Vrk1 (VRK serine/threonine kinase 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Vrk1 (VRK serine/threonine kinase 1) Rattus norvegicus
Analyze
Symbol: Vrk1
Name: VRK serine/threonine kinase 1
RGD ID: 1306069
Description: Predicted to enable histone binding activity; histone kinase activity; and protein kinase binding activity. Predicted to be involved in several processes, including Golgi disassembly; peptidyl-serine phosphorylation; and positive regulation of protein localization to chromatin. Predicted to act upstream of or within protein autophosphorylation. Predicted to be located in Golgi stack; cytosol; and nuclear lumen. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1A. Orthologous to human VRK1 (VRK serine/threonine kinase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC362779; serine/threonine-protein kinase VRK1; vaccinia related kinase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26124,914,770 - 124,981,508 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl6124,914,855 - 124,981,436 (+)Ensembl
Rnor_6.06129,835,788 - 129,902,839 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6129,835,919 - 129,902,793 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06139,031,607 - 139,098,569 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46130,181,610 - 130,249,361 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16130,185,356 - 130,253,107 (+)NCBI
Celera6122,475,358 - 122,561,934 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytosol  (ISO)
Golgi stack  (ISO)
nucleolus  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14645249   PMID:17938195   PMID:19103756   PMID:21543316   PMID:22194607   PMID:22572157  


Genomics

Comparative Map Data
Vrk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26124,914,770 - 124,981,508 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl6124,914,855 - 124,981,436 (+)Ensembl
Rnor_6.06129,835,788 - 129,902,839 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6129,835,919 - 129,902,793 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06139,031,607 - 139,098,569 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46130,181,610 - 130,249,361 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16130,185,356 - 130,253,107 (+)NCBI
Celera6122,475,358 - 122,561,934 (+)NCBICelera
Cytogenetic Map6q32NCBI
VRK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381496,797,382 - 96,881,609 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1496,797,304 - 96,954,846 (+)EnsemblGRCh38hg38GRCh38
GRCh371497,263,719 - 97,347,946 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361496,333,437 - 96,417,704 (+)NCBINCBI36hg18NCBI36
Build 341496,333,467 - 96,417,693NCBI
Celera1477,319,099 - 77,403,366 (+)NCBI
Cytogenetic Map14q32.2NCBI
HuRef1477,447,214 - 77,531,474 (+)NCBIHuRef
CHM1_11497,202,026 - 97,286,310 (+)NCBICHM1_1
T2T-CHM13v2.01491,029,172 - 91,113,426 (+)NCBI
Vrk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912105,976,398 - 106,044,577 (+)NCBIGRCm39mm39
GRCm39 Ensembl12105,976,487 - 106,043,685 (+)Ensembl
GRCm3812106,010,139 - 106,078,318 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12106,010,228 - 106,077,426 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712107,248,473 - 107,315,620 (+)NCBIGRCm37mm9NCBIm37
MGSCv3612106,411,313 - 106,478,460 (+)NCBImm8
Celera12107,246,468 - 107,313,845 (+)NCBICelera
Cytogenetic Map12E- F1NCBI
Vrk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543818,508,769 - 18,595,704 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543818,508,915 - 18,595,104 (+)NCBIChiLan1.0ChiLan1.0
VRK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11496,783,489 - 96,831,954 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1496,756,397 - 96,831,954 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01477,429,970 - 77,514,217 (+)NCBIMhudiblu_PPA_v0panPan3
VRK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1865,444,404 - 65,551,348 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl865,443,949 - 65,551,151 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha864,961,338 - 65,068,324 (+)NCBI
ROS_Cfam_1.0865,718,203 - 65,825,229 (+)NCBI
ROS_Cfam_1.0 Ensembl865,717,954 - 65,825,232 (+)Ensembl
UMICH_Zoey_3.1865,390,164 - 65,497,054 (+)NCBI
UNSW_CanFamBas_1.0865,451,536 - 65,558,390 (+)NCBI
UU_Cfam_GSD_1.0865,775,210 - 65,882,284 (+)NCBI
Vrk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086408,985,074 - 9,071,452 (-)NCBI
SpeTri2.0NW_0049366041,011,048 - 1,097,388 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VRK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7117,942,973 - 118,028,923 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17117,942,929 - 118,025,991 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27125,203,973 - 125,310,693 (+)NCBISscrofa10.2Sscrofa10.2susScr3
VRK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12474,686,102 - 74,770,496 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2474,686,111 - 74,770,874 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605361,835,736 - 61,920,212 (+)NCBIVero_WHO_p1.0
Vrk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247346,595,814 - 6,678,081 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247346,595,827 - 6,678,139 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
BF416556  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26124,921,695 - 124,921,788 (+)MAPPERmRatBN7.2
Rnor_6.06129,842,260 - 129,842,352NCBIRnor6.0
Rnor_5.06139,037,990 - 139,038,082UniSTSRnor5.0
RGSC_v3.46130,188,403 - 130,188,495UniSTSRGSC3.4
Celera6122,482,134 - 122,482,226UniSTS
Cytogenetic Map6q32UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:177
Count of miRNA genes:112
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000036035
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 26 36 22 19 22 1 1 74 23 41 11 1
Low 17 21 19 19 7 10 12 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001012194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC079130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000036035   ⟹   ENSRNOP00000029546
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6124,914,855 - 124,981,436 (+)Ensembl
Rnor_6.0 Ensembl6129,835,919 - 129,902,793 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098742   ⟹   ENSRNOP00000090784
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6124,914,911 - 124,977,374 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100741   ⟹   ENSRNOP00000093032
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6124,914,890 - 124,981,246 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102103   ⟹   ENSRNOP00000084211
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6124,914,911 - 124,981,125 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104154   ⟹   ENSRNOP00000077410
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6124,914,911 - 124,981,125 (+)Ensembl
RefSeq Acc Id: NM_001012194   ⟹   NP_001012194
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26124,914,901 - 124,981,463 (+)NCBI
Rnor_6.06129,835,919 - 129,902,794 (+)NCBI
Rnor_5.06139,031,607 - 139,098,569 (+)NCBI
RGSC_v3.46130,181,610 - 130,249,361 (+)RGD
Celera6122,475,358 - 122,561,934 (+)RGD
Sequence:
RefSeq Acc Id: XM_006240530   ⟹   XP_006240592
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26124,914,796 - 124,981,508 (+)NCBI
Rnor_6.06129,835,881 - 129,902,839 (+)NCBI
Rnor_5.06139,031,607 - 139,098,569 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240531   ⟹   XP_006240593
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26124,914,822 - 124,981,508 (+)NCBI
Rnor_6.06129,835,895 - 129,902,839 (+)NCBI
Rnor_5.06139,031,607 - 139,098,569 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240532   ⟹   XP_006240594
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26124,914,770 - 124,981,508 (+)NCBI
Rnor_6.06129,836,250 - 129,902,839 (+)NCBI
Rnor_5.06139,031,607 - 139,098,569 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039112534   ⟹   XP_038968462
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26124,914,770 - 124,981,508 (+)NCBI
RefSeq Acc Id: XM_039112535   ⟹   XP_038968463
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26124,914,832 - 124,981,508 (+)NCBI
RefSeq Acc Id: XM_039112536   ⟹   XP_038968464
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26124,914,832 - 124,981,508 (+)NCBI
RefSeq Acc Id: XM_039112537   ⟹   XP_038968465
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26124,914,831 - 124,981,508 (+)NCBI
RefSeq Acc Id: XM_039112538   ⟹   XP_038968466
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26124,914,832 - 124,981,508 (+)NCBI
RefSeq Acc Id: XM_039112540   ⟹   XP_038968468
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26124,914,806 - 124,981,508 (+)NCBI
RefSeq Acc Id: XM_039112541   ⟹   XP_038968469
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26124,926,067 - 124,981,508 (+)NCBI
RefSeq Acc Id: XM_039112542   ⟹   XP_038968470
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26124,914,770 - 124,981,508 (+)NCBI
RefSeq Acc Id: XM_039112543   ⟹   XP_038968471
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26124,914,795 - 124,981,257 (+)NCBI
RefSeq Acc Id: XM_039112544   ⟹   XP_038968472
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26124,943,681 - 124,981,508 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001012194   ⟸   NM_001012194
- UniProtKB: Q6AYA2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240592   ⟸   XM_006240530
- Peptide Label: isoform X1
- UniProtKB: Q6AYA2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240593   ⟸   XM_006240531
- Peptide Label: isoform X1
- UniProtKB: Q6AYA2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240594   ⟸   XM_006240532
- Peptide Label: isoform X1
- UniProtKB: Q6AYA2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000029546   ⟸   ENSRNOT00000036035
RefSeq Acc Id: XP_038968462   ⟸   XM_039112534
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038968470   ⟸   XM_039112542
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038968471   ⟸   XM_039112543
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038968468   ⟸   XM_039112540
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038968465   ⟸   XM_039112537
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038968463   ⟸   XM_039112535
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038968464   ⟸   XM_039112536
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038968466   ⟸   XM_039112538
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038968469   ⟸   XM_039112541
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038968472   ⟸   XM_039112544
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000077410   ⟸   ENSRNOT00000104154
RefSeq Acc Id: ENSRNOP00000093032   ⟸   ENSRNOT00000100741
RefSeq Acc Id: ENSRNOP00000084211   ⟸   ENSRNOT00000102103
RefSeq Acc Id: ENSRNOP00000090784   ⟸   ENSRNOT00000098742
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYA2-F1-model_v2 AlphaFold Q6AYA2 1-414 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694818
Promoter ID:EPDNEW_R5340
Type:initiation region
Name:Vrk1_1
Description:vaccinia related kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06129,835,903 - 129,835,963EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306069 AgrOrtholog
BioCyc Gene G2FUF-36324 BioCyc
Ensembl Genes ENSRNOG00000005274 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000029546 ENTREZGENE
  ENSRNOP00000029546.5 UniProtKB/TrEMBL
  ENSRNOP00000077410.1 UniProtKB/TrEMBL
  ENSRNOP00000084211 ENTREZGENE
  ENSRNOP00000084211.1 UniProtKB/TrEMBL
  ENSRNOP00000090784.1 UniProtKB/TrEMBL
  ENSRNOP00000093032 ENTREZGENE
  ENSRNOP00000093032.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036035 ENTREZGENE
  ENSRNOT00000036035.5 UniProtKB/TrEMBL
  ENSRNOT00000098742.1 UniProtKB/TrEMBL
  ENSRNOT00000100741 ENTREZGENE
  ENSRNOT00000100741.1 UniProtKB/TrEMBL
  ENSRNOT00000102103 ENTREZGENE
  ENSRNOT00000102103.1 UniProtKB/TrEMBL
  ENSRNOT00000104154.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7127355 IMAGE-MGC_LOAD
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:362779 UniProtKB/TrEMBL
MGC_CLONE MGC:94140 IMAGE-MGC_LOAD
NCBI Gene 362779 ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Vrk1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I5XW39_RAT UniProtKB/TrEMBL
  A0A8I6AD98_RAT UniProtKB/TrEMBL
  A0A8I6AIR3_RAT UniProtKB/TrEMBL
  A0A8I6GA19_RAT UniProtKB/TrEMBL
  F7ENT3_RAT UniProtKB/TrEMBL
  Q6AYA2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-24 Vrk1  VRK serine/threonine kinase 1  Vrk1  vaccinia related kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Vrk1  vaccinia related kinase 1  Vrk1_predicted  vaccinia related kinase 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Vrk1_predicted  vaccinia related kinase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED