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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619868
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
Acc ID: CHEBI:2948
Term: azathioprine
Definition: A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Chemical ID: MESH:D001379
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclcincreases expressionISOGCLC (Homo sapiens)6480464CTDAzathioprine results in increased expression of GCLC mRNAPMID:22623647 PMID:26198647
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