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Gene: THOP1 (thimet oligopeptidase 1) Canis lupus familiaris

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Symbol:

THOP1

Name:

thimet oligopeptidase 1

RGD ID:

12239867

Description:

ENCODES a protein that exhibits peptidase activity (ortholog); peptide binding (ortholog); INVOLVED IN intracellular signal transduction (ortholog); peptide catabolic process (ortholog); peptide metabolic process (ortholog); ASSOCIATED WITH Neurodevelopmental Disorders (ortholog); progressive myoclonus epilepsy 9 (ortholog); RASopathy (ortholog); FOUND IN cytoplasm (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

thimet oligopeptidase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	THOP1 (thimet oligopeptidase 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Thop1 (thimet oligopeptidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Thop1 (thimet oligopeptidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Thop1 (thimet oligopeptidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	THOP1 (thimet oligopeptidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Thop1 (thimet oligopeptidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	THOP1 (thimet oligopeptidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	THOP1 (thimet oligopeptidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Thop1 (thimet oligopeptidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	NLN (neurolysin)	HGNC	OrthoDB

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	56,412,578 - 56,432,480 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	56,412,908 - 56,432,446 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	56,208,964 - 56,228,856 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	57,146,032 - 57,165,932 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	57,146,042 - 57,165,951 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	56,199,077 - 56,218,944 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	56,683,949 - 56,703,847 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	56,884,291 - 56,904,201 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
THOP1	Dog	Neurodevelopmental Disorders		ISO	THOP1 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Neurodevelopmental disorder	ClinVar	PMID:25741868
THOP1	Dog	progressive myoclonus epilepsy 9		ISO	THOP1 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Progressive myoclonic epilepsy type 9	ClinVar	PMID:28492532
THOP1	Dog	RASopathy		ISO	THOP1 (Homo sapiens)	8554872	ClinVar Annotator: match by term: RASopathy	ClinVar	PMID:23379592 more ...

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
THOP1	Dog	intracellular signal transduction	acts_upstream_of_or_within	ISO	Thop1 (Mus musculus)	9068941	PMID:10969067	MGI	PMID:10969067
THOP1	Dog	peptide catabolic process	involved_in	ISO	Thop1 (Rattus norvegicus)	9068941	PMID:12500972	UniProt	PMID:12500972 and REF_RGD_ID:152025518
THOP1	Dog	peptide metabolic process	involved_in	IBA	MGI:1354165 more ...	150520179		GO_Central	GO_REF:0000033
THOP1	Dog	peptide metabolic process	acts_upstream_of_or_within	ISO	Thop1 (Mus musculus)	9068941	PMID:10969067	MGI	PMID:10969067
THOP1	Dog	proteolysis	involved_in	IEA	UniProtKB-KW:KW-0645	150520179		UniProt	GO_REF:0000043
THOP1	Dog	proteolysis	involved_in	IEA	InterPro:IPR001567 and InterPro:IPR045090	150520179		InterPro	GO_REF:0000002
THOP1	Dog	proteolysis	involved_in	IBA	PANTHER:PTN000211184 more ...	150520179		GO_Central	GO_REF:0000033

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
THOP1	Dog	cytoplasm	located_in	IEA	UniProtKB-SubCell:SL-0086	150520179		UniProt	GO_REF:0000044
THOP1	Dog	mitochondrial intermembrane space	is_active_in	IBA	PANTHER:PTN000211242 more ...	150520179		GO_Central	GO_REF:0000033

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
THOP1	Dog	hydrolase activity	enables	IEA	UniProtKB-KW:KW-0378	150520179		UniProt	GO_REF:0000043
THOP1	Dog	metal ion binding	enables	IEA	UniProtKB-KW:KW-0479	150520179		UniProt	GO_REF:0000043
THOP1	Dog	metal ion binding	enables	IEA	UniRule:UR000000453	150520179		UniProt	GO_REF:0000104
THOP1	Dog	metalloendopeptidase activity	enables	IEA	InterPro:IPR001567 and InterPro:IPR045090	150520179		InterPro	GO_REF:0000002
THOP1	Dog	metalloendopeptidase activity	enables	IBA	MGI:1354165 more ...	150520179		GO_Central	GO_REF:0000033
THOP1	Dog	metallopeptidase activity	enables	IEA	InterPro:IPR024079	150520179		InterPro	GO_REF:0000002
THOP1	Dog	metallopeptidase activity	enables	IEA	UniProtKB-KW:KW-0482	150520179		UniProt	GO_REF:0000043
THOP1	Dog	peptidase activity		ISO	Thop1 (Rattus norvegicus)	9068941		RGD	PMID:8702598 and REF_RGD_ID:1625498
THOP1	Dog	peptidase activity	enables	IEA	UniProtKB-KW:KW-0645	150520179		UniProt	GO_REF:0000043
THOP1	Dog	peptide binding		ISO	Thop1 (Rattus norvegicus)	9068941		RGD	PMID:8702598 and REF_RGD_ID:1625498
THOP1	Dog	protein binding	enables	ISO	UniProtKB:O95208-2	9068941	PMID:32296183	IntAct	PMID:32296183
THOP1	Dog	protein binding	enables	ISO	UniProtKB:Q12933	9068941	PMID:25416956	IntAct	PMID:25416956
THOP1	Dog	protein binding	enables	ISO	UniProtKB:Q96CV9	9068941	PMID:32814053	IntAct	PMID:32814053

PMID:22301074	PMID:30032202

THOP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	56,412,578 - 56,432,480 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	56,412,908 - 56,432,446 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	56,208,964 - 56,228,856 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	57,146,032 - 57,165,932 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	57,146,042 - 57,165,951 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	56,199,077 - 56,218,944 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	56,683,949 - 56,703,847 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	56,884,291 - 56,904,201 (-)	NCBI		UU_Cfam_GSD_1.0

THOP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	2,785,503 - 2,815,807 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	2,785,503 - 2,815,807 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	2,785,501 - 2,815,805 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	2,736,506 - 2,764,599 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	2,736,505 - 2,764,598	NCBI
Celera	19	2,721,390 - 2,749,643 (+)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	2,554,996 - 2,583,295 (+)	NCBI		HuRef
CHM1_1	19	2,785,096 - 2,813,188 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	2,760,790 - 2,791,094 (+)	NCBI		T2T-CHM13v2.0

Thop1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	80,905,917 - 80,918,194 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	80,905,869 - 80,918,393 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	81,070,083 - 81,082,360 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	81,070,035 - 81,082,559 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	80,532,828 - 80,545,105 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	80,473,279 - 80,485,687 (+)	NCBI		MGSCv36	mm8
Celera	10	82,090,182 - 82,102,459 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

Thop1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	9,283,617 - 9,295,957 (-)	NCBI		GRCr8
mRatBN7.2	7	8,632,911 - 8,645,339 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	8,632,916 - 8,645,275 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	11,517,596 - 11,530,108 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	13,393,093 - 13,405,605 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	11,259,596 - 11,272,104 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	11,501,145 - 11,513,576 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	11,501,146 - 11,513,581 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	11,668,512 - 11,680,946 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	10,116,822 - 10,129,162 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	10,116,821 - 10,129,088 (-)	NCBI
Celera	7	6,820,402 - 6,832,744 (-)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

Thop1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	5,054,986 - 5,071,279 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	5,055,389 - 5,070,710 (+)	NCBI	ChiLan1.0	ChiLan1.0

THOP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	7,179,830 - 7,209,333 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	6,412,831 - 6,442,294 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	1,810,316 - 1,839,523 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	2,765,550 - 2,793,235 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	2,765,550 - 2,793,235 (+)	Ensembl	panpan1.1		panPan2

Thop1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	216,196,995 - 216,216,192 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	1,618,541 - 1,637,821 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	1,618,585 - 1,637,788 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

THOP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	75,853,429 - 75,877,494 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	75,857,788 - 75,877,430 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	76,370,019 - 76,389,661 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

THOP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	2,564,445 - 2,590,029 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666081	6,013,877 - 6,039,353 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Thop1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	5,857,846 - 5,873,462 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624828	5,857,667 - 5,873,055 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in THOP1
381 total Variants

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10


RefSeq Transcripts	XM_022407259	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038429208	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038429209	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038504741	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038567882	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038567883	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038632005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_533954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000058	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000291	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000030803 ⟹ ENSCAFP00000028637

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	20	56,412,908 - 56,432,446 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845020033 ⟹ ENSCAFP00845015697

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	20	57,146,042 - 57,165,951 (-)	Ensembl

RefSeq Acc Id:

XM_022407259 ⟹ XP_022262967

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	20	56,412,578 - 56,432,480 (-)	NCBI
Dog10K_Boxer_Tasha	20	56,208,964 - 56,228,856 (-)	NCBI

Sequence:

show sequence

CGCGGGCGCGCGGGCGGCGGGCGCCTCGGTCCCGGCTGCTGCGGACCCGGAGCACACGGAGGCGGCCGGCTGCGGCGGCTCAGGCGGCGCGACGCGGAGCGGGAGGACCGAGGGGCGGCCGGCGCACA
GCTGCCCACCATGAAGCCCCCAGCAGCCTGTGTAGGAGATGCCCTGGACACAGCGGCCCCGTGCTCCGTGGTGAACTACCTGAGATGGGACCTGAGCGCCCAGCAAATAGAGGAGCTCACTGTGGAGC
TCATCGAGCAGACTAAGCGTGTGTATGACCAGGTGGGCTCCCAGAAGTTTGAAGACGTGTCCTATGAGAGTACCCTCAAGGCGCTGGCCGATGTGGAGGTGTCCTACACAGTTCAGAGGAACATCCTG
GACTTCCCGCAGCACGTTTCTCCATCCAAGGACATTCGGACGGCCAGCACAGAGGCGGACAAAAAGCTGTCTGAGTTTGACGTGGAGATGAGCATGAGGCAGGATGTGTACCAGAGGATTGTCTGGCT
GCAGGAGAAAGTTCAGAAGGACTCGTTGAGGCCGGAGGCCCTGCGGTACCTGGAGCGACTGGTCAAGCTGGGCAGAAGGAACGGCCTACATCTACCTGAGGACACTCAACAGAAAATCAAGAGCATTA
AGAAGAAGCTGAGTCTTCTGTGCATCGACTTCAACAAGAACTTGAACGAGGACACGACCTTCCTGCCACTCACGCGAGAGGAGCTGGGAGGGCTCCCGGAGGACTTTCTGAACTCGCTGGAGAAGGCT
GGGGATGACAAGTTGAAAGTCACTCTCAAGTACCCACATTATTTTCCTCTCCTGAAGAAGTGCCACGTGCCCGAGACCAGGAGGAAGGTGGAGGAGGCCTTCAACTGCCGGTGCAAGCAGGAGAATTG
TGCGATCCTCAGAGAGCTGGTGACCCTCCGGGCCCAGAAGTCCAGCCTGCTGGGGTTTAGCACACACGCCGACTACGTCCTGGAGATGAACATGGCTAAGAGCAGCCAGGTGGTGGCCACTTTCCTAG
ATGAGCTGGCCCAGAAGCTGAAGCCCCTTGGGGAGCAGGAGCGCGCCGTGATCCTGGAGCTGAAGAAGGCCGAGTGCGAGAAGCGGGGCCTGGACTTCGACGGGCGCATCAACGCCTGGGACATGCGC
TACTACATGAACCAGGTGGAGGAGACCCGCTACAGCGTGGACCAGAACCTGCTCAAGGAGTACTTCCCCATGCAGGTGGTCACCCAGGGCTTGCTCAGCATCTACCAGGAGCTGCTGGGGCTGACCTT
CGACCTGGAGGAGGGCGCCACCGTGTGGCACGAGGACGTGAAGCTCTACTCCGTGAGGGACTCGGCGTCGGGGAGGGTCATCGGGAAGTTCTACCTGGACCTCTACCCGCGGGAAGGGAAGTACGGGC
ACGCGGCCTGCTTTGGCTTGCAGCCCGGCTGCCTGCGGCAGGACGGGAGCCGCCAGATTGCCATCGCGGCCATGGTGGCCAACTTCACCAAGCCTACCCCGGACGCCCCCTCCCTGCTGCAGCACGAC
GAGGTGGAGACCTACTTCCACGAGTTTGGGCACGTGATGCACCAGCTGTGCTCTCAGGCGGAGTTTGCCATGTTTAGCGGGACACACGTGGAGCGGGACTTCGTGGAAGCACCTTCCCAGATGCTGGA
GAACTGGGTGTGGGAGAAGGAGCCGCTGCTCAGGATGTCCCAGCACTACAGGACGGGCAGCGCCATCCCCCAGGAGCTGCTCGAGAAGCTCATCAAGTCCCGGCAGGCCAACACAGGTCTCTTCAACC
TGCGCCAGATCGTACTGGCCAAGGTGGATCAGGCCCTGCACACGCAGACGGCTGCCGACCCGGCTGAGGAGTATGCCCGCCTCTGCCAGGAGATCCTTGGGGTCCCTGCCACGCCAGGGACCAACATG
CCTGCGACCTTTGGCCACCTGGCCGGTGGCTACGACGCCCAGTACTACGGCTACCTGTGGAGTGAGGTGTACTCCATGGACATGTTCCACACACGCTTCAAGCAGGAGGGCATCCTGAACGGCAAGCA
GGTCGGCATGGACTACAGACGCTGCATCCTGAGACCCGGCGGCTCCCAGGATGCCAGCGTCATGCTGAAGCTCTTCCTGGGCCGAGACCCCAAGCAGGATGCCTTCCTCCTGAGCAAGGGGCTGCAGG
TGGACAGCAGCGAGCCACCGGCCTGCTGACGCACCAGGGCTCTGCTGGCCCCGGGCCACGGGCTCAGCCCCACCCCAGCTCCTGCTGCCCTGTTGCCTTAGCTCCCAGTCGGGAAACGGGGTGGCCTG
CCGCTCAGGGTGGGCGGGTGGGGGCAGGGTGAGGAGACGGGCTCTTCGTCCTCCCTGTCCGTTCCTCGTGTCTGGTCTCTACAGGCCCCCGTCGGTGGCCAGCCTGGGCTGATGGGGCCTTGTCCTCG
AGATGCCCGGAGAACTCTGTGTTCAGTCACGCCCGCCAATTTGTTGCACTAATCCATCCCCTTCCTGGGAAGTTTTCTGAGTGAAAAGATGGTGGTTCTTTGAAATGCAGCCATTAAAAAAAAAAAAA
AAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_038429208 ⟹ XP_038285136

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	20	57,146,032 - 57,165,932 (-)	NCBI

RefSeq Acc Id:

XM_038429209 ⟹ XP_038285137

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	20	57,146,032 - 57,165,932 (-)	NCBI

RefSeq Acc Id:

XM_038504741 ⟹ XP_038360669

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	20	56,199,077 - 56,218,944 (-)	NCBI

RefSeq Acc Id:

XM_038567882 ⟹ XP_038423810

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	20	56,884,291 - 56,904,201 (-)	NCBI

RefSeq Acc Id:

XM_038567883 ⟹ XP_038423811

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	20	56,884,291 - 56,904,201 (-)	NCBI

RefSeq Acc Id:

XM_038632005 ⟹ XP_038487933

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	20	56,683,949 - 56,703,847 (-)	NCBI

RefSeq Acc Id:

XM_533954 ⟹ XP_533954

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	20	56,412,578 - 56,432,480 (-)	NCBI
Dog10K_Boxer_Tasha	20	56,208,964 - 56,228,856 (-)	NCBI

Sequence:

show sequence

CGCGGGCGCGCGGGCGGCGGGCGCCTCGGTCCCGGCTGCTGCGGACCCGGAGCACACGGAGGCG
GCCGGCTGCGGCGGCTCAGGCGGCGCGACGCGGAGCGGGAGGACCGAGGGGCGGCCGGCGCACAGCTGCCCACCATGAAGCCCCCAGCAGCCTGTGTAGGAGATGCCCTGGACACAGCGGCCCCGTGC
TCCGTGGTGAACTACCTGAGATGGGACCTGAGCGCCCAGCAAATAGAGGAGCTCACTGTGGAGCTCATCGAGCAGACTAAGCGTGTGTATGACCAGGTGGGCTCCCAGAAGTTTGAAGACGTGTCCTA
TGAGAGTACCCTCAAGGCGCTGGCCGATGTGGAGGTGTCCTACACAGTTCAGAGGAACATCCTGGACTTCCCGCAGCACGTTTCTCCATCCAAGGACATTCGGACGGCCAGCACAGAGGCGGACAAAA
AGCTGTCTGAGTTTGACGTGGAGATGAGCATGAGGCAGGATGTGTACCAGAGGATTGTCTGGCTGCAGGAGAAAGTTCAGAAGGACTCGTTGAGGCCGGAGGCCCTGCGGTACCTGGAGCGACTGGTC
AAGCTGGGCAGAAGGAACGGCCTACATCTACCTGAGGACACTCAACAGAAAATCAAGAGCATTAAGAAGAAGCTGAGTCTTCTGTGCATCGACTTCAACAAGAACTTGAACGAGGACACGACCTTCCT
GCCACTCACGCGAGAGGAGCTGGGAGGGCTCCCGGAGGACTTTCTGAACTCGCTGGAGAAGGCTGGGGATGACAAGTTGAAAGTCACTCTCAAGTACCCACATTATTTTCCTCTCCTGAAGAAGTGCC
ACGTGCCCGAGACCAGGAGGAAGGTGGAGGAGGCCTTCAACTGCCGGTGCAAGCAGGAGAATTGTGCGATCCTCAGAGAGCTGGTGACCCTCCGGGCCCAGAAGTCCAGCCTGCTGGGGTTTAGCACA
CACGCCGACTACGTCCTGGAGATGAACATGGCTAAGAGCAGCCAGGTGGTGGCCACTTTCCTAGATGAGCTGGCCCAGAAGCTGAAGCCCCTTGGGGAGCAGGAGCGCGCCGTGATCCTGGAGCTGAA
GAAGGCCGAGTGCGAGAAGCGGGGCCTGGACTTCGACGGGCGCATCAACGCCTGGGACATGCGCTACTACATGAACCAGGTGGAGGAGACCCGCTACAGCGTGGACCAGAACCTGCTCAAGGAGTACT
TCCCCATGCAGGTGGTCACCCAGGGCTTGCTCAGCATCTACCAGGAGCTGCTGGGGCTGACCTTCGACCTGGAGGAGGGCGCCACCGTGTGGCACGAGGACGTGAAGCTCTACTCCGTGAGGGACTCG
GCGTCGGGGAGGGTCATCGGGAAGTTCTACCTGGACCTCTACCCGCGGGAAGGGAAGTACGGGCACGCGGCCTGCTTTGGCTTGCAGCCCGGCTGCCTGCGGCAGGACGGGAGCCGCCAGATTGCCAT
CGCGGCCATGGTGGCCAACTTCACCAAGCCTACCCCGGACGCCCCCTCCCTGCTGCAGCACGACGAGGTGGAGACCTACTTCCACGAGTTTGGGCACGTGATGCACCAGCTGTGCTCTCAGGCGGAGT
TTGCCATGTTTAGCGGGACACACGTGGAGCGGGACTTCGTGGAAGCACCTTCCCAGATGCTGGAGAACTGGGTGTGGGAGAAGGAGCCGCTGCTCAGGATGTCCCAGCACTACAGGACGGGCAGCGCC
ATCCCCCAGGAGCTGCTCGAGAAGCTCATCAAGTCCCGGCAGGCCAACACAGGTCTCTTCAACCTGCGCCAGATCGTACTGGCCAAGGTGGATCAGGCCCTGCACACGCAGACGGCTGCCGACCCGGC
TGAGGAGTATGCCCGCCTCTGCCAGGAGATCCTTGGGGTCCCTGCCACGCCAGGGACCAACATGCCTGCGACCTTTGGCCACCTGGCCGGTGGCTACGACGCCCAGTACTACGGCTACCTGTGGAGTG
AGGTGTACTCCATGGACATGTTCCACACACGCTTCAAGCAGGAGGGCATCCTGAACGGCAAGGTCGGCATGGACTACAGACGCTGCATCCTGAGACCCGGCGGCTCCCAGGATGCCAGCGTCATGCTG
AAGCTCTTCCTGGGCCGAGACCCCAAGCAGGATGCCTTCCTCCTGAGCAAGGGGCTGCAGGTGGACAGCAGCGAGCCACCGGCCTGCTGACGCACCAGGGCTCTGCTGGCCCCGGGCCACGGGCTCAG
CCCCACCCCAGCTCCTGCTGCCCTGTTGCCTTAGCTCCCAGTCGGGAAACGGGGTGGCCTGCCGCTCAGGGTGGGCGGGTGGGGGCAGGGTGAGGAGACGGGCTCTTCGTCCTCCCTGTCCGTTCCTC
GTGTCTGGTCTCTACAGGCCCCCGTCGGTGGCCAGCCTGGGCTGATGGGGCCTTGTCCTCGAGATGCCCGGAGAACTCTGTGTTCAGTCACGCCCGCCAATTTGTTGCACTAATCCATCCCCTTCCTG
GGAAGTTTTCTGAGTGAAAAGATGGTGGTTCTTTGAAATGCAGCCATTAAAAAAAAAAAAAAAAAAAAAA

hide sequence


Protein RefSeqs	XP_022262967	(Get FASTA)	NCBI Sequence Viewer
	XP_038285136	(Get FASTA)	NCBI Sequence Viewer
	XP_038285137	(Get FASTA)	NCBI Sequence Viewer
	XP_038360669	(Get FASTA)	NCBI Sequence Viewer
	XP_038423810	(Get FASTA)	NCBI Sequence Viewer
	XP_038423811	(Get FASTA)	NCBI Sequence Viewer
	XP_038487933	(Get FASTA)	NCBI Sequence Viewer
	XP_533954	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000028637.4
	ENSCAFP00000069028.1
	ENSCAFP00030012996.1
	ENSCAFP00040016398.1
	ENSCAFP00845015697
	ENSCAFP00845015697.1

RefSeq Acc Id:	XP_533954 ⟸ XM_533954
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0L3C3 (UniProtKB/TrEMBL), A0A8C0S6C7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKPPAACVGDALDTAAPCSVVNYLRWDLSAQQIEELTVELIEQTKRVYDQVGSQKFEDVSYESTLKALADVEVSYTVQRNILDFPQHVSPSKDIRTASTEADKKLSEFDVEMSMRQDVYQRIVWLQEK VQKDSLRPEALRYLERLVKLGRRNGLHLPEDTQQKIKSIKKKLSLLCIDFNKNLNEDTTFLPLTREELGGLPEDFLNSLEKAGDDKLKVTLKYPHYFPLLKKCHVPETRRKVEEAFNCRCKQENCAIL RELVTLRAQKSSLLGFSTHADYVLEMNMAKSSQVVATFLDELAQKLKPLGEQERAVILELKKAECEKRGLDFDGRINAWDMRYYMNQVEETRYSVDQNLLKEYFPMQVVTQGLLSIYQELLGLTFDLE EGATVWHEDVKLYSVRDSASGRVIGKFYLDLYPREGKYGHAACFGLQPGCLRQDGSRQIAIAAMVANFTKPTPDAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWV WEKEPLLRMSQHYRTGSAIPQELLEKLIKSRQANTGLFNLRQIVLAKVDQALHTQTAADPAEEYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGILNGKVGMD YRRCILRPGGSQDASVMLKLFLGRDPKQDAFLLSKGLQVDSSEPPAC hide sequence

RefSeq Acc Id:	XP_022262967 ⟸ XM_022407259
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0MK53 (UniProtKB/TrEMBL), A0A8I3N7K6 (UniProtKB/TrEMBL), A0A8C0S6C7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKPPAACVGDALDTAAPCSVVNYLRWDLSAQQIEELTVELIEQTKRVYDQVGSQKFEDVSYEST LKALADVEVSYTVQRNILDFPQHVSPSKDIRTASTEADKKLSEFDVEMSMRQDVYQRIVWLQEKVQKDSLRPEALRYLERLVKLGRRNGLHLPEDTQQKIKSIKKKLSLLCIDFNKNLNEDTTFLPLT REELGGLPEDFLNSLEKAGDDKLKVTLKYPHYFPLLKKCHVPETRRKVEEAFNCRCKQENCAILRELVTLRAQKSSLLGFSTHADYVLEMNMAKSSQVVATFLDELAQKLKPLGEQERAVILELKKAE CEKRGLDFDGRINAWDMRYYMNQVEETRYSVDQNLLKEYFPMQVVTQGLLSIYQELLGLTFDLEEGATVWHEDVKLYSVRDSASGRVIGKFYLDLYPREGKYGHAACFGLQPGCLRQDGSRQIAIAAM VANFTKPTPDAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEKEPLLRMSQHYRTGSAIPQELLEKLIKSRQANTGLFNLRQIVLAKVDQALHTQTAADPAEEY ARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGILNGKQVGMDYRRCILRPGGSQDASVMLKLFLGRDPKQDAFLLSKGLQVDSSEPPAC hide sequence

Ensembl Acc Id:

ENSCAFP00000028637 ⟸ ENSCAFT00000030803

RefSeq Acc Id:	XP_038360669 ⟸ XM_038504741
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038487933 ⟸ XM_038632005
- Peptide Label:	isoform X2

Protein Domains

Peptidase M3A/M3B catalytic

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000019378	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030008050	UniProtKB/TrEMBL
	ENSCAFG00040010209	UniProtKB/TrEMBL
	ENSCAFG00845011294	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000030803.5	UniProtKB/TrEMBL
	ENSCAFT00000101092.1	UniProtKB/TrEMBL
	ENSCAFT00030014897.1	UniProtKB/TrEMBL
	ENSCAFT00040018904.1	UniProtKB/TrEMBL
	ENSCAFT00845020033	ENTREZGENE
	ENSCAFT00845020033.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.1370.10	UniProtKB/TrEMBL
	3.40.390.10	UniProtKB/TrEMBL
	Endopeptidase. Chain P, domain 1	UniProtKB/TrEMBL
InterPro	MetalloPept_cat_dom_sf	UniProtKB/TrEMBL
	Neurolysin/TOP_dom2	UniProtKB/TrEMBL
	Neurolysin/TOP_N	UniProtKB/TrEMBL
	Pept_M3A_M3B	UniProtKB/TrEMBL
	Pept_M3A_M3B	UniProtKB/TrEMBL
NCBI Gene	THOP1	ENTREZGENE
PANTHER	PTHR11804	UniProtKB/TrEMBL
	THIMET OLIGOPEPTIDASE	UniProtKB/TrEMBL
Pfam	Peptidase_M3	UniProtKB/TrEMBL
Superfamily-SCOP	Metalloproteases ('zincins'), catalytic domain	UniProtKB/TrEMBL
UniProt	A0A8C0L3C3	ENTREZGENE
	A0A8C0MK53	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0S6C7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3N7K6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0TLA1_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:47353	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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Imported Disease Annotations - ClinVar