Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Spdl1 | Rat | (+)-catechin | multiple interactions | ISO | SPDL1 (Homo sapiens) | 6480464 | [Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of SPDL1 mRNA | CTD | PMID:24763279 | Spdl1 | Rat | 1,1-dichloroethene | increases expression | ISO | Spdl1 (Mus musculus) | 6480464 | vinylidene chloride results in increased expression of SPDL1 mRNA | CTD | PMID:26682919 | Spdl1 | Rat | 1-naphthyl isothiocyanate | increases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in increased expression of SPDL1 mRNA | CTD | PMID:30723492 | Spdl1 | Rat | 17beta-estradiol | increases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Estradiol results in increased expression of SPDL1 mRNA | CTD | PMID:19167446 | Spdl1 | Rat | 17beta-estradiol | multiple interactions | ISO | SPDL1 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of SPDL1 mRNA | CTD | PMID:30165855 | Spdl1 | Rat | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | Spdl1 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | Spdl1 | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:27291303 | Spdl1 | Rat | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | Spdl1 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | Spdl1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Spdl1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SPDL1 mRNA | CTD | PMID:21570461 and PMID:26377647 | Spdl1 | Rat | 2-hydroxypropanoic acid | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of SPDL1 mRNA | CTD | PMID:30851411 | Spdl1 | Rat | 2-methylcholine | affects expression | ISO | SPDL1 (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of SPDL1 mRNA | CTD | PMID:21179406 | Spdl1 | Rat | 3-methylcholanthrene | increases expression | ISO | Spdl1 (Mus musculus) | 6480464 | Methylcholanthrene results in increased expression of SPDL1 mRNA | CTD | PMID:20713471 | Spdl1 | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of SPDL1 mRNA | CTD | PMID:30047161 | Spdl1 | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of SPDL1 mRNA | CTD | PMID:31881176 | Spdl1 | Rat | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of SPDL1 mRNA | CTD | PMID:28959563 | Spdl1 | Rat | aflatoxin B1 | affects expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of SPDL1 protein | CTD | PMID:20106945 | Spdl1 | Rat | all-trans-retinoic acid | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of SPDL1 mRNA | CTD | PMID:33167477 | Spdl1 | Rat | amitrole | increases expression | EXP | | 6480464 | Amitrole results in increased expression of SPDL1 mRNA | CTD | PMID:30047161 | Spdl1 | Rat | arsane | multiple interactions | ISO | SPDL1 (Homo sapiens) | 6480464 | SPDL1 protein results in increased export of and results in decreased abundance of Arsenic | CTD | PMID:24391030 | Spdl1 | Rat | arsenic atom | multiple interactions | ISO | SPDL1 (Homo sapiens) | 6480464 | SPDL1 protein results in increased export of and results in decreased abundance of Arsenic | CTD | PMID:24391030 | Spdl1 | Rat | atrazine | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of SPDL1 mRNA | CTD | PMID:22378314 | Spdl1 | Rat | azathioprine | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Azathioprine results in decreased expression of SPDL1 mRNA | CTD | PMID:22623647 | Spdl1 | Rat | benzo[a]pyrene | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of SPDL1 mRNA | CTD | PMID:22316170 | Spdl1 | Rat | benzo[a]pyrene | increases expression | ISO | Spdl1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of SPDL1 mRNA | CTD | PMID:32417428 | Spdl1 | Rat | benzo[a]pyrene | affects methylation | ISO | SPDL1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SPDL1 5' UTR | CTD | PMID:27901495 | Spdl1 | Rat | beta-lapachone | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | beta-lapachone results in decreased expression of SPDL1 mRNA | CTD | PMID:38218311 | Spdl1 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SPDL1 mRNA | CTD | PMID:25181051 | Spdl1 | Rat | bisphenol A | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of SPDL1 mRNA | CTD | PMID:27685785 more ... | Spdl1 | Rat | cadmium atom | multiple interactions | ISO | SPDL1 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SPDL1 mRNA | CTD | PMID:35301059 | Spdl1 | Rat | cadmium dichloride | increases methylation | EXP | | 6480464 | Cadmium Chloride results in increased methylation of SPDL1 promoter | CTD | PMID:22457795 | Spdl1 | Rat | cadmium dichloride | multiple interactions | ISO | SPDL1 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SPDL1 mRNA | CTD | PMID:35301059 | Spdl1 | Rat | calcitriol | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Calcitriol results in decreased expression of SPDL1 mRNA | CTD | PMID:21592394 | Spdl1 | Rat | calcitriol | multiple interactions | ISO | SPDL1 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of SPDL1 mRNA | CTD | PMID:21592394 | Spdl1 | Rat | carbon nanotube | increases expression | ISO | Spdl1 (Mus musculus) | 6480464 | Nanotubes and Carbon analog results in increased expression of SPDL1 mRNA | CTD | PMID:21624382 and PMID:25554681 | Spdl1 | Rat | chlorpyrifos | decreases expression | ISO | Spdl1 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of SPDL1 mRNA | CTD | PMID:37019170 | Spdl1 | Rat | choline | multiple interactions | ISO | Spdl1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPDL1 mRNA | CTD | PMID:20938992 | Spdl1 | Rat | cisplatin | multiple interactions | ISO | SPDL1 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of SPDL1 mRNA | CTD | PMID:27392435 | Spdl1 | Rat | cisplatin | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of SPDL1 mRNA | CTD | PMID:27392435 | Spdl1 | Rat | cobalt dichloride | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of SPDL1 mRNA | CTD | PMID:19320972 | Spdl1 | Rat | copper(II) sulfate | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of SPDL1 mRNA | CTD | PMID:19549813 | Spdl1 | Rat | coumestrol | multiple interactions | ISO | SPDL1 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 more ... | CTD | PMID:19167446 | Spdl1 | Rat | coumestrol | increases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Coumestrol results in increased expression of SPDL1 mRNA | CTD | PMID:19167446 | Spdl1 | Rat | cyclosporin A | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of SPDL1 mRNA | CTD | PMID:20106945 more ... | Spdl1 | Rat | DDE | increases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Dichlorodiphenyl Dichloroethylene results in increased expression of SPDL1 mRNA | CTD | PMID:38568856 | Spdl1 | Rat | dibutyl phthalate | decreases expression | ISO | Spdl1 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of SPDL1 mRNA | CTD | PMID:21266533 | Spdl1 | Rat | dichloroacetic acid | increases expression | ISO | Spdl1 (Mus musculus) | 6480464 | Dichloroacetic Acid results in increased expression of SPDL1 mRNA | CTD | PMID:28962523 | Spdl1 | Rat | diclofenac | decreases expression | ISO | Spdl1 (Mus musculus) | 6480464 | Diclofenac results in decreased expression of SPDL1 mRNA | CTD | PMID:35537566 | Spdl1 | Rat | dicrotophos | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of SPDL1 mRNA | CTD | PMID:28302478 | Spdl1 | Rat | diquat | decreases expression | ISO | Spdl1 (Mus musculus) | 6480464 | Diquat results in decreased expression of SPDL1 mRNA | CTD | PMID:36851058 | Spdl1 | Rat | disodium selenite | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Sodium Selenite results in decreased expression of SPDL1 mRNA | CTD | PMID:18175754 | Spdl1 | Rat | doxorubicin | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of SPDL1 mRNA | CTD | PMID:29803840 | Spdl1 | Rat | Enterolactone | multiple interactions | ISO | SPDL1 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SPDL1 mRNA | CTD | PMID:19167446 | Spdl1 | Rat | folic acid | multiple interactions | ISO | Spdl1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPDL1 mRNA | CTD | PMID:20938992 | Spdl1 | Rat | FR900359 | decreases phosphorylation | ISO | SPDL1 (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of SPDL1 protein | CTD | PMID:37730182 | Spdl1 | Rat | furan | increases expression | EXP | | 6480464 | furan results in increased expression of SPDL1 mRNA | CTD | PMID:25539665 | Spdl1 | Rat | hydrogen peroxide | affects expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of SPDL1 mRNA | CTD | PMID:23410634 | Spdl1 | Rat | ivermectin | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of SPDL1 protein | CTD | PMID:32959892 | Spdl1 | Rat | L-methionine | multiple interactions | ISO | Spdl1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPDL1 mRNA | CTD | PMID:20938992 | Spdl1 | Rat | lead diacetate | increases expression | ISO | Spdl1 (Mus musculus) | 6480464 | lead acetate results in increased expression of SPDL1 mRNA | CTD | PMID:22609695 | Spdl1 | Rat | leflunomide | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | leflunomide results in decreased expression of SPDL1 mRNA | CTD | PMID:28988120 | Spdl1 | Rat | lucanthone | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Lucanthone results in decreased expression of SPDL1 mRNA | CTD | PMID:21148553 | Spdl1 | Rat | menadione | affects expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Vitamin K 3 affects the expression of SPDL1 mRNA | CTD | PMID:23410634 | Spdl1 | Rat | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of SPDL1 mRNA | CTD | PMID:30047161 | Spdl1 | Rat | methylmercury chloride | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of SPDL1 mRNA | CTD | PMID:28001369 | Spdl1 | Rat | methylparaben | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | methylparaben results in decreased expression of SPDL1 mRNA | CTD | PMID:31745603 | Spdl1 | Rat | ochratoxin A | increases expression | EXP | | 6480464 | ochratoxin A results in increased expression of SPDL1 mRNA | CTD | PMID:23358140 | Spdl1 | Rat | oxaliplatin | decreases expression | EXP | | 6480464 | oxaliplatin results in decreased expression of SPDL1 mRNA | CTD | PMID:25729387 | Spdl1 | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of SPDL1 mRNA | CTD | PMID:25729387 | Spdl1 | Rat | ozone | decreases expression | ISO | Spdl1 (Mus musculus) | 6480464 | Ozone results in decreased expression of SPDL1 mRNA | CTD | PMID:24336422 | Spdl1 | Rat | ozone | multiple interactions | ISO | Spdl1 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of SPDL1 mRNA more ... | CTD | PMID:25658374 and PMID:34911549 | Spdl1 | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of SPDL1 mRNA | CTD | PMID:33387578 | Spdl1 | Rat | PCB138 | multiple interactions | ISO | Spdl1 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | Spdl1 | Rat | phenobarbital | affects expression | ISO | Spdl1 (Mus musculus) | 6480464 | Phenobarbital affects the expression of SPDL1 mRNA | CTD | PMID:23091169 | Spdl1 | Rat | piroxicam | increases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Piroxicam results in increased expression of SPDL1 mRNA | CTD | PMID:21858171 | Spdl1 | Rat | pregnenolone 16alpha-carbonitrile | increases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased expression of SPDL1 mRNA | CTD | PMID:30047161 | Spdl1 | Rat | rac-lactic acid | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of SPDL1 mRNA | CTD | PMID:30851411 | Spdl1 | Rat | resveratrol | multiple interactions | ISO | SPDL1 (Homo sapiens) | 6480464 | [Coumestrol co-treated with resveratrol] results in increased expression of SPDL1 mRNA | CTD | PMID:19167446 | Spdl1 | Rat | silicon dioxide | increases expression | ISO | Spdl1 (Mus musculus) | 6480464 | Silicon Dioxide results in increased expression of SPDL1 mRNA | CTD | PMID:29341224 | Spdl1 | Rat | sodium arsenite | decreases response to substance | ISO | SPDL1 (Homo sapiens) | 6480464 | SPDL1 protein results in decreased susceptibility to sodium arsenite | CTD | PMID:24391030 | Spdl1 | Rat | sodium arsenite | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of SPDL1 mRNA | CTD | PMID:38568856 | Spdl1 | Rat | sodium arsenite | increases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of SPDL1 mRNA | CTD | PMID:29301061 | Spdl1 | Rat | sodium arsenite | multiple interactions | ISO | SPDL1 (Homo sapiens) | 6480464 | SPDL1 protein promotes the reaction [sodium arsenite results in increased expression of ABCC2 protein] | CTD | PMID:24391030 | Spdl1 | Rat | succimer | multiple interactions | ISO | Spdl1 (Mus musculus) | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SPDL1 mRNA | CTD | PMID:21641980 | Spdl1 | Rat | sulfadimethoxine | increases expression | EXP | | 6480464 | Sulfadimethoxine results in increased expression of SPDL1 mRNA | CTD | PMID:30047161 | Spdl1 | Rat | sunitinib | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of SPDL1 mRNA | CTD | PMID:31533062 | Spdl1 | Rat | temozolomide | increases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of SPDL1 mRNA | CTD | PMID:31758290 | Spdl1 | Rat | tert-butyl hydroperoxide | affects expression | ISO | SPDL1 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide affects the expression of SPDL1 mRNA | CTD | PMID:23410634 | Spdl1 | Rat | testosterone | multiple interactions | ISO | SPDL1 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of SPDL1 mRNA | CTD | PMID:21592394 | Spdl1 | Rat | testosterone | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Testosterone results in decreased expression of SPDL1 mRNA | CTD | PMID:21592394 | Spdl1 | Rat | tetrachloromethane | affects expression | ISO | Spdl1 (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of SPDL1 mRNA | CTD | PMID:17484886 | Spdl1 | Rat | tetrachloromethane | increases expression | ISO | Spdl1 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of SPDL1 mRNA | CTD | PMID:27339419 and PMID:31919559 | Spdl1 | Rat | tetrahydropalmatine | decreases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | tetrahydropalmatine results in decreased expression of SPDL1 protein | CTD | PMID:20109541 | Spdl1 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of SPDL1 mRNA | CTD | PMID:23411599 and PMID:34492290 | Spdl1 | Rat | titanium dioxide | affects expression | ISO | Spdl1 (Mus musculus) | 6480464 | titanium dioxide affects the expression of SPDL1 mRNA | CTD | PMID:35295148 | Spdl1 | Rat | titanium dioxide | decreases methylation | ISO | Spdl1 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of SPDL1 gene and titanium dioxide results in decreased methylation of SPDL1 promoter | CTD | PMID:35295148 | Spdl1 | Rat | topotecan | decreases expression | EXP | | 6480464 | Topotecan results in decreased expression of SPDL1 mRNA | CTD | PMID:25729387 | Spdl1 | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of SPDL1 mRNA | CTD | PMID:25729387 | Spdl1 | Rat | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of SPDL1 mRNA | CTD | PMID:33387578 | Spdl1 | Rat | trimellitic anhydride | increases expression | ISO | Spdl1 (Mus musculus) | 6480464 | trimellitic anhydride results in increased expression of SPDL1 mRNA | CTD | PMID:19042947 | Spdl1 | Rat | triphenyl phosphate | affects expression | ISO | SPDL1 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of SPDL1 mRNA | CTD | PMID:37042841 | Spdl1 | Rat | trovafloxacin | decreases expression | ISO | Spdl1 (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of SPDL1 mRNA | CTD | PMID:35537566 | Spdl1 | Rat | tungsten | decreases expression | ISO | Spdl1 (Mus musculus) | 6480464 | Tungsten results in decreased expression of SPDL1 mRNA | CTD | PMID:30912803 | Spdl1 | Rat | valproic acid | increases expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of SPDL1 mRNA | CTD | PMID:29154799 | Spdl1 | Rat | valproic acid | affects expression | ISO | SPDL1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SPDL1 mRNA | CTD | PMID:25979313 | |