Rmi2 (RecQ mediated genome instability 2)

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Gene: Rmi2 (RecQ mediated genome instability 2) Rattus norvegicus

Analyze

Symbol:

Rmi2

Name:

RecQ mediated genome instability 2

RGD ID:

1563163

Description:

Predicted to be involved in DNA metabolic process; negative regulation of double-strand break repair via homologous recombination; and regulation of sister chromatid segregation. Predicted to be part of RecQ family helicase-topoisomerase III complex. Predicted to be active in cytosol and nuclear speck. Orthologous to human RMI2 (RecQ mediated genome instability 2); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC497856; recQ-mediated genome instability protein 2; RGD1563163; RMI2, RecQ mediated genome instability 2, homolog; RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae); similar to hypothetical protein MGC24665

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	4,829,333 - 4,837,264 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	4,830,553 - 4,837,235 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	10	4,904,458 - 4,910,339 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	4,905,210 - 4,910,305 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	3,732,669 - 3,738,527 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	4,765,965 - 4,771,062 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	3,850,779 - 3,858,692 (-)	NCBI		Celera
Cytogenetic Map	10	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Charcot-Marie-Tooth disease type 1C (ISO)

genetic disease (ISO)

Landau-Kleffner syndrome (ISO)

MHC class II deficiency (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (ISO)

1,2-dichloroethane (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

arsenous acid (ISO)

azathioprine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

calcitriol (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

Enterolactone (ISO)

ethyl methanesulfonate (ISO)

formaldehyde (ISO)

genistein (ISO)

gentamycin (EXP)

hydrogen peroxide (ISO)

leflunomide (ISO)

menadione (ISO)

N-methyl-4-phenylpyridinium (ISO)

ozone (ISO)

paracetamol (EXP)

paraquat (EXP)

phenylmercury acetate (ISO)

potassium dichromate (ISO)

propanal (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

temozolomide (ISO)

testosterone (ISO)

tetrachloromethane (EXP)

thapsigargin (ISO)

trovafloxacin (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA repair (IBA)

double-strand break repair via homologous recombination (ISO)

maintenance of rDNA (IBA)

negative regulation of double-strand break repair via homologous recombination (IBA)

regulation of sister chromatid segregation (IBA,ISO)

resolution of recombination intermediates (ISO)

Cellular Component

cytosol (IBA,ISO)

nuclear speck (IBA,ISO)

RecQ family helicase-topoisomerase III complex (ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:27977684

Genomics

Comparative Map Data

Rmi2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	4,829,333 - 4,837,264 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	4,830,553 - 4,837,235 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	10	4,904,458 - 4,910,339 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	4,905,210 - 4,910,305 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	3,732,669 - 3,738,527 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	4,765,965 - 4,771,062 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	3,850,779 - 3,858,692 (-)	NCBI		Celera
Cytogenetic Map	10	q11	NCBI

RMI2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	11,345,459 - 11,351,760 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	16	11,249,619 - 11,381,662 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	11,439,316 - 11,445,617 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	11,346,812 - 11,353,118 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	16	11,608,616 - 11,614,921 (+)	NCBI		Celera
Cytogenetic Map	16	p13.13	NCBI
HuRef	16	11,357,810 - 11,364,115 (+)	NCBI		HuRef
CHM1_1	16	11,439,267 - 11,445,572 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	11,381,793 - 11,388,092 (+)	NCBI		T2T-CHM13v2.0

Rmi2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	10,652,923 - 10,661,099 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	10,652,923 - 10,710,830 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	10,835,059 - 10,843,235 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	10,835,059 - 10,892,966 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	10,835,152 - 10,843,328 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	10,748,666 - 10,806,544 (+)	NCBI		MGSCv36	mm8
Celera	16	11,462,481 - 11,470,677 (+)	NCBI		Celera
Cytogenetic Map	16	A1	NCBI

Rmi2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	7,262,381 - 7,267,428 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	7,262,381 - 7,266,992 (-)	NCBI	ChiLan1.0	ChiLan1.0

RMI2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	16	15,663,793 - 15,670,045 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	10,286,136 - 10,292,377 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	11,507,406 - 11,513,561 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	11,480,066 - 11,513,561 (+)	Ensembl	panpan1.1		panPan2

RMI2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	31,440,493 - 31,445,318 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	31,441,517 - 31,445,310 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	32,823,483 - 32,828,205 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	31,622,956 - 31,627,934 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	31,623,980 - 31,627,934 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	31,436,565 - 31,441,272 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	31,310,713 - 31,315,555 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	31,734,810 - 31,739,775 (-)	NCBI		UU_Cfam_GSD_1.0

Rmi2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	111,521,681 - 111,523,875 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936530	9,367,122 - 9,369,316 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RMI2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	31,808,015 - 31,814,843 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	31,807,717 - 31,814,869 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	32,597,640 - 32,604,726 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RMI2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	10,825,721 - 10,832,563 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	10,826,182 - 10,832,563 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	19,330,567 - 19,337,196 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rmi2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624824	8,494,606 - 8,499,878 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624824	8,494,591 - 8,502,597 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Rmi2
55 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	98
Count of miRNA genes:	71
Interacting mature miRNAs:	75
Transcripts:	ENSRNOT00000033122
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634329	Pia15	Pristane induced arthritis QTL 15	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	1	24158324	Rat
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35225947	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38328221	Rat
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
1549898	Neuinf3	Neuroinflammation QTL 3	26.4		nervous system integrity trait (VT:0010566)	MHC Class II RT1A-positive spinal cord ventral horn area to total spinal cord ventral horn area ratio (CMO:0001980)	10	3406320	5387112	Rat
1576304	Schws7	Schwannoma susceptibility QTL 7		0.0115	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	4765527	19816042	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1	2	6	2	4	2			18	12	20
Low	2	27	32	25	15	25	1	1	37	11	20	9	1
Below cutoff		12	11	7		7	5	7	13	8		2	5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_001078307	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_573037	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACYVU010000217	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000033122 ⟹ ENSRNOP00000033277

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	10	4,905,210 - 4,910,305 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000095584 ⟹ ENSRNOP00000084849

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	4,830,553 - 4,837,235 (-)	Ensembl

RefSeq Acc Id:

XM_573037 ⟹ XP_573037

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	4,829,333 - 4,837,264 (-)	NCBI
Rnor_6.0	10	4,904,458 - 4,910,339 (-)	NCBI
Rnor_5.0	10	3,732,669 - 3,738,527 (-)	NCBI
RGSC_v3.4	10	4,765,965 - 4,771,062 (-)	RGD

Sequence:

show sequence

ATCAGAGTTGGCGGGAAAGTGGCAGTAGCTCAGCATGGCAGCTGCAGCGTCTGAGTCGCTGTCT
TCGGGTGGCCCCGGGGCCGTGCGGCTGCCGCGCTCGCCGCCCCTCAAGGTGCTGGCAGAACAGC
TGCGGCAGCACGCAGAAGGTGGCCCGGGCGCGTGGCGGCTGTCCCGGGCGGCGGTGGGCCGCAC
GCCGCTGGAGCTGGCGGCCGTGTGGATGCAGGGTACTGTGCTGGCGGCGGAAGGCGGCCAGGCG
CGGCTGCGGGACCCGAGCGGTACCTTCTCCGTGCGTGGCCTGGAGCGCGTACCACGCGGCCGGC
CTTGCCTGTTCCCAGGAAAGTACGTGATGGTCATGGGGGTGGTTCAGGCCTGCAGTCCTGAGCC
CTGCCTGCAGGCCGTGAAGATGACGGACCTTTCTAACAATCCTGTCCACGAAAGCATGTGGGAA
CTGGAGGTGGAAGACTTACACAGGAACATCCCTTAGAGCTGGGACCCTCTAAGAAGAGCTCCCC
CTAAAGGAATCTACGCCCAGCTGGGTCTCAGGAACAGCATGAAAGTTTCTTGAAGACATTTGCT
TTGGTTGAGTCAGACGTCTGGACCCTGGGAGCTGGAGCTTCAGTTGTCTCAGCCACCACTCCCT
GCCCGTGCTTTGCTTGCATGAGAAGCAGATGTCCCCCCCTTTGTCCCTAACGTGTGTTCCTTTC
TCTCGCTGAAGCACATGGAAAATTCCTGTCGTCATTTCCTGATTCTGCGAGGGATGACACTTTC
TCCTTGACTGCACCTCTGAATTTCAGTCGTTGCCAGTGGGTTAAAATTATGGACATAAGGACAG
AATGGCATGGTGGCCTGCCTTCCATCACCAGCCATTGCCATCTTGTAGGGCAGGTGCCAACCTC
TTGCTGACAGCTTTCTCTCTCTGCTTCGATGTGCTTTTTCCTCATTGTCTGTGTCCTTAGACTC
TGAAGCTGAGGCCACCTGTTGAGAATGGTCAGAATCCTCACAATGCTCCGTTGAACTTAAAAAT
CCAAGATGGAGACAGACTTTTCAAACACTTCTCCTTCAAAACTATTGTGGAGAGACAGCCAGGG
TGGGACTAGTCTGCAGGCTTAGAGTCCTGACCTCCTTTCTGTATGAAATGCCTTTCTATTGGGA
TTGTGTCAGTGTTGGGTTTGACTTTCTGCTGATGACCCAGGCTAGGTTCATATTTGGATGACAA
AAACCAAGCAGCCCACCTTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_573037	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	XP_573037 ⟸ XM_573037
- UniProtKB:	D4ACT0 (UniProtKB/TrEMBL), A0A8I6A014 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAAASESLSSGGPGAVRLPRSPPLKVLAEQLRQHAEGGPGAWRLSRAAVGRTPLELAAVWMQG TVLAAEGGQARLRDPSGTFSVRGLERVPRGRPCLFPGKYVMVMGVVQACSPEPCLQAVKMTDLS NNPVHESMWELEVEDLHRNIP hide sequence

RefSeq Acc Id:

ENSRNOP00000033277 ⟸ ENSRNOT00000033122

RefSeq Acc Id:

ENSRNOP00000084849 ⟸ ENSRNOT00000095584

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4ACT0-F1-model_v2	AlphaFold	D4ACT0	1-149	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696942

Promoter ID:

EPDNEW_R7463

Type:

multiple initiation site

Name:

Rmi2_1

Description:

RecQ mediated genome instability 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	4,910,324 - 4,910,384	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1563163	AgrOrtholog
BioCyc Gene	G2FUF-26147	BioCyc
Ensembl Genes	ENSRNOG00000021902	Ensembl
	ENSRNOG00000065770	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000084849	ENTREZGENE
	ENSRNOP00000084849.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000095584	ENTREZGENE
	ENSRNOT00000095584.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.50.140	UniProtKB/TrEMBL
InterPro	NA-bd_OB-fold	UniProtKB/TrEMBL
	RMI2	UniProtKB/TrEMBL
KEGG Report	rno:497856	UniProtKB/TrEMBL
NCBI Gene	497856	ENTREZGENE
PANTHER	PTHR33962	UniProtKB/TrEMBL
	RECQ-MEDIATED GENOME INSTABILITY PROTEIN 2	UniProtKB/TrEMBL
Pfam	RMI2	UniProtKB/TrEMBL
PhenoGen	Rmi2	PhenoGen
UniProt	A0A8I6A014	ENTREZGENE, UniProtKB/TrEMBL
	D4ACT0	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-06-02	Rmi2	RecQ mediated genome instability 2	Rmi2	RecQ mediated genome instability 2	Data Merged	737654	PROVISIONAL
2021-08-09	Rmi2	RecQ mediated genome instability 2			Symbol and Name status set to provisional	45752	PROVISIONAL
2013-07-12	Rmi2	RecQ mediated genome instability 2	Rmi2	RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-10-12	Rmi2	RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)	RGD1563163	similar to hypothetical protein MGC24665	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1563163	similar to hypothetical protein MGC24665	RGD1563163_predicted	similar to hypothetical protein MGC24665 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1563163_predicted	similar to hypothetical protein MGC24665 (predicted)	LOC497856	similar to hypothetical protein MGC24665	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC497856	similar to hypothetical protein MGC24665			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar