Rmi2 (RecQ mediated genome instability 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Rmi2 (RecQ mediated genome instability 2) Rattus norvegicus
Analyze
Symbol: Rmi2
Name: RecQ mediated genome instability 2
RGD ID: 1563163
Description: Predicted to be involved in DNA metabolic process; negative regulation of double-strand break repair via homologous recombination; and regulation of sister chromatid segregation. Predicted to be part of RecQ family helicase-topoisomerase III complex. Predicted to be active in cytosol and nuclear speck. Orthologous to human RMI2 (RecQ mediated genome instability 2); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC497856; recQ-mediated genome instability protein 2; RGD1563163; RMI2, RecQ mediated genome instability 2, homolog; RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae); similar to hypothetical protein MGC24665
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8105,336,269 - 5,344,202 (-)NCBIGRCr8
mRatBN7.2104,829,333 - 4,837,264 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl104,830,553 - 4,837,235 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0104,904,458 - 4,910,339 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl104,905,210 - 4,910,305 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0103,732,669 - 3,738,527 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4104,765,965 - 4,771,062 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera103,850,779 - 3,858,692 (-)NCBICelera
Cytogenetic Map10q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:27977684  


Genomics

Comparative Map Data
Rmi2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8105,336,269 - 5,344,202 (-)NCBIGRCr8
mRatBN7.2104,829,333 - 4,837,264 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl104,830,553 - 4,837,235 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0104,904,458 - 4,910,339 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl104,905,210 - 4,910,305 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0103,732,669 - 3,738,527 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4104,765,965 - 4,771,062 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera103,850,779 - 3,858,692 (-)NCBICelera
Cytogenetic Map10q11NCBI
RMI2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381611,345,459 - 11,351,760 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1611,249,619 - 11,381,662 (+)EnsemblGRCh38hg38GRCh38
GRCh371611,439,316 - 11,445,617 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361611,346,812 - 11,353,118 (+)NCBINCBI36Build 36hg18NCBI36
Celera1611,608,616 - 11,614,921 (+)NCBICelera
Cytogenetic Map16p13.13NCBI
HuRef1611,357,810 - 11,364,115 (+)NCBIHuRef
CHM1_11611,439,267 - 11,445,572 (+)NCBICHM1_1
T2T-CHM13v2.01611,381,793 - 11,388,092 (+)NCBIT2T-CHM13v2.0
Rmi2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391610,652,923 - 10,661,099 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1610,652,923 - 10,710,830 (+)EnsemblGRCm39 Ensembl
GRCm381610,835,059 - 10,843,235 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1610,835,059 - 10,892,966 (+)EnsemblGRCm38mm10GRCm38
MGSCv371610,835,152 - 10,843,328 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361610,748,666 - 10,806,544 (+)NCBIMGSCv36mm8
Celera1611,462,481 - 11,470,677 (+)NCBICelera
Cytogenetic Map16A1NCBI
cM Map166.06NCBI
Rmi2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554427,262,381 - 7,267,428 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554427,262,381 - 7,266,992 (-)NCBIChiLan1.0ChiLan1.0
RMI2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21811,893,310 - 11,899,568 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11615,663,793 - 15,670,045 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01610,286,136 - 10,292,377 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11611,507,406 - 11,513,561 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1611,480,066 - 11,513,561 (+)Ensemblpanpan1.1panPan2
RMI2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1631,440,493 - 31,445,318 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl631,441,517 - 31,445,310 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha632,823,483 - 32,828,205 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0631,622,956 - 31,627,934 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl631,623,980 - 31,627,934 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1631,436,565 - 31,441,272 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0631,310,713 - 31,315,555 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0631,734,810 - 31,739,775 (-)NCBIUU_Cfam_GSD_1.0
Rmi2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344111,521,681 - 111,523,875 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365309,367,122 - 9,369,316 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RMI2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl331,808,015 - 31,814,843 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1331,807,717 - 31,814,869 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2332,597,640 - 32,604,726 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RMI2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1510,825,721 - 10,832,563 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl510,826,182 - 10,832,563 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606819,330,567 - 19,337,196 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rmi2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248248,494,606 - 8,499,878 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248248,494,591 - 8,502,597 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rmi2
63 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:98
Count of miRNA genes:71
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000033122
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1549898Neuinf3Neuroinflammation QTL 326.4nervous system integrity trait (VT:0010566)MHC Class II RT1A-positive spinal cord ventral horn area to total spinal cord ventral horn area ratio (CMO:0001980)1034063205387112Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 2 6 2 4 2 18 12 20
Low 2 27 32 25 15 25 1 1 37 11 20 9 1
Below cutoff 12 11 7 7 5 7 13 8 2 5

Sequence


RefSeq Acc Id: ENSRNOT00000033122   ⟹   ENSRNOP00000033277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl104,905,210 - 4,910,305 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095584   ⟹   ENSRNOP00000084849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl104,830,553 - 4,837,235 (-)Ensembl
RefSeq Acc Id: XM_573037   ⟹   XP_573037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8105,336,269 - 5,344,202 (-)NCBI
mRatBN7.2104,829,333 - 4,837,264 (-)NCBI
Rnor_6.0104,904,458 - 4,910,339 (-)NCBI
Rnor_5.0103,732,669 - 3,738,527 (-)NCBI
RGSC_v3.4104,765,965 - 4,771,062 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001417172 (Get FASTA)   NCBI Sequence Viewer  
  XP_573037 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000084849
  ENSRNOP00000084849.1
RefSeq Acc Id: XP_573037   ⟸   XM_573037
- Sequence:
RefSeq Acc Id: ENSRNOP00000033277   ⟸   ENSRNOT00000033122
RefSeq Acc Id: ENSRNOP00000084849   ⟸   ENSRNOT00000095584

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ACT0-F1-model_v2 AlphaFold D4ACT0 1-149 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696942
Promoter ID:EPDNEW_R7463
Type:multiple initiation site
Name:Rmi2_1
Description:RecQ mediated genome instability 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0104,910,324 - 4,910,384EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563163 AgrOrtholog
BioCyc Gene G2FUF-26147 BioCyc
Ensembl Genes ENSRNOG00000021902 Ensembl
  ENSRNOG00000065770 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000095584.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.140 UniProtKB/TrEMBL
InterPro NA-bd_OB-fold UniProtKB/TrEMBL
  RMI2 UniProtKB/TrEMBL
KEGG Report rno:497856 UniProtKB/TrEMBL
NCBI Gene 497856 ENTREZGENE
PANTHER PTHR33962 UniProtKB/TrEMBL
  RECQ-MEDIATED GENOME INSTABILITY PROTEIN 2 UniProtKB/TrEMBL
Pfam RMI2 UniProtKB/TrEMBL
PhenoGen Rmi2 PhenoGen
RatGTEx ENSRNOG00000021902 RatGTEx
  ENSRNOG00000065770 RatGTEx
UniProt A0A8I6A014 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Rmi2  RecQ mediated genome instability 2  Rmi2  RecQ mediated genome instability 2  Data merged from RGD:149736169 737654 PROVISIONAL
2021-08-09 Rmi2  RecQ mediated genome instability 2      Symbol and Name status set to provisional 45752 PROVISIONAL
2013-07-12 Rmi2  RecQ mediated genome instability 2  Rmi2  RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-12 Rmi2  RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)  RGD1563163  similar to hypothetical protein MGC24665  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1563163  similar to hypothetical protein MGC24665   RGD1563163_predicted  similar to hypothetical protein MGC24665 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1563163_predicted  similar to hypothetical protein MGC24665 (predicted)  LOC497856  similar to hypothetical protein MGC24665  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC497856  similar to hypothetical protein MGC24665      Symbol and Name status set to provisional 70820 PROVISIONAL