased expression of STS mRNA

NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402

G

syntaxin 3

increases expression

Azathioprine results in increased expression of STX3 mRNA

NCBI chr 1:208,617,018...208,686,240
Ensembl chr 1:208,639,115...208,685,805

G

syncoilin, intermediate filament protein

decreases expression

Azathioprine results in decreased expression of SYNC mRNA

NCBI chr 5:141,631,837...141,656,184
Ensembl chr 5:141,632,367...141,688,659

G

TAFA chemokine like family member 5

decreases expression

Azathioprine results in decreased expression of TAFA5 mRNA

NCBI chr 7:118,613,731...118,835,016
Ensembl chr 7:118,613,889...118,834,353

G

TBC1 domain family member 8B

decreases expression

Azathioprine results in decreased expression of TBC1D8B mRNA

NCBI chr X:103,319,181...103,407,137
Ensembl chr X:103,319,340...103,407,133

G

T-box transcription factor 21

increases expression

Azathioprine results in increased expression of TBX21 mRNA

NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831

G

transcription elongation factor A3

decreases expression

Azathioprine results in decreased expression of TCEA3 mRNA

NCBI chr 5:148,476,941...148,509,452
Ensembl chr 5:148,476,941...148,509,448

G

transcription elongation factor A like 1

decreases expression

Azathioprine results in decreased expression of TCEAL1 mRNA

NCBI chr X:100,058,485...100,060,439
Ensembl chr X:100,058,132...100,060,551

G

transcription factor 19

decreases expression

Azathioprine results in decreased expression of TCF19 mRNA

NCBI chr20:3,218,756...3,222,861
Ensembl chr20:3,218,693...3,223,271

G

tet methylcytosine dioxygenase 1

decreases expression

Azathioprine results in decreased expression of TET1 mRNA

NCBI chr20:25,761,042...25,840,926
Ensembl chr20:25,768,120...25,833,052

G

testis expressed 261

increases expression

Azathioprine results in increased expression of TEX261 mRNA

NCBI chr 4:116,253,547...116,260,730
Ensembl chr 4:116,244,600...116,260,253

G

testis expressed 9

decreases expression

Azathioprine results in decreased expression of TEX9 mRNA

NCBI chr 8:73,168,519...73,213,935
Ensembl chr 8:73,177,810...73,214,261

G

transcription factor Dp-1

decreases expression

Azathioprine results in decreased expression of TFDP1 mRNA

NCBI chr16:76,162,040...76,200,871
Ensembl chr16:76,162,043...76,200,817

G

transcription factor binding to IGHM enhancer 3

increases expression

Azathioprine results in increased expression of TFE3 mRNA

NCBI chr X:14,729,547...14,742,830
Ensembl chr X:14,729,550...14,742,571

G

transforming growth factor, beta 1

increases expression

Azathioprine results in increased expression of TGFB1 mRNA

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor beta 1 induced transcript 1

increases expression

Azathioprine results in increased expression of TGFB1I1 mRNA

NCBI chr 1:182,828,553...182,835,465
Ensembl chr 1:182,828,544...182,837,080

G

transforming growth factor beta receptor 3

decreases expression

Azathioprine results in decreased expression of TGFBR3 mRNA

NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341

G

thrombospondin 2

increases expression

Azathioprine results in increased expression of THBS2 mRNA

NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789

G

thimet oligopeptidase 1

increases expression

Azathioprine results in increased expression of THOP1 mRNA

NCBI chr 7:8,632,911...8,645,339
Ensembl chr 7:8,632,916...8,645,275

G

TIMP metallopeptidase inhibitor 1

increases expression

Azathioprine results in increased expression of TIMP1 mRNA

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

thymidine kinase 1

decreases expression

Azathioprine results in decreased expression of TK1 mRNA

NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920

G

toll-like receptor 2

increases expression
decreases expression

Azathioprine results in increased expression of TLR2 mRNA
Azathioprine results in decreased expression of TLR2 mRNA

PMID:19192274 PMID:24184165

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

toll-like receptor 4

increases expression

Azathioprine results in increased expression of TLR4 mRNA

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

transmembrane channel like 6

increases expression

Azathioprine results in increased expression of TMC6 mRNA

NCBI chr10:102,982,059...102,999,509
Ensembl chr10:102,971,229...102,998,960

G

transmembrane channel-like 7

increases expression

Azathioprine results in increased expression of TMC7 mRNA

NCBI chr 1:172,853,531...172,905,796
Ensembl chr 1:172,854,658...172,905,824

G

transmembrane channel-like 8

increases expression

Azathioprine results in increased expression of TMC8 mRNA

NCBI chr10:103,000,038...103,010,601
Ensembl chr10:102,998,402...103,010,590

G

transmembrane protein 140

increases expression

Azathioprine results in increased expression of TMEM140 mRNA

NCBI chr 4:63,536,477...63,547,478
Ensembl chr 4:63,536,168...63,548,455

G

transmembrane protein 170B

decreases expression

Azathioprine results in decreased expression of TMEM170B mRNA

NCBI chr17:23,131,151...23,169,946
Ensembl chr17:23,131,456...23,170,248

G

transmembrane protein 237

decreases expression

Azathioprine results in decreased expression of TMEM237 mRNA

NCBI chr 9:60,533,348...60,569,253
Ensembl chr 9:60,535,233...60,572,567

G

thymopoietin

decreases expression

Azathioprine results in decreased expression of TMPO mRNA

NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727

G

thiol methyltransferase 1A

decreases expression

Azathioprine results in decreased expression of TMT1A mRNA

NCBI chr 7:131,452,099...131,460,154
Ensembl chr 7:131,451,641...131,460,154

G

tumor necrosis factor

increases expression
multiple interactions

Azathioprine results in increased expression of TNF protein
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Azathioprine; Azathioprine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]
Azathioprine results in increased expression of TNF mRNA

PMID:19362101 PMID:19584951 PMID:24184165 PMID:36416909

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 2

decreases expression

Azathioprine results in decreased expression of TNFAIP2 mRNA

NCBI chr 6:130,476,832...130,489,914
Ensembl chr 6:130,476,889...130,489,914

G

TNF receptor superfamily member 12A

increases expression

Azathioprine results in increased expression of TNFRSF12A mRNA

NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045

G

TNF receptor superfamily member 19

decreases expression

Azathioprine results in decreased expression of TNFRSF19 mRNA

NCBI chr15:35,092,206...35,158,472
Ensembl chr15:35,092,206...35,180,795

G

TNF receptor superfamily member 1A

increases expression

Azathioprine results in increased expression of TNFRSF1A mRNA

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

DNA topoisomerase II alpha

decreases expression

Azathioprine results in decreased expression of TOP2A mRNA

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

tumor protein p53

increases expression
increases mutagenesis

Azathioprine results in increased expression of TP53 protein
Azathioprine results in increased mutagenesis of TP53 gene

PMID:14961032 PMID:17979968

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

thiopurine S-methyltransferase

affects activity
affects response to substance
affects metabolic processing

Azathioprine affects the activity of TPMT protein
TPMT gene affects the susceptibility to Azathioprine; TPMT gene polymorphism affects the susceptibility to Azathioprine; TPMT gene SNP affects the susceptibility to Azathioprine; TPMT polymorphism affects the susceptibility to Azathioprine; TPMT promoter polymorphism affects the susceptibility to Azathioprine
TPMT protein affects the metabolism of Azathioprine

PMID:12168480 PMID:12269967 PMID:12509611 PMID:14505127 PMID:15167706 More...

NCBI chr17:17,644,088...17,662,709
Ensembl chr17:17,644,173...17,662,709

G

TPX2, microtubule nucleation factor

decreases expression

Azathioprine results in decreased expression of TPX2 mRNA

NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468

G

transformer 2 alpha

decreases expression

Azathioprine results in decreased expression of TRA2A mRNA

NCBI chr 4:78,220,838...78,239,737
Ensembl chr 4:78,220,883...78,239,712

G

tribbles pseudokinase 1

increases expression

Azathioprine results in increased expression of TRIB1 mRNA

NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731

G

tribbles pseudokinase 3

increases expression

Azathioprine results in increased expression of TRIB3 mRNA

NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497

G

thyroid hormone receptor interactor 13

decreases expression

Azathioprine results in decreased expression of TRIP13 mRNA

NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074

G

TSC complex subunit 2

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Azathioprine promotes the reaction [MAPK1 protein binds to TSC2 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Azathioprine promotes the reaction [MAPK3 protein binds to TSC2 protein]]; Azathioprine promotes the reaction [MAPK1 protein binds to TSC2 protein]; Azathioprine promotes the reaction [MAPK3 protein binds to TSC2 protein]

NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951

G

Ttk protein kinase

decreases expression

Azathioprine results in decreased expression of TTK mRNA

NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651

G

tubulin, alpha 1B

decreases expression

Azathioprine results in decreased expression of TUBA1B mRNA

NCBI chr 7:130,090,663...130,093,644
Ensembl chr 7:130,081,032...130,196,186

G

tubulin, beta 1 class VI

decreases expression

Azathioprine results in decreased expression of TUBB1 mRNA

NCBI chr 3:163,247,990...163,257,460
Ensembl chr 3:163,247,967...163,256,063

G

tubulin, beta 4B class IVb

decreases expression

Azathioprine results in decreased expression of TUBB4B mRNA

NCBI chr 3:8,037,838...8,040,294
Ensembl chr 3:8,037,799...8,040,296

G

tubulin, beta 5 class I

decreases expression

Azathioprine results in decreased expression of TUBB mRNA

NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940

G

tumor suppressor candidate 3

increases expression

Azathioprine results in increased expression of TUSC3 mRNA

NCBI chr16:53,196,195...53,345,241
Ensembl chr16:53,196,195...53,344,781

G

thioredoxin domain containing 16

decreases expression

Azathioprine results in decreased expression of TXNDC16 mRNA

NCBI chr15:18,351,688...18,425,833
Ensembl chr15:18,351,694...18,425,722

G

thioredoxin interacting protein

increases expression

Azathioprine results in increased expression of TXNIP mRNA

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

thioredoxin reductase 1

increases expression

Azathioprine results in increased expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

thymidylate synthetase

decreases expression

Azathioprine results in decreased expression of TYMS mRNA

NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536

G

ubiquitin D

decreases expression

Azathioprine results in decreased expression of UBD mRNA

NCBI chr20:1,385,487...1,387,438
Ensembl chr20:1,385,864...1,408,639
Ensembl chr20:1,385,864...1,408,639

G

ubiquitin-conjugating enzyme E2C

decreases expression

Azathioprine results in decreased expression of UBE2C mRNA

NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339

G

ubiquitin-conjugating enzyme E2T

decreases expression

Azathioprine results in decreased expression of UBE2T mRNA

NCBI chr13:46,403,352...46,413,854
Ensembl chr13:46,403,375...46,414,835

G

uracil-DNA glycosylase

decreases expression

Azathioprine results in decreased expression of UNG mRNA

NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206

G

uridine phosphorylase 1

increases expression

Azathioprine results in increased expression of UPP1 mRNA

NCBI chr14:83,809,495...83,829,299
Ensembl chr14:83,809,960...83,829,462

G

ubiquitin specific peptidase 35

increases expression

Azathioprine results in increased expression of USP35 mRNA

NCBI chr 1:151,626,195...151,649,926
Ensembl chr 1:151,626,196...151,650,015

G

vav guanine nucleotide exchange factor 1

increases expression

Azathioprine results in increased expression of VAV1 protein

NCBI chr 9:2,161,985...2,209,951
Ensembl chr 9:2,157,900...2,208,937

G

vanin 1

increases expression

Azathioprine results in increased expression of VNN1 mRNA

NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395

G

VRK serine/threonine kinase 1

decreases expression

Azathioprine results in decreased expression of VRK1 mRNA

NCBI chr 6:124,914,770...124,981,508
Ensembl chr 6:124,914,855...124,981,436

G

visinin-like 1

decreases expression

Azathioprine results in decreased expression of VSNL1 mRNA

NCBI chr 6:34,038,641...34,159,479
Ensembl chr 6:34,038,642...34,159,479

G

WD repeat domain 45

increases expression

Azathioprine results in increased expression of WDR45 mRNA

NCBI chr X:14,776,280...14,782,202
Ensembl chr X:14,776,293...14,782,202

G

zinc finger AN1-type containing 2A

increases expression

Azathioprine results in increased expression of ZFAND2A mRNA

NCBI chr12:15,161,601...15,172,679
Ensembl chr12:15,161,639...15,172,677

G

zinc finger protein 362

decreases expression

Azathioprine results in decreased expression of ZNF362 mRNA

NCBI chr 5:141,119,073...141,153,304
Ensembl chr 5:141,119,898...141,156,716

G

zinc finger protein 385B

decreases expression

Azathioprine results in decreased expression of ZNF385B mRNA

NCBI chr 3:62,355,182...62,640,417
Ensembl chr 3:62,355,196...62,640,510

G

zinc finger protein 746

increases expression

Azathioprine results in increased expression of ZNF746 mRNA

NCBI chr 4:77,055,008...77,078,968
Ensembl chr 4:77,055,008...77,078,897

G

zymogen granule protein 16B

increases expression

Azathioprine results in increased expression of ZG16B mRNA

NCBI chr10:12,970,888...12,984,170
Ensembl chr10:12,979,020...12,983,572

G

zwilch kinetochore protein

decreases expression

Azathioprine results in decreased expression of ZWILCH mRNA

NCBI chr 8:64,638,401...64,670,911
Ensembl chr 8:64,637,672...64,675,916

G

ZW10 interacting kinetochore protein

decreases expression

Azathioprine results in decreased expression of ZWINT mRNA

NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19890
chemical entity	19867
atom	19888
nonmetal atom	19789
sulfur atom	17766
sulfur molecular entity	17745
sulfide	10108
organic sulfide	10119
thiopurine	639
1 ́-Methylzeatin	0
2-(4-morpholinyl)-9-(3-thiophenyl)-N-[[6-(trifluoromethyl)-1H-benzimidazol-2-yl]methyl]-6-purinamine	0
2-(4-morpholinyl)-N-[(4-nitro-1H-benzimidazol-2-yl)methyl]-9-(3-thiophenyl)-6-purinamine	0
2-(4-morpholinyl)-N-[(6-nitro-1H-benzimidazol-2-yl)methyl]-9-(3-thiophenyl)-6-purinamine	0
2-Amino-6-(benzylthio)purine	0
2-Methylthio-cis-zeatin	0
2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]ethanol	0
2-[[7-methyl-6-[(phenylmethyl)amino]-2-purinyl]amino]ethanol	0
2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol	0
2-[[[2-(1-hydroxybutan-2-ylamino)-9-propan-2-yl-6-purinyl]amino]methyl]phenol	0
2-methylthio-N(6)-isopentenyladenine	0
4-[[[2-[[(2R)-1-hydroxy-3-methylbutan-2-yl]amino]-9-propan-2-yl-6-purinyl]amino]methyl]benzenesulfonamide	0
6-(2-Chloroallylthio)purine	0
6-(Allylthio)purine	0
6-(Isopropylthio)purine	0
6-(Pentylthio)-1H-purine	0
6-Ethylthiopurine	0
6-methylthioguanine	0
6-methylthioinosine	1
6-methylthiopurine	0
8-oxo-isopentenyladenine	0
9-(5-phosphoribofuranosyl)-6-mercaptopurine	0
9-ethyl-6-[2-(3-pyridinyl)ethylamino]-2-purinecarbonitrile	0
LSM-16966	0
LSM-18500	0
LSM-21130	0
LSM-24071	0
LSM-26232	0
LSM-31454	0
LSM-32859	0
N-((1R,2S,4S)-Bicyclo[2.2.1]heptan-2-yl)-9-methyl-9H-purin-6-amine	0
N-(1H-benzimidazol-2-ylmethyl)-2-(4-morpholinyl)-9-(3-thiophenyl)-6-purinamine	0
N-(1H-benzo[f]benzimidazol-2-ylmethyl)-2-(4-morpholinyl)-9-(3-thiophenyl)-6-purinamine	0
N-[(6-chloro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)-9-(3-thiophenyl)-6-purinamine	0
N-[3-(1H-imidazol-3-ium-3-yl)propyl]-7H-purin-6-amine	0
N-methyl-N-[4-[[6-[[1-(1-oxoprop-2-enyl)-3-piperidinyl]amino]-7H-purin-2-yl]amino]phenyl]propanamide	0
azathioprine	638
Path 2
Term	Annotations
CHEBI ontology	19890
subatomic particle	19867
composite particle	19888
hadron	19888
baryon	19888
nucleon	19867
atomic nucleus	19888
atom	19888
main group element atom	19806
p-block element atom	19806
carbon group element atom	19746
carbon atom	19743
organic molecular entity	19743
organic molecule	19714
organic cyclic compound	19485
organic heterocyclic compound	18881
organic heteropolycyclic compound	18290
organic heterobicyclic compound	17234
imidazopyrimidine	7763
purines	7762
thiopurine	639
1 ́-Methylzeatin	0
2-(4-morpholinyl)-9-(3-thiophenyl)-N-[[6-(trifluoromethyl)-1H-benzimidazol-2-yl]methyl]-6-purinamine	0
2-(4-morpholinyl)-N-[(4-nitro-1H-benzimidazol-2-yl)methyl]-9-(3-thiophenyl)-6-purinamine	0
2-(4-morpholinyl)-N-[(6-nitro-1H-benzimidazol-2-yl)methyl]-9-(3-thiophenyl)-6-purinamine	0
2-Amino-6-(benzylthio)purine	0
2-Methylthio-cis-zeatin	0
2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]ethanol	0
2-[[7-methyl-6-[(phenylmethyl)amino]-2-purinyl]amino]ethanol	0
2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol	0
2-[[[2-(1-hydroxybutan-2-ylamino)-9-propan-2-yl-6-purinyl]amino]methyl]phenol	0
2-methylthio-N(6)-isopentenyladenine	0
4-[[[2-[[(2R)-1-hydroxy-3-methylbutan-2-yl]amino]-9-propan-2-yl-6-purinyl]amino]methyl]benzenesulfonamide	0
6-(2-Chloroallylthio)purine	0
6-(Allylthio)purine	0
6-(Isopropylthio)purine	0
6-(Pentylthio)-1H-purine	0
6-Ethylthiopurine	0
6-methylthioguanine	0
6-methylthioinosine	1
6-methylthiopurine	0
8-oxo-isopentenyladenine	0
9-(5-phosphoribofuranosyl)-6-mercaptopurine	0
9-ethyl-6-[2-(3-pyridinyl)ethylamino]-2-purinecarbonitrile	0
LSM-16966	0
LSM-18500	0
LSM-21130	0
LSM-24071	0
LSM-26232	0
LSM-31454	0
LSM-32859	0
N-((1R,2S,4S)-Bicyclo[2.2.1]heptan-2-yl)-9-methyl-9H-purin-6-amine	0
N-(1H-benzimidazol-2-ylmethyl)-2-(4-morpholinyl)-9-(3-thiophenyl)-6-purinamine	0
N-(1H-benzo[f]benzimidazol-2-ylmethyl)-2-(4-morpholinyl)-9-(3-thiophenyl)-6-purinamine	0
N-[(6-chloro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)-9-(3-thiophenyl)-6-purinamine	0
N-[3-(1H-imidazol-3-ium-3-yl)propyl]-7H-purin-6-amine	0
N-methyl-N-[4-[[6-[[1-(1-oxoprop-2-enyl)-3-piperidinyl]amino]-7H-purin-2-yl]amino]phenyl]propanamide	0
azathioprine	638

paths to the root