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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2869
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igf1r
Name: insulin-like growth factor 1 receptor
Acc ID: CHEBI:2948
Term: azathioprine
Definition: A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Chemical ID: MESH:D001379
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1rdecreases expressionISOIGF1R (Homo sapiens)6480464CTDAzathioprine results in decreased expression of IGF1R proteinPMID:23958494
Igf1rmultiple interactionsISOIGF1R (Homo sapiens)6480464CTDAzathioprine inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]PMID:23958494
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