Itpa (inosine triphosphatase) - Rat Genome Database

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Gene: Itpa (inosine triphosphatase) Rattus norvegicus
Analyze
Symbol: Itpa
Name: inosine triphosphatase
RGD ID: 1589751
Description: Predicted to enable dITP diphosphatase activity and identical protein binding activity. Predicted to be involved in nucleoside triphosphate catabolic process. Predicted to act upstream of or within ITP catabolic process and chromosome organization. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); developmental and epileptic encephalopathy 35; hepatitis C; rheumatoid arthritis; and thrombocytopenia. Orthologous to human ITPA (inosine triphosphatase); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: inosine triphosphatase (nucleoside triphosphate pyrophosphatase); inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (mapped); inosine triphosphate pyrophosphatase; Itpa_mapped; ITPase; non-canonical purine NTP pyrophosphatase; non-standard purine NTP pyrophosphatase; NTPase; nucleoside-triphosphate diphosphatase; nucleoside-triphosphate pyrophosphatase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83138,338,549 - 138,350,329 (+)NCBIGRCr8
mRatBN7.23117,885,464 - 117,897,247 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3117,885,099 - 117,897,249 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3121,779,700 - 121,791,613 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03130,377,306 - 130,389,249 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03128,035,835 - 128,047,749 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03123,209,611 - 123,221,266 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,209,608 - 123,221,269 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03129,707,739 - 129,719,394 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,298,330 - 118,310,110 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3116,696,317 - 116,708,064 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Gene expression profiles associated with anaemia and ITPA genotypes in patients with chronic hepatitis C (CH-C). Birerdinc A, etal., J Viral Hepat. 2012 Jun;19(6):414-22. doi: 10.1111/j.1365-2893.2011.01564.x. Epub 2011 Dec 7.
2. Association of ITPA polymorphisms rs6051702/rs1127354 instead of rs7270101/rs1127354 as predictor of ribavirin-associated anemia in chronic hepatitis C treated patients. D'Avolio A, etal., Antiviral Res. 2013 Oct;100(1):114-9. doi: 10.1016/j.antiviral.2013.07.021. Epub 2013 Aug 8.
3. Inosine triphosphatase allele frequency and association with ribavirin-induced anaemia in Brazilian patients receiving antiviral therapy for chronic hepatitis C. Delvaux N, etal., Mem Inst Oswaldo Cruz. 2015 Aug;110(5):636-43. doi: 10.1590/0074-02760150104. Epub 2015 Jul 7.
4. Epistatic interactions between thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) variations determine 6-mercaptopurine toxicity in Indian children with acute lymphoblastic leukemia. Dorababu P, etal., Eur J Clin Pharmacol. 2012 Apr;68(4):379-87. doi: 10.1007/s00228-011-1133-1. Epub 2011 Oct 19.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. Variants of the inosine triphosphate pyrophosphatase gene are associated with reduced relapse risk following treatment for HCV genotype 2/3. Rembeck K, etal., Hepatology. 2014 Jun;59(6):2131-9. doi: 10.1002/hep.27009. Epub 2014 Apr 25.
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia. Stocco G, etal., Clin Pharmacol Ther. 2009 Feb;85(2):164-72. doi: 10.1038/clpt.2008.154. Epub 2008 Aug 6.
14. Inosine triphosphatase genetic variants are protective against anemia during antiviral therapy for HCV2/3 but do not decrease dose reductions of RBV or increase SVR. Thompson AJ, etal., Hepatology. 2011 Feb;53(2):389-95. doi: 10.1002/hep.24068. Epub 2011 Jan 10.
15. Effect of genetic polymorphisms of azathioprine-metabolizing enzymes on response to rheumatoid arthritis treatment. Tsuchiya A, etal., Pharmazie. 2017 Jan 10;72(1):22-28. doi: 10.1691/ph.2017.6799.
Additional References at PubMed
PMID:1914521   PMID:7323947   PMID:11278832   PMID:20081199   PMID:25416956  


Genomics

Comparative Map Data
Itpa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83138,338,549 - 138,350,329 (+)NCBIGRCr8
mRatBN7.23117,885,464 - 117,897,247 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3117,885,099 - 117,897,249 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3121,779,700 - 121,791,613 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03130,377,306 - 130,389,249 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03128,035,835 - 128,047,749 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03123,209,611 - 123,221,266 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,209,608 - 123,221,269 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03129,707,739 - 129,719,394 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,298,330 - 118,310,110 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3116,696,317 - 116,708,064 (+)NCBICelera
Cytogenetic Map3q36NCBI
ITPA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38203,204,065 - 3,227,449 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl203,208,868 - 3,223,870 (+)EnsemblGRCh38hg38GRCh38
GRCh37203,184,711 - 3,208,095 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36203,138,056 - 3,152,506 (+)NCBINCBI36Build 36hg18NCBI36
Build 34203,138,055 - 3,152,504NCBI
Celera203,252,018 - 3,266,469 (+)NCBICelera
Cytogenetic Map20p13NCBI
HuRef203,137,390 - 3,152,825 (+)NCBIHuRef
CHM1_1203,189,574 - 3,204,578 (+)NCBICHM1_1
T2T-CHM13v2.0203,234,474 - 3,258,399 (+)NCBIT2T-CHM13v2.0
Itpa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392130,506,702 - 130,523,534 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2130,509,530 - 130,523,534 (+)EnsemblGRCm39 Ensembl
GRCm382130,664,692 - 130,681,614 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2130,667,610 - 130,681,614 (+)EnsemblGRCm38mm10GRCm38
MGSCv372130,493,577 - 130,507,350 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362130,359,282 - 130,373,055 (+)NCBIMGSCv36mm8
Celera2131,892,647 - 131,906,412 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.24NCBI
Itpa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541514,107,380 - 14,121,619 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541514,106,786 - 14,121,975 (+)NCBIChiLan1.0ChiLan1.0
ITPA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2214,175,151 - 4,190,553 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1204,171,972 - 4,187,379 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0203,295,075 - 3,309,546 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1203,056,395 - 3,074,466 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl203,056,395 - 3,070,924 (+)Ensemblpanpan1.1panPan2
ITPA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12418,070,980 - 18,081,815 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2418,064,983 - 18,082,163 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2417,899,408 - 17,910,225 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02418,489,683 - 18,500,338 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2418,484,647 - 18,500,667 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12418,083,389 - 18,094,040 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02418,195,716 - 18,206,381 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02418,523,354 - 18,534,007 (-)NCBIUU_Cfam_GSD_1.0
Itpa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640167,068,324 - 167,080,629 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648515,497,822 - 15,511,992 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648515,499,688 - 15,511,992 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITPA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1732,455,459 - 32,474,784 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11732,458,351 - 32,474,827 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21736,828,072 - 36,835,384 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITPA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1233,873,231 - 33,893,329 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl233,873,339 - 33,893,556 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607110,617,572 - 10,634,540 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itpa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247414,312,360 - 4,325,825 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247414,312,363 - 4,341,996 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itpa
80 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:64
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000028838
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3115638168135181505Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat

Markers in Region
RH133565  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23117,896,966 - 117,897,155 (+)MAPPERmRatBN7.2
Rnor_6.03123,220,986 - 123,221,174NCBIRnor6.0
Rnor_5.03129,719,114 - 129,719,302UniSTSRnor5.0
RGSC_v3.43118,309,830 - 118,310,018UniSTSRGSC3.4
Celera3116,707,784 - 116,707,972UniSTS
RH 3.4 Map31022.5UniSTS
Cytogenetic Map3q36UniSTS
RH142612  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23117,887,916 - 117,888,091 (+)MAPPERmRatBN7.2
Rnor_6.03123,212,064 - 123,212,238NCBIRnor6.0
Rnor_5.03129,710,192 - 129,710,366UniSTSRnor5.0
RGSC_v3.43118,300,783 - 118,300,957UniSTSRGSC3.4
Celera3116,698,770 - 116,698,944UniSTS
RH 3.4 Map31023.1UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000028838   ⟹   ENSRNOP00000028838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3117,885,459 - 117,897,249 (+)Ensembl
Rnor_6.0 Ensembl3123,209,608 - 123,221,269 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095754   ⟹   ENSRNOP00000090904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3117,885,978 - 117,897,247 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112815   ⟹   ENSRNOP00000092263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3117,885,486 - 117,897,249 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112870   ⟹   ENSRNOP00000077246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3117,885,099 - 117,897,247 (+)Ensembl
RefSeq Acc Id: NM_001107774   ⟹   NP_001101244
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,338,549 - 138,350,329 (+)NCBI
mRatBN7.23117,885,464 - 117,897,247 (+)NCBI
Rnor_6.03123,209,611 - 123,221,266 (+)NCBI
Rnor_5.03129,707,739 - 129,719,394 (+)NCBI
RGSC_v3.43118,298,330 - 118,310,110 (+)RGD
Celera3116,696,317 - 116,708,064 (+)RGD
Sequence:
RefSeq Acc Id: NP_001101244   ⟸   NM_001107774
- UniProtKB: D3ZW55 (UniProtKB/Swiss-Prot),   A0A8L2QG09 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028838   ⟸   ENSRNOT00000028838
Ensembl Acc Id: ENSRNOP00000090904   ⟸   ENSRNOT00000095754
Ensembl Acc Id: ENSRNOP00000092263   ⟸   ENSRNOT00000112815
Ensembl Acc Id: ENSRNOP00000077246   ⟸   ENSRNOT00000112870

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZW55-F1-model_v2 AlphaFold D3ZW55 1-198 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692439
Promoter ID:EPDNEW_R2963
Type:multiple initiation site
Name:Itpa_1
Description:inosine triphosphatase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03123,209,648 - 123,209,708EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589751 AgrOrtholog
BioCyc Gene G2FUF-47844 BioCyc
Ensembl Genes ENSRNOG00000021233 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028838.7 UniProtKB/TrEMBL
  ENSRNOT00000095754.1 UniProtKB/TrEMBL
  ENSRNOT00000112815.1 UniProtKB/TrEMBL
  ENSRNOT00000112870.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.950.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ham1p-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ITPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ITPase-like_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:311422 UniProtKB/Swiss-Prot
NCBI Gene 311422 ENTREZGENE
PANTHER INOSINE TRIPHOSPHATE PYROPHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ham1p_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ITPA RGD
PhenoGen Itpa PhenoGen
RatGTEx ENSRNOG00000021233 RatGTEx
Superfamily-SCOP SSF52972 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5XVY2_RAT UniProtKB/TrEMBL
  A0A8I6ABW8_RAT UniProtKB/TrEMBL
  A0A8I6AG77_RAT UniProtKB/TrEMBL
  A0A8L2QG09 ENTREZGENE, UniProtKB/TrEMBL
  A6HQA7_RAT UniProtKB/TrEMBL
  A6HQA8_RAT UniProtKB/TrEMBL
  D3ZW55 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Itpa  inosine triphosphatase  Itpa  inosine triphosphatase (nucleoside triphosphate pyrophosphatase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   inosine triphosphatase (nucleoside triphosphate pyrophosphatase)  Itpa  inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (mapped)  Name updated 737654 APPROVED
2007-04-11 Itpa  inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (mapped)  Itpa_mapped  inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (mapped)  Data merged from RGD:2931 737654 APPROVED
2006-11-19 Itpa  inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Itpa_mapped  inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (mapped)      Symbol and Name updated 1556543 APPROVED
2004-09-10 Itpa  inosine triphosphatase (nucleoside triphosphate pyrophosphatase)    inosine triphosphatase  Name updated 1299863 APPROVED
2002-06-10 Itpa  Inosine triphosphatase (nucleoside triphosphate pyrophosphatase)      Symbol and Name status set to approved 70586 APPROVED