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Gene: Itpa (inosine triphosphatase) Rattus norvegicus
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Symbol: Itpa
Name: inosine triphosphatase
Description: Predicted to have dITP diphosphatase activity and identical protein binding activity. Predicted to be involved in ITP catabolic process and chromosome organization. Predicted to localize to the cytosol. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 35; hemolytic anemia; hepatitis C; precursor lymphoblastic lymphoma/leukemia; and thrombocytopenia. Orthologous to human ITPA (inosine triphosphatase); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: inosine triphosphatase (nucleoside triphosphate pyrophosphatase); inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (mapped); inosine triphosphate pyrophosphatase; Itpa_mapped; ITPase; non-canonical purine NTP pyrophosphatase; non-standard purine NTP pyrophosphatase; NTPase; nucleoside-triphosphate diphosphatase; nucleoside-triphosphate pyrophosphatase
Orthologs:
Homo sapiens (human) : ITPA (inosine triphosphatase)  HGNC  Alliance
Mus musculus (house mouse) : Itpa (inosine triphosphatase (nucleoside triphosphate pyrophosphatase))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itpa (inosine triphosphatase)
Pan paniscus (bonobo/pygmy chimpanzee) : ITPA (inosine triphosphatase)
Canis lupus familiaris (dog) : ITPA (inosine triphosphatase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itpa (inosine triphosphatase)
Sus scrofa (pig) : ITPA (inosine triphosphatase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03123,209,611 - 123,221,266 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03129,707,739 - 129,719,394 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,298,330 - 118,310,110 (+)NCBIRGSC3.4rn4RGSC3.4
Celera3116,696,317 - 116,708,064 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Itpa
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1589751
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.