Thop1 (thimet oligopeptidase 1) - Rat Genome Database

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Gene: Thop1 (thimet oligopeptidase 1) Rattus norvegicus
Analyze
Symbol: Thop1
Name: thimet oligopeptidase 1
RGD ID: 68330
Description: Enables peptidase activity and peptide binding activity. Involved in peptide catabolic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrial intermembrane space. Orthologous to human THOP1 (thimet oligopeptidase 1); PARTICIPATES IN renin-angiotensin cascade pathway; sleeping sickness pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: endo-oligopeptidase A; endopeptidase 24.15; EP24.15; metalloendopeptidase; MGC93105; PZ-peptidase; soluble metallo-endopeptidase; Thimet oligopeptidase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,283,617 - 9,295,957 (-)NCBIGRCr8
mRatBN7.278,632,911 - 8,645,339 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,632,916 - 8,645,275 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,517,596 - 11,530,108 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,393,093 - 13,405,605 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,259,596 - 11,272,104 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,501,145 - 11,513,576 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,501,146 - 11,513,581 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,668,512 - 11,680,946 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,116,822 - 10,129,162 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,116,821 - 10,129,088 (-)NCBI
Celera76,820,402 - 6,832,744 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
Brodifacoum  (EXP)
capsaicin  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
hydrogen cyanide  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lovastatin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-nitrosodiethylamine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
potassium cyanide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trimellitic anhydride  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Expression of the thimet oligopeptidase gene is regulated by positively and negatively acting elements. McCool S and Pierotti AR, DNA Cell Biol 2000 Dec;19(12):729-38.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Thimet oligopeptidase expression is differentially regulated in neuroendocrine and spermatid cell lines by transcription factor binding to SRY (sex-determining region Y), CAAT and CREB (cAMP-response-element-binding protein) promoter consensus sequences. Morrison LS and Pierotti AR, Biochem J 2003 Nov 15;376(Pt 1):189-97.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Metalloendopeptidases EC 3.4.24.15/16 regulate bradykinin activity in the cerebral microvasculature. Norman MU, etal., Am J Physiol Heart Circ Physiol 2003 Jun;284(6):H1942-8. Epub 2003 Feb 13.
8. Molecular cloning and primary structure of rat testes metalloendopeptidase EC 3.4.24.15. Pierotti A, etal., Biochemistry 1990 Nov 13;29(45):10323-9.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. Mapping sequence differences between thimet oligopeptidase and neurolysin implicates key residues in substrate recognition. Ray K, etal., Protein Sci 2002 Sep;11(9):2237-46.
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme. Rioli V, etal., J Biol Chem. 2003 Mar 7;278(10):8547-55. doi: 10.1074/jbc.M212030200. Epub 2002 Dec 24.
15. Natural intracellular peptides can modulate the interactions of mouse brain proteins and thimet oligopeptidase with 14-3-3epsilon and calmodulin. Russo LC, etal., Proteomics. 2012 Aug;12(17):2641-55. doi: 10.1002/pmic.201200032. Epub 2012 Jul 26.
16. Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis. Sleat DE, etal., J Biol Chem. 1996 Aug 9;271(32):19191-8.
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8216239   PMID:10969067   PMID:15955058   PMID:15985312   PMID:16515556   PMID:18571100   PMID:22082260   PMID:22387539   PMID:24041943   PMID:26653570  


Genomics

Comparative Map Data
Thop1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,283,617 - 9,295,957 (-)NCBIGRCr8
mRatBN7.278,632,911 - 8,645,339 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,632,916 - 8,645,275 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,517,596 - 11,530,108 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,393,093 - 13,405,605 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,259,596 - 11,272,104 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,501,145 - 11,513,576 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,501,146 - 11,513,581 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,668,512 - 11,680,946 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,116,822 - 10,129,162 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,116,821 - 10,129,088 (-)NCBI
Celera76,820,402 - 6,832,744 (-)NCBICelera
Cytogenetic Map7q11NCBI
THOP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38192,785,503 - 2,815,807 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl192,785,503 - 2,815,807 (+)EnsemblGRCh38hg38GRCh38
GRCh37192,785,501 - 2,815,805 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,736,506 - 2,764,599 (+)NCBINCBI36Build 36hg18NCBI36
Build 34192,736,505 - 2,764,598NCBI
Celera192,721,390 - 2,749,643 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef192,554,996 - 2,583,295 (+)NCBIHuRef
CHM1_1192,785,096 - 2,813,188 (+)NCBICHM1_1
T2T-CHM13v2.0192,760,790 - 2,791,094 (+)NCBIT2T-CHM13v2.0
Thop1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,905,917 - 80,918,194 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,905,869 - 80,918,393 (+)EnsemblGRCm39 Ensembl
GRCm381081,070,083 - 81,082,360 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,070,035 - 81,082,559 (+)EnsemblGRCm38mm10GRCm38
MGSCv371080,532,828 - 80,545,105 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,473,279 - 80,485,687 (+)NCBIMGSCv36mm8
Celera1082,090,182 - 82,102,459 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Thop1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,054,986 - 5,071,279 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554955,055,389 - 5,070,710 (+)NCBIChiLan1.0ChiLan1.0
THOP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2207,179,830 - 7,209,333 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1196,412,831 - 6,442,294 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0191,810,316 - 1,839,523 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1192,765,550 - 2,793,235 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl192,765,550 - 2,793,235 (+)Ensemblpanpan1.1panPan2
THOP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,412,578 - 56,432,480 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2056,412,908 - 56,432,446 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2056,208,964 - 56,228,856 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02057,146,032 - 57,165,932 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2057,146,042 - 57,165,951 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12056,199,077 - 56,218,944 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02056,683,949 - 56,703,847 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02056,884,291 - 56,904,201 (-)NCBIUU_Cfam_GSD_1.0
Thop1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,196,995 - 216,216,192 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,618,541 - 1,637,821 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365881,618,585 - 1,637,788 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THOP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl275,853,429 - 75,877,494 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1275,857,788 - 75,877,430 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2276,370,019 - 76,389,661 (-)NCBISscrofa10.2Sscrofa10.2susScr3
THOP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.162,564,445 - 2,590,029 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660816,013,877 - 6,039,353 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thop1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,857,846 - 5,873,462 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248285,857,667 - 5,873,055 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Thop1
88 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:49
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000027045
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat

Markers in Region
D7Wox43  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,645,666 - 8,645,826 (+)MAPPERmRatBN7.2
Rnor_6.0711,513,899 - 11,514,058NCBIRnor6.0
Rnor_5.0711,681,263 - 11,681,422UniSTSRnor5.0
RGSC_v3.4710,129,572 - 10,129,731UniSTSRGSC3.4
Celera76,833,154 - 6,833,313UniSTS
Cytogenetic Map7q11UniSTS
UniSTS:236402  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,642,216 - 8,642,299 (+)MAPPERmRatBN7.2
Rnor_6.0711,510,451 - 11,510,533NCBIRnor6.0
Rnor_5.0711,677,815 - 11,677,897UniSTSRnor5.0
RGSC_v3.4710,126,124 - 10,126,206UniSTSRGSC3.4
Celera76,829,706 - 6,829,788UniSTS
Cytogenetic Map7q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 27 30 22 17 22 2 5 74 33 40 9 2
Low 1 16 27 19 2 19 6 6 2 1 2 6
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000027045   ⟹   ENSRNOP00000027045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,632,916 - 8,645,275 (-)Ensembl
Rnor_6.0 Ensembl711,501,146 - 11,513,581 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082486   ⟹   ENSRNOP00000075551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,632,916 - 8,645,275 (-)Ensembl
Rnor_6.0 Ensembl711,501,149 - 11,513,415 (-)Ensembl
RefSeq Acc Id: NM_172075   ⟹   NP_742072
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,283,617 - 9,295,957 (-)NCBI
mRatBN7.278,632,915 - 8,645,257 (-)NCBI
Rnor_6.0711,501,149 - 11,513,489 (-)NCBI
Rnor_5.0711,668,512 - 11,680,946 (-)NCBI
RGSC_v3.4710,116,822 - 10,129,162 (-)RGD
Celera76,820,402 - 6,832,744 (-)RGD
Sequence:
RefSeq Acc Id: NP_742072   ⟸   NM_172075
- UniProtKB: Q66HS4 (UniProtKB/Swiss-Prot),   P24155 (UniProtKB/Swiss-Prot),   A6K8C9 (UniProtKB/TrEMBL),   A0A0G2KAW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075551   ⟸   ENSRNOT00000082486
RefSeq Acc Id: ENSRNOP00000027045   ⟸   ENSRNOT00000027045
Protein Domains
Peptidase M3A/M3B catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24155-F1-model_v2 AlphaFold P24155 1-687 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694996
Promoter ID:EPDNEW_R5516
Type:multiple initiation site
Name:Thop1_1
Description:thimet oligopeptidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,513,510 - 11,513,570EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68330 AgrOrtholog
BioCyc Gene G2FUF-34992 BioCyc
Ensembl Genes ENSRNOG00000019924 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055032661 UniProtKB/Swiss-Prot
  ENSRNOG00060031896 UniProtKB/Swiss-Prot
  ENSRNOG00065022268 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027045 ENTREZGENE
  ENSRNOT00000027045.7 UniProtKB/Swiss-Prot
  ENSRNOT00000082486.2 UniProtKB/TrEMBL
  ENSRNOT00055056438 UniProtKB/Swiss-Prot
  ENSRNOT00060055312 UniProtKB/Swiss-Prot
  ENSRNOT00065037968 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1370.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7111806 IMAGE-MGC_LOAD
InterPro MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurolysin/TOP_dom2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurolysin/TOP_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M3A_M3B UniProtKB/Swiss-Prot
  Pept_M3A_M3B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M3A_M3B UniProtKB/TrEMBL
KEGG Report rno:64517 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93105 IMAGE-MGC_LOAD
NCBI Gene 64517 ENTREZGENE
PANTHER PTHR11804 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIMET OLIGOPEPTIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Thop1 PhenoGen
PROSITE ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019924 RatGTEx
  ENSRNOG00055032661 RatGTEx
  ENSRNOG00060031896 RatGTEx
  ENSRNOG00065022268 RatGTEx
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC229917
UniProt A0A0G2KAW4 ENTREZGENE, UniProtKB/TrEMBL
  A6K8C9 ENTREZGENE, UniProtKB/TrEMBL
  A6K8D0_RAT UniProtKB/TrEMBL
  P24155 ENTREZGENE
  Q66HS4 ENTREZGENE
  THOP1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q66HS4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Thop1  thimet oligopeptidase 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression highest enzyme activity is detected in testis, also expressed in brain and pituitary 730190
gene_process involved in the degradation of Bradykinin, a vasoactive peptide 1299146