Pask (PAS domain containing serine/threonine kinase) - Rat Genome Database

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Gene: Pask (PAS domain containing serine/threonine kinase) Rattus norvegicus
Analyze
Symbol: Pask
Name: PAS domain containing serine/threonine kinase
RGD ID: 1306146
Description: Predicted to enable phosphatidylinositol binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including negative regulation of glycogen biosynthetic process; protein autophosphorylation; and regulation of glucagon secretion. Predicted to be active in cytosol and nucleus. Orthologous to human PASK (PAS domain containing serine/threonine kinase); INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC301617; MGC93882; PAS domain-containing serine/threonine-protein kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,291,673 - 101,333,288 (-)NCBIGRCr8
mRatBN7.2993,844,275 - 93,886,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl993,844,278 - 93,885,111 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9102,279,835 - 102,320,665 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,415,644 - 107,456,467 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09105,771,786 - 105,812,609 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09100,450,595 - 100,479,719 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9100,450,586 - 100,479,868 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09100,106,950 - 100,136,074 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4992,582,177 - 92,623,004 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1992,786,946 - 92,827,773 (-)NCBI
Celera991,379,229 - 91,420,042 (-)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (IBA,ISO)
nucleus  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:16275910   PMID:17595531   PMID:17878307   PMID:18509100   PMID:19502418   PMID:20943661   PMID:21181396   PMID:21418524   PMID:22065581   PMID:23765195   PMID:23853095  
PMID:25515571   PMID:26003800  


Genomics

Comparative Map Data
Pask
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,291,673 - 101,333,288 (-)NCBIGRCr8
mRatBN7.2993,844,275 - 93,886,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl993,844,278 - 93,885,111 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9102,279,835 - 102,320,665 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,415,644 - 107,456,467 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09105,771,786 - 105,812,609 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09100,450,595 - 100,479,719 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9100,450,586 - 100,479,868 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09100,106,950 - 100,136,074 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4992,582,177 - 92,623,004 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1992,786,946 - 92,827,773 (-)NCBI
Celera991,379,229 - 91,420,042 (-)NCBICelera
Cytogenetic Map9q36NCBI
PASK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,106,099 - 241,150,347 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2241,106,099 - 241,150,264 (-)EnsemblGRCh38hg38GRCh38
GRCh372242,045,514 - 242,089,637 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,694,188 - 241,737,551 (-)NCBINCBI36Build 36hg18NCBI36
Build 342241,765,504 - 241,808,868NCBI
Celera2235,715,217 - 235,758,602 (-)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2233,801,521 - 233,845,836 (-)NCBIHuRef
CHM1_12242,051,569 - 242,095,450 (-)NCBICHM1_1
T2T-CHM13v2.02241,605,207 - 241,649,447 (-)NCBIT2T-CHM13v2.0
Pask
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,237,165 - 93,271,237 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,236,492 - 93,271,204 (-)EnsemblGRCm39 Ensembl
GRCm38193,309,437 - 93,343,522 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,308,770 - 93,343,482 (-)EnsemblGRCm38mm10GRCm38
MGSCv37195,206,014 - 95,239,365 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,139,843 - 95,167,980 (-)NCBIMGSCv36mm8
Celera196,254,103 - 96,287,403 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.24NCBI
Pask
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955542555,030 - 578,227 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955542539,806 - 578,496 (+)NCBIChiLan1.0ChiLan1.0
PASK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213143,795,782 - 143,850,798 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B143,810,747 - 143,865,694 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B128,364,745 - 128,418,837 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B247,162,011 - 247,215,451 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B247,162,011 - 247,214,803 (-)Ensemblpanpan1.1panPan2
PASK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12551,145,094 - 51,181,040 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2551,144,912 - 51,177,818 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2551,358,398 - 51,393,714 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02551,340,211 - 51,375,472 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2551,338,043 - 51,375,448 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12551,187,899 - 51,223,198 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02550,927,406 - 50,962,618 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02551,203,734 - 51,238,468 (-)NCBIUU_Cfam_GSD_1.0
Pask
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303192,515,388 - 192,555,345 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936745664,062 - 704,027 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PASK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15139,890,178 - 139,917,069 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115139,887,439 - 139,917,887 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215155,006,110 - 155,031,416 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PASK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110127,156,577 - 127,206,745 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10127,156,558 - 127,199,845 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604072,175,714 - 72,226,448 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pask
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248475,216,441 - 5,238,908 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248475,215,626 - 5,246,540 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pask
115 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:35
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000022748
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)992491589100929786Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat

Markers in Region
BG379473  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2993,844,433 - 93,844,525 (+)MAPPERmRatBN7.2
Rnor_6.09100,450,754 - 100,450,845NCBIRnor6.0
Rnor_5.09100,107,109 - 100,107,200UniSTSRnor5.0
RGSC_v3.4992,582,336 - 92,582,427UniSTSRGSC3.4
Celera991,379,388 - 91,379,479UniSTS
RH 3.4 Map9815.3UniSTS
Cytogenetic Map9q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000022748   ⟹   ENSRNOP00000022748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl993,844,278 - 93,885,111 (-)Ensembl
Rnor_6.0 Ensembl9100,450,586 - 100,479,868 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095651   ⟹   ENSRNOP00000087231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl993,844,278 - 93,885,111 (-)Ensembl
RefSeq Acc Id: NM_001009362   ⟹   NP_001009362
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,291,673 - 101,332,504 (-)NCBI
mRatBN7.2993,844,275 - 93,885,111 (-)NCBI
Rnor_6.09100,450,595 - 100,479,719 (-)NCBI
Rnor_5.09100,106,950 - 100,136,074 (-)NCBI
RGSC_v3.4992,582,177 - 92,623,004 (-)RGD
Celera991,379,229 - 91,420,042 (-)RGD
Sequence:
RefSeq Acc Id: XM_039083419   ⟹   XP_038939347
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,291,673 - 101,332,773 (-)NCBI
mRatBN7.2993,844,275 - 93,886,036 (-)NCBI
RefSeq Acc Id: XM_039083420   ⟹   XP_038939348
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,291,673 - 101,333,288 (-)NCBI
mRatBN7.2993,844,275 - 93,886,036 (-)NCBI
RefSeq Acc Id: XM_039083422   ⟹   XP_038939350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,291,673 - 101,332,773 (-)NCBI
mRatBN7.2993,844,275 - 93,886,036 (-)NCBI
RefSeq Acc Id: XM_063267041   ⟹   XP_063123111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,291,673 - 101,332,626 (-)NCBI
RefSeq Acc Id: NP_001009362   ⟸   NM_001009362
- UniProtKB: Q5PQT0 (UniProtKB/TrEMBL),   F7F091 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022748   ⟸   ENSRNOT00000022748
RefSeq Acc Id: XP_038939348   ⟸   XM_039083420
- Peptide Label: isoform X1
- UniProtKB: Q5PQT0 (UniProtKB/TrEMBL),   F7F091 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939350   ⟸   XM_039083422
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038939347   ⟸   XM_039083419
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000087231   ⟸   ENSRNOT00000095651
RefSeq Acc Id: XP_063123111   ⟸   XM_063267041
- Peptide Label: isoform X2
Protein Domains
PAS   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5PQT0-F1-model_v2 AlphaFold Q5PQT0 1-1385 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306146 AgrOrtholog
BioCyc Gene G2FUF-26649 BioCyc
Ensembl Genes ENSRNOG00000016888 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022748.7 UniProtKB/TrEMBL
  ENSRNOT00000095651.1 UniProtKB/TrEMBL
Gene3D-CATH PAS domain UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7112450 IMAGE-MGC_LOAD
InterPro Kinase-like_dom UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:301617 UniProtKB/TrEMBL
MGC_CLONE MGC:93882 IMAGE-MGC_LOAD
NCBI Gene 301617 ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/TrEMBL
  PAS DOMAIN-CONTAINING SERINE/THREONINE-PROTEIN KINASE UniProtKB/TrEMBL
Pfam PAS_9 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Pask PhenoGen
PROSITE PAS UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016888 RatGTEx
SMART PAS UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SSF55785 UniProtKB/TrEMBL
UniProt A0A8I6GFT4 ENTREZGENE, UniProtKB/TrEMBL
  F7F091 ENTREZGENE, UniProtKB/TrEMBL
  Q5PQT0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Pask  PAS domain containing serine/threonine kinase  Pask_predicted  PAS domain containing serine/threonine kinase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Pask_predicted  PAS domain containing serine/threonine kinase (predicted)      Symbol and Name status set to approved 70820 APPROVED