Mis18bp1 (MIS18 binding protein 1) - Rat Genome Database

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Gene: Mis18bp1 (MIS18 binding protein 1) Rattus norvegicus
Analyze
Symbol: Mis18bp1
Name: MIS18 binding protein 1
RGD ID: 1594757
Description: Orthologous to human MIS18BP1 (MIS18 binding protein 1); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC689296; LOC314173; LOC689296; mis18-binding protein 1; RGD1305497; similar to expressed sequence C79407
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2683,182,497 - 83,231,978 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl683,182,499 - 83,231,383 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx683,542,064 - 83,590,889 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0683,841,426 - 83,890,248 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0683,283,159 - 83,332,060 (-)NCBIRnor_WKY
Rnor_6.0686,879,106 - 86,925,209 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl686,879,719 - 86,924,146 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0696,368,085 - 96,413,853 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4686,479,583 - 86,529,071 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera681,750,433 - 81,799,296 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Mis18bp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2683,182,497 - 83,231,978 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl683,182,499 - 83,231,383 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx683,542,064 - 83,590,889 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0683,841,426 - 83,890,248 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0683,283,159 - 83,332,060 (-)NCBIRnor_WKY
Rnor_6.0686,879,106 - 86,925,209 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl686,879,719 - 86,924,146 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0696,368,085 - 96,413,853 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4686,479,583 - 86,529,071 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera681,750,433 - 81,799,296 (-)NCBICelera
Cytogenetic Map6q24NCBI
MIS18BP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381445,203,190 - 45,253,202 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1445,203,190 - 45,253,540 (-)EnsemblGRCh38hg38GRCh38
GRCh371445,672,393 - 45,722,405 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361444,742,143 - 44,792,146 (-)NCBINCBI36Build 36hg18NCBI36
Build 341444,742,143 - 44,792,146NCBI
Celera1425,533,645 - 25,583,858 (-)NCBICelera
Cytogenetic Map14q21.2NCBI
HuRef1425,783,114 - 25,833,326 (-)NCBIHuRef
CHM1_11445,610,538 - 45,660,754 (-)NCBICHM1_1
T2T-CHM13v2.01439,395,200 - 39,445,212 (-)NCBIT2T-CHM13v2.0
Mis18bp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391265,179,508 - 65,219,354 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1265,179,508 - 65,219,378 (-)EnsemblGRCm39 Ensembl
GRCm381265,132,734 - 65,172,581 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1265,132,734 - 65,172,604 (-)EnsemblGRCm38mm10GRCm38
MGSCv371266,233,721 - 66,273,567 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361266,051,339 - 66,091,185 (-)NCBIMGSCv36mm8
Celera1266,262,434 - 66,302,397 (-)NCBICelera
Cytogenetic Map12C1NCBI
Mis18bp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540916,710,362 - 16,750,434 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540916,704,414 - 16,751,469 (+)NCBIChiLan1.0ChiLan1.0
MIS18BP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11444,146,267 - 44,196,076 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1444,147,183 - 44,189,888 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01425,819,302 - 25,869,819 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MIS18BP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1822,626,082 - 22,673,550 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl822,525,301 - 22,668,507 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha822,444,217 - 22,491,261 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0822,785,324 - 22,832,826 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl822,684,506 - 22,832,791 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1822,447,699 - 22,494,944 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0822,514,049 - 22,561,510 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0822,849,837 - 22,896,935 (-)NCBIUU_Cfam_GSD_1.0
Mis18bp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864054,605,758 - 54,638,685 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365834,052,207 - 4,083,679 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MIS18BP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1175,401,390 - 175,448,276 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11175,401,386 - 175,449,399 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21195,196,729 - 195,219,436 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MIS18BP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12422,329,965 - 22,385,321 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2422,344,596 - 22,378,898 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666116152,261 - 213,642 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mis18bp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473123,290,631 - 23,339,687 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473123,288,240 - 23,339,568 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mis18bp1
80 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:257
Count of miRNA genes:176
Interacting mature miRNAs:194
Transcripts:ENSRNOT00000029411
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)65672856290198260Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat

Markers in Region
RH133008  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2683,205,843 - 83,206,048 (+)MAPPERmRatBN7.2
Rnor_6.0686,902,495 - 86,902,699NCBIRnor6.0
Rnor_5.0696,391,459 - 96,391,663UniSTSRnor5.0
RGSC_v3.4686,502,887 - 86,503,091UniSTSRGSC3.4
Celera681,773,778 - 81,773,982UniSTS
Cytogenetic Map6q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12 25 18 16 18 24 16 29
Low 3 26 32 23 3 23 7 7 46 19 12 11 7
Below cutoff 5 1 3 4 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000029411   ⟹   ENSRNOP00000034593
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl683,182,499 - 83,231,383 (-)Ensembl
Rnor_6.0 Ensembl686,879,871 - 86,924,146 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091202   ⟹   ENSRNOP00000071245
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl683,197,263 - 83,231,383 (-)Ensembl
Rnor_6.0 Ensembl686,879,719 - 86,914,883 (-)Ensembl
RefSeq Acc Id: NM_001109531   ⟹   NP_001103001
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2683,182,499 - 83,231,383 (-)NCBI
Rnor_6.0686,879,111 - 86,924,300 (-)NCBI
Rnor_5.0696,368,085 - 96,413,853 (-)NCBI
RGSC_v3.4686,479,583 - 86,529,071 (-)RGD
Celera681,750,433 - 81,799,296 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240138   ⟹   XP_006240200
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2683,182,497 - 83,231,978 (-)NCBI
Rnor_6.0686,879,106 - 86,925,209 (-)NCBI
Rnor_5.0696,368,085 - 96,413,853 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039112961   ⟹   XP_038968889
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2683,182,497 - 83,231,978 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001103001 (Get FASTA)   NCBI Sequence Viewer  
  XP_006240200 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968889 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM03489 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001103001   ⟸   NM_001109531
- UniProtKB: D3ZKM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240200   ⟸   XM_006240138
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JZZ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000034593   ⟸   ENSRNOT00000029411
RefSeq Acc Id: ENSRNOP00000071245   ⟸   ENSRNOT00000091202
RefSeq Acc Id: XP_038968889   ⟸   XM_039112961
- Peptide Label: isoform X2
Protein Domains
Myb-like   SANTA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JZZ6-F1-model_v2 AlphaFold A0A0G2JZZ6 1-1057 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1594757 AgrOrtholog
BioCyc Gene G2FUF-37318 BioCyc
Ensembl Genes ENSRNOG00000023093 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000034593 ENTREZGENE
  ENSRNOP00000034593.3 UniProtKB/TrEMBL
  ENSRNOP00000071245.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029411 ENTREZGENE
  ENSRNOT00000029411.5 UniProtKB/TrEMBL
  ENSRNOT00000091202.2 UniProtKB/TrEMBL
InterPro Homeodomain-like UniProtKB/TrEMBL
  KNL2-like UniProtKB/TrEMBL
  SANT_DNA-bd UniProtKB/TrEMBL
  SANTA UniProtKB/TrEMBL
KEGG Report rno:689296 UniProtKB/TrEMBL
NCBI Gene 689296 ENTREZGENE
PANTHER PTHR16124 UniProtKB/TrEMBL
Pfam SANTA UniProtKB/TrEMBL
PhenoGen Mis18bp1 PhenoGen
PROSITE MYB_LIKE UniProtKB/TrEMBL
SMART SANT UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A0A0G2JZZ6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZKM9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-05-31 Mis18bp1  MIS18 binding protein 1  LOC689296  similar to expressed sequence C79407  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC689296  similar to expressed sequence C79407  RGD1305497_predicted  similar to Expressed sequence C79407 (predicted)  Data Merged 1643240 APPROVED
2006-11-20 LOC689296  similar to expressed sequence C79407      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 RGD1305497_predicted  similar to Expressed sequence C79407 (predicted)  LOC314173_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC314173_predicted  similar to Expressed sequence C79407 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL