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Gene: Thop1 (thimet oligopeptidase 1) Rattus norvegicus
Symbol: Thop1
Name: thimet oligopeptidase 1
Description: Exhibits peptidase activity and peptide binding activity. Predicted to be involved in intracellular signal transduction; peptide metabolic process; and proteolysis. Predicted to localize to the mitochondrial intermembrane space. Orthologous to human THOP1 (thimet oligopeptidase 1); PARTICIPATES IN renin-angiotensin cascade pathway; sleeping sickness pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: endo-oligopeptidase A; endopeptidase 24.15; EP24.15; metalloendopeptidase; MGC93105; PZ-peptidase; soluble metallo-endopeptidase; Thimet oligopeptidase
Homo sapiens (human) : THOP1 (thimet oligopeptidase 1)  HGNC  Alliance
Mus musculus (house mouse) : Thop1 (thimet oligopeptidase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Thop1 (thimet oligopeptidase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : THOP1 (thimet oligopeptidase 1)
Canis lupus familiaris (dog) : THOP1 (thimet oligopeptidase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Thop1 (thimet oligopeptidase 1)
Sus scrofa (pig) : THOP1 (thimet oligopeptidase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0711,501,145 - 11,513,576 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,501,146 - 11,513,581 (-)Ensembl
Rnor_5.0711,668,512 - 11,680,946 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,116,822 - 10,129,162 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1710,116,821 - 10,129,088 (-)NCBI
Celera76,820,402 - 6,832,744 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Thop1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68330
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.